730 research outputs found
Dynamical entropy of generalized quantum Markov chains on gauge invariant -algebras
We prove that the mean entropy and the dynamical entropy are equal for
generalized quantum Markov chains on gauge-invariant -algebras.Comment: 8 page
Dynamic characteristics of flow meters for fuel consumption measurement in ships
The dynamic characteristics of various flow meters for fuel
consumption measurement aboard shipswere evaluated. The
flow rate was measured using the Korea Research Institute of
Standards and Science (KRISS) oil flow standard system using
K-oil(density : 0.804 g/cm3, viscosity : 3.679 cSt), which has
similar fluid properties as diesel oil. The flow meters were tested
in a test bed that simulated the vibration conditions in ships. The
vibration conditions were established in accordance to vibration
standard IEC 60068-2-6 as follows: a±0.7g acceleration and 30
Hz frequency. The K-factors (mL/pulse) of various flow meters
(PD meter, turbine flow meter, Coriolis flow meter, and
ultrasonic flow meter) were obtained for various flow rates (60
L/h ~ 300 L/h). The PD meter, Coriolis flow meter, and
ultrasonic flow meter were found to have almost constant Kfactors
according to the flow rates. However, the K-factor of the
turbine flow meter was reduced at a low flow rate owing to
bearing friction in the turbine blade. The flow rate errors of the
PD meter, Coriolis flow meter, and ultrasonic flow meter were
found to be under ±0.5 % with and without vibration. However,
the flow rate error of the turbine flow meter was approximately
-4.3 % at a low flow rate (60 L/h) owing to the friction effect.
The Coriolis flow meter had the lowest flow rate error (< 0.1%)
according to the flow rate. The vibration influenced the flow rate
error of the Coriolis flow meter at high flow rates owing to its
measuring principle. However, the difference in flow rate errors
was a negligible value (0.05 %) with and without vibration.
Therefore, we confirmed that the PD meter, turbine meter,
Coriolis flow meter and ultrasonic flow meter could be used for
measuring flow rates in ships with a ±0.5 % flow rate error.Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .International centre for heat and mass transfer.American society of thermal and fluids engineers
Enhanced production of tropane alkaloids in transgenic Scopolia parviflora hairy root cultures over-expressing putrescine N-methyl transferase (PMT) and hyoscyamine-6ÎČ-hydroxylase (H6H)
Scopolia parviflora adventitious roots were metabolically engineered by co-expression of the two gene putrescine N-methyl transferase (PMT) and hyoscyamine-6ÎČ-hydroxylase (H6H) cDNAs with the aid of Agrobacterium rhizogenes. The transformed roots developed into morphologically distinct S. parviflora PMT1 (SpPMT1), S. parviflora PMT1 (SpPMT2), and S. parviflora H6H (SpH6H) transgenic hairy root lines. Consequent to the introduction of these key enzyme genes, the production of the alkaloids hyoscyamine and scopolamine was enhanced. Among the transgenic hairy root lines, SpPMT2 line possessed the highest growth index. The treatment of transgenic hairy roots with growth regulators further enhanced the production of scopolamine. Thus, the results suggest that PMT1, PMT2, and H6H genes may not only be involved in the metabolic regulation of alkaloid production but also that these genes may play a role in the root development
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (T(FH)) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of T(FH) cells and GC responses in a T-cell-intrinsic manner. ETV5 expression is derepressed in Cic null T(FH) cells and knockdown of Etv5 suppresses the enhanced T(FH) cell differentiation in Cic-deficient CD4+ T cells, suggesting that Etv5 is a critical CIC target gene in T(FH) cell differentiation. Furthermore, we identify Maf as a downstream target of the CIC-ETV5 axis in this process. These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates T(FH) cell development and autoimmunity. ? The Author(s) 2017.117Nsciescopu
Gemcitabine-Based Neoadjuvant Treatment in Borderline Resectable Pancreatic Ductal Adenocarcinoma: A Meta-Analysis of Individual Patient Data
Background: Non-randomized studies have investigated multi-agent gemcitabinebased neo-adjuvant therapies (GEM-NAT) in borderline resectable pancreatic
ductal adenocarcinoma (BR-PDAC). Treatment sequencing and specific elements
of neoadjuvant treatment are still under investigation. The present meta-analysis aims to
assess the effectiveness of GEM-NAT on overall survival (OS) in BR-PDAC.
Patients and Methods: A meta-analysis of individual participant data (IPD) on GEMNAT for BR-PDAC were performed. The primary outcome was OS after treatment with
GEM-based chemotherapy. In the Individual Patient Data analysis data were reappraised
and confirmed as BR-PDAC on provided radiological data.
