The Clustering of the SDSS DR7 Main Galaxy Sample I: A 4 per cent Distance Measure at z=0.15

We create a sample of spectroscopically identified galaxies with $z < 0.2$ from the Sloan Digital Sky Survey (SDSS) Data Release 7, covering 6813 deg$^2$. Galaxies are chosen to sample the highest mass haloes, with an effective bias of 1.5, allowing us to construct 1000 mock galaxy catalogs (described in Paper II), which we use to estimate statistical errors and test our methods. We use an estimate of the gravitational potential to "reconstruct" the linear density fluctuations, enhancing the Baryon Acoustic Oscillation (BAO) signal in the measured correlation function and power spectrum. Fitting to these measurements, we determine $D_{V}(z_{\rm eff}=0.15) = (664\pm25)(r_d/r_{d,{\rm fid}})$ Mpc; this is a better than 4 per cent distance measurement. This "fills the gap" in BAO distance ladder between previously measured local and higher redshift measurements, and affords significant improvement in constraining the properties of dark energy. Combining our measurement with other BAO measurements from BOSS and 6dFGS galaxy samples provides a 15 per cent improvement in the determination of the equation of state of dark energy and the value of the Hubble parameter at $z=0$ ($H_0$). Our measurement is fully consistent with the Planck results and the $\Lambda$CDM concordance cosmology, but increases the tension between Planck$+$BAO $H_0$ determinations and direct $H_0$ measurements.Comment: Accepted by MNRAS, distance likelihood is available in source file

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: mock galaxy catalogues for the low-redshift sample

We present one thousand mock galaxy catalogues for the analysis of the Low Redshift Sample (LOWZ, effective redshift z ~ 10.32) of the Baryon Oscillation Spectroscopic Survey Data Releases 10 and 11. These mocks have been created following the PTHalos method of Manera13 et al. (2013) revised to include new developments. The main improvement is the introduction of a redshift dependence in the Halo Occupation Distribution in order to account for the change of the galaxy number density with redshift. These mock catalogues are used in the analyses of the LOWZ galaxy clustering by the BOSS collaboration.Comment: 10 pages, 8 figure

Inpatient opioid prescribing patterns and their effect on rehospitalisations: a nested case-control study using data from a Swiss public acute hospital.

AIMS OF THE STUDY Opioid prescriptions have increased in Switzerland, even though current guidelines warn of their harms. If opioids for postoperative analgesia are not tapered before hospital discharge, patients are at risk of adverse events such as constipation, drowsiness, dependence, tolerance and withdrawal. The aim of this study was to investigate and quantify the potential association between opioids prescribed at discharge from hospital and rehospitalisation. METHODS We conducted a nested case-control study using routinely collected electronic health records from a Swiss public acute hospital. Cases were patients aged 65 years or older admitted between November 2014 and December 2018, with documented opioid administration on the day of discharge and rehospitalisation within 18 or 30 days after discharge. Each case was matched to five controls for age, sex, year of hospitalisation and Charlson Comorbidity Index. We calculated odds ratios for 18-day and 30-day rehospitalisation based on exposure to opioids using a conditional logistic regression adjusted for potential confounders. Secondary analyses included stratifications into morphine-equivalent doses of <50 mg, 50-89 mg and ≥90 mg, and co-prescriptions of gabapentinoids and benzodiazepines. RESULTS Of 22,471 included patients, 3144 rehospitalisations were identified, of which 1698 were 18-day rehospitalisations and 1446 were 30-day rehospitalisations. Documented opioid administration on the day of discharge was associated with 30-day rehospitalisation after adjustment for confounders (adjusted odds ratio 1.48; 95% CI 1.25-1.75, p 50 mg were rare. CONCLUSIONS Patients receiving opioids on the day of discharge were 48% more likely to be readmitted to hospital within 30 days. Clinicians should aim to discontinue opioids started in hospital before discharge if possible. Patients receiving an opioid prescription should be educated and monitored as part of opioid stewardship programmes

