119 research outputs found

    Promoción del empleo de las videoconferencias como elemento de potenciación de la calidad en el aprendizaje en la ETSEIAT

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    En esta comunicación se describen dos experiencias de aplicación de las videoconferencias en asignaturas de elevado contenido tecnológico, dentro de la titulación de Ingeniería Aeronáutica que se imparte en la Escuela Técnica Superior de Ingenierías Industrial y Aeronáutica de Terrassa (ETSEIAT).Postprint (published version

    Exile Vol. X No. 2

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    FICTION The Fragile Colour of Eyes by Susan Brady 6-17 The Trickster by Ed Brunner 19-26 On Passing by Sharon Haddock 32-42 POETRY Fishing with Light Tackle by Robert Hoyt 18 Poem by Sharon Haddock 27 On Insects by Robert Hoyt 28 A Chopper of Trees by Jerry Bryce 29 Nefertiti by Peggy Schmidt 31 The Gambler and the Corinthian by Robert Chester 42 Shades of Spring by Jane Cogie 43 GRAPHICS Monocut by Carol Kubie 5 Monocut by Parker Waite 18 Monocut by Doris Farrington 27 Watercolor by Kathy Koenig 31 Pen and Ink by Karen Gernenz 43 Awarded the semi-annual EXILE-Denison Bookstore Writing Prize: The Fragile Colour of Eyes by Susan Brady 6-17 Page numbers in the published table of contents are off by one. Page numbers given indicate where the works actually appear in the issue

    Portfolio Vol. II N 2

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    Browne, Phil. Beaver ad Sawyer at Night . Picture. 2. Varney, Chester. To Dream Beyond . Prose. 3. West, Bill C. Admonition Poem. 6. West, Bill C. Insomnia Poem. 6. Barlow, Don. Heart Determines . Prose. 7. Gordon, Robert. From an Unknown Innocent to... Poem, 11. Black, James. Playing Around . Prose. 13. Parsons, Edith. The Turtle Baby . Picture. 14. Deeds, Ed. Raymond Scott - - Classic Swing . Prose. 15. Schrechkengost, Viktor. Black Sheep-The Creature God Forgot . Picture. 14. Smith, Bob. Review of New Recordings . Prose. 15. Saunders, Paul. Book Reviews and Comments . Prose. 16. Browne, Phil. to Patsy . Picture. 17. Sandor, Joseph. Meditation . Picture. 18. Maxwell, Kenneth. Unnamed. Poem. 18. Sweitzer, Harry J. Social Life at Denison . Prose. 19. Flory Doris. The Student Rationalizes . Poem. 20. Flory Doris. On Noisess . Poem. 20. Bethune, Don. Senior\u27s Lament . Poem. 20. Flory, Doris. Lines on Lines . Poem. 20. Beckham, Adela. My Man . Poem. 20

    Promoción del empleo de las videoconferencias como elemento de potenciación dela calidad en el aprendizaje en la ETSEIAT

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    En esta comunicación se describen dos experiencias de aplicación de las videoconferencias en asignaturas de elevado contenido tecnológico, dentro de la titulación de Ingeniería Aeronáutica que se imparte en la Escuela Técnica Superior de Ingenierías Industrial y Aeronáutica de Terrassa (ETSEIAT).Postprint (published version

    Portfolio Vol. II N 4

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    Browne, Phil. Alumni . Picture. 2. Martindale, Virginia. A Statue By Jude . Prose. 3. Maxwell, Robert. Reflections . Poem. 6. Lewis, Lucy. Quiet Zone . Prose. 7. Varney, Chester. Tinder Box . Prose. 9. Beckham, Adela. Spring Harvest . Poem. 10. Beckham, Adela. Morning . Poem. 10. Black, James. The Drama at Denison . Prose. 11. Mackie, Reino. Landscape . Picture. 6. Flory, Doris. April Showers . Poem. 14. Flory, Doris. Aspiration . Poem. 14. Wager, Dick. Solitude . Poem. 14. Wager, Dick. Regret . Poem. 14. Bastida, Sorella y. Children on the Beach . Picture. 14. Saunders, Paul. Review of New Books . Prose. 15. Smith, Bob. Review of New Recordings . Prose. 15. Mitchell, Dave. A Farmyard . Picture. 16. Bonnet, Elsie. Hidden Village . Picture. 16. Taylor, Dave. Concerning Art . Prose. 17. Browne, Phil. Master Craftsman . Picture. 18. Deeds, Ed. Brothers, Sing On . Prose. 19. Boyd, Kate Olive. Spring at Denison . Poem. 20. Barss, William. Landscape . Picture. 20. Deane, Dorothy. The Taming of the Shrew . Prose. 21

    Clinical trial of laronidase in Hurler syndrome after hematopoietic cell transplantation.

