Missing hard states and regular outbursts: the puzzling case of the black hole candidate 4U 1630-472

4U 1630-472 is a recurrent X-ray transient classified as a black-hole candidate from its spectral and timing properties. One of the peculiarities of this source is the presence of regular outbursts with a recurrence period between 600 and 730 d that has been observed since the discovery of the source in 1969. We report on a comparative study on the spectral and timing behaviour of three consecutive outbursts occurred in 2006, 2008 and 2010. We analysed all the data collected by the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) and the Rossi X-ray timing Explorer (RXTE) during these three years of activity. We show that, in spite of having a similar spectral and timing behaviour in the energy range between 3 and 30 keV, these three outbursts show pronounced differences above 30 keV. In fact, the 2010 outburst extends at high energies without any detectable cut-off until 150-200 keV, while the two previous outbursts that occurred in 2006 and 2008 are not detected at all above 30 keV. Thus, in spite of a very similar accretion disk evolution, these three outbursts exhibit totally different characteristics of the Compton electron corona, showing a softening in their evolution rarely observed before in a low mass X-ray binary hosting a black hole. We argue the possibility that the unknown perturbation that causes the outbursts to be equally spaced in time could be at the origin of this particular behaviour. Finally we describe several possible scenarios that could explain the regularity of the outbursts, identifying the most plausible, such as a third body orbiting around the binary system.Comment: April 2015: accepted for publication in MNRAS. May 2015: in pres

The cytochrome chain of mitochondria exhibits variable H+/e− stoichiometry

AbstractA study is presented of the ←H+/e− stoichiometry for H+ pumping by the cytochrome chain in isolated rat liver mitochondria under level-flow and steady-state conditions. It is shown that the ←H+/e− stoichiometry for the cytochrome chain varies under the influence of the flow rate and transmembrane ΔμH+. The rate-dependence is shown to be associated with cytochrome c oxidase, whose ←H+/e− ratio varies from 0 to 1, whilst the ←H+/c− ratio for the span covered by cytochrome c reductase is invariably 2

Missing hard states and regular outbursts: the puzzling case of the black hole candidate 4U 1630-472

4U 1630-472 is a recurrent X-ray transient classified as a black hole candidate from its spectral and timing properties. One of the peculiarities of this source is the presence of regular outbursts with a recurrence period between 600 and 730d that has been observed since the discovery of the source in 1969. We report on a comparative study of the spectral and timing behaviour of three consecutive outbursts that occurred in 2006, 2008 and 2010. We have analysed all the data collected by INTEGRAL and the Rossi X-ray Timing Explorer (RXTE) during these three years of activity. We show that, in spite of having a similar spectral and timing behaviour in the energy range between 3 and 30keV, these three outbursts show pronounced differences above 30keV. In fact, the 2010 outburst extends at high energies without any detectable cut-off until 150-200keV, while the two previous outbursts that occurred in 2006 and 2008 are not detected at all above 30keV. Thus, in spite of a very similar accretion disc evolution, these three outbursts exhibit totally different characteristics of the Compton electron corona, showing a softening in their evolution rarely observed before in a low-mass X-ray binary hosting a black hole. We argue the possibility that the unknown perturbation that causes the outbursts to be equally spaced in time could be at the origin of this particular behaviour. Finally, we describe several possible scenarios that could explain the regularity of the outbursts, identifying the most plausible, such as a third body orbiting around the binary syste

Variations in some of the body fluid hormone levels currently used for endocrine monitoring during the third trimester of pregnancy

Peer Reviewe

The peculiar 2011 outburst of the black hole candidate IGR J17091−3624, a GRS 1915+105-like source?

