8 research outputs found
Some comments of countries that collected empirical and clinical data. Comment A, concerning Italian empirical data
- Author
- Publication venue
- place:London
- Publication date
- 01/01/2008
- Field of study
Dilemmi etici legati alla diagnosi prenatale: metodi di uno studio multicentrico
- Author
- Publication venue
- place:Roma
- Publication date
- 01/01/2008
- Field of study
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
- Author
- Abrate Paolo
- Accordino Silvia
- Ageno Walter
- Agnoletti Vanni
- Agosti Michele
- Agostini Carlo
- Agostini Moreno
- Agostinone Adriana
- Agrati Antonio Maria
- Aiello Giuseppe
- Aiuti Massimo
- Albano Giovanni
- Alberico Marielisa
- Alborghetti Armando
- Alborghetti Leonardo
- Aldegheri Giorgio
- Allevi Elisabetta
- Amadasi Silvia
- Amaglio Angelo
- Amitrano Maria
- Amoroso Filippo
- Andrea Antonini
- Andrea Bellone
- Andreassi Silvia
- Andreoni Massimo
- Angarano Gioacchino
- Angeletti Chiara
- Angelici Stefano
- Angheben Andrea
- Angileri Manuela
- Angrisani Claudio
- Annnunziata Maria Laura
- Annunziata Anna
- Anselmo null
- Ansuini Andrea
- Antivalle Marco
- Antonio Fioravanti
- Antonioli Chiara Maria
- Aondio Gianmarco
- Appiani Camilla
- Aquilini Donatella
- Arcidiacono Antonio
- Arcoleo Giuseppe
- Arenare Laura
- Arenare Laura
- Argilloni Elena
- Ariani Alarico
- Arlotti Massimo
- Artiol Stefania
- Artoni Paola Daniela
- Ascierto Paolo Antonio
- Ascierto Paolo Antonio
- Ashofarir Najat
- Atripaldi Luigi
- Atripaldi Luigi
- Atteno Mariangela
- Babudieri Sergio
- Baccari Laura
- Baciu Izabela
- Badagliacca Rita
- Bakhtadze Nikoloz
- Baldessari Chiara
- Ballarin Andrea
- Ballotta Andrea
- Bandiera Francesco
- Banfi Elisa
- Baratta Alberto
- Barattini Massimo
- Baratto Fabio
- Barbato Valentina
- Baré Cristina
- Barone Antonietta
- Baroni Irene
- Baronio Barabara
- Barreca Filippo
- Bartolaminelli Clara
- Barzan Daniela
- Basile Adriano
- Bassetti Matteo
- Bassi Flavio
- Battistini Nicholas
- Bausi Simona
- Bella Anna Maria
- Bellan Mattia
- Bellintani Claudio
- Bellinzona Guido
- Bellucci Francesco
- Belsito Agata
- Beltrame Angela
- Beltramini Sabrina
- Belvisi Valeria
- Benatti Elisa
- Benatti Francesco
- Benedetti Valentina
- Benigni Giovanni
- Beretta Flavio Niccolò
- Berlendis Marialma
- Berlot Giorgio
- Bernardi Cristina
- Bernardi Enrico
- Bernardi Livio
- Bernardi Paola
- Bernasconi Mara
- Bernhart Othmar
- Bertellini Elisabetta
- Berté Ylenia
- Bertoldi Marco
- Bettazzi Laura
- Bettega Donato
- Bettini Daniela
- Bevilacqua Simona
- Beyene Nebiat Balei
- Bezzi Michela
- Bianchetti Angel
- Bianchi Attilio Antonio Montano
- Bianchi Cristina
- Bianchi Michele
- Bianchin Andrea
- Bianco Antonella
- Bianco Vincenzo
- Bina Niccolò
- Binda Francesca
- Binda Francesca
- Bindoli Sara
- Bini Francesco
- Biondi Andrea
- Bisio Claudia
- Bitetto Michele
- Bitti Giuseppina
- Bizzotto Giada
- Blanc Pierluigi
- Blanzuoli Laura
- Blasi Livio
- Boari Gianluca Edoardo Mario
- Boccalatte Daniela
- Boccasile Laura
- Bocchi Federica
- Bocchi Pietro
- Boglione Lucio
- Bokor Daniela
- Bonazzi Maurizio
- Bonetti Silvia
- Bonfante Salvatore
- Bonfanti Paolo
- Bonfanti Paolo
- Boni Fabrizio
- Boni Sabrina
- Bonifazi Marina
- Bonizzoli Manuela
- Bonizzoli Mnuela
- Boracchia Luca
- Bordignon Susanna
- Bordonali Alessandro
- Borghetti Paolo
- Borroni Vittorio
- Boschi Andrea
- Bosco Enrico
- Bosco Francesca
- Bossini Nicola
- Bottalico Irene
- Bottega Roberta
- Botti Gerardo
- Botti Gerardo
- Bottiroli Maurizio
- Bottoli Maria Grazia
- Bovetto Elena
- Bragantini Damiano
- Bragazzi Maria Consiglia
- Brancaleoni Paolo
- Bravi Stefania
- Bravi Stefano
- Brentana Loretta
- Bretto Cristina
- Brianti Annalisa
- Brioschi Paolo
- Brocchieri Alessandra
- Brollo Lucio
- Brugioni Lucio
- Bruno Raffaele
- Bucci Lucio
- Buetto Giovanni
- Buglione Amalia
- Buonfanti Gaetano
- Buonomo Antonio Riccardo
- Bussini Linda
- Bussolari Cecilia
- Buzzigoli Stefano
- Cabrini Luca
- Cacopardo Bruno
- Caimi Marina
- Calabria Giosuè
- Calcagno Andrea
- Caldini Eleonora
- Calleri Guido
- Calvi Rovberta
- Calzetti Carlo
- Calzetti Carlo
- Camarda Gaetana
- Camici Laura
- Caminati Antonella
- Caminiti Giulia
- Campagna Giuseppe
- Campomori Annalisa
- Cancanelli Luca
- Canetta Ciro
- Cannizzo Stefania
- Canta Francesca
- Cantadori Luca
- Canzanella Giuliana
- Capici Serena
- Capitanio Chiara
- Caporusso Rosa Roberta
- Cappelli Carlo
- Cappi Cinzia
- Capuozzo Antonio
- Caputo Anna Maria
- Carai Antonina
- Carbonara Sergio
- Carbone Giorgio
- Carbonelli Cristiano Matteo
- Cardinale Vincenzo
- Cardone Claudia
- Cardone Claudia
- Caria Federico Carlo
- Carletti Massimo
- Carli Tiziana
- Carlotto Antonio
- Carpinteri Giuseppe
- Carpinteri Maurilio
- Carraro Anna
- Cartella Stefania
- Carubia Giulia
- Caruso Andrea
- Caruso Maria Grazia
- Casadio Lorenzo
- Casati Giorgio
- Casati Giovanni
- Cascella Marco
- Casella Giampaolo
- Casella Orazio
- Casella Silvia
- Casinelli Katia
- Castellan Andrea
- Castellano Maurizio
- Castelli Francesco
- Castelli Francesco
- Castellini Mariateresa
- Castello Luigi
- Castelvecchio Serenella
- Castenetto Enzo
- Castiglione Giacomo
- Catalano Filippo
- Catalano Mario
- Catania Alberto
- Catellani Jacopo
- Cattaneo Alessandra
- Cattaneo Paolo
- Cattaneo Sergio
- Cattelan Anna Maria
- Cauda Roberto
- Cavanna Luigi
- Cazzaniga Marina
- Celesia Benedetto Maurizio
- Celeste Mariagrazia
- Cemuschi Alessandra Maria
- Cerbo Lidia
- Cerino Giulia
- Cerri Maria Chiara
- Cerutti Alessandro
- Cerutti Elisabetta
- Cesareo Roberto
- Cesira Nencioni
- Cettolo Francesca
- Cherubini Antonio
- Chiarello Tosca
- Chiari Silvia
- Chiereleson Francesco
- Chierico Katiuscia
- Chiesa Elena
- Chinello Pierangelo
- Chiodelli Giulia
- Chiodini Paolo
- Chiodini Paolo
- Chiumiento Fernando
- Ciani Silvia
- Ciarrochi Erika
- Ciccone Antonello
- Ciccullo Arturo
- Cicognini Daniela
- Cimolato Barbara
- Cinnella Gilda
- Ciofetti Morena
- Cioni Giorgio
- Cipolla Giuseppe
- Cipollone Francesco
- Cirasa Maria Teresa
- Cirillo Fernanda
- Cirri Silvia
- Citarella Michele
- Citterio Chiara
- Ciuffreda Marcello
- Civita Marina
- Claudio Norbiato
- Clementi Stefano
- Clerici Raffaella
- Clini Enrico
- Cocchi Silvia
- Cocco Livio
- Codeluppi Mauro
- Cogi Enrico
- Cola Luisanna
- Columpsi Paola
- Conforti Francesco
- Consales Guglielmo
- Consorte Augusta
- Converso Marcella
- Coppola Marina
- Coppola Nicola
- Corcione Silvia
- Corda Luciano
- Corridi Marta
- Corsaro Annamaria
- Corsini Romina
- Corso Luisella
- Corvini Federica
- Cosentino Carmine
- Cosimo Franco
- Cosseta Daniele
- Cossu Maria Vittoria
- Costa Chiara
- Costa Isabella
- Costa Raffaella
- Costantini Massimo
- Costantini Paolo
- Covesnon Maria Grazia
- Cozzio Susanna
- Crapis Massimo
- Crepaldi Monica
- Crespi Stefano
- Crespi Tiziano
- Crippa Ilaria Alice
- Crippa Massimo
- Crisafulli Ernesto
- Cristiana Seravalle
- Cristina Zocchetti
- Cristini Francesco
- Criveller Pietro
- Croci Leonardo
- Cuppone Maria Teresa
- Curtolo Ambrogio
- Curvietto Marcello
- Cuzzone Vincenzo
- Dagna Lorenzo
- Dalbeni Andrea
- Dalè Michael
- Damiani Carla
- Damiano Terenzio
- Daniele Antonio
- Daniele De Nardo
- Daniele Italiani
- Danieli Elisabetta
- Danzi Maria
- Dasseni Nicola
- David Marco
- De Almeida Neves Naile
- De Arroyabe Blanca Martinez Lopez
- De Candia Daniele
- De Caro Monica
- De Conti Fabio
- De Cristoforo Maria Giovanna
- De Donno Giuseppe
- De Feo Gianfranco
- De Filippi Claudia
- De Franco Daniela
- De Gennaro Fabio
- De Luca Silvana
- De Marco Mario
- De Masi Margherita
- De Matteis Giovanni
- De Michele Fausto
- De Monte Andrea
- De Negri Pasquale
- de Paduanis Giovanna Attilia
- De Palma Raffaele
- De Ponti Simona
- De Rosa Annunziata
- De Rosa Francesco
- De Rosa Francesco Giuseppe
- De Stefano Giulio
- De Struppi Silvia
- De Vito Andrea
- Deidda Silvia
- Dejaco Christian
- Del Bono Valerio
- Del Borgo Cosmo
- del Duca Sara
- Del Fabbro Roberto
- Del Giudice Antonia
- Del Giudice Emanuela
- Del Prete Maria Simona
- Del Punta Veronica
- Del Vecchio Rosa Fontana
- Delfanti Fanny
- Delfrate Nichola Walter
- Delliponti Mariangela
- Dell’Aquila Giuseppina
- dell’Ara Francesca
- Dell’uomo Vanessa
- Delmonte Vito
- Delnero Pietro
- Delucchi Maurizio
- Dennetta Donatella
- Dentali Francesco
- Desiderio Emilia
- Di Biase Valeria
- Di Carlo Anna Maria
- Di Carlo Marco
- Di Caterino Emilio
- Di Cato Luca
- Di Cura Villa Giada Pallotti Casa
- Di Filippo Alessandro
- di Grigoli Paola
- Di Lorenzo Andrea
- Di Nunzio Camilla
- Di Perna Felicia
- Di Perri Giovanni
- Di Pietro Massimo Antonio
- Di Rosa Zaira
- Di Rosolini Maria Antonietta
- Di Sanzo Daniela
- Di Sciacca Riccardo
- Di Stefano Daniela Emanuela
- Di Stefano Michele
- Diberardino Stefania
- Dognini Giuseppina
- Dolci Giovanni
- Dolci Giovanni
- Dolfini Viola
- Donati Luca
- Donghi Lorenzo
- Donne Livia Delle
- Donno Davide R.
