13 research outputs found
Partial belief and expert testimony
- Publication venue
- Massachusetts Institute of Technology
- Publication date
- 01/01/2009
- Field of study
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2009.Includes bibliographical references (p. [83]-86).My dissertation investigates two questions from within a partial belief framework: First, when and how should deference to experts or other information sources be qualified? Second, how closely is epistemology related to other philosophical fields, such as metaphysics, ethics, and decision theory? Chapter 1 discusses David Lewis's "Big Bad Bug", an argument for the conclusion that the Principal Principle-the thesis that one's credence in a proposition A should equal one's expectation of A's chance, provided one has no inadmissible information-is incompatible with Humean Supervenience-the thesis that that laws of nature, dispositions, and objective chances supervene on the distribution of categorical properties in the world (past, present, and future). I map out the logical structure of the Big Bad Bug, survey a range of possible responses to it, and argue that none of the responses are very appealing. Chapter 2 discusses Bas van Fraassen's Reflection principle-the thesis that one's current credence in a proposition A should equal one's expected future credence in A. Van Fraassen has formulated a diachronic Dutch book argument for Reflection, but other authors cite counterexamples to Reflection that appear to undermine the credibility of diachronic Dutch books. I argue that a suitably qualified version of Reflection gets around the counterexamples. I distinguish between Dutch books that reveal incoherence-like the diachronic Dutch book for conditionalization-and Dutch books that reveal a type of problem I call selfdoubt. I argue that violating Reflection is a type of self-doubt rather than a type of incoherence.(cont.) Chapter 3 argues that the halfer and thirder solutions to Adam Elga's Sleeping Beauty problem correspond to two more general approaches to de se information. Which approach is right depends on which approach to decision theory is right. I use Dutch books and scoring rules to argue that causal decision theorists should favor the approach that corresponds to thirding, while evidential decision theorists should favor the approach that corresponds to halfing.by Rachael Briggs.Ph.D
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
- Author
- Abani Obbina
- Abbas Ali
- Abbas Fatima
- Abbas Mustafa
- Abbasi Sadia
- Abbass Hakam
- Abbott Alfie
- Abdallah Nabeel
- Abdelaziz Ashraf
- Abdelfattah Mohamed
- Abdelqader Bushra
- Abdo David
- Abdul Rasheed Althaf
- Abdul Basir
- Abdul-Kadir Rezan
- Abdul-Raheem Rasheed
- Abdulakeem Ajibode
- Abdulle Amina
- Abdulmumeen Abdulfatahi
- Abdulshukkoor Niyaz
- Abdusamad Kula
- Abed El Khaleq Yazeed
- Abedalla Mai
- Abeer Ul Amna Abeer Ul Amna
- Abernethy Katrina
- Abo-Leyah Hani
- Aboaba Adebanke
- Abou-Haggar Ahmed
- Abouibrahim Mahmoud
- Abraham Miriam
- Abraham Tizzy
- Abraheem Abraheem
- Abrams Judith
- Abu Hyacinth-John
- Abu-Arafeh Ahmed
- Abubacker Syed M
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- Publication venue
- 'Elsevier BV'
- Publication date
- 13/02/2021
- Field of study
SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication
Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study
- Author
- Aamir Ayesha
- Abdelbadiee Sherif
- Abdullah Saad
- Abiola Oluwatosin O.
- Abras Ahmed
- Abu Emmy
- Abu-Arafeh Hashem
- Achara Amaka
- Adam Muhammad
- Adams Lawrence A. T.
- Adams Phillipa
- Aggarwal Nisha
- Ahmad Asim
- Ahmad Sarah
- Ahmed Bilquis
- Ahmed Hamza
- Ahmed Jabed
- Ahmed Rohan
- Ain Qurrat Ul
- Akintade Olugbenro
- Alareed Ahmad
- Alhadadi Baraa
- Ali Jawad
- Allain Theresa J.
- Allen James
- Alsahab Mustafa
- Amarnani Raj
- Amin Zarah
- Anderson Clementine
- Andrusca Ana
- Annamalai Arunkumar
- Ansell Matthew
- Appiah-Odame Paapa
- Arkle Thomas
- Ashton Caroline
- Astaire Emma
- Austin Keziah
- Babar Laxmi
- Babb Laura
- Bahsoon Farrah
- Baillie Jonathan
- Baldwin Jack B. G.
