Desarrollo de prototipo de aplicación móvil para el registro de asistencia a eventos de interés General en Uniminuto Vicerrectoría Regional Orinoquía.

Desarrollar aplicación móvil para el registro de asistencia a eventos de interés general en UNIMINUTO Vicerrectoría Regional Orinoquia.El Desarrollo de la aplicación busca optimizar el proceso de control de asistencia a eventos, presenciales y virtuales, el usuario realizará un registro en la aplicación el cual le permitirá conocer los eventos institucionales del semestre académico, dando la posibilidad de registrarse como participante.The development of the application seeks to optimize the process of control of attendance to events, face-to-face and virtual, the user will make a registration in the application which will allow him to know the institutional events of the academic semester, giving the possibility of registering as a participant. During the execution of the event, the participant may indicate that he is present and mark his attendance record, in face-to-face events he would avoid filling out the format provided by the institution for this purpose, which has generated delays in the punctuality of attendees, crowds in the income of the event, paper expenses for the collection of the information and loss of time by the organizers filling out the form and printing, in addition to the end of the event the organizers take the lists and must enter them into the Banner information system, in the case of The institutional events organized by Bienestar have generated traumas in this unit, due to the quantification of teachers, students and administrators in their activities since they do not have enough staff to carry out this work. In the virtual events registration, a form is sent that has the same information as the registration, forcing the user to register a form to register for the event, a form to mark their attendance, what is sought is that this process is optimized to guarantee that both registers have the same information. In response to this problem, it is proposed to develop a mobile and web application for event attendance control, using programming languages such as HTML, Java, PHP, JavaScript, CSS, using the FIREBASE database engine and the Android development environment. Studio

Desarrollo de prototipo de aplicación móvil para el registro de asistencia a eventos de interés General en Uniminuto Vicerrectoría Regional Orinoquía.

Desarrollar aplicación móvil para el registro de asistencia a eventos de interés general en UNIMINUTO Vicerrectoría Regional Orinoquia.El Desarrollo de la aplicación busca optimizar el proceso de control de asistencia a eventos, presenciales y virtuales, el usuario realizará un registro en la aplicación el cual le permitirá conocer los eventos institucionales del semestre académico, dando la posibilidad de registrarse como participante.The development of the application seeks to optimize the process of control of attendance to events, face-to-face and virtual, the user will make a registration in the application which will allow him to know the institutional events of the academic semester, giving the possibility of registering as a participant. During the execution of the event, the participant may indicate that he is present and mark his attendance record, in face-to-face events he would avoid filling out the format provided by the institution for this purpose, which has generated delays in the punctuality of attendees, crowds in the income of the event, paper expenses for the collection of the information and loss of time by the organizers filling out the form and printing, in addition to the end of the event the organizers take the lists and must enter them into the Banner information system, in the case of The institutional events organized by Bienestar have generated traumas in this unit, due to the quantification of teachers, students and administrators in their activities since they do not have enough staff to carry out this work. In the virtual events registration, a form is sent that has the same information as the registration, forcing the user to register a form to register for the event, a form to mark their attendance, what is sought is that this process is optimized to guarantee that both registers have the same information. In response to this problem, it is proposed to develop a mobile and web application for event attendance control, using programming languages such as HTML, Java, PHP, JavaScript, CSS, using the FIREBASE database engine and the Android development environment. Studio

The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description

On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2-7 m, while providing data at sub-mm to mm scales. We report on SuperCam's science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.In France was provided by the Centre National d'Etudes Spatiales (CNES). Human resources were provided in part by the Centre National de la Recherche Scientifique (CNRS) and universities. Funding was provided in the US by NASA's Mars Exploration Program. Some funding of data analyses at Los Alamos National Laboratory (LANL) was provided by laboratory-directed research and development funds

Manejo Multidisciplinario del Adenocarcinoma de Páncreas: Guía de Práctica Clínica AUNA