Results: Six studies investigating GEM-NAT were included in the IPD metanalysis.
The IPD metanalysis was conducted on 271 patients who received GEM-NAT.
Pooled median patient-level OS was 22.2 months (95%CI 19.1â25.2). R0 rates
ranged between 81 and 95% (I
2 = 0%, p = 0.64), respectively. Median OS was
27.8 months (95%CI 23.9â31.6) in the patients who received NAT-GEM followed
by resection compared to 15.4 months (95%CI 12.3â18.4) for NAT-GEM without
resection and 13.0 months (95%CI 7.4â18.5) in the group of patients who received
upfront surgery (p < 0.0001). R0 rates ranged between 81 and 95% (I
2 = 0%,
p = 0.64), respectively. Overall survival in the R0 group was 29.3 months (95%
CI 24.3â34.2) vs. 16.2 months (95% CI 7·9â24.5) in the R1 group (p = 0·001). Conclusions: The present study is the first meta-analysis combining IPD from a
number of international centers with BR-PDAC in a cohort that underwent multi-agent
gemcitabine neoadjuvant therapy (GEM-NAT) before surgery. GEM-NAT followed by
surgical resection improve sur
DeepTetrad: high-throughput image analysis of meiotic tetrads by deep learning in Arabidopsis thaliana
Meiotic crossovers facilitate chromosome segregation and create new combinations of alleles in gametes. Crossover frequency varies along chromosomes and crossover interference limits the coincidence of closely spaced crossovers. Crossovers can be measured by observing the inheritance of linked transgenes expressing different colors of fluorescent protein in Arabidopsis pollen tetrads. Here we establish DeepTetrad, a deep learning-based image recognition package for pollen tetrad analysis that enables high-throughput measurements of crossover frequency and interference in individual plants. DeepTetrad will accelerate the genetic dissection of mechanisms that control meiotic recombination
Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV
We report the results of a study of color coherence effects in ppbar
collisions based on data collected by the D0 detector during the 1994-1995 run
of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8
TeV. Initial-to-final state color interference effects are studied by examining
particle distribution patterns in events with a W boson and at least one jet.
The data are compared to Monte Carlo simulations with different color coherence
implementations and to an analytic modified-leading-logarithm perturbative
calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters
Measurement of the p-pbar -> Wgamma + X cross section at sqrt(s) = 1.96 TeV and WWgamma anomalous coupling limits
The WWgamma triple gauge boson coupling parameters are studied using p-pbar
-> l nu gamma + X (l = e,mu) events at sqrt(s) = 1.96 TeV. The data were
collected with the DO detector from an integrated luminosity of 162 pb^{-1}
delivered by the Fermilab Tevatron Collider. The cross section times branching
fraction for p-pbar -> W(gamma) + X -> l nu gamma + X with E_T^{gamma} > 8 GeV
and Delta R_{l gamma} > 0.7 is 14.8 +/- 1.6 (stat) +/- 1.0 (syst) +/- 1.0 (lum)
pb. The one-dimensional 95% confidence level limits on anomalous couplings are
-0.88 < Delta kappa_{gamma} < 0.96 and -0.20 < lambda_{gamma} < 0.20.Comment: Submitted to Phys. Rev. D Rapid Communication
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events
We present a measurement of the top quark pair ttbar production cross section
in ppbar collisions at a center-of-mass energy of 1.96 TeV using 230 pb**{-1}
of data collected by the DO detector at the Fermilab Tevatron Collider. We
select events with one charged lepton (electron or muon), large missing
transverse energy, and at least four jets, and extract the ttbar content of the
sample based on the kinematic characteristics of the events. For a top quark
mass of 175 GeV, we measure sigma(ttbar) = 6.7 {+1.4-1.3} (stat) {+1.6- 1.1}
(syst) +/-0.4 (lumi) pb, in good agreement with the standard model prediction.Comment: submitted to Phys.Rev.Let
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Lepton + Jets Events with Lifetime b-tagging
We present a measurement of the top quark pair () production cross
section () in collisions at TeV
using 230 pb of data collected by the D0 experiment at the Fermilab
Tevatron Collider. We select events with one charged lepton (electron or muon),
missing transverse energy, and jets in the final state. We employ
lifetime-based b-jet identification techniques to further enhance the
purity of the selected sample. For a top quark mass of 175 GeV, we
measure pb, in
agreement with the standard model expectation.Comment: 7 pages, 2 figures, 3 tables Submitted to Phys.Rev.Let
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