The effect of input frequency and linguistic complexity on the learning of bei2 constructions in Cantonese preschoolers

Thesis (B.Sc)--University of Hong Kong, 2005.Also available in print.A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2005.published_or_final_versionSpeech and Hearing SciencesBachelorBachelor of Science in Speech and Hearing Science

The role of Tm5NM1/2 on early neuritogenesis

The actin cytoskeleton is important in many cellular processes such as motility, and establishing and maintaining cell morphology. Members of the tropomyosin protein family associate with the actin cytoskeleton along the major groove of actin filaments (F-actin), stabilising them and regulating actin-filament dynamics. To date over 40 non-muscle tropomyosin isoforms have been identified, which are encoded by 4 different genes (α, β, γ, δ). Individual tropomyosin isoforms define functionally distinct F-actin populations. Previous studies have shown that tropomyosins sort to distinct subcellular compartments at different stages of development in polarised cells. Neuronal growth cones are highly dynamic polarised structures, dependent on a constant reorganisation of the actin cytoskeleton. By eliminating tropomyosins in a knockout (KO) mouse model, we investigated the role of two tropomyosin isoforms, Tm5NM1 and Tm5NM2 (γTm gene products) in growth cone dynamics and neurite outgrowth. Growth cone protrusion rates were significantly increased in one day old Tm5NM1/2 KO hippocampal neurons compared to WT controls. Neuritogenesis was significantly affected by the elimination of Tm5NM1/2, with a slight decrease in neurite length and an increase in neuronal branching in neurons cultured for four days. At the molecular level, the depletion of Tm5NM1/2 had no impact on the protein levels and activity of ADF/cofilin in hippocampal neurons while in cortical neurons a subtle but significant increase in ADF/cofilin activity was observed. The subtle phenotype in the early stages of neuritogenesis observed from eliminating Tm5NM1/2 may be explained with functional compensation by other tropomyosin isoforms. Functional compensation for the loss of Tm5NM1/2 may be provided by isoforms Tm5a/5b, TmBr2 and Tm4 as they localise to the growth cones, structures where Tm5NM1/2 are normally found. These results suggest that Tm5NM1/2 may not be required for early stages of neuritogenesis but may still play a fine-tuning role for this process

Embedding of a pseudo-residual design into a Möbius plane

AbstractLet U be a class of subsets of a finite set X. Elements of U are called blocks. Let v, t and λ1, 0 ⩽ i ⩽ t, be nonnegative integers, and K be a subset of nonnegative integers such that every member of K is at most v. A pair (X, U) is called a (λ0, λ1,…, λt; K, υ)t-design if (1) |X| = υ, (2) every i-subset of X is contained in exactly λt blocks, 0 ⩽ i ⩽ t, and (3) for every block A in U, |A| ϵ K. It is well-known that if K consists of a singleton k, then λ0,…, λt − 1 can be determined from υ, t, k and λt. Hence, we shall denote a (λ0,…, λt; {k}, υ)t-design by Sλ(t, k, υ), where λ = λt. A Möbius plane M is an S1(3, q + 1, q2 + 1), where q is a positive integer. Let A be a fixed block in M. If A is deleted from M together with the points contained in A, then we obtain a residual design M′ with parameters λ0 = q3 + q − 1, λ1 = q2 + q, λ2 = q + 1, λ3 = 1, K = {q + 1, q, q − 1}, and υ = q2 − 1. We define a design to be a pseudo-block-residual design of order q (abbreviated by PBRD(q)) if it has these parameters. We consider the reconstruction problem of a Möbius plane from a given PBRD(q). Let B and B′ be two blocks in a residual design M′. If B and B′ are tangent to each other at a point x, and there exists a block C of size q + 1 such that C is tangent to B at x and is secant to B′, then we say B is r-tangent to B′ at x. A PBRD(q) is said to satisfy the r-tangency condition if for every block B of size q, and any two points x and y not in B, there exists at most one block which is r-tangent to B and contains x and y. We show that any PBRD(q)D can be uniquely embedded into a Möbius plane if and only if D satisfies the r-tangency condition

Photobiomodulation may enhance cognitive efficiency in older adults: a functional near-infrared spectroscopy study

IntroductionThe relative oxygenated hemoglobin (HbO) measured using functional near-infrared spectroscopy (fNIRS) has been considered as an index for cognitive loading, with the more difficult the task, the higher the level. A previous study reported that young adults who received transcranial photobiomodulation (tPBM) showed a reduced HbO of a difficult task, suggesting that tPBM may enhance cognitive efficiency. The present study further investigated the effect of tPBM on cognitive efficiency in older adults.MethodsThirty participants received a single tPBM on the forehead for 350 s. Before and after tPBM, their HbO in the visual span task with various difficulties was measured with fNIRS.ResultsAfter tPBM, participants exhibited significantly lower HbO in a harder (span 7) but not an easier level (span 2) of the task, but their behavioral performance remained unchanged. In addition, factors affecting the reduction of HbO were examined, and the results showed that individuals with better memory (as measured by a 30-min delayed recall test) showed more reduction of HbO.DiscussionThe results suggest that tPBM may enhance cognitive efficiency, with individuals with better memory tend to benefit more

The role and expression of trehalase and [Beta]-glucosidase during spore germination of Dictyostelium discoideum.

Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.Sc.)--University of Windsor (Canada), 1981

NASA advanced design program: Analysis, design, and construction of a solar powered aircraft

Increase in energy demands coupled with rapid depletion of natural energy resources have deemed solar energy as the most logical alternative source of power. The major objective of this project was to build a solar powered remotely controlled aircraft to demonstrate the feasibility of solar energy as an effective, alternate source of power. The final design was optimized for minimum weight and maximum strength of the structure. These design constraints necessitated a carbon fiber composite structure. Surya is a lightweight, durable aircraft capable of achieving level flight powered entirely by solar cells

A Chinese Chan-based lifestyle intervention improves memory of older adults

This study aims to explore the potential benefits of a Chinese Chan-based lifestyle intervention on enhancing memory in older people with lower memory function. Forty-four aged 60–83 adults with various level of memory ability participated in the study. Their memories (including verbal and visual components) were assessed before and after 3 months intervention. The intervention consisted of 12 sessions, with one 90 min session per week. The intervention involved components of adopting a special vegetarian diet, practicing a type of mind–body exercises, and learning self-realization. Elderly with lower memory function at the baseline (i.e., their performance on standardized memory tests was within 25th percentile) showed a significant memory improvement after the intervention. Their verbal and visual memory performance has showed 50 and 49% enhancement, respectively. In addition, their improvement can be considered as a reliable and clinically significant change as reflected by their significant pre–post differences and reliable change indices. Such robust treatment effect was found to be specific to memory functions, but less influencing on the other cognitive functions. These preliminary encouraging results have shed some light on the potential applicability of the Chinese Chan-based lifestyle intervention as a method for enhancing memory in the elderly population

Sustained Effects of Memory and Lifestyle Interventions on Memory Functioning of Older Adults: An 18-Month Follow-Up Study

Background: There has been much research devoted to examining the short-term effects of different interventions for improving memory functioning of older adults with memory complaints. Nevertheless, very few studies have examined the long-term effects of these interventions. Thus, the present study compared the sustained effects of a conventional memory intervention (MI) and a Chinese lifestyle intervention on improving memory functioning in older adults.Methods: Twenty-nine older adults who were aged 60 years and older and had memory complaints were recruited. Each completed 10 weekly sessions of the Dejian Mind-body Intervention (DMBI; n = 11) or MI (n = 18) approximately 18 months ago. Participants’ verbal and visual memory functioning and their subjective impression of the changes of their memory performance and physical and psychological health status were evaluated.Results: Results showed significant improvements in memory in both intervention groups at the follow-up assessments when compared with baseline. In addition, older adults in both intervention groups perceived improved memory performance and physical and psychological wellness at follow-up, with the DMBI group reporting significantly greater improvements in physical health compared to the MI group.Conclusion: Altogether, the present study provides supportive evidence that the DMBI and MI might be two effective remedies for older adults to improve or preserve their memory functioning with relatively sustained effects

A Chan Dietary Intervention Enhances Executive Functions and Anterior Cingulate Activity in Autism Spectrum Disorders: A Randomized Controlled Trial

Executive dysfunctions have been found to be related to repetitive/disinhibited behaviors and social deficits in autism spectrum disorders (ASDs). This study aims to investigate the potential effect of a Shaolin-medicine-based dietary modification on improving executive functions and behavioral symptoms of ASD and exploring the possible underlying neurophysiological mechanisms. Twenty-four children with ASD were randomly assigned into the experimental (receiving dietary modification for one month) and the control (no modification) groups. Each child was assessed on his/her executive functions, behavioral problems based on parental ratings, and event-related electroencephalography (EEG) activity during a response-monitoring task before and after the one month. The experimental group demonstrated significantly improved mental flexibility and inhibitory control after the diet modification, which continued to have a large effect size within the low-functioning subgroup. Such improvements coincided with positive evaluations by their parents on social communication abilities and flexible inhibitory control of daily behaviors and significantly enhanced event-related EEG activity at the rostral and subgenual anterior cingulate cortex. In contrast, the control group did not show any significant improvements. These positive outcomes of a one-month dietary modification on children with ASD have implicated its potential clinical applicability for patients with executive function deficits