Profiles of an Ideal Society:The Utopian Visions of Ordinary People

Throughout history, people have expressed the desire for an ideal society—a utopia. These imagined societies have motivated action for social change. Recent research has demonstrated this motivational effect among ordinary people in English-speaking countries, but we know little about the specific content of ordinary people’s utopian visions in different cultures. Here we report that a majority of samples from four countries—Australia, China, the United Kingdom, and the United States—converge on a small number of utopian visions: a Modern Green utopia, a Primitivist utopia, a Futurist utopia, and a Religious utopia. Although the prevalence of these utopia profiles differed across countries, there was a cross-cultural convergence in utopian visions. These shared visions may provide common ground for conversations about how to achieve a better future across cultural borders.</p

Health sector spending and spending on HIV/AIDS, tuberculosis, and malaria, and development assistance for health : progress towards Sustainable Development Goal 3

Background Sustainable Development Goal (SDG) 3 aims to "ensure healthy lives and promote well-being for all at all ages". While a substantial effort has been made to quantify progress towards SDG3, less research has focused on tracking spending towards this goal. We used spending estimates to measure progress in financing the priority areas of SDG3, examine the association between outcomes and financing, and identify where resource gains are most needed to achieve the SDG3 indicators for which data are available. Methods We estimated domestic health spending, disaggregated by source (government, out-of-pocket, and prepaid private) from 1995 to 2017 for 195 countries and territories. For disease-specific health spending, we estimated spending for HIV/AIDS and tuberculosis for 135 low-income and middle-income countries, and malaria in 106 malaria-endemic countries, from 2000 to 2017. We also estimated development assistance for health (DAH) from 1990 to 2019, by source, disbursing development agency, recipient, and health focus area, including DAH for pandemic preparedness. Finally, we estimated future health spending for 195 countries and territories from 2018 until 2030. We report all spending estimates in inflation-adjusted 2019 US$, unless otherwise stated. Findings Since the development and implementation of the SDGs in 2015, global health spending has increased, reaching$7.9 trillion (95% uncertainty interval 7.8-8.0) in 2017 and is expected to increase to $11.0 trillion (10.7-11.2) by 2030. In 2017, in low-income and middle-income countries spending on HIV/AIDS was$20.2 billion (17.0-25.0) and on tuberculosis it was $10.9 billion (10.3-11.8), and in malaria-endemic countries spending on malaria was$5.1 billion (4.9-5.4). Development assistance for health was $40.6 billion in 2019 and HIV/AIDS has been the health focus area to receive the highest contribution since 2004. In 2019,$374 million of DAH was provided for pandemic preparedness, less than 1% of DAH. Although spending has increased across HIV/AIDS, tuberculosis, and malaria since 2015, spending has not increased in all countries, and outcomes in terms of prevalence, incidence, and per-capita spending have been mixed. The proportion of health spending from pooled sources is expected to increase from 81.6% (81.6-81.7) in 2015 to 83.1% (82.8-83.3) in 2030. Interpretation Health spending on SDG3 priority areas has increased, but not in all countries, and progress towards meeting the SDG3 targets has been mixed and has varied by country and by target. The evidence on the scale-up of spending and improvements in health outcomes suggest a nuanced relationship, such that increases in spending do not always results in improvements in outcomes. Although countries will probably need more resources to achieve SDG3, other constraints in the broader health system such as inefficient allocation of resources across interventions and populations, weak governance systems, human resource shortages, and drug shortages, will also need to be addressed. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.Peer reviewe

Unbiased clustering estimates with the DESI fibre assignment

The Emission Line Galaxy survey made by the Dark Energy Spectroscopic Instrument (DESI) survey will be created from five passes of the instrument on the sky. On each pass, the constrained mobility of the ends of the fibres in the DESI focal plane means that the angular-distribution of targets that can be observed is limited. Thus, the clustering of samples constructed using a limited number of passes will be strongly affected by missing targets. In two recent papers, we showed how the effect of missing galaxies can be corrected when calculating the correlation function using a weighting scheme for pairs. Using mock galaxy catalogues we now show that this method provides an unbiased estimator of the true correlation function for the DESI survey after any number of passes. We use multiple mocks to determine the expected errors given one to four passes, compared to an idealised survey observing an equivalent number of randomly selected targets. On BAO scales, we find that the error is a factor 2 worse after one pass, but that after three or more passes, the errors are very similar. Thus we find that the fibre assignment strategy enforced by the design of DESI will not affect the cosmological measurements to be made by the survey, and can be removed as a potential risk for this experiment.Comment: 11 pages, 8 figure

