52 research outputs found
Role network project to attraction adult population for sports and recreational activities sports facilities
In the work the potential educational impact of physical culture and national sports as factor of increase of health preservation and physical cultureΠ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ°ΡΠΊΡΡΠ²Π°Π΅ΡΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» Π²ΠΎΡΠΏΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΈΠ·ΠΊΡΠ»ΡΡΡΡΠ½ΠΎ-ΠΎΠ·Π΄ΠΎΡΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΈ Π½Π°ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΡΠΏΠΎΡΡΠ° ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡΠ° ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ΡΠ±Π΅ΡΠ΅ΠΆΠ΅Π½ΠΈΡ ΠΈ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠ»ΡΡΡΡ
The use of innovative assessment tools in the process of physical education students at the university
The article deals with the problem of fund formation evaluation meansΠ ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΠ½Π΄Π° ΠΎΡΠ΅Π½ΠΎΡΠ½ΡΡ
ΡΡΠ΅Π΄ΡΡ
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood. We show here that exposure of expansively growing human WM852 melanoma cells, but not singly invasive Bowes cells, to lymphatic endothelial cells (LEC) in 3D co-culture facilitates melanoma distant organ metastasis in mice. To dissect the underlying molecular mechanisms, we established LEC co-cultures with different melanoma cells originating from primary tumors or metastases. Notably, the expansively growing metastatic melanoma cells adopted an invasively sprouting phenotype in 3D matrix that was dependent on MMP14, Notch3 and Ξ²1-integrin. Unexpectedly, MMP14 was necessary for LEC-induced Notch3 induction and coincident Ξ²1-integrin activation. Moreover, MMP14 and Notch3 were required for LEC-mediated metastasis of zebrafish xenografts. This study uncovers a unique mechanism whereby LEC contact promotes melanoma metastasis by inducing a reversible switch from 3D growth to invasively sprouting cell phenotype
Productivity of peppermint varieties (menta piperita) when grown in vitro using hydroponics
The article describes the method of hydroponics, explores the history of the origin of hydroponics and also describes a plan for the future practical part of the work aimed at analyzing the productivity of peppermint varieties (Menta piperita) when grown in vitro using the method of hydroponics.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ ΠΌΠ΅ΡΠΎΠ΄ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ, ΠΈΡΡΠΎΡΠΈΡ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΠΈΡΠ°Π½ ΠΏΠ»Π°Π½ Π±ΡΠ΄ΡΡΠ΅ΠΉ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΡΠΈ ΡΠ°Π±ΠΎΡΡ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ Π½Π° Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠΎΠ² ΠΌΡΡΡ ΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠΉ (Menta piperita) ΠΏΡΠΈ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠΈ in vitro ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ
Productivity of peppermint varieties (menta piperita) when grown in vitro using hydroponics
The article describes the method of hydroponics, explores the history of the origin of hydroponics and also describes a plan for the future practical part of the work aimed at analyzing the productivity of peppermint varieties (Menta piperita) when grown in vitro using the method of hydroponics.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ ΠΌΠ΅ΡΠΎΠ΄ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ, ΠΈΡΡΠΎΡΠΈΡ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΠΈΡΠ°Π½ ΠΏΠ»Π°Π½ Π±ΡΠ΄ΡΡΠ΅ΠΉ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΡΠΈ ΡΠ°Π±ΠΎΡΡ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ Π½Π° Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠΎΠ² ΠΌΡΡΡ ΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠΉ (Menta piperita) ΠΏΡΠΈ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠΈ in vitro ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ
Productivity of peppermint varieties (menta piperita) when grown in vitro using hydroponics
