The NASA CYGNSS SmallSat Constellation

The NASA Cyclone Global Navigation Satellite System (CYGNSS) is a constellation of eight microsatellites in low earth orbit at ~525 km altitude and 35 deg inclination. CYGNSS was launched in December 2016 for a planned 2 year mission and 7 of the 8 spacecraft continue to operatue nominally as of May 2023. Each microsatellites carries a bistatic radar receiver to measure reflected GPS signals from the Earth surface. The measurements can be converted to surface wind speed and latent and sensible heat flux over the ocean, and to surface soil moisture and wetland extent over land. Measurements penetrate through all levels of precipitation as well as moderate to heavy vegetation due to the low microwave frequency used by GPS. The number of satellites in the constellation results in sub-daily refresh rates which supports imaging of short time scale weather events such as hurricane rapid intensification, flood inundation dynamics, and sudden soil saturation after major rain events. CYGNSS satellites uses a single string design architecture to reduce the complexity and recurring cost of each unit. Mission redundancy is obtained at the constellation level. Data products are produced by combining measurements from all satellites in such a way that the sampling requirements can be met using only a subset of the satellites. Constellation-level redundancy also permits individual satellites to be switched from their nominal science data taking mode to various engineering test and calibration modes while the overall mission is still able to meet its science requirements

Description of the UCAR/CU Soil Moisture Product

Currently, the ability to use remotely sensed soil moisture to investigate linkages between the water and energy cycles and for use in data assimilation studies is limited to passive microwave data whose temporal revisit time is 2&ndash;3 days or active microwave products with a much longer (&gt;10 days) revisit time. This paper describes a dataset that provides soil moisture retrievals, which are gridded to 36 km, for the upper 5 cm of the soil surface at sparsely sampled 6-hour intervals for +/&minus; 38 degrees latitude for 2017&ndash;present. Retrievals are derived from the Cyclone Global Navigation Satellite System (CYGNSS) constellation, which uses GNSS-Reflectometry to obtain L-band reflectivity observations over the Earth&rsquo;s surface. The product was developed by calibrating CYGNSS reflectivity observations to soil moisture retrievals from NASA&rsquo;s Soil Moisture Active Passive (SMAP) mission. Retrievals were validated against observations from 171 in-situ soil moisture probes, with a median unbiased root-mean-square error (ubRMSE) of 0.049 cm3 cm&minus;3 (standard deviation = 0.026 cm3 cm&minus;3) and median correlation coefficient of 0.4 (standard deviation = 0.27). For the same stations, the median ubRMSE between SMAP and in-situ observations was 0.045 cm3 cm&minus;3 (standard deviation = 0.025 cm3 cm&minus;3) and median correlation coefficient was 0.69 (standard deviation = 0.27). The UCAR/CU Soil Moisture Product is thus complementary to SMAP, albeit with a larger random noise component, providing soil moisture retrievals for applications that require faster revisit times than passive microwave remote sensing currently provides.</p

CYGNSS data map flood inundation during the 2017 Atlantic hurricane season.

The 2017 Atlantic Hurricane Season was one of the most active and destructive on record, leading to significant flooding in many parts of the United States and the Caribbean. During flooding events such as these, there is an urgent need to quickly map in detail which areas have been severely affected, yet current satellite missions are not capable of sampling the global land surface at high enough spatio-temporal scales for flooding applications. Here, we demonstrate a novel approach to high-resolution flood mapping by repurposing data from the new NASA mission, CYGNSS. The CYGNSS multi-satellite constellation was designed for frequent temporal sampling of the ocean surface in the tropics. We demonstrate that CYGNSS data provide clear signals of surface saturation and inundation extent over land at higher spatio-temporal resolution than radiometers like SMAP. Using a simple thresholding technique, we are able to estimate that approximately 32,580 km2 of land area in Texas flooded during Hurricane Harvey, and approximately 7210 km2 of land area flooded in Cuba during Hurricane Irma, or about 7% of Cuba's total area.</p

Germline and somatic imprinting in the nonhuman primate highlights species differences in oocyte methylation.