The clustering of Galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : including covariance matrix errors

JP acknowledges support from the UK Science & Technology Facilities Council (STFC) through the consolidated grant ST/K0090X/1 and from the European Research Council through the ‘Starting Independent Research’ grant 202686, MDEPUGS. AGS acknowledges support from the Trans-regional Collaborative Research Centre TR33 ‘The Dark Universe’ of the German Research Foundation (DFG).We present improved methodology for including covariance matrices in the error budget of Baryon Oscillation Spectroscopic Survey (BOSS) galaxy clustering measurements, revisiting Data Release 9 (DR9) analyses, and describing a method that is used in DR10/11 analyses presented in companion papers. The precise analysis method adopted is becoming increasingly important, due to the precision that BOSS can now reach: even using as many as 600 mock catalogues to estimate covariance of two-point clustering measurements can still lead to an increase in the errors of ∼20 per cent, depending on how the cosmological parameters of interest are measured. In this paper, we extend previous work on this contribution to the error budget, deriving formulae for errors measured by integrating over the likelihood, and to the distribution of recovered best-fitting parameters fitting the simulations also used to estimate the covariance matrix. Both are situations that previous analyses of BOSS have considered. We apply the formulae derived to baryon acoustic oscillation (BAO) and redshift-space distortion (RSD) measurements from BOSS in our companion papers. To further aid these analyses, we consider the optimum number of bins to use for two-point measurements using the monopole power spectrum or correlation function for BAO, and the monopole and quadrupole moments of the correlation function for anisotropic-BAO and RSD measurements.Publisher PDFPeer reviewe

Efficient reconstruction of linear baryon acoustic oscillations in galaxy surveys

Reconstructing an estimate of linear baryon acoustic oscillations (BAO) from an evolved galaxy field has become a standard technique in recent analyses. By partially removing non-linear damping caused by bulk motions, the real-space BAO peak in the correlation function is sharpened, and oscillations in the power spectrum are visible to smaller scales. In turn these lead to stronger measurements of the BAO scale. Future surveys are being designed assuming that this improvement has been applied, and this technique is therefore of critical importance for future BAO measurements. A number of reconstruction techniques are available, but the most widely used is a simple algorithm that decorrelates large-scale and small-scale modes approximately removing the bulk-flow displacements by moving the overdensity field. We consider the practical implementation of this algorithm, looking at the efficiency of reconstruction as a function of the assumptions made for the bulk-flow scale, the shot-noise level in a random catalogue used to quantify the mask and the method used to estimate the bulk-flow shifts. We also examine the efficiency of reconstruction against external factors including galaxy density, volume and edge effects, and consider their impact for future surveys. Throughout we make use of the mocks catalogues created for the Baryon Oscillation Spectroscopic Survey (BOSS) Date Release 11 samples covering 0.43 < z < 0.7 (CMASS) and 0.15 < z < 0.43 (LOWZ), to empirically test these changes

Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study.

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line therapeutic antibody ustekinumab. The impact of differing dosing strategies on response was explored. Data were collected from a UK prospective multicenter observational cohort (491 patients on ustekinumab monotherapy, drug levels, and anti-drug antibody measurements on 797 serum samples, 1,590 measurements of Psoriasis Area Severity Index (PASI)). Ustekinumab PKs were described with a linear one-compartment model. A maximum effect (Emax ) model inhibited progression of psoriatic skin lesions in the turnover PD mechanism describing PASI evolution while on treatment. A mixture model on half-maximal effective concentration identified a potential nonresponder group, with simulations suggesting that, in future, the model could be incorporated into a Bayesian therapeutic drug monitoring "dashboard" to individualize dosing and improve treatment outcomes

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : baryon acoustic oscillations in the Data Releases 10 and 11 Galaxy samples

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations (BAO) in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 (DR11) sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released DR9 and DR10 samples. Assuming a concordance Λ cold dark matter (ΛCDM) cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = (1264 ± 25 Mpc)(rd/rd,fid) at z = 0.32 and DV = (2056 ± 20 Mpc)(rd/rd,fid) at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = (1421 ± 20 Mpc)(rd/rd,fid) and H = (96.8 ± 3.4 km s−1 Mpc−1)(rd,fid/rd). Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant.Publisher PDFPeer reviewe