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    BackgroundMucopolysaccharidosis I (MPS IH) is a lysosomal storage disease treated with hematopoietic cell transplantation (HCT) because it stabilizes cognitive deterioration, but is insufficient to alleviate all somatic manifestations. Intravenous laronidase improves somatic burden in attenuated MPS I. It is unknown whether laronidase can improve somatic disease following HCT in MPS IH. The objective of this study was to evaluate the effects of laronidase on somatic outcomes of patients with MPS IH previously treated with HCT.MethodsThis 2-year open-label pilot study of laronidase included ten patients (age 5-13 years) who were at least 2 years post-HCT and donor engrafted. Outcomes were assessed semi-annually and compared to historic controls.ResultsThe two youngest participants had a statistically significant improvement in growth compared to controls. Development of persistent high-titer anti-drug antibodies (ADA) was associated with poorer 6-min walk test (6MWT) performance; when patients with high ADA titers were excluded, there was a significant improvement in the 6MWT in the remaining seven patients.ConclusionsLaronidase seemed to improve growth in participants <8 years old, and 6MWT performance in participants without ADA. Given the small number of patients treated in this pilot study, additional study is needed before definitive conclusions can be made

    Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743 individuals

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    <p>Abstract</p> <p>Background</p> <p>Use of fenfluramines for weight loss has been associated with the development of characteristic plaques on cardiac valves causing regurgitation. However, previously published studies of exposure to fenfluramines have been limited by relatively small sample size, short duration of follow-up, and the lack of any estimate of the frequency of subsequent valvular surgery. We performed an observational study of 5743 users of fenfluramines examined by echocardiography between July 1997 and February 2004 in a single large cardiology clinic.</p> <p>Results</p> <p>The prevalence of at least mild aortic regurgitation (AR) or moderate mitral regurgitation (MR) was 19.6% in women and 11.8% in men (<it>p </it>< 0.0001 for gender difference). Duration of use was strongly predictive of mild or greater AR (<it>p </it>< 0.0001 for trend), MR (<it>p </it>= 0.002), and tricuspid regurgitation (TR) (<it>p </it>< 0.0001), as was earlier scan date (<it>p </it>< 0.0001 for those scanned prior to 1 January 2000 versus later). Increasing age was also independently associated with increased risk of AR and MR (both <it>p </it>< 0.0001). With mean follow-up of 30.3 months, AR worsened in 15.2%, remained the same in 63.1%, and improved in 21.7%. Corresponding values for MR were 24.8%, 47.4% and 27.9%. Pulmonary hypertension was strongly associated with MR but not AR. Valve surgery was performed on 38 patients (0.66% of 5743), 25 (0.44%) with clear evidence of fenfluramine-related etiology.</p> <p>Conclusion</p> <p>Regurgitant valvulopathy was common in individuals exposed to fenfluramines, more frequent in females, and associated with duration of use in all valves assessed. Valve surgery was performed as frequently for aortic as mitral valves and some tricuspid valve surgeries were also performed. The incidence of surgery appeared to be substantially increased compared with limited general population data.</p

    Thermoregulation and fluid balance during a 30-km march in 60-versus 80-year-old subjects

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    The presence of impaired thermoregulatory and fluid balance responses to exercise in older individuals is well established. To improve our understanding on thermoregulation and fluid balance during exercise in older individuals, we compared thermoregulatory and fluid balance responses between sexagenarians and octogenarians during prolonged exercise. Forty sexagenarians (60 ± 1 year) and 36 octogenarians (81 ± 2 year) volunteered to participate in a 30-km march at a self-selected pace. Intestinal temperature (T in) and heart rate were recorded every 5 km. Subjects reported fluid intake, while urine output was measured and sweat rate was calculated. Octogenarians demonstrated a lower baseline T in and a larger exercise-induced increase in T in compared to sexagenarians (1.2 ± 0.5 °C versus 0.7 ± 0.4 °C, p  0.05). These results suggest that thermoregulatory responses deteriorate with advancing age, while fluid balance is regulated appropriately during a 30-km walking march under moderate ambient conditions

    Skeleton of an unusual cat-sized marsupial relative (Metatheria: Marsupialiformes) from the middle Eocene (Lutetian: 44-43 million years ago) of Turkey

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    We describe a near-complete, three-dimensionally preserved skeleton of a metatherian (relative of modern marsupials) from the middle Eocene (Lutetian: 44–43 million years ago) Lülük member of the Uzunçarşıdere Formation, central Turkey. With an estimated body mass of 3–4 kg, about the size of a domestic cat (Felis catus) or spotted quoll (Dasyurus maculatus), it is an order of magnitude larger than the largest fossil metatherians previously known from the Cenozoic of the northern hemisphere. This new taxon is characterised by large, broad third premolars that probably represent adaptations for hard object feeding (durophagy), and its craniodental morphology suggests the capacity to generate high bite forces. Qualitative and quantitative functional analyses of its postcranial skeleton indicate that it was probably scansorial and relatively agile, perhaps broadly similar in locomotor mode to the spotted quoll, but with a greater capacity for climbing and grasping. Bayesian phylogenetic analysis of a total evidence dataset comprising 259 morphological characters and 9kb of DNA sequence data from five nuclear protein-coding genes, using both undated and “tip-and-node dating” approaches, place the new taxon outside the marsupial crown-clade, but within the clade Marsupialiformes. It demonstrates that at least one metatherian lineage evolved to occupy the small-medium, meso- or hypo-carnivore niche in the northern hemisphere during the early Cenozoic, at a time when there were numerous eutherians (placentals and their fossil relatives) filling similar niches. However, the known mammal fauna from Uzunçarşıdere Formation appears highly endemic, and geological evidence suggests that this region of Turkey was an island for at least part of the early Cenozoic, and so the new taxon may have evolved in isolation from potential eutherian competitors. Nevertheless, the new taxon reveals previously unsuspected ecomorphological disparity among northern hemisphere metatherians during the first half of the Cenozoic

    Mapping and Imaging the Aggressive Brain in Animals and Humans

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