Encodage et reproduction d'intervalles de temps : interférence de traitement non temporel

Dans la présente étude, l’effet de traitement non temporel sur la tâche de reproduction d’intervalles de temps est testé dans quatre expériences. Trois tâches non temporelles nécessitant l’encodage ou la récupération d’information en mémoire ainsi qu’une tâche d’interruption d’estimation temporelle sont combinées à une tâche de reproduction temporelle nécessitant l’encodage et la reproduction de durées (environ 2 secondes). Les résultats obtenus révèlent que les tâches non temporelles affectent davantage la phase de reproduction que la phase d’encodage de durées suggérant ainsi que l’interférence du traitement non temporel avec la reproduction temporelle simultanée diffère selon que le traitement prenne place durant la phase d’encodage ou la phase de reproduction. Une hypothèse explicative est proposée selon laquelle l’interférence du traitement non temporel avec l’estimation temporelle concurrente varie selon les processus impliqués et les ressources requises dans les deux phases de la tâche temporelle. L’ensemble des résultats est interprété dans le cadre des modèles d’accumulation de l’information temporelle

Traitement d'ordre temporel en mémoire à court-terme et reproduction temporelle

Dans la présente étude, Peffet d’un traitement d’ordre temporel d’item en MCT sur la reproduction d’un intervalle de temps est testé dans deux expériences. La tâche non temporelle des participants consiste à vérifier si un chiffre indique ou non la bonne position temporelle d ’une lettre cible dans un ensemble mémoire présenté au préalable. Le traitement de l’information d’item est réduit au minimum par l’utilisation d’un ensemble fermé de lettres qui ne changent pas pendant un bloc expérimental. Dans la première expérience, le traitement de l’ordre en MCT se fait pendant la phase d’encodage de l’intervalle à reproduire. Dans la deuxième expérience, le traitement de l’ordre se fait pendant la phase de reproduction. L’identification d’ordre temporel en MCT perturbe l’estimation temporelle simultanée dans des conditions où la quantité d’information d’item à traiter en mémoire est minimale. Ces résultats suggèrent que l’estimation d’un intervalle temporel et le traitement d’ordre temporel en mémoire utilisent des ressources communes

An Investigation of the Character Strengths and Resilience of Future Military Leaders

Introduction: The importance of both character and resilience for critical occupations (military, emergency medicine, first responders, and correctional officers) has been emphasized at the highest levels of military leadership. No studies to date have examined the relationship between character strengths and resilience within military populations. The purpose of this study was to evaluate the perceived importance of character strengths for Canadian military cadet success, the top strengths endorsed by cadets, and, in a subset of cadets, the relationships among core strengths and resilience. In line with previous research on character strengths in military populations, we predicted that bravery, honesty, perseverance, and teamwork might be included in the five most frequent signature strengths. Methods: A total of 360 Naval/Officer Cadets from a Canadian Military College were invited to participate in a study during two training sessions. Participants (n = 153) first completed a survey comprised of a resilience measure and demographic items. Then, one month later, students (n=134) were asked to complete a Values in Action (VIA) character strengths profile, and a survey with questions related to character strengths (their personal top-five character strengths, and strengths they believed were important for military-related stressors and leadership, academic success, resilience, and completion of military challenge). We were only able to match responses for a subset of participants, allowing a final sample of 94 participants. Results: Findings indicated that military cadets consider perseverance, judgment, teamwork, perspective, and self-regulation to be most critical for bouncing back from stressors. However, in line with our predictions, the most frequently endorsed strengths that characterized cadets were bravery, honesty, and perseverance. Finally, perseverance (p = .029), bravery (p = .01), and humor = .01) were positively correlated with cadet resilience, while endorsement of love was negatively correlated with resilience (p = .002). Conclusion: Focus on character strengths in military cadets can enhance academic and physical performance. Resilience assessment could be important for the purposes of military selection, performance, and well-being. Our findings indicate perseverance, bravery, and humor in particular might be relevant indicators of cadet resilience

Character strengths and inner peace

This research explored the relationships among inner peace and character strengths, both of which are understood to contribute to wellbeing, using a cross-sectional design. In Study One (N = 25,302), we examined individuals’ perceptions of the strengths most relevant to fostering a sense of inner peace. In Study Two (N = 21,201), we examined relationships among individuals’ scores on the 24 character strengths and serenity and harmony in life. Interestingly, the strengths individuals believed to be important for fostering inner peace (in Study One) were different from those found to actually correlate with measures of inner peace (in Study Two). Hope was most strongly associated with facets of serenity (inner haven, trust, and acceptance) and harmony in life. Our findings indicate that, hope, zest, and gratitude are likely primary facets of inner peace, with spirituality and forgiveness acting as secondary facets for inner peace. Implications and future directions are discussed

Risk Factors for Recurrence of Borderline Ovarian Tumours after Conservative Surgery and Impact on Fertility: A Multicentre Study by the Francogyn Group