- Doria Andrea
- Dorina Balan
- Dragonetti Maria Margherita
- Drera Monica
- D’Abraccio Maurizio
- D’Alagni Giancarlo
- D’amico Federico
- D’amico Maria
- D’Andrea Giovanna
- D’offizi Gianpiero
- Ebbreo Gabriele
- Eisendle Frederik
- Enrica Caviglia
- Equitani Francesco
- Ercolino Giovanna
- Erne Elke Maria
- Espinosa Emma
- Esposito Vincenzo
- Fabbri Camilla
- Fabietti Paolo
- Fabio Toffoletto
- Facchini Cesarina
- Faccio Luciana
- Facciolongo Nicola Cosimo
- Facondini Francesca
- Fadda Andrea
- Faggioli Paola
- Fancoli Fabiana
- Faoro Sonia
- Fara Claudio
- Farina Antonella
- Farina Martina
- Farinazzo Maddalena
- Fasolo Martina
- Favero Vittoria
- Felicietti Mara
- Fendt Doris
- Ferrante Patrizia
- Ferrara Maurizio
- Ferrari Alessandra
- Ferrari Alessandro
- Ferrari Davide
- Ferrari Luisella
- Ferraris Laurenzia
- Ferraris Laurenzia
- Ferreri Enrico
- Ferrero Giovanna
- Fiammengo Fabio
- Fico Lorenzo
- Filippelli Amelia
- Filippini Matteo
- Filtz Annalisa
- Fiorentino Giuseppe
- Fiorini Barbara
- Fiscon Marta
- Flocco Romeo
- Flores Kristoffer
- Florio Manuela
- Focà Emanuele
- Fondaco Laura
- Fontana Costantino
- Fontana Matteo
- Foresta Giancarlo
- Fornaro Giacomo
- Fraganza Fiorentino
- Fraganza Fiorentino
- Franceschini Franco
- Francesco Claudio
- Francesco Lemut
- Franchi Federico
- Francisci Daniela
- Francisco Chiara
- Franco Antonina
- Franzetti Fabio
- Frascati Andrea
- Frattari Antonella
- Frausini Gabriele
- Fregoni Vittorio
- Frigerio Sillia
- Frigieri Francesca Covani
- Froldi Marco
- Fronti Elisa
- Fumagalli Roberto
- Furiani Silvia
- Furino Ermenegildo
- Fusar Maurizio
- Fusco Francesco Maria
- Fusco Pierluigi
- Gabriele Frausini
- Gaggiotti Mario
- Gaglio Leonardo
- Gaglione Gianfranco
- Galante Dario
- Galati Vincenzo
- Galderisi Feliciano
- Gallazzi Chiara
- Gallo Andrea
- Gallo Ciro
- Gallo Ciro
- Gallotti Pietro
- Gandino Anna
- Gardellini Angelo
- Gargiulo Piera
- Gargiulo Piera
- Gasparini Stefano
- Gasperini Beatrice
- Gatti Francesca
- Gatti Pietro
- Gaudiano Gianfranco
- Gazzola Lisa
- Gazzola Ospedale Erika
- Gelormini Domenico
- Generali Daniele
- Gennarini Silvia
- Genovese Elvira
- Gentile Ivan
- Gentili Vincenzo
- Gentilini Claudio
- Germanà Giuseppe
- Ghidoni Giulia
- Ghirardi Gianluca
- Ghirardi Leonardo
- Ghiringhelli Paolo
- Giachi Andrea
- Giacomazzi Francesca
- Giacomini Matteo
- Gianelli Davide
- Giannandrea Giusy
- Giannelli Luciana
- Giannotti Michella
- Giglio Omar
- Gilberto Fiore
- Gilio Michele
- Gilioli Fabio
- Ginanni Roberta
- Gioacchini Maria Teresa
- Giogré Giuseppina
- Gioia Stefania
- Giorgi Riccardo
- Giorgis Silvia
- Giovanni Cenderello
- Gipponi Paola
- Girardis Massimo
- Girelli Domenico
- Girolimetti Rita
- Giubellino Elena
- Giuseppe Lain
- Giustinetti Giulia
- Gnesin Paolo
- Gnessi Camillo
- Gnudi Umberto
- Gobbo Giulia
- Gori Daniela
- Gori Gianluca
- Gottin Leonardo
- Granata Maria Luisa
- Grassi Walter
- Grasso Ilaria
- Gravina Adriano
- Gravina Adriano
- Graziosi Camilla
- Greco Antonio
- Greco Stefano
- Grio Michele
- Grisolia Antoenlla
- Gritti Giuseppe
- Grossi Paolo Antonio
- Guadagnin Maria Licia
- Guaraldi Giovanni
- Guarino Salvatore
- Guarneri Luigi
- Guelfi Paolo
- Guerini Fabio
- Guerra Alberto
- Guerrini Giulio
- Gugliemi Gaspare
- Guidelli Giacomo Maria
- Guidi Maria Francesca
- Gulisano Leonardo
- Harari Sergio
- Henchi Sonia
- Hofer Alex
- Iacobello Carmelo
- Iemoli Enrico
- Iengo Bianca
- Ilaria Blangetti
- Imitazione Pasquale
- Imperiale Daniele
- Inchiostro Sandro
- Infantino Gessica
- Inglese Francesco
- Ingrosso Marco
- Innocenti Giorgio
- Iommelli Chiara
- Ippoliti Giovanbattista
- Isgrò Valentina
- Iuorio Angela
- Jocollé Genny
- Kertusha Blerta
- Kokaly Francesco
- Labate Demetrio
- Labella Daniela
- Lacedonia Donato
- Lambertenghi Lorenza
- Lamonica Silvia
- Lancione Luca
- Landi Raffaella
- Landini Giancarlo
- Lanfranco Maurizio
- Langer Thomas
- Larussa Dora
- Latronico Nicola
- Lavoretano Sabrina
- Lavorini Federico
- Lazzeri Chiara
- Leone Armando
- Leonetti Frida
- Leto Gaetano
- Liberato Nicola Lucio
- Liccardi Marco Maria
- Lichtner Miriam
- Lichtner Miriam
- Lilli Marianna
- Lingua Anna
- Lipani Filippo
- Lipari Alessio
- Liparulo Luigi
- Liuzzi Nicola
- Livigni Sergio
- Lo Caputo Sergio
- Lonati Veronica
- Lorenzotti Silvia
- Losappio Ruggero
- Lubrano Giuseppe
- Lubrano Riccardo
- Luca Boracchia
- Lucci Antonella
- Lucernoni Paolo
- Luchi Sauro
- Lui Stefania
- Lutri Lorenzo
- Maccari Daniela
- Macheda Sebastiano
- Machiavelli Andrea Marco
- Madeddu Giordano
- Maffezzini Elena
- Maffongelli Gaetano
- Maggi Paolo
- Maggioni Paola
- Magnaca Andrea
- Magni Marta
- Magrini Stefano
- Magro Gaetano
- Mahlknecht Klaus
- Maietta Pasquale
- Maimone Patrizia
- Mainardi Stefano
- Malberti Fabio
- Malcontenti Costanza
- Malena Marina
- Malgorzata Mikulska
- Mancini Annalisa
- Mancini Mauro
- Mandelli Anna
- Manfredini Elena
- Manfrin Vinicio
- Mangano Carmelo
- Mangiacapra Sara
- Manini Alessandra
- Manini Arianna
- Manno Emilpaolo
- Mantovani Barbara
- Mantovani Lorenzo Filippo
- Manuele Rosa
- Manzi Andrea
- Manzillo Elio
- Maraolo Alberto
- Marata Anna Maria
- Marchesoni Ivan
- Marchetti Giulia
- Marchetti Valentina
- Marchi Maria Rita
- Marco Baiocchi
- Marcon Elisabetta
- Mariani Roberta
- Marinangeli Franco
- Marinelli Alfredo
- Marini Enrico
- Marini Sara Francesca
- Marino Andrea
- Marino Francesco
- Marino Pietro
- Maroccia Alessio
- Marocco Raffaella
- Maroni Lorenzo
- Marra Lorenzo
- Marrazzo Gerarda
- Marrocco Francesca
- Marrocco-Trischitta Massimiliano M.
- Marrocco-Trischitta Massimiliano M.