- Ball Katie
- Bargaoanu Imola
- Barlow Ciaran
- Baron Alexander
- Basker Karthik
- Batho Rachel
- Bazaraa Amr
- Bedi Simran
- Beeley Laura J.
- Beharry Karen
- Behbahani Abolfazl
- Behbahani Ayoub
- Bei Zhao Xiao
- Bell Charlotte
- Bertagne Marc
- Berwick L.
- Beveridge Louise
- Bhakta Shiv
- Bhat Ganapathy
- Bhattacharya Saurav
- Bhatti Jamal
- Bilton Edward
- Blair Mairi
- Bowden Helen
- Bowen Emily
- Bowman Mark A.
- Box Emma
- Bremakumar Sanojan
- Briggs Laura
- Broadhurst Karen
- Brown Harriet
- Browne Marylin
- Bryant Catherine
- Bullock Stuart
- Bultynck Celine
- Burton Jenni K.
- Bygate Rachael
- Byravan Swetha
- Caines Laurence
- Cairns Christopher
- Cameron Ewen
- Campbell Angela
- Capek Eileen
- Carter Sammy
- Cavaliere Chiara
- Chai Chung Sien
- Chamberlain Helen
- Chamboult Aimee-Louise
- Champion Jennifer
- Chapman George
- Cheah Khai L.
- Cheema Anum
- Chevolleau Jasmine
- Chilton Angharad
- Chourot Christian
- Christie Lorna
- Christodoulides Natasha
- Chuter Charlotte
- Clayton Victoria
- Cleaver Sarah L.
- Clements Hollie A.
- Coffey Farah
- Cohen Samuel
- Connell Laura
- Connor Louise
- Cook Alan
- Cooper Freya
- Cooper Olivia
- Copeland Claire
- Cox Natalie
- Cricklow Tamsin
- Croft Paul
- Crofts Jodie
- Cummings Laura
- Cunningham Emma L.
- Currie Hannah
- Cushen Claire
- Dama Sindhoora
- Darko Sandra
- Davies Rhianna
- Davies-Morris Jayne
- Davis Daniel
- De Mucha Pedro Vila
- Deacon Elizabeth
- Debrah Kwasi
- Deosaran Jordanna
- Dhillon Amber
- Doherty Cal
- Dove James
- Dovey Julie
- Drozdowska Bogna
- Durcan Rory
- Durrant Sabrina K.
- Edwards Sarah
- Einarsson Alice
- Elliott Emma
- Elliott Marianne
- Ellis Elizabeth J.
- Enfield-Bance Amy
- Evans Elizabeth
- Evans Jenny
- Evans Olivia
- Evans Sarah
- Faheem Waleed
- Fancourt Sarah
- Farah Rinata
- Faruq Sana
- Fenneley Grace
- Ferguson Eilidh E. C.
- Fergusson Niall
- Ferreira Ana Silva
- Fisken Emma
- Foster Kate
- Fraser Debbie
- Frewen John
- Furmedge Daniel
- Gallagher Michael
- Gaskell Natalie
- Gaunt Victoria
- Gaywood James
- Giblin Eleanor
- Giddings Jane
- Giet Leeying
- Giles Alexis
- Giridharan Kumudhini
- Glasser Martin
- Glasser Martin
- Gluck Ilan
- Goujon Marie
- Govindji Suriti
- Grange Robert
- Greaves Isabel
- Green Jessica
- Gregory Jemma
- Griffiths Eliza
- Grundmann Natalie
- Gui Jonathan
- Gupta Abhishek
- Gurung Sneha
- Hackett Beth
- Haddad Nedaa
- Haley Michael
- Hall Giles
- Hall Susan A.
- Handley Olivia
- Harbinson Alexander
- Harkin Teresa
- Hart Jasmine
- Hayat Yasmeen
- Headlam John
- Healy Roisin
- Henderson Neil
- Henderson Sarah
- Herbert Fiona
- Hindley Esther
- Hodhody Ghazal
- Hoffman Katrin
- Holmes Elizabeth A. M.
- Horner Sarah
- Hornsby Alex
- Horton Robbie
- Houldershaw Katie
- House Shannelle
- Hughes Clare
- Hunt Clare
- Hunt William
- Hunter Elisabeth
- Hussain Ambreen
- Hussain Zainab
- Ibanichuka Jacqueline
- Ikhwan Wan Idoracaera C.