International audienceIntroduction: Borderline ovarian tumours (BOT) represent 10–20% of epithelial tumours of the ovary. Although their prognosis is excellent, the recurrence rate can be as high as 30%, and recurrence in the infiltrative form accounts for 3% to 5% of recurrences. Affecting, in one third of cases, women of childbearing age, the surgical strategy with ovarian conservation is now recommended despite a significant risk of recurrence. Few studies have focused exclusively on patients who have received ovarian conservative treatment in an attempt to identify factors predictive of recurrence and the impact on fertility. The objective of this study was to identify the risk factors for recurrence of BOT after conservative treatment and the impact on fertility. Material and methods: This was a retrospective, multicentre study of women who received conservative surgery for BOT between February 1997 and September 2020. We divided the patients into two groups, the “R group” with recurrence and the “NR group” without recurrence. Results: Of 175 patients included, 35 had a recurrence (R group, 20%) and 140 had no recurrence (NR group, 80%). With a mean follow‐up of 30 months (IQ 8–62.5), the overall recurrence rate was 20%. Recurrence was BOT in 17.7% (31/175) and invasive in 2.3% (4/175). The mean time to recurrence was 29.5 months (IQ 16.5–52.5). Initial complete peritoneal staging (ICPS) was performed in 42.5% of patients (n = 75). In multivariate analysis, age at diagnosis, nulliparity, advanced FIGO stage, the presence of peritoneal implants, and the presence of a micropapillary component for serous tumours were factors influencing the occurrence of recurrence. The post‐surgery fertility rate was 67%. Conclusion: This multicentre study is to date one of the largest studies analysing the risk factors for recurrence of BOT after conservative surgery. Five risk factors were found: age at diagnosis, nulliparity, advanced FIGO stage, the presence of implants, and a micropapillary component. Only 25% of the patients with recurrence underwent ICPS. These results reinforce the interest of initial peritoneal staging to avoid ignoring an advanced tumour stage

Status of Surgical Management of Borderline Ovarian Tumors in France: are Recommendations Being Followed? Multicentric French Study by the FRANCOGYN Group

International audienceBackground: Borderline ovarian tumors (BOTs) are tumors with a favorable prognosis but whose management by consensus is essential to limit the risk of invasive recurrence. This study aimed to conduct an inventory of surgical practices for BOT in France and to evaluate the conformity of the treatment according to the current French guidelines.Methods: This retrospective, multicenter cohort study included nine referral centers of France between January 2001 and December 2018. It analyzed all patients with serous and mucinous BOT who had undergone surgery. A peritoneal staging in accordance with the recommendations was defined by performance of a peritoneal cytology, an omentectomy, and at least one peritoneal biopsy.Results: The study included 332 patients. A laparoscopy was performed in 79.5% of the cases. Treatment was conservative in 31.9% of the cases. The recurrence rate was significantly increased after conservative treatment (17.3% vs 3.1%; p < 0.001). Peritoneal cytology was performed for 95.5%, omentectomy for 83.1%, and at least one biopsy for 82.2% of the patients. The overall recurrence rate was 7.8%, and the recurrence was invasive in 1.2% of the cases. No link was found between the recurrence rate and the conformity of peritoneal staging. The overall rate of staging noncompliance was 22.9%.Conclusion: The current standards for BOT management seem to be well applied

Adherence to European ovarian cancer guidelines and impact on survival: a French multicenter study (FRANCOGYN)

International audienceOBJECTIVE: The primary objective of the study was to validate the European Society for Medical Oncology (ESMO)-European Society of Gynecologic Oncology (ESGO) ovarian cancer guideline as a method of assessing quality of care, and to identify patient characteristics predictive of non-adherence to European guideline care. The secondary objectives were to analyze the evolution of practices over the years and to evaluate heterogeneity between centers. METHODS: This retrospective multicenter cohort study of invasive epithelial ovarian cancer reported to the FRANCOGYN database included data from 12 French centers between January 2000 and February 2017. The main outcome was adherence to ESMO-ESGO guidelines, defined by recommended surgical procedures according to the International Federation of Gynecology and Obstetrics (FIGO) stage and appropriate chemotherapy. Mixed multivariable logistic regression analysis with a random center effect was performed to estimate the probability of adherence to the guidelines. Survival analysis was carried out using the Kaplan-Meier method and a mixed Cox proportional hazards model. RESULTS: 1463 patients were included in the study. Overall, 317 (30%) patients received complete guideline adherent care. Patients received appropriate surgical treatment in 69% of cases, while adequate chemotherapy was administered to 44% of patients. Both patient demographics and disease characteristics were significantly associated with the likelihood of receiving guideline adherent care, such as age, performance status, FIGO stage, and initial burden of disease. In univariate and multivariate survival analysis, adherence to the guidelines was a statistically significant and independent predictor of decreased overall survival. Patients receiving suboptimal care experienced an increased risk of death of more than 100% compared with those treated according to the guidelines (hazard ratio 2.14, 95% confidence interval 1.32 to 3.47, p&lt;0.01). In both models, a significant random center effect was observed, confirming the heterogeneity between centers (p&lt;0.001). CONCLUSIONS: Adherence to ESMO-ESGO guidelines in ovarian cancer was associated with a higher overall survival and may be a useful method of assessing quality of care