- Martelli Domenico
- Martellucci Salvatore
- Martinelli Laura
- Martino Giuseppe Pio
- Martino Marilena
- Masolin Tiziana
- Maspero Sonia
- Massari Marco
- Massari Marco
- Masserini Federico
- Mastroianni Alessandro
- Mastroianni Antonio
- Mastroianni Claudio
- Mastroianni Claudio Maria
- Mastroianni Franco
- Mastropasqua Bernardino
- Masullo Alfonso
- Matei Anaflorina
- Matsuno Jun Sebastian
- Mauro Immacolata
- Mazzola Francesca
- Mazzola Giovanni
- Mazzoleni Manuel
- Mazzone Antonino
- Mecozzi Alessandra
- Mei Federico
- Meli Alessandro
- Meliante Piero Giuseppe
- Melica Tiziana
- Mencarini Jessica
- Mengoli Caterina
- Menicacci Lorenzo
- Menicanti Lorenzo
- Mensi Giulio
- Mercurio Vito Sante
- Meschi Tiziana
- Meschiari Marianna
- Meschini Carlo
- Messina Antonio
- Messina Florinda
- Messina Vincenzo
- Metra Marco
- Micarelli David
- Miceli Marco
- Michieletto Lucio
- Mietta Sabrina
- Mighali Pasquale
- Migliori Lucia
- Milia Mario
- Mina Federica
- Minato Milena
- Minelli Enrica
- Minoja Guja
- Minuz Pietro
- Miscio Leonardo
- Modica Sara
- Molaro Raffaele
- Molino Paola
- Mollica Mariano
- Molteni Alfredo
- Molteni Chiara
- Momesso Elena
- Monacci Cecilia
- Mondino Michele
- Mondino Vincenzo
- Moneta Sara
- Monforte Antonella D’arminio
- Montagnini Francesca
- Montalto Maria Teresa
- Montani Giovanni
- Monteforte Gabriella
- Montemurro Lidia
- Montesarchio Vincenzo
- Montesarchio Vincenzo
- Monti Roberto
- Monticelli Jacopo
- Montineri Arturo
- Montisci Andrea
- Montrucchio Chiara
- Morando Giovanni
- Morbidoni Laura
- Morettini Alessandro
- Morgana Gianfranco
- Moroni Alice
- Moroni Carlo
- Moroni Federico
- Mosca Giacomo
- Moschini Greta
- Mosti Silvia
- Motta Leonardo
- Mucci Luciano
- Muiesan Maria Lorenza
- Muiesan Maria Lorenza
- Murdaca Giuseppe
- Mussini Cristina
- Mussini Cristina
- Musumeci Diana
- Muttini Stefano
- Nallino Gabriella
- Napoli Giovanna
- Nardecchia Anna Laura
- Nardi Stefano
- Nasta Paola
- Nava Antonella
- Nava Valeria
- Navalesi Paolo
- Navarra Mauro
- Negri Emanuele Alberto
- Negri Emanuele Alberto
- Negro Cristina
- Negro Enrica
- Nespola Giorgio Amadio
- Nicastri Emanuele
- Nico Andrea
- Nicolini Laura Ambra
- Nijhawan Parni
- Niro Dario
- Nonini Sandra
- Noto Concetta
- Nouvenne Antonio
- Novali Mauro
- Nucera Antonia
- Nucera Gabriella
- Nuceri Antonia
- Numis Fabio Giuliano
- Odolini Silvia
- Oggionni Tiberio
- Olivetti Alessandro
- Omega Luca
- Oppedisano Peppino
- Orlandi Matteo
- Ornella Calderone
- Otero Manuela
- Ottaviano Mario
- Pace Erminio
- Pacentra Enrico
- Pacetti Veronica
- Pagani Silvia
- Pagliano Pasquale
- Pagnoni Carlo
- Pagnozzi Fiammetta
- Paini Anna
- Palagano Nicolas
- Palla Marco
- Palladino Marcello
- Pallotto Carlo
- Palmieri Fabrizio
- Palmiero Gerardo
- Palmiotti Giuseppe Antonio
- Palumbo Michele
- Pampaloni Alessio
- Panaccione Anna
- Pandini Chiara Stefania
- Panese Sandro
- Panico Rosanna
- Pannella Greta
- Panzolato Gianluigi
- Paone Tonia Celeste
- Papetti Claudia
- Papi Alberto
- Para Ombretta
- Parrella Roberto
- Parrella Roberto
- Parrocchia Sergio
- Parruti Giustino
- Pascale Renato
- Pasero Daniela
- Pasini Simone Marino
- Pasquini Zeno
- Pasquino Bernadetta
- Pasquino Paola
- Passalacqua Rodolfo
- Pastorelli Mauro
- Pasulo Luisa
- Pavei Chiara
- Pavoni Vittorio
- Peci Paolo
- Pedrini Luciano
- Pelagatti Lorenzo
- Pensa Anna
- Pepe Antonio
- Perego Giovanni Battista
- Peregrinelli Alessio
- Perfetti Elisa
- Perin Tiziana
- Peris Adriano
- Perra Roberto
- Perrone Francesco
- Perrone Francesco
- Perugini Orietta
- Pesce Laura
- Petrone Anna
- Petrosillo Nicola
- Piazza Manuela
- Piazza Ornella
- Piccinni Rosangela
- Piccirillo Maria Carmela
- Piccirillo Maria Carmela
- Piccoli Jolanda
- Piconi Stefania
- Pieralli Filippo
- Pierantozzi Silvia
- Pierfranceschi Matteo Giorgi
- Pierini Simona
- Pietrangelo Antonello
- Piga Sandro
- Pignatti Andrea
- Piluso Martina
- Pinelli Giovanni
- Pinna Simone Mornese
- Pirozzi Maria Rosa
- Pisapia Raffaella
- Pisterna Alessia
- Pitagora Loredana
- Piva Simone
- Plamieri Giulia
- Poggesi Loredana
- Pognuz Erik Roman
- Poisa Paolo
- Polati Enrico
- Poletti Enrico
- Poletti Venerino
- Poli Federica
- Poli Marco Dei
- Polistina Giorgio
- Pollastri Costanza
- Pontali Emanuele
- Ponticiello Antonio
- Pontiggia Silvia
- Pontremoli Roberto
- Popoli Patrizia
- Porta Francesca Della
- Porta Giovanni
- Portale Grazia
- Potenza Domenico
- Prandini Paolo
- Presotto Fabio
- Prestini Katiela
- Principi Tiziana
- Properzi Martina
- Prozzo Alessandra
- Pulitanò Grazia
- Pulvirenti Fabrizio
- Punzi Rodolfo
- Puorto Antonella
- Puoti Massimo
- Pusterla Luigi
- Puttini Camilla
- Quadri Rachele Delli
- Racagni Milena
- Raffaeli Davide
- Raffaelli Valentina
- Raimondo Mariangela
- Rampa Lorenzo
- Ranghitta Melania
- Ranucci Marco
- Rapisarda Giuseppe
- Raponi Gianna
- Rastelli Gianni
- Rastellino Valentina
- Raumer Luigi
- Ravaglia Claudia
- Ravagnani Viviana
- Ravani Serena
- Regazzetti Angelo
- Reghenzi Piera
- Regis Monica
- Repossi Alice
- Rescigno Carolina
- Resimini Silvia
- Resta Marco
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- Ribecco Maria Teresa
- Riccardi Ferdinando
- Riccardi Niccolò
- Ricchiardi Alberto
- Ricci Chiara
- Ricci Clara
- Ricci Maria Anastasia
- Ricci Massimo
- Ricci Silvano
- Riccio null
- Ricioppo Aristodemo
- Ridola Lorenzo
- Riggio Oliviero
- Righetti Giulia
- Righini Erminio
- Ripamonti Diego
- Ripamonti Diego
- Rivitti Rosario
- Rizzardini Giuliano
- Rizzi Eleonora
- Rizzoni Damiano
- Roberti Giuseppe
- Roccaro Aldo
- Roccatello Dario
- Rocchetti Chiara
- Rocco Monica
- Roldan Eugenia Quiros
- Romagnoli Micaela
- Romanelli Michela
- Romano Anacleto
- Romano Annamaria
- Romano Fiorella
- Romeo Domenico
- Romeo Francesca
- Roncaglia Enrica
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- Rossetti Barbara
- Rossi Alberto
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- Ruggeri Ruggero
- Ruggieri Annamaria
- Ruggieri Lorenzoa
- Ruggieri Maria Paola
- Russo Chiara
- Russo Gianluca
- Russo Grazia
- Russo null
- Russo Roberto
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- Sabato Eugenio
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- Sachs Michele
- Saffioti Carolina
- Saglimbene Sebastiana
- Sainaghi Pier Paolo
- Sala Girolamo
- Sala Luca
- Sala Nadia
- Salerno Anna Maria
- Salerno Nicola Duccio
- Salerno Nicola Duccio
- Salsi Pierpaolo
- Saltori Martino
- Salvarani Carlo
- Salvarani Carlo
- Salvetti Massimo
- Sangiovanni Antonella
- Sangiovanni Vincenzo
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- Santoboni Gianluca
- Santopuoli Donato
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- Saracino Annalisa
- Sarmati Loredana
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- Sarteschi Giovanni
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- Satira Roberto
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- Savio Alfonso
- Savio Maria Cristina
- Sbreglia Costanza
- Scabini Silvia
- Scaglione Nadia
- Scala Alberto
- Scalabrino Elisa
- Scapino Bruno
- Scarafino Antonio
- Scarano Francesco
- Scartabellati Alessandro
- Schettino Clorinda
- Schettino Clorinda
- Schettino Giuseppe
- Scimonello Guglielmo
- Sciolè Katiuscia
- Scolari Francesco
- Scollet Sabino
- Scorletti Eva
- Scotto Riccardo
- Scotton Pier Giorgio
- Scozzafava Mariano
- Scudellari Roberta
- Sdanganelli Antonia
- Sellitto Carmine
- Sepulcri Chiara
- Serao Mattia
- Serati Lisa
- Serino Francesco Saverio
- Serra Eugenio
- Servillo Giuseppe
- Sgarabotto Camilla
- Sicheri Domenico
- Sighieri Cinzia
- Silengo Daniela
- Silva Matteo
- Silvia Tamanini
- Sirignano Emanuele
- Sorrentino Carlo
- Sortino Claudio
- Spadoni Claudia
- Spagnolli Walter
- Spagnuolo Giovanni
- Spanu Paolo
- Sparavigna Lucia
- Spatafora Mario
- Spatarella Micaela
- Spaziani Sandra
- Spina Rosario
- Spinicci Michele
- Spizzo Gilbert
- Spolveri Stefano
- Sportato Giuseppe
- Squillace Nicola
- Squillace Nicola
- Stefanetto Ivana Marina
- Stellini Roberto
- Stillante Maria Serafina
- Stobbione Paolo
- Storti Angelo
- Storti Enrico
- Straface Giuseppe
- Strano Giuseppe
- Stroppa Elisa Maria
- Suardi Lorenzo Roberto
- Succu Angela
- Tacconelli Evelina
- Tacconi Danilo
- Tafuri Agostino
- Taglietti Fabrizio
- Taibi Chiara
- Tarquini Giovanna
- Tarsia Paolo
