Perturbations of the local gravity field due to mass distribution on precise measuring instruments: a numerical method applied to a cold atom gravimeter

We present a numerical method, based on a FEM simulation, for the determination of the gravitational field generated by massive objects, whatever geometry and space mass density they have. The method was applied for the determination of the self gravity effect of an absolute cold atom gravimeter which aims at a relative uncertainty of 10-9. The deduced bias, calculated with a perturbative treatment, is finally presented. The perturbation reaches (1.3 \pm 0.1) \times 10-9 of the Earth's gravitational field.Comment: 12 pages, 7 figure

Correlation Differences in Heartbeat Fluctuations During Rest and Exercise

We study the heartbeat activity of healthy individuals at rest and during exercise. We focus on correlation properties of the intervals formed by successive peaks in the pulse wave and find significant scaling differences between rest and exercise. For exercise the interval series is anticorrelated at short time scales and correlated at intermediate time scales, while for rest we observe the opposite crossover pattern -- from strong correlations in the short-time regime to weaker correlations at larger scales. We suggest a physiologically motivated stochastic scenario to explain the scaling differences between rest and exercise and the observed crossover patterns.Comment: 4 pages, 4 figure

Hiding and Confining Charges via "Tube-like" Wormholes

We describe two interesting effects in wormhole physics. First, we find that a genuinely charged matter source may appear neutral to an external observer - a phenomenon opposite to the famous Misner-Wheeler "charge without charge" effect. This phenomenon takes place when coupling a bulk gravity/nonlinear-gauge-field system to a charged lightlike brane as a matter source. The "charge-hiding" effect occurs in a wormhole solution which connects a non-compact "universe", comprising the exterior region of Schwarzschild-(anti-)de-Sitter (SdS) or purely Schwarzschild black hole beyond the Schwarzschild horizon, to a Levi-Civita-Bertotti-Robinson-type (LCBR) "tube-like" "universe" via a wormhole "throat" occupied by the brane. In this solution the whole electric flux produced by the brane is expelled into the "tube-like" "universe" and the brane is detected as neutral by an observer in the non-compact "universe". Next, we find a truly charge-confining wormhole solution when we couple the bulk gravity/nonlinear-gauge-field system to two oppositely charged lightlike branes. The latter system possesses a "two-throat" wormhole solution, where the "left-most" and the "right-most" "universes" are two identical copies of the exterior region of SdS black hole beyond the Schwarzschild horizon, whereas the "middle" "universe" is of LCBR "tube-like" form with geometry dS_2 x S^2. It comprises the finite-extent intermediate region of dS_2 between its two horizons. Both "throats" are occupied by the two oppositely charged lightlike branes and the whole electric flux produced by the latter is confined entirely within the middle "tube-like" "universe". A crucial ingredient is the special form of the nonlinear gauge field action, which contains both the standard Maxwell term as well as a square root of the latter. This theory was previously shown to produce a QCD-like confining dynamics in flat space-time.Comment: 26 pages, 2 figures; v.2 several references added, missing constant factors in few equations inserted, acknowledgement added, results unchanged; v.3 28 pages, several clarifying remarks, references and acknowledgements added, version to appear in International Journal of Modern Physics

Fully Explorable Horned Particles Hiding Charge

The charge-hiding effect by a horned particle, which was studied for the case where gravity/gauge-field system is self-consistently interacting with a charged lightlike brane (LLB) as a matter source, is now studied for the case of a time like brane. From the demand that no surfaces of infinite coordinate time redshift (horizons) appear in the problem we are lead now to a completly explorable horned particle space for traveller that goes through the horned particle (as was the case for the LLB) but now also in addition to this, the horned region is fully visible to a static external observer. This requires negative surface energy density for the shell sitting at the throat. We study a gauge field subsystem which is of a special non-linear form containing a square-root of the Maxwell term and which previously has been shown to produce a QCD-like confining gauge field dynamics in flat space-time. The condition of finite energy of the system or asymptotic flatness on one side of the horned particle implies that the charged object sitting at the throat expels all the flux it produces into the other side of the horned particle, which turns out to be of a "tube-like" nature. An outside observer in the asymptotically flat universe detects, therefore, apparently neutral object. The hiding of the electric flux behind the tube-like region of a horned particle is the only possible way that a truly charged particle can still be of finite energy, in a theory that in flat space describes confinement. This points to the physical relevance of such solutions, even though there is the need of negative energy density at the throat of the horned particle, which can be of quantum mechanical origin.Comment: The new version has been accepted for publication in Classical and Quantum Gravity. Title changed to "Fully Explorable Horned Particles Hiding Charge". Horned Particles terminology is used now instead of "wormholes" to dscribe the solutions here. arXiv admin note: text overlap with arXiv:1108.373

Using Neural Networks for Relation Extraction from Biomedical Literature

Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems. The primary comprehensive source of these relations is biomedical literature. Several relation extraction approaches have been proposed to identify relations between concepts in biomedical literature, namely, using neural networks algorithms. The use of multichannel architectures composed of multiple data representations, as in deep neural networks, is leading to state-of-the-art results. The right combination of data representations can eventually lead us to even higher evaluation scores in relation extraction tasks. Thus, biomedical ontologies play a fundamental role by providing semantic and ancestry information about an entity. The incorporation of biomedical ontologies has already been proved to enhance previous state-of-the-art results.Comment: Artificial Neural Networks book (Springer) - Chapter 1

Increasing condom use in heterosexual men: development of a theory-based interactive digital intervention