- Ingamells Nathan
- Iqbal Shoaib
- Irvine James
- Irwin Sophie J.
- Iwu Chioma
- Jackson Peter
- Jackson Peter
- Jackson Thomas A.
- Jacques Holly
- Jagdeo Sarah
- Jakupaj Adriana
- Janagal Sureena
- Jatti Puja
- Jay Emma
- Jelley Benjamin
- Jenkin Rodric
- Jewell Emilia
- Jones Howell T.
- Jones Karen
- Jones Laura
- Jones Polly
- Kabia Angela
- Kadir Ismail
- Kalyaani Vickneswaran
- Kantczak Ada
- Katz-Summercorn Charles
- Kay Aaron
- Kearney Matthew
- Kelly Dominic
- Khalid Abdullah B.
- Khambay Ethan
- Khan Ali
- Khan Asma
- Khizar Bushra
- Khor Ming
- Kiani Mahum
- King Rachel
- Kirrane Kimberley
- Konda Nagarjun
- Koshedo Sejlo
- Krishan Anjli
- Kuek Dorothy K. C.
- Kumar Anusha
- Kumbun Gary
- Kunaselan Lleika
- Lai Jo
- Large Jamie
- Laud Rose
- Layton Georgia R.
- Le Poideven Andre
- Leah Eleanor
- Lee Helena
- Lee Tammy
- Leishman Felicity
- Lewis Anna
- Lim Su Kwan
- Lim Vee Han
- Livesey Joanna
- Lochlainn Mary Ni
- Lonsdale-Eccles Elizabeth
- Love Ryan
- Lowes Olivia
- Lucocq James E.
- Lyon Emily
- MacCuish Annabel Hentall
- Macdonald Fiona E.
- Macharouthu Ajay
- Mackenzie Eilidh R.
- Macrae Victoria
- Madden Katy F.
- Magill Laura
- Mahmood Al Wakkass
- Majid Zeinab
- Makin Stephen
- Mani Shama
- Marshall John
- Masoli Jane
- Matheswaran Yathu
- Matthews Natasha R.
- Matthews Stephanie A.
- Mayor Kara
- Mazzoleni Antonella
- McCauley Hannah
- McClean Adam
- McClelland Sarah B.
- McCluskey Heather J.
- McCluskey Lauren
- McCormack Roisin
- McCormack Vincent
- McCready Jack
- McCulloch Alison
- McDonald Helen
- McErlean Catherine M.
- McGonigal Gerry
- McKay Siobhan
- McKeown William
- McNicholas Emily
- McQuillan Alex
- McShane David
- Menezes Reema
- Meyer Caitlin
- Miller Christopher J.
- Miller Hazel
- Millichamp Katie
- Millner Helen
- Mills Sam
- Mishra Pranav
- Mishra Rajeev
- Mitchell Oliver
- Mithrakumar Pryankaran
- Moad Mohammad
- Mohammedseid-Nurhussien Awolkhier
- Moore Emily
- Moore Kirsty
- Moorey Hannah
- Morgan Bethan
- Morgan Hannah
- Morrison Kirty
- Morrow Abbie
- Morrow Olivia
- Mosley Alice
- Mukundan Maya
- Mullarkey Emma
- Mumtaz Emma
- Murphy-Ackroyd Emily
- Murray Adam A.
- Murthy Seema
- Mustafa Zeeshan
- Naeem Fariha
- Nagumantry Shonit
- Naish George
- Nandra Taran
- Naqvi Huma
- Nashed Nader
- Ng Liji
- Ngan Esther E. Y.
- Nicholls Isabelle
- Nightingale Peter
- Nneamaka Asiodu
- Noble Jane
- Norman Emma
- Nwabufor Philip
- Nynaes Olga
- Obi Ijeoma T.
- Offer Megan
- Ofoche Gladys
- Ostrowski Caroline
- O’shea Kate
- Page Valerie
- Pailing Adam
- Pang Norman
- Parkinson Megan
- Parry Frances
- Parry Sarah
- Patel Minal D.
- Patel Riana
- Patterson Katherine
- Peck George
- Pendleton Hannah
- Perry Rita
- Pettler Sophie
- Pinkney Thomas
- Pope Leo
- Porter Lucy
- Porter-Bent Sasha
- Poynton Jack
- Prasad Vishnu
- Prendergast Emma L.