- Tasca Francesca
- Tebaldi Alessandra
- Tedeschi Alberto
- Tedeschi Sara
- Tedesco Andrea
- Tedesco Silvia
- Tenti Elena
- Teopompi Elisabetta
- Testa Filippo
- Teti Elisabetta
- Ticinesi Andrea
- Tieghi Tiziana
- Tinti Maria Giulia
- Titolo Giancarlo
- Tognella Silvia
- Tomasoni Gabriele
- Tomasoni Lina
- Tomasoni Lina Rachele
- Topino Simone
- Tornese Daniela
- Torre Federica
- Torretta Giacomo
- Torrini Monica
- Tosti Andrea
- Traballi Gabriella
- Trenti Chiara
- Trequattrini Tiziana
- Trezzi Michele
- Trojaniello Claudia
- Tropea Concetta Maria Gabriella
- Tundo Paolo
- Tura Paolo
- Turati Maria Luisa
- Turrini Mauro
- Uccella Ilaria
- Uccelli Maria Cristina
- Ucciferri Claudio
- Uggeri Cristiano
- Urru Silvana
- Ursillo Antonia
- Usai Carlo Andrea
- Vacca Elisabetta Blasi
- Vairo Giuseppe
- Valastro Federico
- Valenti Marco
- Valenti Vincenzo
- Valenzi Emiliano
- Valli Linda
- Vallone Alfredo
- Vanoni Nicolò
- Varbella Ferdinando
- Vassia Veronica
- Vecchiet Jacopo
- Vella Sabrina
- Venturi Bruna
- Venturini Sergio
- Verhovez Andrea
- Veronese Lorenzo
- Versaci Alessandra
- Vetica Angelo
- Vezzoli Monia
- Viale Pierluigi
- Vianello Andrea
- Vico Carmen
- Vigliarolo Rossana
- Viglietti Rosaria
- Vincenti Antonella
- Vincenzi Marcello
- Vincenzo Brianti
- Vincenzo Valiani
- Viola Emanuela
- Viri Sabrina
- Virzì Giuseppe
- Visconti Giuseppe
- Visconti Stefano
- Visetti Enrico Maria
- Vitale Francesco
- Vitale Giovanni
- Vitale Maria Grazia
- Vitiello Leonarda
- Vitiello Silvio
- Viva Tommaso
- Viviani Rosangela
- Volkl Thomas
- Volpato Francesca
- Volta Carlo Alberto
- Vuotto Pietro
- Zammarchi Lorenzo
- Zanardini Cristina
- Zanatta Paolo
- Zanini Barbara
- Zanini Paola
- Zannetti Pio
- Zanolini Gabriele
- Zappa Maria Crisitna
- Zappulo Emanuela
- Zavarise Paola
- Zeme Angela Daniela
- Zenoni Davide
- Zini Enea
- Zoia Elena
- Zotti Maria Gioconda
- Zuccalà Francesco
- Zuccalà Paola
- Zuccarini Andrea
- Zummo Ugo
- Zunino Alessia
- Publication venue
- Publication date
- 01/01/2020
- Field of study
BackgroundTocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients.MethodsA multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled after the first cohort was accomplished, was used as a secondary validation dataset. The two cohorts were evaluated jointly in an exploratory multivariable logistic regression model to assess prognostic variables on survival.ResultsIn the primary intention-to-treat (ITT) phase 2 population, 180/301 (59.8%) subjects received tocilizumab, and 67 deaths were observed overall. Lethality rates were equal to 18.4% (97.5% CI: 13.6-24.0, P=0.52) and 22.4% (97.5% CI: 17.2-28.3, P<0.001) at 14 and 30 days, respectively. Lethality rates were lower in the validation dataset, that included 920 patients. No signal of specific drug toxicity was reported. In the exploratory multivariable logistic regression analysis, older age and lower PaO2/FiO2 ratio negatively affected survival, while the concurrent use of steroids was associated with greater survival. A statistically significant interaction was found between tocilizumab and respiratory support, suggesting that tocilizumab might be more effective in patients not requiring mechanical respiratory support at baseline.ConclusionsTocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory support at baseline.Registration EudraCT (2020-001110-38); clinicaltrials.gov (NCT04317092)
Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
- Author
- Adriana Agostinone
- Adriano Basile
- Adriano Gravina
- Adriano Gravina
- Adriano Peris
- Agata Belsito
- Agostino Tafuri
- Alarico Ariani
- Alberto Baratta
- Alberto Catania
- Alberto Guerra
- Alberto Maraolo
- Alberto Papi
- Alberto Ricchiardi
- Alberto Rossi
- Alberto Scala
- Alberto Tedeschi
- Aldo Roccaro
- Alessandra Brocchieri
- Alessandra Cattaneo
- Alessandra Ferrari
- Alessandra Manini
- Alessandra Maria Cemuschi
- Alessandra Mecozzi
- Alessandra Prozzo
- Alessandra Tebaldi
- Alessandra Versaci
- Alessandro Bordonali
- Alessandro Cerutti
- Alessandro Di Filippo
- Alessandro Ferrari
- Alessandro Mastroianni
- Alessandro Meli
- Alessandro Morettini
- Alessandro Olivetti
- Alessandro Scartabellati
- Alessia Pisterna
- Alessia Zunino
- Alessio Lipari
- Alessio Maroccia
- Alessio Pampaloni
- Alessio Peregrinelli
- Alex Hofer
- Alfonso Masullo
- Alfonso Savio
- Alfredo Marinelli
- Alfredo Molteni
- Alfredo Molteni
- Alfredo Vallone
- Alice Moroni
- Alice Repossi
- Amalia Buglione
- Ambrogio Curtolo
- Amelia Filippelli
- Anacleto Romano
- Anaflorina Matei
- Andrea Angheben
- Andrea Ansuini
- Andrea Antonini
- Andrea Ballarin
- Andrea Ballotta
- Andrea Bellone
- Andrea Bianchin
- Andrea Biondi
- Andrea Boschi
- Andrea Calcagno
- Andrea Caruso
- Andrea Castellan
- Andrea Dalbeni
- Andrea De Monte
- Andrea De Vito
- Andrea Di Lorenzo
- Andrea Doria
- Andrea Fadda
- Andrea Frascati
- Andrea Gallo
- Andrea Giachi
- Andrea Magnaca
- Andrea Manzi
- Andrea Marco Machiavelli
- Andrea Marino
- Andrea Montisci
- Andrea Nico
- Andrea Pignatti
- Andrea Tedesco
- Andrea Ticinesi
- Andrea Tosti
- Andrea Verhovez
- Andrea Vianello
- Andrea Zuccarini
- Angel Bianchetti
- Angela Beltrame
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- Anna Pensa
- Anna Petrone
- Annalisa Brianti
- Annalisa Campomori
- Annalisa Filtz
- Annalisa Mancini
- Annalisa Saracino
- Annamaria Corsaro
- Annamaria Romano
- Annamaria Ruggieri
- Annunziata De Rosa
- Anselmo Riccio
- Antoenlla Grisolia
- Antonella Bianco
- Antonella Caminati
- Antonella D'arminio Monforte
- Antonella Farina
- Antonella Frattari
- Antonella Lucci
- Antonella Nava
- Antonella Puorto
- Antonella Rossati
- Antonella Sangiovanni
- Antonella Sarni
- Antonella Vincenti
- Antonello Ciccone
- Antonello Pietrangelo
- Antonia Del Giudice
- Antonia Nucera
- Antonia Nuceri
- Antonia Sdanganelli
- Antonia Ursillo
- Antonietta Barone
- Antonina Carai
- Antonina Franco
- Antonino Mazzone
- Antonio Arcidiacono
- Antonio Capuozzo
- Antonio Carlotto
- Antonio Cherubini
- Antonio Daniele
- Antonio Fioravanti
- Antonio Greco
- Antonio Maria Agrati
- Antonio Mastroianni
- Antonio Messina
- Antonio Nouvenne
- Antonio Pepe
- Antonio Ponticiello
- Antonio Riccardo Buonomo
- Antonio Scarafino
- Arianna Manini
- Aristodemo Ricioppo
- Armando Alborghetti
- Armando Leone
- Armando Santoro
- Arturo Ciccullo
- Arturo Montineri
- Attilio Antonio Montano Bianchi
- Augusta Consorte
- Balan Dorina
- Barabara Baronio
- Barbara Cimolato
- Barbara Fiorini
- Barbara Mantovani
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- Benedetto Maurizio Celesia
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- Blangetti Ilaria
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- Brianti Vincenzo
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- Camilla Di Nunzio
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- Camilla Puttini
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- Camillo Gnessi
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- Carlo Agostini
- Carlo Alberto Volta
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- Carlo Calzetti
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- Carlo Meschini
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- Carlo Pallotto
- Carlo Pallotto
- Carlo Salvarani
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- Clorinda Schettino
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- Cristiano Matteo Carbonelli
- Cristiano Uggeri
- Cristina Baré
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- Cristina Negro
- Cristina Zanardini
- Damiano Bragantini
- Damiano Rizzoni
- Daniela Barzan
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- Daniela Emanuela Di Stefano
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- Daniela Gori
- Daniela Labella
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- Daniela Silengo
- Daniela Tornese
- Daniele Cosseta
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- Daniele De Nardo
- Daniele Generali
- Daniele Imperiale
- Danilo Tacconi
- Dario Galante
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- Dario Niro
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- David Micarelli
- Davide Ferrari
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- Davide R Donno
- Davide Raffaeli
- Davide Zenoni
