Early intervention screening involves more than “simple” screening

From the perspective of preventive medical discourse, early interventional screening is one of the most important ways to intervene with developmentally delayed children and an important service for children’s public health. This paper details an historical perspective of early developmental screening in the United States and reexamines the concepts of early screening in widespread use in children’s populations to expose undisclosed facts. These facts remind us that early developmental screening might not be totally based on children’s needs, but on both the government’s desires and political activities. As a result, a certain population was identified as subjects that required developmental screening resulting in very large numbers studies. Under these circumstances, developmental screening instruments were used in conjunction with pediatricians’ individualized appraisals. The approach to developmental surveillance was to expand from the children to the parents’ concern. The instrument not only legitimately recruited parents and facilitated parents’ surveillance of their children’s development, but was also was a platform for highlighting parent-child interactions. This discussion may help community health nurses further understand different perspectives of early interventional screening in practice

Reactive Oxygen Species in the Development and Resolution of Autoimmune and Inflammatory Disease

Reactive oxygen species (ROS) have been associated with a wide variety of human diseases and disorders. The ability of these molecules can incapacitate antioxidant activity leading to an imbalance between oxidants and anti-oxidants, with the latter being more pronounced. ROS are no strangers to immune cell relationships and function and consequently the development of autoimmune and inflammatory diseases. The collateral damage of excessive ROS (collectively called Oxidative stress) to the cells or tissue due to nucleic acid damage and oxidation of macromolecules such as proteins and lipids is linked to the manifestation, malfunction and translation to the disease state of cells. Contrary to this view, recent studies have shown that ROS have protective roles in certain autoimmune and inflammatory diseases. Despite significant advances in our understanding of inflammatory and autoimmune diseases, therapeutics for these diseases still need further development and identification of new targets for improved therapeutic effect. ROS molecules and inflammation modulators appear before disease development making them great therapeutic targets with the potential to inhibit disease manifestation

Identification of an antibacterial protein by functional screening of a human oral metagenomic library

This is a corrigendum to the original article published in 2015, updating the author list to include Philip Warburton

A community-engaged interprofessional project led by medical students, school of social work students, and resident physicians: lessons learned and recommendations for success

Addressing health disparities through community engagement and interprofessional partnerships is increasingly critical. However, learner-led approaches that integrate medical students, resident physicians, and social work students are not well-studied. We designed a learner-led, interprofessional, public health campaign for a majority Hispanic community, with the goals of building interprofessional leadership skills, engaging learners to address COVID-19 inequities, and disseminating lessons learned. Faculty and students from the University of Texas Rio Grande Valley Schools of Medicine and Social Work partnered with community leaders to pilot an interprofessional project supported by the American Association of Medical Colleges’ Nurturing Experiences for Tomorrow’s Community Leaders (AAMC NEXT) Award. We describe the process of selection of a 12-member learner team of medical students, resident physicians, and social work students, and how we enacted the project from December 2020 to June 2021. Lessons learned in implementing our learner-led, community-engaged, interprofessional approach included: building interprofessional leadership skills, setting member roles and responsibilities, instilling requisite knowledge and skills, engaging with the community, and disseminating research findings. These lessons can guide other institutions seeking community-engaged interprofessional projects with learners

Transhiatal esophagectomy in the profoundly obese: implications and experience.

BACKGROUND: Historically, obesity contraindicated an abdominal approach to the esophagogastric junction. The technique of transhiatal esophagectomy (THE) evolved without specific regard to body habitus. The dramatic increase in obese patients requiring an esophagectomy for complications of reflux disease prompted this evaluation of the impact of obesity on the outcomes of esophagectomy to determine whether profound obesity should contraindicate the transhiatal approach. METHODS: We used our Esophagectomy Database to identify 133 profoundly obese patients (body mass index [BMI] > or = 35 kg/m2) from among 2176 undergoing a THE from 1977 to 2006. This group was matched to a randomly selected, non-obese (BMI, 18.5 to 30 kg/m2) control population of 133 patients. Intraoperative, postoperative, and long-term follow-up results were compared retrospectively. RESULTS: Profoundly obese patients had significantly greater intraoperative blood loss (mean, 492.2 mL versus 361.8 mL, p = 0.001), need for partial sternotomy (18 versus 3, p = 0.001), and frequency of recurrent laryngeal nerve injury (6 versus 0, p = 0.04). The two groups did not differ significantly in the occurrence of chylothorax, wound infection, or dehiscence rate; length of hospital stay or need for intensive care unit stay; or hospital or operative mortality. Follow-up results for dysphagia, dumping, regurgitation, and overall functional score were also comparable between the two groups. CONCLUSIONS: With appropriate instrumentation, transhiatal esophagectomy in obese patients has similar morbidity and outcomes as in non-obese patients. Obesity, even when profound, does not contraindicate a transhiatal esophagectomy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57503/6/Scipione 2007.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/57503/5/Benign BMI Control.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/57503/4/Benign BMI CS07.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/57503/3/CA BMI Control no pt id.txthttp://deepblue.lib.umich.edu/bitstream/2027.42/57503/2/CA BMI 35 CS.tx

An anomaly detector with immediate feedback to hunt for planets of Earth mass and below by microlensing

(abridged) The discovery of OGLE 2005-BLG-390Lb, the first cool rocky/icy exoplanet, impressively demonstrated the sensitivity of the microlensing technique to extra-solar planets below 10 M_earth. A planet of 1 M_earth in the same spot would have provided a detectable deviation with an amplitude of ~ 3 % and a duration of ~ 12 h. An early detection of a deviation could trigger higher-cadence sampling which would have allowed the discovery of an Earth-mass planet in this case. Here, we describe the implementation of an automated anomaly detector, embedded into the eSTAR system, that profits from immediate feedback provided by the robotic telescopes that form the RoboNet-1.0 network. It went into operation for the 2007 microlensing observing season. As part of our discussion about an optimal strategy for planet detection, we shed some new light on whether concentrating on highly-magnified events is promising and planets in the 'resonant' angular separation equal to the angular Einstein radius are revealed most easily. Given that sub-Neptune mass planets can be considered being common around the host stars probed by microlensing (preferentially M- and K-dwarfs), the higher number of events that can be monitored with a network of 2m telescopes and the increased detection efficiency for planets below 5 M_earth arising from an optimized strategy gives a common effort of current microlensing campaigns a fair chance to detect an Earth-mass planet (from the ground) ahead of the COROT or Kepler missions. The detection limit of gravitational microlensing extends even below 0.1 M_earth, but such planets are not very likely to be detected from current campaigns. However, these will be within the reach of high-cadence monitoring with a network of wide-field telescopes or a space-based telescope.Comment: 13 pages, 4 figures and 1 table. Accepted for publication in MNRA

Articulated Multi-Instrument 2D Pose Estimation Using Fully Convolutional Networks

Instrument detection, pose estimation and tracking in surgical videos is an important vision component for computer assisted interventions. While significant advances have been made in recent years, articulation detection is still a major challenge. In this paper, we propose a deep neural network for articulated multi-instrument 2D pose estimation, which is trained on a detailed annotations of endoscopic and microscopic datasets. Our model is formed by a fully convolutional detection-regression network. Joints and associations between joint pairs in our instrument model are located by the detection subnetwork and are subsequently refined through a regression subnetwork. Based on the output from the model, the poses of the instruments are inferred using maximum bipartite graph matching. Our estimation framework is powered by deep learning techniques without any direct kinematic information from a robot. Our framework is tested on single-instrument RMIT data, and also on multi-instrument EndoVis and in vivo data with promising results. In addition, the dataset annotations are publicly released along with our code and model