A model structure for coloured operads in symmetric spectra

We describe a model structure for coloured operads with values in the category of symmetric spectra (with the positive model structure), in which fibrations and weak equivalences are defined at the level of the underlying collections. This allows us to treat R-module spectra (where R is a cofibrant ring spectrum) as algebras over a cofibrant spectrum-valued operad with R as its first term. Using this model structure, we give suficient conditions for homotopical localizations in the category of symmetric spectra to preserve module structures.Comment: 16 page

Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis

Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in elderly people. Mitochondrial abnormalities at the histological level are present in these patients. We hypothesize that mitochondrial dysfunction may play a role in disease aetiology. We took the following measurements of muscle and peripheral blood mononuclear cells (PBMCs) from 30 sIBM patients and 38 age-and gender-paired controls: mitochondrial DNA (mtDNA) deletions, amount of mtDNA and mtRNA, mitochondrial protein synthesis, mitochondrial respiratory chain (MRC) complex I and IV enzymatic activity, mitochondrial mass, oxidative stress and mitochondrial dynamics (mitofusin 2 and optic atrophy 1 levels). Depletion of mtDNA was present in muscle from sIBM patients and PBMCs showed deregulated expression of mitochondrial proteins in oxidative phosphorylation. MRC complex IV/citrate synthase activity was significantly decreased in both tissues and mitochondrial dynamics were affected in muscle. Depletion of mtDNA was significantly more severe in patients with mtDNA deletions, which also presented deregulation of mitochondrial fusion proteins. Imbalance in mitochondrial dynamics in muscle was associated with increased mitochondrial genetic disturbances (both depletion and deletions), demonstrating that proper mitochondrial turnover is essential for mitochondrial homoeostasis and muscle function in these patients

Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure

Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups. LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted

Plant Transposable Elements

International audienc

BARRAGEM DE PORTO PRIMAVERA E O TRANSPORTE FLUVIAL NA SEÇÃO DE PORTO SÃO JOSÉ, RIO PARANÁ

The Porto Primavera Dam caused the decrease of the concentration of suspended load and reduction of the size of the bed forms of Paraná River, but the effects of the construction on fluvial transport have not yet been quantified. In order to do that, this paper aims to evaluate the influence of the dam on the sediment transport in the section of Porto São José. Thus, data of Porto São José Fluviometric Station, field and or - bital images information available in literature were used. The data were analyzed by linear regression to obtain significant correlation between sediment transport and river discharge. The equations with significant coefficient of determination were used to estimate the annual average transport for different time periods. The suspended transport before construction was 214.1 kg/s, increased to 222.2 kg/s during construction and decreased to 56.4 kg/s after completion of the dam. The bed load transport was 99.7 kg/s during the construction, decreased to 86.2 kg/s during 1999 and 2000 and to 41.2 kg/s after 2001. In the same period the total transport decreased from 321.9 kg/s to 177.8 and finally to 91.2 kg/s. These results indicated that the Porto Primavera Dam reduced 74.6% of the suspended transport, 58.7% of the bed load transport, 71.7% of the total transport and increased the proportion of the bed load of 33, 9% to 44.5% of total

Régulation de l'expression du retrotransposon TnT1 du tabac

National audienc

The evolutionary analysis of the Tnt1 retrotransposon in Nicotiana species reveals the high variability of its regulatory sequences

5 graph.International audienc

In vivo characterization of transcriptional regulatory sequences involved in the defense-associated expression of the tobacco retrotransposon Tnt1

International audienc