- Demetrio Labate
- Diana Musumeci
- Diego Ripamonti
- Diego Ripamonti
- Domenico Gelormini
- Domenico Girelli
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- Domenico Potenza
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- Donatella Aquilini
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- Doris Fendt
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- Elena Maffezzini
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- Erik Roman Pognuz
- Erika Ciarrochi
- Ermenegildo Furino
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- Erminio Righini
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- Eugenia Quiros Roldan
- Eugenio Sabato
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- Fabrizio Boni
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- Fabrizio Pulvirenti
- Fabrizio Taglietti
- Fanny Delfanti
- Fausto De Michele
- Federica Bocchi
- Federica Corvini
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- Federica Poli
- Federica Torre
- Federico Carlo Caria
- Federico D'amico
- Federico Franchi
- Federico Lavorini
- Federico Masserini
- Federico Mei
- Federico Moroni
- Federico Valastro
- Felicia Di Perna
- Feliciano Galderisi
- Ferdinando Riccardi
- Ferdinando Varbella
- Fernanda Cirillo
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- Gianluca Edoardo Mario Boari
- Gianluca Ghirardi
- Gianluca Gori
- Gianluca Russo
- Gianluca Russo
- Gianluca Russo
- Gianluca Santoboni
- Gianluigi Panzolato
- Gianmarco Aondio
- Gianna Raponi
- Gianni Rastelli
- Gianpiero D'offizi
- Gilbert Spizzo
- Gilda Cinnella
- Gioacchino Angarano
- Giordano Madeddu
- Giorgio Aldegheri
- Giorgio Amadio Nespola
- Giorgio Berlot
- Giorgio Carbone
- Giorgio Casati
- Giorgio Cioni
- Giorgio Innocenti
- Giorgio Polistina
- Giosuè Calabria
- Giovanbattista Ippoliti
- Giovanna Attilia de Paduanis
- Giovanna D'Andrea
- Giovanna Ercolino
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- Giovanna Tarquini
- Giovanni Albano
- Giovanni Battista Perego
- Giovanni Benigni
- Giovanni Buetto
- Giovanni Casati
- Giovanni Cenderello
- Giovanni De Matteis
- Giovanni Di Perri
- Giovanni Dolci
- Giovanni Dolci
- Giovanni Guaraldi
- Giovanni Mazzola
- Giovanni Montani
- Giovanni Morando
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- Giulia Caminiti
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- Giulio Mensi
- Giuseppe Aiello
- Giuseppe Antonio Palmiotti
- Giuseppe Arcoleo
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- Giuseppe Carpinteri
- Giuseppe Cipolla
- Giuseppe De Donno
- Giuseppe Fiorentino
- Giuseppe Germanà
- Giuseppe Gritti
- Giuseppe Lain
- Giuseppe Lubrano
- Giuseppe Murdaca
- Giuseppe Pio Martino
- Giuseppe Rapisarda
- Giuseppe Roberti
- Giuseppe Schettino
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- Giuseppe Sportato
- Giuseppe Straface
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- Giuseppina Bitti
- Giuseppina Dell'Aquila
- Giuseppina Dognini
- Giuseppina Giogré
- Giuseppina Santilli
- Giustino Parruti
- Giusy Giannandrea
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- Greta Moschini
- Greta Pannella
- Guglielmo Consales
- Guglielmo Scimonello
- Guido Bellinzona
- Guido Calleri
- Guido Calleri
- Guja Minoja
- Ilaria Alice Crippa
- Ilaria Grasso
- Ilaria Uccella
- Immacolata Mauro
- Irene Baroni
- Irene Bottalico
- Isabella Costa
- Italiani Daniele
- Italy TOCIVID-19 investigators
- Italy: Francesco Perrone
- Ivan Gentile
- Ivan Marchesoni
- Ivana Marina Stefanetto
- Izabela Baciu
- Jacopo Catellani
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- Tiziano Crespi
- TOCIVID-19 investigators
- Tommaso Viva
- Tonia Celeste Paone
- Tosca Chiarello
- Ugo Zummo
- Umberto Gnudi
- Valentina Barbato
- Valentina Benedetti
- Valentina Isgrò
- Valentina Marchetti
- Valentina Raffaelli
- Valentina Rastellino
- Valeria Belvisi
- Valeria Di Biase
- Valeria Nava
- Valerio Del Bono
- Vanessa Dell'uomo
- Vanni Agnoletti
- Venerino Poletti
- Veronica Del Punta
- Veronica Lonati
- Veronica Pacetti
- Veronica Vassia
- Vincenzo Bianco
- Vincenzo Cardinale
- Vincenzo Cuzzone
- Vincenzo Esposito
- Vincenzo Galati
- Vincenzo Gentili
- Vincenzo Messina
- Vincenzo Mondino
- Vincenzo Montesarchio
- Vincenzo Montesarchio
- Vincenzo Sangiovanni
- Vincenzo Valenti
- Vincenzo Valiani
- Vinicio Manfrin
- Viola Dolfini
- Vito Delmonte
- Vito Sante Mercurio
- Vittoria Favero
- Vittorio Borroni
- Vittorio Fregoni
- Vittorio Pavoni
- Viviana Ravagnani
- Walter Ageno
- Walter Grassi
- Walter Spagnolli
- Ylenia Berté
- Zaira Di Rosa
- Zeno Pasquini
- Zocchetti Cristina
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients
- Author
- Aalbers Arend G.J.
- Abbas Ayman
- Abbood Ali Hashim
- Abdeen Basel
- Abdelaal Ahmed Samir
- Abdullah Nik A.N.
- Abdulwahed Eman
- Abelevich Alexander
- Abujamra Saleh
- Acar Nihan Coşgun
- Afzal Asma
- Agalianos Christos
- Agapov Mikhail N.
- Agostinelli Laura
- Ahmed Nagm Eldin Abu Elnga
- Ahmed Safia
- Aigner Felix
- Akyol Cihangir
- Al-Eryani Fatima
- Al-Juaifari Maytham A.
- Al-Najami Issam
- Alanez-Saavedra Javier
- Albakry Rudaina
- Alhardan Anas
- Alhisi Ahmed Jehad
- Ali Ahmed K.
- Alkady Eithar
- Allmer Caterina
- Alonso Alfredo
- Alrayes Bourhan M.H.
- Alshareea Entisar
- Altomare Donato F.
- Altrabulsi Amani
- Alvarez-Bautista Francisco E.
- Amano Takahiro
- Amelung Femke J.
- Anderin Kajsa
- Annicchiarico Alfredo
- Ansorena Yolanda Saralegui
- Antona Francisco Blanco
- Antonopoulou Maria-Ioanna
- Aprile Alessandra
- Aranda María J. Pizarro
- Aretxabala Izaskun del Hoyo
- Armao Francesca T.
- Arroyo Antonio
- Ashmore Daniel
- Ashoush Fouad M. Bassyouni
- Atak İbrahim
- Atanasov Boyko
- Atici Semra Demirli
- Atienza Paula González
- Avanagh Dara O.
- Avellaneda Nicolas
- Aversano Alessia
- Aybar Ahmet B. CiftciEngin
- Aydin Oguzhan
- Ayoub Kusay
- Azevedo Constanca
- Baatrup Gunnar
- Baban Bayar
- Badiani Sarit
- Bahadoer Renu R.
- Baili Efstratia
- Balalis Dimitrios
- Balci Bengi
- Balik Emre
- Ballabio Michele
- Baloyiannis Ioannis
- Barbero-Valenzuela Alejandro
- Bavikatte Akshay
- Bazaev Andrey
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan P.
- Belvedere Angela
- Benkabbou Amine
- Benčurik Vladimir
- Bernal-Sprekelsen Juan C.
- Berney Christophe
- Bethune Rob M.
- Bhandari Santosh
- Bhat Sameer
- Binder Alf-Dorian
- Biondi Alberto
- Bisagni Pietro
- Bislenghi Gabriele
- Bissett Ian
- Bişgin Tayfun
- Bjorsum-Meyer Thomas
- Blas Juan L.
- Bloemen Johanne G.
- Boerma Evert-Jan G.
- Bonito Alba Correa
- Borda Francisco Javier García
- Borda-Arrizabalaga Nerea
- Bottazzoli Elisa I.
- Boutall Adam
- Bouvy Nicole D.
- Božič Tajda Košir
- Brachini Gioia
- Bradley Nicholas
- Bremers Andreas J.A.
- Buchs Nicolas
- Buchwald Pamela
- Bulut Mehmet Turker
- Burger Jacobus W.A.
- Burghgraef Thijs A.
- Busund Sondre
- Buzzi Gianluca
- Buğra Dursun
- Calabro Marcello
- Calero-Lillo Aránzazu
- Calik Bulent
- Carbone Fabio
- Carreño-Villarreal Guillermo
- Carrie Augusto
- Carvello Michele
- Carvello Michele
- Catena Fausto
- Cengiz Fevzi
- Cerbo Daniele
- Ceretti Andrea P.
- Chandio Ashfaq
- Chaoui Ahmed
- Charalabopoulos Alexandros
- Chaudhri Sanjay
- Chautems Roland
- Chawla Tabish
- Chawla Tabish
- Cholewa Hannia
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Cifuentes-Ródenas José A.
- Cirillo Bruno
- Ciubotaru Cezar
- Ciubotaru Cezar
- Clerici Federico
- Coco Claudio
- Coetzee Emile
- Colak Elif
- Collard Maxime K.
- Colucci Nicola
- Colás-Ruiz Enrique
- Connelly Tara M.
- Consten Esther C.J.
- Consten Esther C.J.
- Corbellini Carlo
- Cotte Eddy
- Creemers Davy M.J.
- Crescentini Giacomo
- D'Agostino Luca
- D'Alimonte Lucrezia
- D'Hoore André
- da Costa Devesa Helena M.
- da Silva Nigel
- Daester Silvio
- Darias Iván Soto
- Darlin Lotten
- Darwich Haitham
- Dattani Mit
- de Andrés Beatriz
- de Gheldere Charles
- de Graaf Eelco J.R.
- de Groot-Van Veen Irene
- de Haan Jael
- de La Cruz Cuadrado Cristina
- de Lacy F. Borja
- de Manzoni Giovanni
- de Nes Lindsey C.F.
- de Paola Gilda
- de Pasqual Carlo A.
- de Simone Belinda D.
- de Vriendt Stefanie
- de Wilt Johannes H.W.
- de Ángelis Nicola
- Deeknah Abdulqudus
- Defoort Barbara
- deGiuli Maurizio
- Dekker Jan-Willem T.
- Delrio Paolo
- Demirkiran Ahmet
- den Boer Frank
- Denost Quentin
- Dewulf Maxime
- di Cosmo Maria A.