We report on the long-term monitoring campaign of the black hole candidate IGR J17091−3624 performed with INTEGRAL and Swift during the peculiar outburst started on 2011 January. We have studied the two-month spectral evolution of the source in detail. Unlike the previous outbursts, the initial transition from the hard to the soft state in 2011 was not followed by the standard spectral evolution expected for a transient black hole binary. IGR J17091−3624 showed pseudo-periodic flare-like events in the light curve, closely resembling those observed from GRS 1915+105. We find evidence that these phenomena are due to the same physical instability process ascribed to GRS 1915+105. Finally, we speculate that the faintness of IGR J17091−3624 could be not only due to the high distance of the source but also due to the high inclination angle of the syste

Effect of chicken bone extracts on metabolic and mitochondrial functions of K562 cell line

Background: Tetracyclines’ use in intensive animal farming has raised some concerns regarding the biosafety for humans. Increasing evidences have revealed the presence of these drugs in processed animal by-products, such as bone, throughout the food chain. A potential off-target of tetracyclines is the bacterial-like mitochondrial translational machinery, thereby causing proteostatic alterations in mitochondrial DNA-encoded components of the oxidative phosphorylation system. Methods: The Seahorse methodology, confocal microscopy imaging of mitochondrial potential and reactive oxygen species, and q-RT-PCR analysis of the expression of genes involved in mitochondrial biogenesis and mitophagy were carried out on human lymphoblast derived K562 cell line challenged with bone powder derived from chicken treated with or without oxytetracycline and pure oxytetracycline. Results: A complex dose-dependent profile was attained with a low dosage of bone powder extracts causing a metabolic adaptation hallmarked by stimulation of the mitochondrial respiration and enhanced expression of mitochondriogenic factors in particular in cells challenged with oxytetracycline-free bone extract. Conversely, a higher dosage of bone powder extracts, regardless of their source, caused a progressive inhibition of mitochondrial respiration and glycolysis, ultimately leading to cell death. No significant effects of the pure oxytetracycline were observed. Conclusion: Bone powder, regardless of chicken treatment, contains and releases factors/chemicals responsible for the observed effects on energy metabolism. Quantitative differential effects appear to depend on biochemical alterations in the bone matrix caused by antibiotics rather than antibiotics themselves

Crop insurance subsidies and environmental externalities: evidence from Southern Italy

Rapid environmental changes can affect agriculture by introducing additional sources of uncertainty. Conversely, policy interventions to help farmers cope with risks may have strong impacts on the environment. In this paper, we evaluate the effects of public risk management programmes, particularly subsidies on crop insurance, on fertilizer use and land allocation. We implement a mathematical programming model based on data collected from 1,092 farms in Puglia, a southern Italy region. The results show that under the current crop insurance programmes, input use is expected to increase, while the effect on production is likely to be crop-specific. The policy and environmental implications are discussed

Crop insurance subsidies and environmental externalities: evidence from Southern Italy

Rapid environmental changes can affect agriculture by introducing additional sources of uncertainty. Conversely, policy interventions to help farmers cope with risks may have strong impacts on the environment. In this paper, we evaluate the effects of public risk management programmes, particularly subsidies on crop insurance, on fertilizer use and land allocation. We implement a mathematical programming model based on data collected from 1,092 farms in Puglia, a southern Italy region. The results show that under the current crop insurance programmes, input use is expected to increase, while the effect on production is likely to be crop-specific. The policy and environmental implications are discussed

INTEGRAL/IBIS search for e-e+ annihilation radiation from the Galactic Center Region

Electron-positron annihilation radiation from the Galactic Center region has been detected since the seventies, but its astrophysical origin is still a topic of a scientific debate. We have analyzed data of the gamma-ray imager IBIS/ISGRI onboard of ESA's INTEGRAL platform in the e$^{-}$e$^{+}$ line. During the first year of the missions Galactic Center Deep Exposure no evidence for point sources at 511 keV has been found in the ISGRI data; the $2 \sigma$ upper limit for resolved single point sources is estimated to be $1.6\times 10^{-4} ph cm^{-2} s^{-1}$.Comment: 6 pages, 3 figures; Cospar 2004. To be published in: Advances in Space Researc

Ultrafast force-clamp spectroscopy of single molecules reveals load dependence of myosin working stroke

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