The article describes the method of hydroponics, explores the history of the origin of hydroponics and also describes a plan for the future practical part of the work aimed at analyzing the productivity of peppermint varieties (Menta piperita) when grown in vitro using the method of hydroponics.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½ ΠΌΠ΅ΡΠΎΠ΄ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ, ΠΈΡΡΠΎΡΠΈΡ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠΏΠΈΡΠ°Π½ ΠΏΠ»Π°Π½ Π±ΡΠ΄ΡΡΠ΅ΠΉ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°ΡΡΠΈ ΡΠ°Π±ΠΎΡΡ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ Π½Π° Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠΎΠ² ΠΌΡΡΡ ΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠΉ (Menta piperita) ΠΏΡΠΈ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΠΈ in vitro ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π³ΠΈΠ΄ΡΠΎΠΏΠΎΠ½ΠΈΠΊΠΈ
StopCOVID cohort : An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection
Β© 2020 Oxford University Press. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record is available online at: https://doi.org/10.1093/cid/ciaa1535.BACKGROUND: The epidemiology, clinical course, and outcomes of COVID-19 patients in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically-diagnosed COVID-19 in real-life settings is lacking. METHODS: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow, between April 8 and May 28, 2020. RESULTS: Of the 4261 patients hospitalised for suspected COVID-19, outcomes were available for 3480 patients (median age 56 years (interquartile range 45-66). The commonest comorbidities were hypertension, obesity, chronic cardiac disease and diabetes. Half of the patients (n=1728) had a positive RT-PCR while 1748 were negative on RT-PCR but had clinical symptoms and characteristic CT signs suggestive of COVID-19 infection.No significant differences in frequency of symptoms, laboratory test results and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive SARS-CoV-2 RT-PCR.In a multivariable logistic regression model the following were associated with in-hospital mortality; older age (per 1 year increase) odds ratio [OR] 1.05 (95% confidence interval (CI) 1.03 - 1.06); male sex (OR 1.71, 1.24 - 2.37); chronic kidney disease (OR 2.99, 1.89 - 4.64); diabetes (OR 2.1, 1.46 - 2.99); chronic cardiac disease (OR 1.78, 1.24 - 2.57) and dementia (OR 2.73, 1.34 - 5.47). CONCLUSIONS: Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features were sufficient to diagnoseCOVID-19 infection indicating that laboratory testing is not critical in real-life clinical practice.Peer reviewe
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Characterising long COVID: a living systematic review
BACKGROUND: While it is now apparent clinical sequelae (long COVID) may persist after acute COVID-19, their nature, frequency and aetiology are poorly characterised. This study aims to regularly synthesise evidence on long COVID characteristics, to help inform clinical management, rehabilitation strategies and interventional studies to improve long-term outcomes.
METHODS: A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research on COVID-19 database, LitCovid and Google Scholar were searched till 17 March 2021. Studies including at least 100 people with confirmed or clinically suspected COVID-19 at 12 weeks or more post onset were included. Risk of bias was assessed using the tool produced by Hoy et al. Results were analysed using descriptive statistics and meta-analyses to estimate prevalence.
RESULTS: A total of 39 studies were included: 32 cohort, 6 cross-sectional and 1 case-control. Most showed high or moderate risk of bias. None were set in low-income countries and few included children. Studies reported on 10β951 people (48% female) in 12 countries. Most included previously hospitalised people (78%, 8520/10 951). The longest mean follow-up time was 221.7 (SD: 10.9) days post COVID-19 onset. Over 60 physical and psychological signs and symptoms with wide prevalence were reported, most commonly weakness (41%; 95%βCI 25% to 59%), general malaise (33%; 95%βCI 15% to 57%), fatigue (31%; 95%βCI 24% to 39%), concentration impairment (26%; 95%βCI 21% to 32%) and breathlessness (25%; 95%βCI 18% to 34%). 37% (95% CI 18% to 60%) of patients reported reduced quality of life; 26% (10/39) of studies presented evidence of reduced pulmonary function.