- Di Saverio Salomone
- Dimofte Gabriel-Mihail
- Dinaux Anne M.
- Dittrich Luca S.
- Diéguez Beatriz
- Docampo Iria Losada
- Dogan Lutfi
- Doornebosch Pascal G.
- Drozdov Evgeniy S.
- Dudi-Venkata Nagendra N.
- Dursun Ayberk
- Duzgun Ozgul
- Dziakova Jana
- Díez-Alonso Manuel
- Echaniz Garazi Elorza
- Echiguer Sabrillah
- Eduard Galliamov
- Egea Jorge García
- el Muhtaseb Mohammad S.
- El-Massoudi Youssef
- Elhadi Muhammed
- Elshennawy Eslam M.
- Enriquez-Navascués José M.
- Erdinc Kemal
- Eriksen Jacob D.
- Ersryd Amanda L.
- Escartín Jorge
- Espín-Basany Eloy
- Estaire-Gómez Mercedes
- Estefania Diego
- Ewedah Moataz
- Fabbri Nicolo
- Fares Hala
- Farguell Jordi
- Faria Luis Queiroz
- Farnesi Francesca
- Fazzin Marta
- Feo Carlo V.
- Ferenschild Floris T.
- Fernández C.L.
- Fernández-Hevia María
- Fernández-Hurtado Ignacio
- Fernández-Martínez Daniel
- Ferreira Catia
- Ferreira Rita Marques
- Ferrer Rocío
- Filimonov Victor B.
- Filipov Emil
- Fioravanti Emanuela
- Flamey Nicolas
- Florea Sabrina
- Folkesson Joakim
- Foppa Caterina
- Foppa Caterina
- Forgan Tim
- Fowler George E.
- Frasson Matteo
- Frivold Tone
- Frontali Alice
- Fujiwara Hajime
- Futaba Kaori
- Gaard Maria
- Gadan Soran
- Galleano Raffaele
- Gallo Gaetano
- García-Flórez Luis J.
- Gareb Fahed
- Garmanova Tatiana
- Garulli Gianluca
- Gecim Ibrahim E.
- Geitenbeek Ritch
- George Sarah
- Ghazouani Omar
- Ghignone Federico
- Ghmagh Reem
- Gialamas Eleftherios
- Gielis Manuel
- Giuffrida Mario
- Gobut Huseyin
- Golshani Parisa
- Gonzalez Ricardo
- Gonzálvez Paula
- Goutard Claire-Angéline
- Grass Julia-Kristin
- Graure Giorgiana M.
- Gregussen Hilde
- Greijdanus Nynke G.
- Gribnev Petar
- Grosek Jan
- Grossi Ugo
- Grotenhuis Brechtje A.
- Gruter Alexander A.J.
- Guel-Klein Safak
- Guenin Marc-Olivier
- Gunenc Erşan
- Gurjar Shashank
- Gurtler Thomas
- Guzel Melek
- Gómez Tania
- Gómez-Abril Segundo Á.
- Gómez-Jurado María J.
- Haberal Elifcan
- Haddad Anis
- Hajjaj Baraa Nabil
- Hamdan Alaa
- Hamid Hytham K.S.
- Hammoodi Hayder
- Hani Mohammad Bani
- Hannink Gerjon
- Hasan Bassam
- Hassan Naya
- Hassan Soha Y.
- Havenga Klaas
- Hazen Sanne J.A.
- Heemskerk Jeroen
- Heesink Vera
- Heidsma Charlotte M.
- Heijnen Bob H.M.
- Herman Ayesiga
- Hernández Miguel
- Herrero Eduardo Ferrero
- Hess Gabriel F.
- Ho Man-Fung
- Ho Yiu M.
- Hoff Christiaan
- Hol Jeroen C.
- Hollington Paul
- Holman Fabian A.
- Hompes Roel
- Hoogteijling Tijs J.
- Huguet José M. Muguerza
- Hulshof Lorenzo G.W.L.
- Hussein Mohamed
- Iacomino Alessandro
- Ibrahim Aini F.
- Ismail Razif
- Ivanov Tsvetomir
- Iversen Lene H.
- Jadid Kaveh Dehlaghi
- Jakubauskas Matas
- Jakubauskiene Lina
- Jangmalm Staffan
- Janssen Paul T.J.
- Jarimba Aldo M. Rodrigues
- Jou-Valencia Daniela
- Julaihi Rokayah
- Jutesten Henrik
- Kacem Montasser
- Kader Rawaz
- Kamer Erdinc
- Kapadia Raj
- Kara Yasin
- Karamanliev Martin
- Karavokyros Ioannis
- Karmi Fahed
- Karsten Tom
- Karydakis Lysandros
- Kaya Tayfun
- Kelly Michael E.
- Keskin Metin
- Ketelaers Stijn H.J.
- Khader Ahmed A.E.
- Khedr Gehan Abd Elatti
- Koc Mehmet A.
- Koemans Willem J.
- Konishi Tsuyoshi
- Korkolis Dimitrios
- Kostromitskiy Dmitriy N.
- Kozan Ramazan
- Košir Jurij A.
- Kraft Miquel
- Krastev Panche
- Krohn Nina
- Kroon Hidde M.
- Kryzauskas Marius
- Kulle Cemil B.
- Kulle Cemil B.
- Kusters Miranda
- Kynaston James
- La Terra Antonio
- Lacy Antonio M.
- Lambrechts Anton
- Lamme Bas
- Lamparelli Michael
- Lantone Giuliano
- Lapolla Pierfrancesco
- Lara Juan E. Sánchez
- Larcinese Antonella
- Larkin John O.
- Larkin John O.
- Larsson Per-Anders
- Latkauskas Tadas
- Lauka Lelde
- Leeuwenburgh Marjolein M.
- Lefevre Jérémie H.
- Leijtens Jeroen W.A.
- Leung Edmund
- Leventoğlu Sezai
- Lindqvist Ebba
- Liu Jianliang
- Longhi Marco
- Lopez Jose M. Gil
- Lorenzon Laura
- Lorusso Leonardo
- Losada Manuel
- Lucchi Andrea
- Luncă Sorinel
- Lutfi Hamid
- Lydrup Marie-Louise
- López-Lara Manuel
- López-Rodríguez-Arias Francisco
- Macau Florin
- Machackova Maria
- Maghrebi Houcine
- Majbar Mohammed A.
- Mak Tony Wing-Chung
- Manatakis Dimitrios
- Mansour Ali
- Manzo Carlo A.
- Marchegiani Francesco
- Marcos Elena Bermejo
- Mariani Nicolò M.
- Marinelli Andreas
- Markaryan Daniil G.
- Maroli Annalisa
- Marques Sonia M. Ribeiro
- Martinek Lubomir
- Martins Sonia Fortuna
- Martínez María Labalde
- Martínez-Pinedo Carlos
- Maslyankov Svilen
- Massey Lisa
- Matthiessen Peter
- Mattioni Laura A.
- Matías-García Belén
- McCormick Paul H.
- McCullough Peter
- Mehigan Brian J.
- Melling Nathaniel
- Melnikov Andrey A.
- Mendes Ana Filipa Dias
- Mendoza-Moreno Fernando
- Meroni Paola
- Mia Imraan
- Mikalauskas Saulius
- Mingoli Andrea
- Mishra Amitabh
- Mitteregger Martin
- Miu Victor
- Moctezuma-Velázquez Paulina
- Mohamed Abudi
- Mohsine Raouf
- Monib Fatma A.
- Monson John
- Montero José A. Alcázar
- Montroni Isacco
- Morales Bernaldo de Quirós Javier T.
- Morgan Matthew
- Msherghi Ahmed A.
- Mueller Simone
- Mugla Naser
- Mukherjee Tanmoy
- Muratore Andrea
- Muriel Jorge Sancho
- Musters Gijsbert D.
- Muñoz-Collado Salvador
- Muşină Ana-Maria
- Mínguez-Ruiz Germán
- Nair Gavin
- Navarro-Sánchez Antonio
- Neary Peter
- Negoi Ionut
- Negoita Valentina M.
- Nespoli Luca
- Ng Simon Siuman
- Niazi Ammar
- Nichita Vladimir-Ion
- Niemer Quirine
- Nieto-Moreno Elena
- Nilsson Karl
- Nonner Joost
- Novello Simone
- Nygren Jonas
- O'Grady Greg
- Obihara Ndidi J.
- Oldani Massimo
- Oliveira Antonio
- Oosterling Steven J.
- Opocher Enrico
- Osborne Laura
- Ozata İbrahim H.
- Ozgur İlker
- Ozkan Omer Faruk
- Pachajoa Diana A. Pantoja
- Palini Gian M.
- Panel Nathalie
- Panis Yves
- Parc Yann
- Parise Cristiano
- Park Jennifer M.
- Parodi Matias
- Pasini Francesco
- Pasini Franceso
- Passuello Nicola
- Pattyn Paul
- Pavlov Vasil
- Peeters Koen C.M.J.
- Pellino Gianluca
- Pennings Alexander J.
- Pereira Ricardo
- Perez Daniel
- Perez Rodrigo O.
- Perivoliotis Konstantinos
- Perrone Gennaro
- Persiani Roberto
- Pesce Antonio
- Petropolou Thalia
- Pezzuto Roberto
- Picciariello Arcangelo
- Picone Emanuele
- Pikuniene Ingrida
- Pinto Francisca Lima
- Pire-Abaitua Gerardo
- Pirozzolo Giovanni
- Piyadeoğlu Deniz
- Plastiras Aris
- Pletinckx Pieter
- Polat Fatih
- Polle Sebastiaan W.
- Polydorou Adreas
- Porta Andrea
- Poskus Tomas
- Pratschke Johann
- Pringle Heather C.M.
- Puca Lucia
- Pucciarelli Salvatore
- Qandeel Mahmoud W.M.
- Quintana Rita E. Medina
- Quiroga Ignacio Bodega
- Quiroga-Valcárcel Ana
- Rabadi Alexander
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- Ramsay George
- Rani Pallavi
- Rani Pallavi
- Rauf Hareem
- Rauf Hareem
- Recordare Alfonso
- Reddavid Rossella
- Rega Daniela
- Reudink Muriël
- Riedl Peter
- Riis Rolf
- Ripoli Maria Cristina
- Ris Frederic
- Rizzo Gianluca
- Roată Cristian-Ene
- Rodimov Sergey V.
