486 research outputs found
Insights Into Sibling Relationships and Longevity From Genetics of Healthy Ageing Nonagenarians: The Importance of Optimisation, Resilience and Social Networks
Understanding how to âAge Longer and Age Wellâ is a priority for people personally, for populations and for government policy. Approximately ten percent of nonagenarians reach 90 years and beyond in good condition and seem to have a combination of both age-span and health-span. However, the factors which contribute to human longevity remain challenging. Culture is a shared system of learning ideas, feelings, and survival strategies. It has a strong influence on each personâs psychological development, behavior, values and beliefs. Nonagenarians have rich life experiences that can teach us much about aging well; they are rich reservoirs of genetic, lifestyle and psychological information which can help understanding about how to live longer and better. Sibling or trio nonagenarians are important sources of family beliefs and behaviors upon which individual personalities may have been built. Their personal family histories and narratives are powerful tools that help to determine familial traits, beliefs and social behaviors which may help establish factors important in the siblingsâ longevity. Using purposefully selected subjects, recruited to the Genetics of Healthy Ageing (GeHA) project in four European countries, this research used the simple life story and qualitative research methods to analyze contrasting and distinctive questions about the interface between the psychological and social worlds as presented in the nonagenarian siblingsâ insights about their longevity. Their stories aimed to give better understanding about which psychological aspects of their common life journey and the degree of emotional support in their sibling relationships may have supported their paths to longevity. The most universal finding in each of the four European countries was that nonagenarians demonstrated high positivity, resilience and coping skills and were supported in social networks. Around this theme, nonagenarians reported âbeing happy,â âalways cheerful,â ânever melancholyâ and having a contentment with a ârich lifeâ and family relationships which fits with accumulating evidence that life satisfaction comes from a perceived self-efficacy and optimism. Most sibling relationships in this study, when analyzed according to the Gold classification, fit the âcongenialâ or âloyalâ relationship type â demonstrating a healthy respect for the othersâ opinion without overt dependence, which may help individual coping and survival mechanisms
DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France
We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39â3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18â0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
Il pubblico di Palazzo Davanzati nei libri dei visitatori. 1910-1924
A pochi mesi dall\u2019apertura di Palazzo Davanzati, Elia Volpi ebbe l\u2019idea di mettere a disposizione dei visitatori del suo museo privato un libro, dalle pagine bianche, sul quale ognuno avrebbe potuto lasciare la propria firma e un commento, seguendo forse l\u2019esempio di altri musei privati come quello di Frederick Stibbert o il milanese Bagatti Valsecchi. I due libri con le firme dei visitatori dal 1910 al 1924 furono poi donati, per volont\ue0 della moglie Marina Volpi, da Mario Vannini Parenti, genero dell\u2019antiquario e sono oggi conservati nel museo. Lo spoglio sistematico dei dati contenuti in questi straordinari documenti ha fatto emergere aspetti molto significativi riguardanti il numero e la provenienza dei visitatori di Palazzo Davanzati, cos\uec come i riflessi della societ\ue0 del tempo e del contesto storico, rappresentando un interessante caso di studio sul pubblico dei musei in un\u2019epoca precedente all\u2019affermazione del turismo di massa. \uc8 il museo visto dalla parte dei suoi visitatori, studenti, educande, persone comuni o aristocratici d\u2019alto lignaggio, turisti stranieri e non con la passione per Firenze e la sua storia, molti dei quali lasciano un commento, una battuta, anche una poesia, o semplicemente la traccia della loro visita. Davvero numerosi, poi, sono i nomi dei personaggi celebri: storici dell\u2019arte (Adolfo e Lionello Venturi, Roberto Longhi), artisti, letterati e intellettuali (Giovanni Boldini, Sibilla Aleramo, Benedetto Croce), mercanti e collezionisti (Salvatore Romano, Georges Wildenstein, Peggy Guggenheim) o personaggi dello spettacolo (Ettore Petrolini, Rodolfo Valentino). La loro presenza, cos\uec come quella di moltissimi architetti e decoratori stranieri e dei tanti visitatori meno noti, restituiscono un feedback importante a tutte quelle iniziative di promozione del museo che Elia Volpi aveva intrapreso sin dal giorno della sua inaugurazione, attraverso campagne fotografiche, pubblicazioni, cartoline illustrate ed eventi a tema
Emotion Recognition in Children With Down Syndrome: Influence of Emotion Label and Expression Intensity
Some children with Down syndrome may experience difficulties in recognising facial emotions, particularly fear, but it is not clear why, nor how such skills can best be facilitated. Using a photo-matching task, emotion recognition was tested in children with Down syndrome, children with non-specific intellectual disabilities and cognitively-matched typically-developing children (all groups N = 21) under four conditions: veridical vs exaggerated emotions and emotion-labelling vs generic task instructions. In all groups, exaggerating emotions facilitated recognition accuracy and speed, with emotion labelling facilitating recognition accuracy. Overall accuracy and speed did not differ in the children with Down syndrome, although recognition of fear was poorer than in the typically developing children and unrelated to emotion label use. Implications for interventions are considered
- âŠ