Genomic imprinting is an epigenetic mechanism resulting in parental allele-specific gene expression. Defects in normal imprinting are found in cancer, assisted reproductive technologies, and several human syndromes. In mouse models, germline-derived DNA methylation is shown to regulate imprinting. Though imprinting is largely conserved between mammals, species- and tissue-specific domains of imprinted expression exist. Using the cynomolgus macaque (Macaca fascicularis) to assess primate-specific imprinting, we present a comprehensive view of tissue-specific imprinted expression and DNA methylation at established imprinted gene clusters. For example, like mouse and unlike human, macaque IGF2R is consistently imprinted, and the PLAGL1, INPP5F transcript variant 2, and PEG3 imprinting control regions are not methylated in the macaque germline but acquire this post-fertilization. Methylome data from human early embryos appear to support this finding. These suggest fundamental differences in imprinting control mechanisms between primate species and rodents at some imprinted domains, with implications for our understanding of the epigenetic programming process in humans and its influence on disease.This study was conducted by all authors while at the Singapore Institute for Clinical Research and was fully supported by funding from the Agency for Science, Technology and Research, Singapore.This is the author accepted manuscript. The final version is available from Cold Spring Harbor Laboratory Press at http://genome.cshlp.org/content/early/2015/04/10/gr.183301.114.abstract

The NASA Cyclone Global Navigation Satellite System SmallSat Constellation

The NASA Cyclone Global Navigation Satellite System (CYGNSS) mission consists of a constellation of eight microsatellites launched on 15 December 2016 into a common circular orbit at ~525 km altitude and 35 deg inclination. Each observatory carries a four channel bistatic radar receiver to measure GPS signals scattered by the Earth surface. Over ocean, near-surface wind speed, air-sea latent and sensible heat flux, and ocean microplastic concentration are derived from the measurements. Over land, near-surface soil moisture and inland water bodies extent are derived. The measurements penetrate through all levels of precipitation and most vegetation due to the 19 cm wavelength of GPS L1 signals. The sampling produced by the constellation makes possible the reliable detection of short time scale weather events such as flood inundation dynamics immediately after a tropical cyclone landfall and rapid soil moisture dry down immediately after major precipitation events. The sun-asynchronous nature of the CYGNSS orbit also supports full sampling of the diurnal cycle of hydrological dynamics within a short period of time. Summaries are presented of engineering and science highlights of the CYGNSS mission, with particular emphasis on those aspects most directly enabled by the use of a constellation of SmallSats

A deep learning framework for the detection and quantification of drusen and reticular pseudodrusen on optical coherence tomography

Purpose - To develop and validate a deep learning (DL) framework for the detection and quantification of drusen and reticular pseudodrusen (RPD) on optical coherence tomography scans. Design - Development and validation of deep learning models for classification and feature segmentation. Methods - A DL framework was developed consisting of a classification model and an out-of-distribution (OOD) detection model for the identification of ungradable scans; a classification model to identify scans with drusen or RPD; and an image segmentation model to independently segment lesions as RPD or drusen. Data were obtained from 1284 participants in the UK Biobank (UKBB) with a self-reported diagnosis of age-related macular degeneration (AMD) and 250 UKBB controls. Drusen and RPD were manually delineated by five retina specialists. The main outcome measures were sensitivity, specificity, area under the ROC curve (AUC), kappa, accuracy and intraclass correlation coefficient (ICC). Results - The classification models performed strongly at their respective tasks (0.95, 0.93, and 0.99 AUC, respectively, for the ungradable scans classifier, the OOD model, and the drusen and RPD classification model). The mean ICC for drusen and RPD area vs. graders was 0.74 and 0.61, respectively, compared with 0.69 and 0.68 for intergrader agreement. FROC curves showed that the model's sensitivity was close to human performance. Conclusions - The models achieved high classification and segmentation performance, similar to human performance. Application of this robust framework will further our understanding of RPD as a separate entity from drusen in both research and clinical settings.Comment: 26 pages, 7 figure