Clinical Medicine Impact of Lymphadenectomy on Survival of Patients with Serous Advanced Ovarian Cancer After Neoadjuvant Chemotherapy: A French National Multicenter Study (FRANCOGYN)

International audienceBackground: The population of interest to this study comprised individuals with advanced-stage ovarian carcinoma who were exposed to neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS). Those who had not received systematic lymphadenectomy (SL; Group 1) were compared to those who had received SL (Group 2). Outcome measures included progression-free survival (PFS), overall survival (OS), and surgical complications.Methods: This was a retrospective, multicenter cohort study in nine referral centers of France between January 2000 and June 2017. OS analysis using the multivariate Cox regression model was performed. PFS and surgery-related morbidity were analyzed.Results: Of the 255 patients included, 100 were in Group 1 and 155 in Group 2. Patient majority was, on average, younger and less comorbid, with predominant R0 surgery in Group 2. Dindo-Clavien score was similar between the two groups (p = 0.15). Median OS was 26.8 months in Group 2 and 27.6 months in Group 1. SL was not statistically significant on OS (p = 0.7). Median PFS was 18.3 months in Group 2 and 16.6 months in Group 1. SL had positive impact on PFS (p = 0.005).Conclusions: patients who had received SL (Group 2) had significantly higher PFS regardless of node-positivity status when compared to those who had not received SL (Group 1)

Comparison of retroperitoneal and transperitoneal surgical routes in laparoscopic nodal staging for locally advanced cervical cancers (FIGO IB3-IVA)

International audienceBACKGROUND: This study compares morbidity and mortality associated with retroperitoneal and transperitoneal para-aortic lymphadenectomy (PAAL) for pretherapeutic nodal staging of locally advanced cervical cancers (FIGO IB3-IVA). METHODS: Pre-, per- and postoperative data of patients treated for locally advanced stage cervical cancer between 1999 and 2018 in 12 French referral centers (FRANCOGYN Study Group) were retrospectively collected. RESULTS: The study was conducted using a sample of 448 patients, of whom 223 (49,8%) underwent retroperitoneal (group 1) and 225 (50,2%) had transperitoneal PAAL (group 2). No differences were noted concerning clinical and histological characteristics between the two groups. Among these 448 patients, 23 (5,1%) had an intraoperative complication (9 (2,0%) in group 1 and 14 (3,1%) in group 2, p = 0.28) and 47 (10,5%) had a postoperative complication (22 (4,9%) in group 1 and 25 (5,6%) in group 2, p = 0.44), only one of which required revision surgery but the patient died. The length of hospital stay was significantly shorter in group 1 than in group 2 (3.97 versus 4.88 days, p &lt; 0.001). There was no significant difference in mortality between the two groups; 34 of 223 patients in group 1 (15.3%) and 40 of 225 patients in group 2 (15.6%) died (HR = 0.968, 95% CI [0.591-1.585]). There was no significant difference in recurrence-free or overall survival between the two groups. CONCLUSION: Retroperitoneal PAAL appears as a valuable and safety surgical route for nodal staging in locally advanced cervical cancer compared with standard transperitoneal PAAL

Recurrence Pattern of Cervical Cancer Based on the Platinum Sensitivity Concept: A Multi-Institutional Study from the FRANCOGYN Group

International audienceThe standard of care for patients with advanced cervical cancer (ACC) includes platinum-based chemotherapy. The concept of platinum sensitivity is a major prognostic factor for patients with ovarian cancer. The aim of this study was to validate the applicability of the platinum sensitivity concept to ACC patients, and to estimate its prognostic interest in terms of overall survival (OS) and pattern of recurrence (location, timing). Data of women with histologically proven FIGO 2019 stages IB3–IV ACC, treated between May 2000 and November 2017 with platinum-based regimens, were retrospectively abstracted from 12 institutions from the FRANCOGYN Group. Respective 3-year OSs were 52% (95% CI: 40.8%–66.8%), 21.6% (95% CI: 12.6%–37.2%), and 14.6% (95% CI: 4.2%–50.2%), in case of recurrence 18 months (p < 0.001). In multivariate analysis, platinum sensitivity status was a strong prognostic factor for OS after recurrence, independent of histological grade, lympho-vascular space involvement, final lymph node status, and treatment. Platinum sensitivity status may help to classify patients in three prognostic subgroups for OS after recurrence, and appears to be a strong prognostic factor correlated to the pattern of recurrenc