Introduction: This article provides recommendations for the Multidisciplinary Management of Pancreatic Adenocarcinoma in the RED AUNA. Methods: A systematic search of clinical practice guidelines (CPG) similar to topics of interest was developed, it was assessed with the AGREE II instrument, a list of questions was elaborated under the PICO structure, a de novo search was carried out prioritizing reviews systematic with or without meta-analysis, followed by primary studies, the elaboration of the evidence tables and the evaluation of the global quality for the outcomes of the clinical questions was carried out following the GRADE methodology. Results: 5 PICO questions corresponding to initial management and systemic management were formulated with 18 recommendations regarding the most effective method for pathological diagnosis, biliary drainage and the most effective and safe systemic treatment in the neoadjuvant, adjuvant and metastatic setting. Conclusions: This article summarizes the methodology and evidence-based recommendations of the CPG for the multidisciplinary management of pancreatic adenocarcinoma of the AUNA Clinic Network.Introducción: Este artículo brinda recomendaciones para el Manejo Multidisciplinario del Adenocarcinoma de Páncreas en la RED AUNA. Métodos: Se desarrolló una búsqueda sistemática de guías de práctica clínica (GPC) similares al tópico de interés, se valoró con el instrumento AGREE II, se elaboró un listado de preguntas bajo la estructura PICO, se realizó una búsqueda de novo priorizando revisiones sistemáticas con o sin meta-análisis, seguida de estudios primarios, la elaboración de las tablas de evidencia y la evaluación de la calidad global para los desenlaces de las preguntas clínicas se realizó siguiendo la metodología GRADE. Resultados: Se formularon 5 preguntas PICO correspondientes al manejo inicial y manejo sistémico con 18 recomendaciones respecto al método más efectivo para el diagnóstico patológico, el drenaje biliar y el tratamiento sistémico más efectivo y seguro en el escenario neoadyuvante, adyuvante y metastásico. Conclusiones: El presente artículo resume la metodología y las recomendaciones basadas en evidencia de la GPC para el manejo multidisciplinario del Adenocarcinoma de páncreas de la Red de Clínicas AUNA

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Maternidad subrogada

Actualmente la maternidad subrogada es un procedimiento cada vez más común en nuestra vida cotidiana, demostrando la existencia de distintos métodos para lograr conformar una familia. Sin embargo, esta no es una técnica muy novedosa como se puede llegar a creer. Esto debido al conocimiento de registros en Estados Unidos en 1976 en los cuales se llevó a cabo la creación de la agencia Surrogate Family Service (Castaño -Bedoya, A 2021) la cual se basaba en la oferta de mujeres para gestar los hijos de parejas que, por diversos motivos, se les impedía realizar la procreación de una forma natural. No obstante, y a pesar de la información existente se tiene gran desinformación respecto a la maternidad subrogada, produciendo la creación de diversos mitos frente a este método de procreación. Por ello el presente trabajo busca explicar a fondo la magnitud de la gestión por sustitución, así mismo se buscará analizar los distintos tipos de métodos de esta práctica; Así como sus consecuencias y beneficios, igualmente se presentarán los diferentes procedimientos legales que se puede entrar a desarrollar en Colombia. (Tomado de la fuente)

Maternidad subrogada

El presente trabajo busca explicar a fondo la magnitud de la gestión por sustitución, así mismo se buscará analizar los distintos tipos de métodos de esta práctica; Así como sus consecuencias y beneficios, igualmente se presentarán los diferentes procedimientos legales que se puede entrar a desarrollar en Colombia. (Tomado de la fuente)

La prostitución desde el marco legal en Colombia

La prostitución es la actividad de una persona a la que se le paga para mantener relaciones íntimas con otras personas, consiste en sexo por dinero, comida, alquiler, drogas o alguna otra cosa de valor. En otros casos se encuentran las mujeres secuestradas y obligadas a ejercer la prostitución y convertirse en víctimas de las redes de trata de personas. (Tomado de la fuente)

Biodiversity 2016. Status and Trends of Colombian Continental Biodiversity

This third volume of the annual report on biodiversity in Colombia continues the editorial line that begun in 2014. Using novel analytical and graphic proposals, these reports have the goal of communicating the contents to a broad public, making it available for discussion without sacrificing the quality of information. The challenge of communication continues to be a major part of the institutional project, and the new languages with which we are learning to communicate with society and other institutions are an experiment that we expect to be increasingly gratifying. The report for 2017 is already under construction and it counts on new digital technologies so the power of a colombian vital connection may be entirely expressed. The included content evidences that we are still far away from having a systematic follow-up about most of the topics related to the management of biodiversity and ecosystem services, which is the only way to evaluate the effectiveness of policies and investments made by society. In fact, a limitation that is recognized is that of identifying positive or negative changes that affect different levels of organization of life on this planet; therefore, our global navigation route of the Aichi targets is still to be verified. An additional purpose of this process includes the invitation of all Colombians to contribute in constructing and maintaining basic monitoring indicators for management since it is impossible to identify long-term trends of flora and fauna in the country without the support of institutions, researchers, and citizens. This challenge is immense in a megadiverse country such as Colombia. For this reason, the report will continue to open its pages to experts, and even indigenous peoples or local communities, for them to present their perspectives about environmental change and its effects on biodiversity in a systematic and documented manner. This has the objective of stimulating the commitment of everyone in the management of biodiversity and ecosystem services. The only way of overcoming the risk of extinction is through the active process of social learning in which all sectors assume a part of the complex responsibility in protecting the forms of life of the country, a roughly counted tenth of all creatures on Earth. I thank all the people that contributed in this Report, those who have supported us in the phases of production, and all readers and users, who are the ultimate judges of its utility.Bogotá, D. C