Increasing condom use to prevent sexually transmitted infections is a key public health goal. Interventions are more likely to be effective if they are theory- and evidence-based. The Behaviour Change Wheel (BCW) provides a framework for intervention development. To provide an example of how the BCW was used to develop an intervention to increase condom use in heterosexual men (the MenSS website), the steps of the BCW intervention development process were followed, incorporating evidence from the research literature and views of experts and the target population. Capability (e.g. knowledge) and motivation (e.g. beliefs about pleasure) were identified as important targets of the intervention. We devised ways to address each intervention target, including selecting interactive features and behaviour change techniques. The BCW provides a useful framework for integrating sources of evidence to inform intervention content and deciding which influences on behaviour to target

Gender perspectives on views and preferences of older people on exercise to prevent falls: a systematic mixed studies review

Background: To offer fall prevention exercise programs that attract older people of both sexes there is a need to understand both womens and mens views and preferences regarding these programs. This paper aims to systematically review the literature to explore any underlying gender perspectives or gender interpretations on older peoples views or preferences regarding uptake and adherence to exercise to prevent falls. Methods: A review of the literature was carried out using a convergent qualitative design based on systematic searches of seven electronic databases (PubMed, CINAHL, Amed, PsycINFO, Scopus, PEDro, and OTseeker). Two investigators identified eligible studies. Each included article was read by at least two authors independently to extract data into tables. Views and preferences reported were coded and summarized in themes of facilitators and barriers using a thematic analysis approach. Results: Nine hundred and nine unique studies were identified. Twenty five studies met the criteria for inclusion. Only five of these contained a gender analysis of mens and womens views on fall prevention exercises. The results suggests that both women and men see women as more receptive to and in more need of fall prevention messages. The synthesis from all 25 studies identified six themes illustrating facilitators and six themes describing barriers for older people either starting or adhering to fall prevention exercise. The facilitators were: support from professionals or family; social interaction; perceived benefits; a supportive exercise context; feelings of commitment; and having fun. Barriers were: practical issues; concerns about exercise; unawareness; reduced health status; lack of support; and lack of interest. Considerably more women than men were included in the studies. Conclusion: Although there is plenty of information on the facilitators and barriers to falls prevention exercise in older people, there is a distinct lack of studies investigating differences or similarities in older womens and mens views regarding fall prevention exercise. In order to ensure that fall prevention exercise is appealing to both sexes and that the inclusion of both men and women are encouraged, more research is needed to find out whether gender differences exists and whether practitioners need to offer a range of opportunities and support strategies to attract both women and men to falls prevention exercise.Funding Agencies|Swedish Research Council [2015-03481]; Strategic Research Programme in Care Sciences, Umea University; Karolinska Institute, Sweden; Umea University</p

Gentle Perturbations of the Free Bose Gas I

It is demonstrated that the thermal structure of the noncritical free Bose Gas is completely described by certain periodic generalized Gaussian stochastic process or equivalently by certain periodic generalized Gaussian random field. Elementary properties of this Gaussian stochastic thermal structure have been established. Gentle perturbations of several types of the free thermal stochastic structure are studied. In particular new models of non-Gaussian thermal structures have been constructed and a new functional integral representation of the corresponding euclidean-time Green functions have been obtained rigorously.Comment: 51 pages, LaTeX fil

A relocatable ocean model in support of environmental emergencies

During the Costa Concordia emergency case, regional, subregional, and relocatable ocean models have been used together with the oil spill model, MEDSLIK-II, to provide ocean currents forecasts, possible oil spill scenarios, and drifters trajectories simulations. The models results together with the evaluation of their performances are presented in this paper. In particular, we focused this work on the implementation of the Interactive Relocatable Nested Ocean Model (IRENOM), based on the Harvard Ocean Prediction System (HOPS), for the Costa Concordia emergency and on its validation using drifters released in the area of the accident. It is shown that thanks to the capability of improving easily and quickly its configuration, the IRENOM results are of greater accuracy than the results achieved using regional or subregional model products. The model topography, and to the initialization procedures, and the horizontal resolution are the key model settings to be configured. Furthermore, the IRENOM currents and the MEDSLIK-II simulated trajectories showed to be sensitive to the spatial resolution of the meteorological fields used, providing higher prediction skills with higher resolution wind forcing.MEDESS4MS Project; TESSA Project; MyOcean2 Projectinfo:eu-repo/semantics/publishedVersio

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts

The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes. At present, very little is known about the role of gene-environment interactions in modulating craniosynostosis phenotypes, but prior evidence suggests a role for endocrine factors. Here we provide a report of the effects of thyroid hormone exposure on murine calvaria cells. Murine derived calvaria cells were exposed to critical doses of pharmaceutical thyroxine and analyzed after 3 and 7 days of treatment. Endpoint assays were designed to determine the effects of the hormone exposure on markers of osteogenesis and included, proliferation assay, quantitative ALP activity assay, targeted qPCR for mRNA expression of Runx2, Alp, Ocn, and Twist1, genechip array for 28,853 targets, and targeted osteogenic microarray with qPCR confirmations. Exposure to thyroxine stimulated the cells to express ALP in a dose dependent manner. There were no patterns of difference observed for proliferation. Targeted RNA expression data confirmed expression increases for Alp and Ocn at 7 days in culture. The genechip array suggests substantive expression differences for 46 gene targets and the targeted osteogenesis microarray indicated 23 targets with substantive differences. 11 gene targets were chosen for qPCR confirmation because of their known association with bone or craniosynostosis (Col2a1, Dmp1, Fgf1, 2, Igf1, Mmp9, Phex, Tnf, Htra1, Por, and Dcn). We confirmed substantive increases in mRNA for Phex, FGF1, 2, Tnf, Dmp1, Htra1, Por, Igf1 and Mmp9, and substantive decreases for Dcn. It appears thyroid hormone may exert its effects through increasing osteogenesis. Targets isolated suggest a possible interaction for those gene products associated with calvarial suture growth and homeostasis as well as craniosynostosis. © 2013 Cray et al