CONCLUSION: Long COVID is a complex condition with prolonged heterogeneous symptoms. The nature of studies precludes a precise case definition or risk evaluation. There is an urgent need for prospective, robust, standardised, controlled studies into aetiology, risk factors and biomarkers to characterise long COVID in different at-risk populations and settings. PROSPERO REGISTRATION NUMBER: CRD42020211131
Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΠΎΠ΄Ρ ΠΎΠ΄Ρ ΠΊ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ²
Objective. Review of the modern methodological approaches for testing and studying the epigenetic activity of xenobiotics.Materials and methods. In preparing the review, we used information databases of biomedical literature SciVerse Scopus (538), PubMed (746), Web of Science (625), RSCI (45). To obtain full-text documents, electronic resources of PubMed Central (PMC), Research Gate, RSCI, CyberLeninka were used. In the text of the review, 87 modern publications (2010β2019) were cited, as well as 17 earlier articles published by the founders of the methods, which are used today.Results. In the review, current data on epigenetic regulation for gene expression at the level of DNA methylation and histone modification are discussed, in vitro model systems and model organisms are described, and modern methods for screening of epigenetically active xenobiotics are presented.Conclusion. Modern data concerning the mechanisms of epigenetic regulation of gene expression, the usage of existing model systems and model organisms, as well as the application of various methodological approaches and techniques, allow extensive screening of xenobiotics (including drugs and compounds synthesized for national economic tasks) for epigenetic activity. The identification of epigenetically active compounds is important in terms of improving the prevention and treatment of a number of diseases and, in particular, malignant neoplasms.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β Π°Π½Π°Π»ΠΈΠ· ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ².ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΠΎΠ±Π·ΠΎΡΠ° Π±ΡΠ»ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ Π±Π°Π·Ρ Π±ΠΈΠΎΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ SciVerse Scopus (538), PubMed (746), Web of Science (625), Π ΠΠΠ¦ (45). ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠ»Π½ΠΎΡΠ΅ΠΊΡΡΠΎΠ²ΡΡ
Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠ΅ ΡΠ΅ΡΡΡΡΡ PubMed Central (PMC), Research Gate, Π ΠΠΠ¦, ΠΠΈΠ±Π΅ΡΠΠ΅Π½ΠΈΠ½ΠΊΠ°. Π ΡΠ΅ΠΊΡΡΠ΅ ΠΎΠ±Π·ΠΎΡΠ° ΠΏΡΠΎΡΠΈΡΠΈΡΠΎΠ²Π°Π½Ρ 87 ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ (2010β2019 Π³Π³.), Π° ΡΠ°ΠΊΠΆΠ΅ 17 ΡΡΠ°ΡΠ΅ΠΉ ΠΎΡΠ½ΠΎΠ²ΠΎΠΏΠΎΠ»ΠΎΠΆΠ½ΠΈΠΊΠΎΠ² Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅ΠΌΡΡ
Π² ΠΎΠ±Π·ΠΎΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ ΠΈ Π² Π½Π°ΡΠΈ Π΄Π½ΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΏΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΡΠΌ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π½Π° ΡΡΠΎΠ²Π½Π΅ ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΠΠ ΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π³ΠΈΡΡΠΎΠ½ΠΎΠ², ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΠΊΠ°ΠΊ ΠΏΡΠΈ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π½Π° ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ, ΡΠ°ΠΊ ΠΈ Π΄Π»Ρ Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΈΡ
ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² Π½Π° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ. ΠΠΎΡΠΊΠΎΠ»ΡΠΊΡ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π΅ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΈΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½ΠΎ ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΡ ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π½Π° ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ, Π² ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΎΡΠ΅Π½ΠΊΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π²Π»ΠΈΡΠ½ΠΈΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ², Π½Π° ΠΌΠ΅ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΠΠ ΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π³ΠΈΡΡΠΎΠ½ΠΎΠ².ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΡΠ΅ΡΡΠ²ΡΡΡΠΈΡ
ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΈ ΠΌΠΎΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΡΠ΅Π½ΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π΄Π»Ρ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ Π½Π°ΡΠΎΠ΄Π½ΠΎΡ
ΠΎΠ·ΡΠΉΡΡΠ²Π΅Π½Π½ΡΡ
Π·Π°Π΄Π°Ρ, Π½Π° ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π²Π°ΠΆΠ½ΠΎ Π² ΠΏΠ»Π°Π½Π΅ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠ΄Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΈ, ΠΏΡΠ΅ΠΆΠ΄Π΅ Π²ΡΠ΅Π³ΠΎ, Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ
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