Importance of Stress Factor in Prameha

Prameha is burning problems of the decade. According to the latest data from World Health Organization, a Global estimate of 422 million adults is living with Prameha. It belongs to the category of chronic Non-Communicable Diseases (NCD) Prameha more specifically Madhumeha can be correlated to the features of Diabetes mellitus. Considering the etiology of Diabetes mellitus, Stress has been found to have a prime place. It not only acts as an etiological factor but also as a triggering factor. Today stress has become an inevitable part of modern life. In today’s materialistic world, there is unhealthy competition in every field and man is compelled to act like a machine. This deteriorates the equilibrium of mind and the person comes under the influence of stress

Perspective and Prospects of Wire Electric Discharge Machining (WEDM)

Wire Electric Discharge Machining (WEDM) is a non-traditional machining method that is widely used in the manufacture of aerospace/aircraft and medical equipment for conductive materials. WEDM products are expected to have good dimensional accuracy, surface roughness, and geometry. Many researchers have done experiments on various materials to optimize the process, which has many parameters and response characteristics. This paper provides an overview of the WEDM process on alloy steels in order to understand the impact of input process variables on output responses and optimization techniques for selecting optimal process parameters. This paper also highlights WEDM process trends as well as workpiece materials, wire varieties, wire diameters, and optimization approaches. This work is expected to be useful in initiating further research on WEDM by documenting substantial research works confirming the latest scenario

A four stranded β-sheet structure in a designed, synthetic polypeptide

A designed four stranded β-sheet peptide has been constructed using three internal D-proline residues to nucleate β -hairpin formation

Perspective and Prospects of Wire Electric Discharge Machining (WEDM)

Wire Electric Discharge Machining (WEDM) is a non-traditional machining method that is widely used in the manufacture of aerospace/aircraft and medical equipment for conductive materials. WEDM products are expected to have good dimensional accuracy, surface roughness, and geometry. Many researchers have done experiments on various materials to optimize the process, which has many parameters and response characteristics. This paper provides an overview of the WEDM process on alloy steels in order to understand the impact of input process variables on output responses and optimization techniques for selecting optimal process parameters. This paper also highlights WEDM process trends as well as workpiece materials, wire varieties, wire diameters, and optimization approaches. This work is expected to be useful in initiating further research on WEDM by documenting substantial research works confirming the latest scenario

Study of multi-objective optimization and its implementation using NSGA-II

This project investigates the Multi-objective optimization strategies and their solutions using Multi-objective evolutionary algorithms (MOEAs). Multi-objective evolutionary algorithms (MOEAs) that use non-dominated sorting and sharing are criticized mainly for their; a) computational complexity, b) lack of elitism, c) need for specifying sharing parameter. In this paper the Non- Dominated Sorting Genetic Algorithm (NSGA) is studied and NSGA-II as proposed by Deb et. al. has been implemented, which alleviates the above three difficulties. In this study different objectives have been considered with different variables and constraints. The algorithm yielded satisfactory simulation results in all the different cases. The effect of the genetic parameters on the Pareto-Optimal front in all the cases has been studied. The results show that NSGA-II find much better spread of solutions and better convergence near the true pareto optimal front compared to other elitist MOEAs

Impacts of vehicle exhaust black soot on germination of gram seed (Cicer arietinum L.)

An investigation was initiated to examine the effects of carbon soot collected from exhaust tube of 15 years old petrol and diesel operated vehicles on gram seed germination and biochemical changes of seedling. In view of the widespread cultivation of gram seed in India and long-term impact of black carbon is the warming of the atmosphere as per the recommendation of IPCC (2007). Black soot were separately treated with different doses and the effects of these treatment had on seed germination, seedling vigor, chlorophyll and carotenoid content, root and shoot growth, protein, sugar, phenol and proline estimation were studied. The treatment T6 significantly affected on seed germination (84%) as well as seedling vigor and chlorophyll content. But other treatment promoted both seed germination and seedling vigor along with enhancement of other biochemical constituents. On the other hand micrograph study revealed that treatments T1 and T4 both showed negative effects on stomata rather than the ultra-structure of xylem and phloem

Nutritional composition of small indigenous species of fishes of Northeast India: A systematic review

