The Bridging Role of the Community Service Director on the Engaged Campus

Declines in civic participation, low voting rates among 18-25 year olds, dwindling federal support for social services, and deficit state budgets have created a climate in which higher education must make a case for the value it adds to society through applications of research and teaching. National and state organizations (such as Campus Compact and state Compacts) dedicated to supporting a culture of service in higher education articulate the university\u27s role as a collective citizen, whose priorities include linking scholarship to community-based needs, using the resources of the college faculty for professional local service, and utilizing federal work study, America Reads, and AmeriCorps programs to support the work of local schools, nonprofit organizations, and faith-based institutions. Over 800 Campus Compact member institutions have devoted attention and resources to enhanced, quality engagement with the local community by addressing current civic, economic, and social challenges through academic-based service-learning and student community service activities

Readers Theatre, Bible, and Fluency

Readers Theatre has been a dramatic genre for many years. Only recently, however, has it been seriously applied to educational endeavors and, even then, seldom to the teaching of Biblical themes and related values. In view of the mandate to integrate literacy into every area of the school curriculum, this article explores how expression, fluency, and intonation of oral reading may be improved using Readers Theatre in faith formation classes

Does Formal Education Have an Impact on Active Citizenship Behaviour?

In the European context Active citizenship has been promoted within the education and training Lisbon Strategy as a tool to support the continuation of democracy, human rights and greater social inclusion. In this article we analyse the impact of education on Active Citizenship and contribute to the existing debates relating to education levels and participation. Our results uniformly suggest that there is a significant democratic return associated with formal education. Indeed, using a large sample of individuals from the 2006/2007 European Social Survey, we find that education is positively and significantly correlated with Active Citizenship behaviour. Tertiary education has by far the biggest impact and this impact is the strongest for the domain of Protest. The findings are robust to the introduction of a large set of control variables and to alternative measures of educational attainment.JRC.DG.G.9-Econometrics and applied statistic

DataCite Implementation Recommendations: A Report of the DataCite Task Force

This is a task force report outlining recommendations for the University of Michigan Library regarding investment in DataCite tools and policies.DataCite (http://datacite.org/) is a non-profit, international consortium whose members collaboratively address challenges of making data visible and accessible. In the United States, DataCite is represented by three organizations: the California Digital Library (CDL), the Office of Scientific and Technical Information (OSTI), and the Purdue University Libraries. As an addition to the growing network of services around data in the library, the University of Michigan Library has joined DataCite as a client through the Member or Allocator Agency, Purdue University Libraries. Purdue uses California Digital Library’s EZID service (http://n2t.net/ezid) to offer DataCite Digital Object Identifiers (DOIs).http://deepblue.lib.umich.edu/bitstream/2027.42/100249/1/DataCiteTaskForceReport.pdf-

'To take care of the patients': Qualitative analysis of Veterans Health Administration personnel experiences with a clinical informatics system

<p>Abstract</p> <p>Background</p> <p>The Veterans Health Administration (VA) has invested significant resources in designing and implementing a comprehensive electronic health record (EHR) that supports clinical priorities. EHRs in general have been difficult to implement, with unclear cost-effectiveness. We describe VA clinical personnel interactions with and evaluations of the EHR.</p> <p>Methods</p> <p>As part of an evaluation of a quality improvement initiative, we interviewed 72 VA clinicians and managers using a semi-structured interview format. We conducted a qualitative analysis of interview transcripts, examining themes relating to participants' interactions with and evaluations of the VA EHR.</p> <p>Results</p> <p>Participants described their perceptions of the positive and negative effects of the EHR on their clinical workflow. Although they appreciated the speed and ease of documentation that the EHR afforded, they were concerned about the time cost of using the technology and the technology's potential for detracting from interpersonal interactions.</p> <p>Conclusions</p> <p>VA personnel value EHRs' contributions to supporting communication, education, and documentation. However, participants are concerned about EHRs' potential interference with other important aspects of healthcare, such as time for clinical care and interpersonal communication with patients and colleagues. We propose that initial implementation of an EHR is one step in an iterative process of ongoing quality improvement.</p

C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response

Mosquitoes rely on RNA interference (RNAi) as their primary defense against viral infections. To this end, the combination of RNAi and invertebrate cell culture systems has become an invaluable tool in studying virus-vector interactions. Nevertheless, a recent study failed to detect an active RNAi response to West Nile virus (WNV) infection in C6/36 (Aedes albopictus) cells, a mosquito cell line frequently used to study arthropod-borne viruses (arboviruses). Therefore, we sought to determine if WNV actively evades the host's RNAi response or if C6/36 cells have a dysfunctional RNAi pathway. C6/36 and Drosophila melanogaster S2 cells were infected with WNV (Flaviviridae), Sindbis virus (SINV, Togaviridae) and La Crosse virus (LACV, Bunyaviridae) and total RNA recovered from cell lysates. Small RNA (sRNA) libraries were constructed and subjected to high-throughput sequencing. In S2 cells, virus-derived small interfering RNAs (viRNAs) from all three viruses were predominantly 21 nt in length, a hallmark of the RNAi pathway. However, in C6/36 cells, viRNAs were primarily 17 nt in length from WNV infected cells and 26–27 nt in length in SINV and LACV infected cells. Furthermore, the origin (positive or negative viral strand) and distribution (position along viral genome) of S2 cell generated viRNA populations was consistent with previously published studies, but the profile of sRNAs isolated from C6/36 cells was altered. In total, these results suggest that C6/36 cells lack a functional antiviral RNAi response. These findings are analogous to the type-I interferon deficiency described in Vero (African green monkey kidney) cells and suggest that C6/36 cells may fail to accurately model mosquito-arbovirus interactions at the molecular level

Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures

Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk of colorectal cancer. We test 5649 colorectal cancers to evaluate the discriminatory potential of a tumor mutational signature specific to MUTYH for identifying biallelic carriers and classifying variants of uncertain clinical significance (VUS). Using a tumor and matched germline targeted multi-gene panel approach, our classifier identifies all biallelic MUTYH carriers and all known non-carriers in an independent test set of 3019 colorectal cancers (accuracy = 100% (95% confidence interval 99.87-100%)). All monoallelic MUTYH carriers are classified with the non-MUTYH carriers. The classifier provides evidence for a pathogenic classification for two VUS and a benign classification for five VUS. Somatic hotspot mutations KRAS p.G12C and PIK3CA p.Q546K are associated with colorectal cancers from biallelic MUTYH carriers compared with non-carriers (p = 2 x 10(-23) and p = 6 x 10(-11), respectively). Here, we demonstrate the potential application of mutational signatures to tumor sequencing workflows to improve the identification of biallelic MUTYH carriers. Germline biallelic pathogenic MUTYH variants predispose patients to colorectal cancer (CRC); however, approaches to identify MUTYH variant carriers are lacking. Here, the authors evaluated mutational signatures that could distinguish MUTYH carriers in large CRC cohorts, and found MUTYH-associated somatic mutations

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types