The philosophy of tragedy : the tragedy of philosophy : the mimetic interrelationship of tragedy and philosophy in the theoretical writings of Friedrich Hölderlin

This study investigates Phillipe Lacoue-Labarthe's claim in "The Caesura of the Speculative" that Hölderlin is a "modern" writer. Its aim is to establish what is at stake in this claim and to evaluate whether it can be substantiated. In Chapter One I discuss the relationship between tragedy and philosophy. I show that the uneasy relationship between philosophy and the arts is premised upon Plato's understanding and judgement of mimesis. I contrast Plato and Aristotle's treatment of poetry by examining how they understand the mimetic process. In Chapter Two I focus on Hölderlin's understanding of the relationship between Ancient Greece and 18th Century Germany. After discussing the background to Hölderlin's work I provide detailed readings of two texts, The Perspective from which We Have to Look at Antiquity, (1799) and the first letter to Böhlendorff, dating from 1801. I argue that in these texts Hölderlin, through his acknowledgement of the divided nature of Greek culture, offers a unique understanding of the relationship between Greece and Germany which isolates him from his contemporaries. In Chapters Three and Four, I examine Hölderlin's understanding of tragedy. After establishing the centrality of the aesthetic presentation for Hölderlin's project I examine the "poetological" writings which date from 1798-1800. I give a close analysis of the implications of Hölderlin's statement that the tragic "is the metaphor of an intellectual intuition" which occurs in the text On the Difference of the Poetic Modes, (1800), showing why the tragic form is central to Hölderlin's poetological project. To illustrate the problems inherent in this project, in Chapter Four I examine Hölderlin's attempts to write a tragic drama which corresponds to his theoretical beliefs. I discuss the two theoretical texts - The Ground to Empedocles and Becoming in Dissolution - which accompany Hölderlin's drama Empedocles. In analysing these texts I argue that there is an inherent tension between the presuppositions of the theory and the way they can be realised in the drama. In Chapter Five, I turn to Hölderlin's final work, his project to translate Sophocles' tragedies. Through close analysis of the theoretical Remarks which accompany the translations, I show how Hölderlin's theoretical and poetological interests in Greece and Tragedy are brought together through this project. I argue that these texts give an insight into the problems which confront Hölderlin's poetological project. However, simultaneously, these texts provide an alternative way of understanding the function of the tragic form. In this discussion I show how the questions concerning the status of dramatic mimesis and the "mimetic" relation between Greece and Germany coincide in the analysis of Sophocles' dramas. In conclusion I return briefly to the questions that I raised in the introduction concerning the status of tragedy in the present time, and assess the accuracy of the claim that Hölderlin is a "modern" thinker

Evaluation of the CRACK approach for the control of drench resistance in sheep worms

The Department of Agriculture launched the CRACK approach to worm control in September 1985 in response to finding that anthelmintic (drench) resistant worms were present on 68 per cent of a random selection of Western Australian sheep farms. The high cost of internal parasites in terms of lost production and drench costs, together with the high prevalence of resistant worms of farms, confirmed that changes were needed to existing parasite control measures in sheep.

Foraging guppies can compensate for low-light conditions, but not via a sensory switch

Animals can adapt to changes in their environment through behavioural or developmental plasticity, but studies of these responses tend to focus on either short-term exposure of adults to the changed conditions, or long-term exposure of juveniles. Juvenile guppies Poecilia reticulata reared in low light environments have previously been shown to make a sensory switch to using olfactory, rather than visual, cues in foraging. It is not clear whether this compensatory sensory plasticity is limited to juveniles, or whether longer-term exposure allows adults to similarly adapt. We investigated how adult guppies that were exposed to light or dark environments for 2 and 4 weeks responded to visual, olfactory and a combination of both food cues, in both dark and light test environments. We found that after 2 weeks exposure, adult guppies were better able to locate a food cue in light test environments regardless of their exposure environment. After 4 weeks, however, guppies were more successful at locating the food cue in the environment they had been exposed to, suggesting that dark-exposed guppies adapted their behaviour in response to their environment. We found that foraging was most successful when both visual and olfactory cues were available and least successful in the presence of olfactory cues, suggesting that the mechanism behind the change in success for dark-exposed guppies was not due to increased reliance on, or sensory switch to olfactory cues

Lessons learned from implementing blended and online undergraduate chemistry laboratory teaching during the Covid-19 pandemic

In March 2020, the Covid-19 pandemic led to unprecedented circumstances which impacted significantly on Higher Education. Since that time, requirements for social distancing and reduced access to in-lab teaching facilities have meant a dramatic redesign of many Chemistry undergraduate laboratory courses. This chapter presents the lessons learned from the redevelopment of the 2020-2021 first-year chemistry undergraduate laboratory course at Durham University. The two pre-existing laboratory modules were converted from their traditional in-lab delivery (supported by online pre- and post-lab activities) to a blended delivery module and a fully online module. The blended module focused on the key manipulative skills students need to gain competence in to progress successfully to second year laboratory work. The fully online module focused on scientific enquiry skills. This chapter presents practical and theoretical considerations for the development of blended or online laboratory courses before discussing lessons learned from the evaluation of the process of implementing the course and the impact for students

