2,212 research outputs found
A new family of S-folds in type IIB string theory
We construct infinite new classes of solutions of
type IIB string theory which have non-trivial monodromy
along the direction. The solutions are supersymmetric and holographically
dual, generically, to SCFTs in . The solutions are first
constructed as solutions in gauged
supergravity and then uplifted to . The solutions all arise as limiting
cases of Janus solutions of , SYM theory which are
supported both by a different value of the coupling constant on either side of
the interface, as well as by fermion and boson mass deformations. As special
cases, the construction recovers three known S-fold constructions, which
preserve and 4 supersymmetry, as well as a recently
constructed solution (not
S-folded). We also present some novel "one-sided Janus" solutions that are
non-singular.Comment: 54 pages, 13 figure
Tetraquark operators in lattice QCD and exotic flavour states in the charm sector
We present a general class of operators resembling compact tetraquarks which
have a range of colour-flavour-spin structures, transform irreducibly under the
symmetries of the lattice and respect other relevant symmetries. These
constructions are demonstrated in lattice QCD calculations with light quarks
corresponding to 391 MeV. Using the distillation framework,
correlation functions involving large bases of meson-meson and tetraquark
operators are computed in the isospin-1 hidden-charm and doubly-charmed
sectors, and finite-volume spectra are extracted with the variational method.
We find the spectra are insensitive to the addition of tetraquark operators to
the bases of meson-meson operators. For the first time, through using diverse
bases of meson-meson operators, the multiple energy levels associated with
meson-meson levels which would be degenerate in the non-interacting limit are
extracted reliably. The number of energy levels in each spectrum is found to be
equal to the number of expected non-interacting meson-meson levels in the
energy region considered and the majority of energies lie close to the
non-interacting levels. Therefore, there is no strong indication for any bound
state or narrow resonance in the channels we study
A newly-developed community microarray resource for transcriptome profiling in Brassica species enables the confirmation of Brassica-specific expressed sequences
<p>Abstract</p> <p>Background</p> <p>The <it>Brassica </it>species include an important group of crops and provide opportunities for studying the evolutionary consequences of polyploidy. They are related to <it>Arabidopsis thaliana</it>, for which the first complete plant genome sequence was obtained and their genomes show extensive, although imperfect, conserved synteny with that of <it>A. thaliana</it>. A large number of EST sequences, derived from a range of different <it>Brassica </it>species, are available in the public database, but no public microarray resource has so far been developed for these species.</p> <p>Results</p> <p>We assembled unigenes using ~800,000 EST sequences, mainly from three species: <it>B. napus</it>, <it>B. rapa </it>and <it>B. oleracea</it>. The assembly was conducted with the aim of co-assembling ESTs of orthologous genes (including homoeologous pairs of genes in <it>B. napus </it>from each of the A and C genomes), but resolving assemblies of paralogous, or paleo-homoeologous, genes (<it>i.e</it>. the genes related by the ancestral genome triplication observed in diploid <it>Brassica </it>species). 90,864 unique sequence assemblies were developed. These were incorporated into the BAC sequence annotation for the <it>Brassica rapa </it>Genome Sequencing Project, enabling the identification of cognate genomic sequences for a proportion of them. A 60-mer oligo microarray comprising 94,558 probes was developed using the unigene sequences. Gene expression was analysed in reciprocal resynthesised <it>B. napus </it>lines and the <it>B. oleracea </it>and <it>B. rapa </it>lines used to produce them. The analysis showed that significant expression could consistently be detected in leaf tissue for 35,386 unigenes. Expression was detected across all four genotypes for 27,355 unigenes, genome-specific expression patterns were observed for 7,851 unigenes and 180 unigenes displayed other classes of expression pattern. Principal component analysis (PCA) clearly resolved the individual microarray datasets for <it>B. rapa</it>, <it>B. oleracea </it>and resynthesised <it>B. napus</it>. Quantitative differences in expression were observed between the resynthesised <it>B. napus </it>lines for 98 unigenes, most of which could be classified into non-additive expression patterns, including 17 that showed cytoplasm-specific patterns. We further characterized the unigenes for which A genome-specific expression was observed and cognate genomic sequences could be identified. Ten of these unigenes were found to be <it>Brassica</it>-specific sequences, including two that originate from complex loci comprising gene clusters.</p> <p>Conclusion</p> <p>We succeeded in developing a <it>Brassica </it>community microarray resource. Although expression can be measured for the majority of unigenes across species, there were numerous probes that reported in a genome-specific manner. We anticipate that some proportion of these will represent species-specific transcripts and the remainder will be the consequence of variation of sequences within the regions represented by the array probes. Our studies demonstrated that the datasets obtained from the arrays can be used for typical analyses, including PCA and the analysis of differential expression. We have also demonstrated that <it>Brassica</it>-specific transcripts identified <it>in silico </it>in the sequence assembly of public EST database accessions are indeed reported by the array. These would not be detectable using arrays designed using <it>A. thaliana </it>sequences.</p
Consistent Factorization of Jet Observables in Exclusive Multijet Cross-Sections
We demonstrate the consistency at the next-to-leading-logarithmic (NLL) level
of a factorization theorem based on Soft-Collinear Effective Theory (SCET) for
jet shapes in e+e- collisions. We consider measuring jet observables in
exclusive multijet final states defined with cone and k_T-type jet algorithms.