- Rodríguez Carlos Sáez-Cazallas
- Rodríguez-Infante Antonio
- Romano Angela
- Rompou Aliki
- Roos Daphne
- Roscio Francesco
- Rosman Camiel
- Rotholtz Nicolas
- Rottoli Matteo
- Ruiz Hernan
- Runau Francois
- Rutegård Martin
- Rutten Harm J.T.
- Ruíz-García Pablo
- Ryan Jessica
- Rydbeck Daniel
- Saad Ahmad
- Sacchi Matteo M.
- Sacchi Matteo M.
- Sainz-Hernández Juan C.
- Salgado-Nesme Noel
- Salomon Mario
- Sambucci Daniele
- Sammarco Giuseppe
- Sammour Tarik
- Sampietro Gianluca M.
- Samsa Mehmet Veysi
- Santacruz Carlos Cerdán
- Santillan Mateo
- Santoro Giulio A.
- Sari Ahmet Can
- Sarmah Panchali
- Sarveswaran Janahan
- Sauvain Marc-Olivier
- Scabini Stefano
- Scheurink Lieke
- Schizas Dimitrios
- Schultz Johannes K.
- Sebai Amine
- Sebastian Boby
- Segelman Josefin
- Seitinger Gerald
- Semiao Miguel
- Septiem Javier García
- Serralta Daniel
- Shaban Mohamed
- Shaikh Shafaque
- Shapiro Joël
- Siaw Oliver
- Sibiç Osman
- Sica Giuseppe
- Sietses Colin
- Singh Baljit
- Singh Nirbhaibir
- Singh-Ranger Deepak
- Sinibaldi Giovanni
- Siragusa Leandro
- Sivrikoz Emre
- Sjo Ole H.
- Sjostrom Olle
- Skrovina Matej
- Sköldberg Filip
- Slavchev Mihail
- Slooter Gerrit D.
- Smeeing Diederik P.J.
- Sokmen Selman
- Sokolov Manol
- Soler-Silva Álvaro
- Solomon Michael
- Soriero Domenico
- Souadka Amine
- Spinelli Antonino
- Spinelli Antonino
- Spolverato Gaya
- Staffan Maria
- Stefanescu Victor
- Steller Ernst J.
- Stienstra Roxane M.
- Stoica Bogdan
- Stoica Bogdan
- Suchkov Igor A.
- Sultan Hytham
- Surlin Valeriu M.
- Suárez Marta Castro
- Suárez-Sánchez Aida
- Syllaios Athanasios
- Sánchez Teresa Rubio
- Sánchez-Guillén Luis
- Tababa Osama W.E.
- Taha-Mehlitz Stephanie
- Talboom Kevin
- Talsma Aaldert K.
- Tamelis Algimantas
- Tamini Nicolò
- Tanase Ioan
- Tanis Pieter J.
- Tantoura Mohammad
- Tanzanu Marta
- Tasende-Presedo Marta M.
- Tasis Nikolaos
- Taverne Sophie B.M.
- Tejedor Patricia
- Teras Juri
- Teras Roland M.
- Tiefenthal Marit
- Tomasicchio Giovanni
- Tomažič Aleš
- Tonchev Pencho
- Toorenvliet Boudewijn R.
- Torres María T.
- Toso Christian
- Tsimogiannis Konstantinos
- Tuynmann Jurriaan B.
- Tzovaras George
- Ubels Sander
- Ugolini Giampaolo
- Ulgur Hanife Şeyda
- Uluk Deniz
- Vailas Michail
- Vailati Bruna B.
- van Dalsen Annette D.
- van den Broek Nathalie E.J.
- van den Hengel Berber
- van der Burg Sjirk
- van der Zijden Charlène J.
- van Gerven Pieter
- van Kessel Charlotte S.
- van Praagh Jasper B.
- van Schaik Ted G.
- van Westreenen Hendrik L.
- van Workum Frans
- Vanclooster Patrick
- Vansteenbrugge Louis
- Vasile Mihai
- Venianaki Maria
- Verdaasdonk Emiel G.G.
- Vergara-Fernández Omar
- Vermaas Maarten
- Verstappen Sonja
- Vignotto Chiara
- Villar Óscar García
- Vittori Laura
- Vles Wouter J.
- von Flue Markus
- Voron Thibault
- Vosbeek Noortje
- Vuagniaux Aurelie
- Vázquez Andrea
- Waqar Usama
- Waqar Usama
- Ward Nicholas
- Warden Claire
- Westerterp Marinke
- Wienholts Kiedo
- Wiering Bastiaan
- Wijma Allard G.
- Wildeboer Aurelia C.L.
- Wolthuis Albert
- Wong Michael P.K.
- Woods Kayla
- Xenaki Sofia
- Xynos Evangelos
- Yalkin Omer
- Yanishev Alexey
- Yuksel Osman
- Zabala Jesús Gómez
- Zakaria Andee D.
- Zakaria Zaidi
- Zanini Nicola
- Zanus Giacomo
- Zazo Aya
- Zazo Rama
- Zucchella Martino
- Zukanović Goran
- Zwakman Marije
- Çakir Murat
- Ćosić Jurica
- Šantak Goran
- Šimleša Damir
- Šlenfuktas Vygintas
- Žilinskas Justas
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2: 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.
- Author
- Abbas Ayman
- Abbood Ali Hashim
- Abdeen Basel
- Abdelaal Ahmed Samir
- Abdullah Nik A N
- Abdulwahed Eman
- Abelevich Alexander
- Abu Elnga Ahmed Nagm Eldin
- Abujamra Saleh
- Acar Nihan Coşgun
- Afzal Asma
- Agalianos Christos
- Agapov Mikhail N
- Agostinelli Laura
- Ahmed Safia
- Aigner Felix
- Akyol Cihangir
- Al-Eryani Fatima
- Al-Juaifari Maytham A
- Al-Najami Issam
- Alanez-Saavedra Javier
- Albakry Rudaina
- Alcázar Montero José A
- Alhardan Anas
- Alhisi Ahmed Jehad
- Ali Ahmed K
- Alkady Eithar
- Allmer Caterina
- Alonso Alfredo
- Alrayes Bourhan M H
- Alshareea Entisar
- Altomare Donato F
- Altrabulsi Amani
- Alvarez-Bautista Francisco E
- Amano Takahiro
- Amelung Femke J
- Anderin Kajsa
- Annicchiarico Alfredo
- Ansorena Yolanda Saralegui
- Antona Francisco Blanco
- Antonopoulou Maria-Ioanna
- Aprile Alessandra
- Armao Francesca T
- Arroyo Antonio
- Ashmore Daniel
- Atak İbrahim
- Atanasov Boyko
- Atici Semra Demirli
- Atienza Paula González
- Avanagh Dara O
- Avellaneda Nicolas
- Aversano Alessia
- Aydın Oguzhan
- Ayoub Kusay
- Azevedo Constança
- Baatrup Gunnar
- Baban Bayar
- Badiani Sarit
- Baili Efstratia
- Balalis Dimitrios
- Balci Bengi
- Balık Emre
- Ballabio Michele
- Baloyiannis Ioannis
- Barbero-Valenzuela Alejandro
- Bassyouni Ashoush Fouad M
- Bavikatte Akshay
- Bazaev Andrey
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan P
- Belvedere Angela
- Benkabbou Amine
- Benčurik Vladimir
- Bernal-Sprekelsen Juan C
- Berney Christophe
- Bethune Rob M
- Bhandari Santosh
- Bhat Sameer
- Binder Alf-Dorian
- Biondi Alberto
- Bisagni Pietro
- Bislenghi Gabriele
- Bissett Ian
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- Blas Juan L
- Bloemen Johanne G
- Boerma Evert-Jan G
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- Borda Francisco Javier García
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- Bottazzoli Elisa I
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- Buchs Nicolas
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- Burghgraef Thijs A
- Busund Sondre
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- Calabrò Marcello
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- Carrie Augusto
- Carvello Michele
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- Ceretti Andrea P
- Chandio Ashfaq
- Chaoui Ahmed
- Charalabopoulos Alexandros
- Chaudhri Sanjay
- Chautems Roland
- Chawla Tabish
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- Cholewa Hannia
- Christodoulidis Grigorios
- Chrysos Emmanuel
- CiftciEngin Aybar Ahmet B
- Cifuentes-Ródenas José A
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- Ciubotaru Cezar
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- El Muhtaseb Mohammad S
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- Enriquez-Navascués José M
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- Fernández-Hevia María
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- Ferreira Cátia
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- Filimonov Victor B
- Filipov Emil
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- Flamey Nicolas
- Florea Sabrina
- Folkesson Joakim
- Foppa Caterina
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- Fowler George E
- Frasson Matteo
- Frivold Tone
- Frontali Alice
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- Gurjar Shashank
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- Göbüt Hüseyin
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- Haberal Elifcan
- Haddad Anis
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- Hamdan Alaa
- Hamid Hytham K S
- Hammoodi Hayder
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- Kader Rawaz
- Kamer Erdinc
- Kapadia Raj
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- Karamanliev Martin
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- Luncă Sorinel
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- López-Rodríguez-Arias Francisco
- Macau Florin
- Machackova Maria
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- Persiani Roberto
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- Petropolou Thalia
- Pezzuto Roberto
- Picciariello Arcangelo
- Picone Emanuele
- Pikūnienė Ingrida
- Pinto Francisca Lima
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- Pletinckx Pieter
- Polat Fatih
- Polle Sebastiaan W
- Polydorou Adreas
- Porta Andrea
- Poskus Tomas
- Pratschke Johann
- Pringle Heather C M
- Puca Lucia
- Pucciarelli Salvatore
- Qandeel Mahmoud W M
- Quiroga Ignacio Bodega
- Rabadi Alexander
- Ramboiu Stefan Patrascu Sandu D
- Ramsay George
- Rani Pallavi
- Rani Pallavi
- Rauf Hareem
- Rauf Hareem
- Recordare Alfonso
- Reddavid Rossella
- Rega Daniela
- Reudink Muriël
- Ribeiro Marques Sónia M
- Riedl Peter
- Riis Rolf
- Ripoli Maria Cristina
- Ris Frédéric
- Rizzo Gianluca
- Roată Cristian-Ene
- Rodimov Sergey V
- Rodrigues Jarimba Aldo M
- Rodríguez Carlos Sáez-Cazallas
- Rodríguez-Infante Antonio
- Romano Angela
- Rompou Aliki
- Roos Daphne
- Roscio Francesco
- Rosman Camiel
- Rotholtz Nicolas
- Rottoli Matteo
- Ruiz Hernán
- Runau Francois
- Rutegård Martin
- Rutten Harm J T
- Ruíz-García Pablo
- Ryan Jessica
- Rydbeck Daniel
- Saad Ahmad
- Sacchi Matteo M
- Sacchi Matteo M
- Sainz-Hernández Juan C
- Salgado-Nesme Noel
- Salomon Mario
- Sambucci Daniele
- Sammarco Giuseppe
- Sammour Tarik
- Sampietro Gianluca M
- Samsa Mehmet Veysi
- Santacruz Carlos Cerdán
- Santillan Mateo
- Santoro Giulio A
- Sari Ahmet Can
- Sarmah Panchali
- Sarveswaran Janahan
- Sauvain Marc-Olivier
- Scabini Stefano
- Scheurink Lieke
- Schizas Dimitrios
- Schultz Johannes K
- Sebai Amine
- Sebastian Boby
- Segelman Josefin
- Seitinger Gerald
- Semião Miguel
- Septiem Javier García
- Serralta Daniel
- Shaban Mohamed
- Shaikh Shafaque
- Shapiro Joël
- Siaw Oliver
- Sıbıç Osman
- Sica Giuseppe
- Sietses Colin