Cold New Zealand Council Housing Getting an Upgrade

As people spend most of their time at home, residential thermal conditions are important. Central government debate about minimum temperature requirements for rental properties requires an evidence base of indoor temperature data. We collected temperature, humidity and energy data from 49 council housing dwellings in Wellington over winter, and self-reported thermal comfort and heating behaviour. Mean indoor temperature was 14.9°C, colder than the national average, with 67% of readings under 16°C, which the World Health Organization associates with health implications. With New Zealand’s high rate of excess winter mortality and children hospitalised for housing-related diseases, cold housing should be addressed

Rheumatoid arthritis synovial fluid neutrophils drive inflammation through production of chemokines, reactive oxygen species and neutrophil extracellular traps

ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints. Neutrophils are believed to play an important role in both the initiation and progression of RA, and large numbers of activated neutrophils are found within both synovial fluid (SF) and synovial tissue from RA joints. In this study we analysed paired blood and SF neutrophils from patients with severe, active RA (DAS28> 5.1, n=3) using RNA-seq. 772 genes were significantly different between blood and SF neutrophils. IPA analysis predicted that SF neutrophils had increased expression of chemokines and ROS production, delayed apoptosis, and activation of signalling cascades regulating the production of NETs. This activated phenotype was confirmed experimentally by incubating healthy control neutrophils in cell-free RA SF, which was able to delay apoptosis and induce ROS production in both unprimed and TNF α primed neutrophils (p< 0.05). RA SF significantly increased neutrophil migration through 3mM transwell chambers (p< 0.05) and also increased production of NETs by healthy control neutrophils, including exposure of myeloperoxidase (MPO) and citrullinated histone-H3-positive DNA NETs. IPA analysis predicted NET production was mediated by signalling networks including AKT, RAF1, SRC and NF- κ B. Our results expand the understanding of the molecular changes that take place in the neutrophil transcriptome during migration into inflamed joints in RA, and the altered phenotype in RA SF neutrophils. Specifically, RA SF neutrophils lose their migratory properties, residing within the joint to generate signals that promote joint damage, as well as inflammation via recruitment and activation of both innate and adaptive immune cells. We propose that this activated SF neutrophil phenotype contributes to the chronic inflammation and progressive damage to cartilage and bone observed in patients with RA

Improving species distribution models for invasive non‐native species with biologically informed pseudo‐absence selection

Aim: We present a novel strategy for species distribution models (SDMs) aimed at predicting the potential distributions of range‐expanding invasive non‐native species (INNS). The strategy combines two established perspectives on defining the background region for sampling “pseudo‐absences” that have hitherto only been applied separately. These are the accessible area, which accounts for dispersal constraints, and the area outside the environmental range of the species and therefore assumed to be unsuitable for the species. We tested an approach to combine these by fitting SDMs using background samples (pseudo‐absences) from both types of background. Location: Global. Taxon: Invasive non‐native plants: Humulus scandens, Lygodium japonicum, Lespedeza cuneata, Triadica sebifera, Cinnamomum camphora. Methods: Presence‐background (or presence‐only) SDMs were developed for the potential global distributions of five plant species native to Asia, invasive elsewhere and prioritised for risk assessment as emerging INNS in Europe. We compared models where the pseudo‐absences were selected from the accessible background, the unsuitable background (defined using biological knowledge of the species’ key limiting factors) or from both types of background. Results: Combining the unsuitable and accessible backgrounds expanded the range of environments available for model fitting and caused biological knowledge about ecological unsuitability to influence the fitted species‐environment relationships. This improved the realism and accuracy of distribution projections globally and, generally, within the species’ ranges. Main conclusions: Correlative SDMs remain valuable for INNS risk mapping and management, but are often criticised for a lack of biological underpinning. Our approach partly addresses this concern by using prior knowledge of species’ requirements or tolerances to define the unsuitable background for modelling, while also accommodating dispersal constraints through considerations of accessibility. It can be implemented with current SDM software and results in more accurate and realistic distribution projections. As such, wider adoption has potential to improve SDMs that support INNS risk assessment

Goals and Social Comparisons Promote Walking Behavior

The effectiveness of a pedometer intervention was affected by manipulating the goals given to participants and by providing social comparison feedback about how participants’ performance compared with others. In study 1 (n = 148), university staff members received a low, medium, or high walking goal (10%, 50%, or 100% increase over baseline walking). Participants walked 1358 more steps per day (95% confidence interval [CI], 729, 1985), when receiving a high goal than when receiving a medium goal, but a medium goal did not increase walking relative to a low goal (554 more steps; 95% CI, –71,1179). In study 2 (n = 64), participants received individual feedback only or individual plus social comparison feedback. Participants walked 1120 more steps per day (95% CI, 538, 1703) when receiving social comparison feedback than when receiving only individual feedback. Goals and the performance of others act as reference points and influence the effect that pedometer feedback has on walking behavior, illustrating the applicability of the principles of behavioral economics and social psychology to the design of health behavior interventions