Predictors of loss to follow up among patients with type 2 diabetes mellitus attending a private not for profit urban diabetes clinic in Uganda : a descriptive retrospective study

BACKGROUND: Although the prevalence of type 2 diabetes mellitus is increasing in Uganda, data on loss to follow up (LTFU) of patients in care is scanty. We aimed to estimate proportions of patients LTFU and document associated factors among patients attending a private not for profit urban diabetes clinic in Uganda. METHODS: We conducted a descriptive retrospective study between March and May 2017. We reviewed 1818 out-patient medical records of adults diagnosed with type 2 diabetes mellitus registered between July 2003 and September 2016 at St. Francis Hospital - Nsambya Diabetes clinic in Uganda. Data was extracted on: patients' registration dates, demographics, socioeconomic status, smoking, glycaemic control, type of treatment, diabetes mellitus complications and last follow-up clinic visit. LTFU was defined as missing collecting medication for six months or more from the date of last clinic visit, excluding situations of death or referral to another clinic. We used Kaplan-Meier technique to estimate time to defaulting medical care after initial registration, log-rank test to test the significance of observed differences between groups. Cox proportional hazards regression model was used to determine predictors of patients' LTFU rates in hazard ratios (HRs). RESULTS: Between July 2003 and September 2016, one thousand eight hundred eighteen patients with type 2 diabetes mellitus were followed for 4847.1 person-years. Majority of patients were female 1066/1818 (59%) and 1317/1818 (72%) had poor glycaemic control. Over the 13 years, 1690/1818 (93%) patients were LTFU, giving a LTFU rate of 34.9 patients per 100 person-years (95%CI: 33.2-36.6). LTFU was significantly higher among males, younger patients (< 45 years), smokers, patients on dual therapy, lower socioeconomic status, and those with diabetes complications like neuropathy and nephropathy. CONCLUSION: We found high proportions of patients LTFU in this diabetes clinic which warrants intervention studies targeting the identified risk factors and strengthening follow up of patients

Germline MBD4-deficiency causes a multi-tumor predisposition syndrome

We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic loss-of-function germline variants in the base excision repair (BER) gene MBD4. We identified five individuals with bi-allelic MBD4 variants within four families and these individuals had a personal and/or family history of adenomatous colorectal polyposis, acute myeloid leukemia, and uveal melanoma. MBD4 encodes a glycosylase involved in repair of G:T mismatches resulting from deamination of 5′-methylcytosine. The colorectal adenomas from MBD4-deficient individuals showed a mutator phenotype attributable to mutational signature SBS1, consistent with the function of MBD4. MBD4-deficient polyps harbored somatic mutations in similar driver genes to sporadic colorectal tumors, although AMER1 mutations were more common and KRAS mutations less frequent. Our findings expand the role of BER deficiencies in tumor predisposition. Inclusion of MBD4 in genetic testing for polyposis and multi-tumor phenotypes is warranted to improve disease management

2020 Asian Pacific Society of Cardiology Consensus Recommendations on Antithrombotic Management for High-risk Chronic Coronary Syndrome

The unique characteristics of patients with chronic coronary syndrome (CCS) in the Asia-Pacific region, heterogeneous approaches because of differences in accesses and resources and low number of patients from the Asia-Pacific region in pivotal studies, mean that international guidelines cannot be routinely applied to these populations. The Asian Pacific Society of Cardiology developed these consensus recommendations to summarise current evidence on the management of CCS and provide recommendations to assist clinicians treat patients from the region. The consensus recommendations were developed by an expert consensus panel who reviewed and appraised the available literature, with focus on data from patients in Asia-Pacific. Consensus statements were developed then put to an online vote. The resulting recommendations provide guidance on the assessment and management of bleeding and ischaemic risks in Asian CCS patients. Furthermore, the selection of long-term antithrombotic therapy is discussed, including the role of single antiplatelet therapy, dual antiplatelet therapy and dual pathway inhibition therapy

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049