- Singh Baljit
- Singh Nirbhaibir
- Singh-Ranger Deepak
- Sinibaldi Giovanni
- Siragusa Leandro
- Sivrikoz Emre
- Sjo Ole H
- Sjöström Olle
- Skrovina Matej
- Sköldberg Filip
- Slavchev Mihail
- Slooter Gerrit D
- Smeeing Diederik P J
- Sokolov Manol
- Soler-Silva Álvaro
- Solomon Michael
- Soriero Domenico
- Souadka Amine
- Spinelli Antonino
- Spinelli Antonino
- Spolverato Gaya
- Staffan Maria
- Stefanescu Victor
- Steller Arend G J Aalbers Ernst J
- Stienstra Roxane M
- Stoica Bogdan
- Stoica Bogdan
- Suchkov Igor A
- Sultan Hytham
- Surlin Valeriu M
- Suárez Marta Castro
- Suárez-Sánchez Aida
- Suárez-Sánchez Aida
- Syllaios Athanasios
- Sánchez Lara Juan E
- Sánchez Teresa Rubio
- Sánchez-Guillén Luis
- Sökmen SELMAN
- Tababa Osama W E
- Taha-Mehlitz Stephanie
- Talboom Kevin
- Talsma Aaldert K
- Tamelis Algimantas
- Tamini Nicolò
- Tanase Ioan
- Tanis Pieter J
- Tantoura Mohammad
- Tanzanu Marta
- Tasende-Presedo Marta M
- Tasis Nikolaos
- Taverne Sophie B M
- Tejedor Patricia
- Teras Jüri
- Teras Roland M
- Terra Antonio La
- Tiefenthal Marit
- Tomasicchio Giovanni
- Tomažič Aleš
- Tonchev Pencho
- Toorenvliet Boudewijn R
- Torres María T
- Toso Christian
- Tsimogiannis Konstantinos
- Tuynmann Jurriaan B
- Tzovaras George
- Ubels Sander
- Ugolini Giampaolo
- Uluk Deniz
- Vailas Michail
- Vailati Bruna B
- van Dalsen Annette D
- van den Broek Nathalie E J
- van den Hengel Berber
- van der Burg Sjirk
- van der Zijden Charlène J
- van Gerven Pieter
- van Kessel Charlotte S
- van Praagh Jasper B
- van Schaik Ted G
- van Westreenen Hendrik L
- van Workum Frans
- Vanclooster Patrick
- Vansteenbrugge Louis
- Vasile Mihai
- Venianaki Maria
- Verdaasdonk Emiel G G
- Vergara-Fernández Omar
- Vermaas Maarten
- Verstappen Sonja
- Vignotto Chiara
- Villar Óscar García
- Vittori Laura
- Vles Wouter J
- von Flüe Markus
- Voron Thibault
- Vosbeek Noortje
- Vuagniaux Aurélie
- Vázquez Andrea
- Waqar Usama
- Waqar Usama
- Ward Nicholas
- Warden Claire
- Westerterp Marinke
- Wienholts Kiedo
- Wiering Bastiaan
- Wijma Allard G
- Wildeboer Aurelia C L
- Wolthuis Albert
- Wong Michael P K
- Woods Kayla
- Xenaki Sofia
- Xynos Evangelos
- Yalkın Ömer
- Yanishev Alexey
- Yüksel Osman
- Zabala Jesús Gómez
- Zakaria Andee D
- Zakaria Zaidi
- Zanini Nicola
- Zanus Giacomo
- Zazo Aya
- Zazo Rama
- Zucchella Martino
- Zukanović Goran
- Zwakman Marije
- Çakır Murat
- Özata İbrahim H
- Özgür İlker
- Özkan Ömer Faruk
- Ülgür Hanife Şeyda
- Šantak Goran
- Šimleša Damir
- Šlenfuktas Vygintas
- Žilinskas Justas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Objective:To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background:AL after RC resection often results in a permanent stoma.Methods:This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results:This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions:The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
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- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
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- Arowolo Olukayode
- Arrangoiz Rodrigo
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- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
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- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
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- Balata Mohamed
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- Ballouhey Quentin
- Balogun Olanrewaju
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- Baltaci Ege
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- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
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- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
- Ben Saoud Abdulsalam Ali
- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
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- Blackman Brighid
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- Bogusevicius Algirdas
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- Bondurri Andrea
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- Borowski David W
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- De Azevedo Bernardo
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- De Giovanni Jasmine
- de Jonge Joske
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- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
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- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
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- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
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- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
- Bergeat Damien
- Bernstein Mitchell
- Beshtawi Doha
- Besli Sevval
- Beuran Mircea
- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
- Bingham Janne
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- Björklund Ida
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- Blok Robin
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- Blomqvist Malin
- Blunnie Eimear
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- Bogusevicius Algirdas
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- Borg Elaine
- Borghi Felice
- Borham Hala
- Borowski David W
- Bortolasi Luca
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- Botes Azel
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- Boyd-Carson Hannah
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- Braccio Bartolomeo
- Bradulskis Saulius
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- Castillo Arrascue José Neiser
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- Clements Joshua Michael
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- Dawidziuk Aleksander
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- De Giovanni Jasmine
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- de Muijnck Cansu
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- Dominguez Joaquina
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- Draganic Brian
- Drake Thomas M
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- Duarte Marina
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- Duggan William
- Duke Kathryn
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- Dworak Jadwiga
- Dzhumabaev Khasan
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- Eismontas Vitalijus
- Eklöv Karolina
- Ekpete Ogbonnia
- Ekwen Gerald
- El Aroussi Nouhaila
- El Gharmoul Tasnim
- El Jamassi Alaa
- El Muhtaseb M.S.
- El Nakeeb Ayman
- El sheikh Enas
- El Zoghby Naira
- El-Kahlout Sahar
- El-remaily Amira
- El-Sawy Aya
- El-taweel Alaa
- Elazab Yasmin
- Elbarouni Sofian
- Elbealawy Mohamed
- Elbeshina Aya Elseed
- Elblbessy Mahmood
- Eldeep Ahmed
- Eldeep Mostafa
- Eldmaty Asmaa
- Eldoseuky mohammed Amany
- Elemile Peter
- Elewaily Mohamed Ibrahim Elsayed
- Elfaituri Taha
- Elfallal Ahmed
- Elfanty Mahmoud
- ElFayoumy Ahmed Moustafa
- Elfeki Hossam
- Elfizri Zatira
- Elgammudi Mala
- Elghareeb Nourhan
- Elhadi Ahmed
- Elhadi Muhammed
- Elhajjaji Yasmine
- Elhelow Esraa
- Elhout Somaya
- Elkabir Osama
- Elkhadragy Ahmed
- Elkhalawy Aya
- Ellaby-Hall Jordan
- Ellul Sarah
- Elmahdy Marwa
- Elmeslemany Nehal
- Elmokadem Aya
- Elqadi Muawiyah
- Elrais Safa
- Elsayed Mai
- Elsayed Mohammad
- Elshafei Houssein
- Elshafey Ahmed
- Elshaibani Mahmoud
- Elshatby Bassant
- Elshawy Mohamed Elemam
- Elsherbeny Mohammed Yasser
- Elsherif Fawzia
- Elshimy Ahmed
- Elsobky Hager
- Elteir Hana
- Eltoum Ruba
- Elzanfaly Ali Abdelazez
- Emara Eman
- Emeghara Okechukwu
- Emile Sameh
- Enumah Zachary
- Eraslan Huseyin
- Eray Ismail Cem
- Erkul Oğuz
- Esbaga Fatima
- Escobar Dennis
- Escrevente Ricardo
- Eskander John
- Eslam Sara
- Esmat Nourhan Ahmed
- Esper Asil
- Espin-Basany Eloy
- Espina Perez Beatriz
- Espinosa-Bravo Martin
- Esposito Giovanni
- Essam Ibrahim El Desouki Muhammad Ahmed Muhammad
- Essam Eman
- Estalagem Inês
- Estevez Tesouro José
- Eswaye Haitem
- Etchill Eric
- Etonyeaku Amarachukwu
- Eusebio Zegarra Ivan Edward
- Ezzat Helmy
- Fadel Ahmed
- Fahira Alessa
- Fahmawee Toqa
- Fairfield Cameron J
- Falato Armando
- Falco Giuseppe
- Falco Nicolò
- Fareleira Ana
- Fares Bucci Andrea
- Fares Jehad
- Farid Mohammad
- Farik Shebani
- Farina Pablo
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- Farnan Richard
- Farooq Muhammad
- Farsi Ali
- Fasolini Fabrizio
- Faustin Ntirenganya
- Fayed Notila
- Fazenda Ana
- Felicia Devi
- Felix Rosa
- Feng Daniel
- Fermani Claudio Gabriel
- Fernandes Cristina
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- Wondoh Paul M.
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- Yanikoğlu Erkan
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- Yates Charlotte
- Ye Geoffrey
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- Yemez Kürşat
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- Yenli Edwin
- Yeo Jeremy
- Yeoh Andrea
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- Yeşilsancak Merve
- Yildirim Reyyan
- Yildiz Alp
- Yilmaz Duygu
- Yip Ching Wan
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- Yong Shun Qi
- Yoong Andrel
- Yorke Joseph
- Yotsov Tsanko
- You Lucia
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- Yüksel Osman
- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research