- Pullen Rosamund
- Pyc Wioletta
- Quinn Sinead
- Quinn Terrence
- Radoja Stephanie
- Rai Nisha
- Ramakrishna Sharan
- Rashid Shayan
- Rayner Helen
- Raza Mahrukh
- Reay Anna
- Reidm James
- Rice Caroline
- Richardson Sarah
- Rickard Frances
- Rimmer Lucy
- Robinson Hannah J.
- Robson Richard
- Ronan Lindsay
- Rose Emily C.
- Ross Anekea
- Rutter Steve
- Ryan Aidan
- Sahnan Kapil
- Saliu David
- Sami Fadi
- Sampson Elizabeth L.
- San Moe Su Su
- Sarma Dhruv
- Satharasinghe Lahiru
- Scarlett Danielle
- Scott Deborah
- Sehmbi Gurpreet
- Sen Michael
- Seymour Elaine
- Shah Hussun-Ara
- Shahid Muhammad
- Shakeel Sohail
- Shaw Megan E.
- Shepherd Alison
- Sloan Gerrard W.
- Smith Abigail
- Smith Gemma M.
- Smith Nina
- Speed James
- Sprosen Charles
- Stambollouian Katharine
- Stapley Simon M.
- Stirling Adam
- Stratton Emma
- Straughan Jacqui
- Studley Mark
- Subhan Zahid
- Sundara Srividya
- Swietoslawski Adam
- Syed Nihaad
- Tan Felicia
- Tantam Kate
- Taranu Roxana
- Taylor Abigail
- Taylor Emily
- Taylor Jemima
- Taylor Joanne
- Taylor-Rowan Martin
- Tencheva Ani
- Tetlow Simon
- Thake Miriam
- Thayabaran Darmiga
- Thomas Philip
- Thyn Thyn
- Timperley Alex
- Tinson Guy
- Todd Oliver
- Torsney Kelli
- Traill Philippa K.
- Treml Jonathan
- Tse Connie
- Tumi Ebrahiem
- Turton Sophie
- Tyagi Bhavyas
- Usmani Kasim
- Valentine Janine
- Vardon Henry
- Varghese Jessel
- Vasudev Ashish
- Vedutla Tarunya
- Velusamy Karthika
- Venkat Shabnam
- Virk Jasmine
- Visvaratnam Parrthiepan
- Wahballa Afnan
- Walker Amy
- Walter Amy
- Waraich Hana
- Warwicker Sarah
- Watson Hannah
- Watt Nicola
- Webb Hannah
- Welch Carly
- Wheeler Alice
- Whyte Lindsay
- Wilcockson James
- Wilkes Claire
- Williamson Emily
- Williamson Katherine
- Willott Ruth
- Wilson Daisy
- Wilson Daisy
- Wilson Darcy S.
- Wilson Faye
- Wilson Joseph B.
- Wilson Michael S. J.
- Winearls Stuart
- Wong Li
- Wong Ting W.
- Woodman Hannah
- Woodward Beth L.
- Wrathall Abigail
- Wright Emily
- Wright Sophie
- Wu Chenxian
- Wu Edward
- Wynne Luke
- Yap Zhi Jiun
- Young Lesley J.
- Yule Ollie
- Yunus Aayenah
- Publication venue
- Springer
- Publication date
- 01/04/2023
- Field of study
Purpose:
Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom.
Methods:
Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded.
Results:
The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia.
Conclusion:
We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
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- Basire Donna
- Basu N.
- Bates A
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- Batterham R
- Baxendale H
- Bayes Hannah
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- Beckett P
- Beggs Mark
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- Beirne Paul
- Bell Murdina
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- Bermperi Areti
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- Bhui K
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- Lim Lai
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- Lingford-Hughes A.
- Lipman M
- Liyanage Kamal
- Lloyd Arwel
- Logan S
- Lomas D
- Lone Nazir I.
- Loosley Ronda
- Lord J M
- Lota Harpreet
- Lovegrove Wayne
- Lucey Alice
- Lukaschuk Elena
- Lye Alison
- Lynch Ceri
- MacDonald S
- MacGowan G.
- Macharia Irene
- Mackie J
- Macliver L.
- Madathil S
- Madzamba Gladys
- Magee N.
- Magtoto Murphy M.
