Long-term effects of hyaluronan on experimental osteoarthritis in the rabbit knee

AbstractObjective: Long-term assessment of the effect of hyaluronan (HA) on the articular cartilage and synovium in an animal knee joint during the development of osteoarthritis (OA).Design: Sixty mature New Zealand white rabbits underwent unilateral anterior cruciate ligament transection (ACLT) and were divided into two groups. Group 1 (SA) received intra-articular injections of 0.3 ml hyaluronan (HA) (i.e., ARTZ, MW: 8×105) beginning 4 weeks after ACLT, once a week for 5 weeks. Group 2 (SV) received injections of the vehicle (phosphate buffered saline) in the same fashion as with the SA group. The contralateral nonoperated knee served as control. All animals were killed 21 weeks after surgery and their knee joints evaluated by gross morphologic, histologic, histomorphometric and biochemical analyses.Results: Gross morphological inspection indicated that the femoral condyles from the knees injected with vehicle suffered more severe cartilage damage than cartilage from the knees injected with HA. Furthermore, two out of three histomorphometric parameters measured in the HA-treated cartilage (i.e., cartilage thickness and cartilage area which were not statistically different than control) provided evidence showing a protective effect of HA on the femoral condyles following ACLT. Biochemical analysis showed articular cartilage remaining on the femoral condyles following ACLT to have similar characteristics to contralateral controls. However, DNA concentration in the synovium from the ACLT knees of the vehicle-treated animals was greater than contralateral control, while this parameter was not statistically different than contralateral control in the HA treated animals.Conclusions: These results demonstrate a protective effect of HA on preservation of the articulating surface of the femoral condyle following ACLT up to 21 weeks post-surgery

Adsorption behavior of natural anthocyanin dye on mesoporous silica

NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Physics and Chemistry of Solids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document.Changes may have been made to this work since it was submitted for publication.A definitive version was subsequently published in Journal of Physics and Chemistry of Solids, VOL75, ISSUE1, 28 August 2013. DOI10.1016/j.jpcs.2013.08.007autho

The change of range of motion in junior high school baseball players

経年的な可動域の変化と障害の状況を知る目的で,野球肘検診を実施した.対象は軟式野球部1年生63名とし,肩・肘関節の疼痛の有無を質問し,可動域測定を行った.3年生時も52名を対象として検診を実施し,入学時と比較・検討した.結果,3年生時では肩・肘関節に疼痛を訴える選手が増加していた.肩関節外旋・内旋(2nd)および股関節内旋可動域は有意に減少したが,頚部回旋は有意に増加していた.The purpose of this study was to investigate the change of range of motion in junior high school baseball players. The subjects were 63 new junior high school baseball players belonging to school baseball team. Physical examinations were performed by physical therapists. In the third-year student, 52 players were checked as well. There were statistically less in the third-year student in average external and internal rotation with the arm in 90 degrees of abduction, internal rotation of the hip joint. Average neck rotation was statistically greater in the third-year student.原著(Original investigation