Northeast India has various water bodies including the tributaries of the Brahmaputra and Barak river systems, wetlands, lakesand beels. These water bodies support the diversity of many fish species. Seasonal changes in the number of fish species inthe SIS category were also observed and they are most abundant during the winter and least abundant during the monsoonseason. Many researchers collected fish data from Assam's rivers and wetlands, particularly small indigenous species (SIS).Small Indigenous Species (SIS) of fish are a vital and conveniently accessible source of rare protein, vitamins, and minerals intraditional diets. The present study aimed to review Assam's small indigenous fish species and their nutritional worth. Thesources of the review article were Google Scholar, Web of Science, ScienceDirect, and PubMed for SIS nutrition composition,fish nutritional profile, and fish proximate composition. Northeast India’s rural inhabitants get their sustenance from fish SIS. TheSIS of Northeast India fish species contain proteins, lipids, vitamins, minerals, and vital macro- and micronutrients. The proteincontent of SIS range from 12.49% to 18.30% (12.49–18.30g/100 g), lipid content from 0.7% to 19.63% (0.7–19.63g/100 g),moisture content from 65.88% to 82.8% (65.88–82.8g/100 g), and ash level from 2% to 6.8% (2–6.8g/100 g). This review suggests SIS has adequate nutritional benefits because it is an excellent source of proteins, lipids, vitamins, minerals, and omega-3 fatty acids necessary for optimal health. Northeast India’s impoverished region might achieve their nutritional demands by eating more SIS of fish

Structural analysis of peptide helices containing centrally positioned lactic acid residues

The effect of insertion of lactic acid (Lac) residues into peptide helices has been probed using specifically designed sequences. The crystal structures of 11-residue and 14-residue depsipeptides Boc-Val-Val-Ala-Leu-Val-Lac-Leu-Aib-Val-Ala-Leu-OMe (1) and Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-Val-Lac-Leu-Aib-Val-Ala-Leu-OMe (3), containing centrally positioned Lac residues, have been determined. The structure of an 11-residue peptide Boc-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-OMe (2), analog of a which is an amide previously determined Lac-containing depsipeptide, Boc-Val-Ala-Leu-Aib-Val-Lac-Leu-Aib-Val-Ala-Leu-OMe I. L. Karle, C. Das, and P. Balaram, Biopolymers, Vol. 59, (2001) pp. 276-289], is also reported. Peptide 1 adopts a helical fold, which is stabilized by mixture of 4→1 and 5→1 hydrogen bonds. Peptide 2 adopts a completely α-helical conformation stabilized by eight successive 5→1 hydrogen bonds. Peptide 3 appears to be predominately α-helical, with seven 5→1 hydrogen bonds and three 4→1 interaction interspersed in the sequence. In the structure of peptide 3 in addition to water molecules in the head-to-tail region, hydration at an internal segment of the helix is also observed. A comparison of five related peptide helices, containing a single Lac residue, reveals that the hydroxy acid can be comfortably accommodated at interior positions in the helix, with the closest C=O...O distances lying between 2.8 and 3.3 Å

Outcome of Eclamptic Mothers Attending Tertiary Care Centre from Home and those Referred from Primary Heath Care Site

Introduction: Magnesium sulphate (MgSO4) is an effective and safe drug which stabilizes the patient within few hours of eclampsia and terminates subsequent seizures if it is given on time. The aim of this study was to compare maternal and fetal outcome between a group of eclamptic mothers who came to the tertiary care hospital directly without receiving MgSO4 (Group 1) and those referred from primary care centers after receiving loading dose of MgSO4 (Group 2). Methods: This is a retrospective cohort study of eclamptic mothers who were admitted and managed from the period of 1st January 2012 to 31st March 2016 at Nepalgunj Medical College Teaching Hospital, Nepal. Sociodemographic characters and maternal and fetal outcome was compared between the two groups. Results: Among 92 cases, 57 (62%) were from Group 1 and 35 (38%) were from Group 2. Most of the mothers attended from Banke district (n=52, 56.5%) followed by Bardia district (n=17, 18.5%). Brahmin and Chhetri were 20 (35%) and 10 (29%); Muslim 16 (28%) and 4(11%); Janajati from Terai 16 (28%) and 8 (23%); Janajati from hilly region 4 (7%) and 5 (14%); and Chaudhari 1 (2%) and 8 (23%) in Group 1 and Group 2 respectively.  More (n=26, 74%) mothers had baby with good Apgar score in Group 2 than in Group 1 (n=33, 58%). There were 14 (15.2%) still births; 9 (16%) in Group 1 and 5 (14%) in Group 2. Complication rate was observed more in Group 1 (n=16, 28%) than in Group 2 (n=7, 20%) and the most common complication in both groups was wound infection. The mean days of hospital stay was 5.96 (SD=3.32) and 5.91 (SD=3.38) in Group 1 and Group 2 respectively. Conclusion: The group receiving magnesium sulphate in primary care centre have good fetal outcome and less maternal complications compared to those who were admitted directly in tertiary care centre and receive the treatment there