Consistency of the factorization theorem requires that the renormalization
group evolution of hard, jet, and soft functions is such that the physical
cross-section is independent of the factorization scale mu. The anomalous
dimensions of the various factorized pieces, however, depend on the color
representation of jets, choice of jet observable, the number of jets whose
shapes are measured, and the jet algorithm, making it highly nontrivial to
satisfy the consistency condition. We demonstrate the intricate cancellations
between anomalous dimensions that occur at the NLL level, so that, up to power
corrections that we identify, our factorization of the jet shape distributions
is consistent for any number of quark and gluon jets, for any number of jets
whose shapes are measured or unmeasured, for any angular size R of the jets,
and for any of the algorithms we consider. Corrections to these results are
suppressed by the SCET expansion parameter lambda (the ratio of soft to
collinear or collinear to hard scales) and in the jet separation measure 1/t^2
= tan^2(R/2)/tan^2(psi/2), where psi is the angular separation between jets.
Our results can be used to calculate a wide variety of jet observables in
multijet final states to NLL accuracy.Comment: 8 pages, 1 figure, uses elsarticle.cls; v2: minor edits, added
reference
The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins in facilitating autophagy; binds to B-cell lymphoma 2, resulting in inhibition of apoptosis; attaches actin to the Z disk, providing structural support for the sarcomere; and links the α-adrenergic receptor with the L-type Ca2+ channel. When BAG3 is overexpressed in cancer cells, it facilitates prosurvival pathways that lead to insensitivity to chemotherapy, metastasis, cell migration, and invasiveness. In contrast, in the heart, mutations in BAG3 have been associated with a variety of phenotypes, including both hypertrophic/restrictive and dilated cardiomyopathy. In murine skeletal muscle and vasculature, a mutation in BAG3 leads to critical limb ischemia after femoral artery ligation. An understanding of the biology of BAG3 is relevant because it may provide a therapeutic target in patients with both cardiac and skeletal muscle disease
Implications of the Muon Anomalous Magnetic Moment for Supersymmetry
We re-examine the bounds on supersymmetric particle masses in light of the
E821 data on the muon anomalous magnetic moment. We confirm, extend and
supersede previous bounds. In particular we find (at one sigma) no lower limit
on tan(beta) or upper limit on the chargino mass implied by the data at
present, but at least 4 sparticles must be lighter than 700 to 820 GeV and at
least one sparticle must be lighter than 345 to 440 GeV. However, the E821
central value bounds tan(beta) > 4.7 and the lighter chargino mass by 690 GeV.
For tan(beta) < 10, the data indicates a high probability for direct discovery
of SUSY at Run II or III of the Tevatron.Comment: 20 pages LaTeX, 14 figures; references adde
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DK I = 0, D K ¯ I = 0, 1 scattering and the D s 0 ∗ (2317) from lattice QCD
Abstract: Elastic scattering amplitudes for I = 0 DK and I = 0, 1 DK¯ are computed in S, P and D partial waves using lattice QCD with light-quark masses corresponding to mπ = 239 MeV and mπ = 391 MeV. The S-waves contain interesting features including a near-threshold JP = 0+ bound state in I = 0 DK, corresponding to the Ds0∗(2317), with an effect that is clearly visible above threshold, and suggestions of a 0+ virtual bound state in I = 0 DK¯. The S-wave I = 1 DK¯ amplitude is found to be weakly repulsive. The computed finite-volume spectra also contain a deeply-bound D* vector resonance, but negligibly small P -wave DK interactions are observed in the energy region considered; the P and D-wave DK¯ amplitudes are also small. There is some evidence of 1+ and 2+ resonances in I = 0 DK at higher energies
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