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- Malein Flora
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- Mallison Georgia
- Man William D-C.
- Mandal S
- Mangion K.
- Manisty Charlotte
- Manley R.
- March Katherine
- Marciniak S.
- Marino Philip
- Mariveles Myril
- Marks Michael
- Marouzet E
- Marsh Sophie
- Marshall B
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- Martin Jane
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- Martinez L.M.
- Maskell Nick
- Matila Darwin
- Matimba-Mupaya Wadzanai
- Matthews Laura
- Mbuyisa Angeline
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- McArdle A
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- McGovern A
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- McInnes I.B.
- McIntosh Jerome
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- McMahon A.
- McMahon Michael J.
- McMorrow L
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- Mears Chloe
- Megson Clare
- Megson Sharon
- Mehta P
- Meiring J
- Melling Lucy
- Mencias Mark
- Menke Ricarda
- Menzies Daniel
- Merida Morillas Marta
- Michael Alice
- Miiler K
- Miller Christopher A
- Miller Karla
- Milligan L.
- Mills Clare
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- Milner L
- Misra S
- Mitchell J.
- Mohamed Abdelrahman
- Mohamed Noura
- Mohammed S.
- Molyneaux P.L.
- Monteiro Will
- Moriera Silvia
- Morley Anna
- Morrison Leigh
- Morriss R
- Morrow A.
- Moss Alastair J
- Moss P
- Motohashi K
- Msimanga N
- Mukaetova-Ladinska Elizabeta
- Munawar Unber
- Murira Jennifer
- Nanda U
- Nassa Heeah
- Nasseri Mariam
- Nathu Rashmita
- Neal A
- Needham Robert
- Neill Paula
- Neubauer Stefan
- Newby D E
- Newell Helen
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- Newton-Cox A
- Nichols Thomas E
- Nicholson T.
- Nicoll Debby
- Nikolaidis Athanasios
- Nikolaidou Chrysovalantou
- Nolan C.M.
- Noonan Matthew J.
- Norman C
- Novotny Petr
- Nunag Jose Lloyd
- Nwafor Lorenza
- Nwanguma Uchechi
- Nyaboko J
- O'Brien Caitlin
- O'Brien Linda
- O'Donnell K
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- Odell Natasha
- Ogbole Godwin
- Ogg G.
- Olaosebikan Olaoluwa
- Oliver Catherine
- Omar Zohra
- Openshaw Peter J.M.
- Orriss-Dib Lorna
- Osborne Lynn
- Osbourne Rebecca
- Ostermann Marlies
- Overton Charlotte
- Owen J.
- Oxton J
- Pack Jamie
- Pacpaco Edmund
- Paddick S.
- Painter Sharon
- Pakzad A
- Palmer Sue
- Papineni Padmasayee
- Paques K
- Paradowski Kerry
- Pareek Manish
- Parekh Dhruv
- Parfrey H
- Pariante C.
- Parker S
- Parkes M.
- Parmar J
- Patale Sheetal
- Patel B.
- Patel Manish
- Patel Suhani
- Pattenadk Dibya
- Pavlides M.
- Payne Sheila
- Pearce Lorraine
- Pearl John E
- Peckham D.
- Pendlebury Jessica
- Peng Yanchun
- Pennington Chris
- Peralta Ida
- Perkins Emma
- Peterkin Z
- Peto T.
- Petousi Nayia
- Petrie J
- Pfeffer Paul
- Phipps Janet
- Piechnik Stefan K
- Pimm John
- Piper Hanley K.
- Pius R
- Plant Hannah
- Plein Sven
- Plekhanova Tatiana
- Plowright Megan
- Poinasamy Krisnah
- Polgar Oliver
- Poll L.
- Popescu Iulia
- Porter Joanna C
- Porter Julie
- Portukhay Sofiya
- Powell Natassia
- Prabhu A.
- Pratt James
- Price Andrea
- Price Carly
- Price Claire
- Price D.
- Price L
- Price L.
- Prickett A
- Prosper Sabrina
- Pugmire S.
- Quaid Sheena
- Quigley Jackie
- Quint Jennifer
- Qureshi H
- Qureshi I N
- Radhakrishnan K.
- Rahman Najib M.
- Ralser M
- Raman Betty
- Ramos Albert
- Ramos Hazel
- Rangeley Jade
- Rangelov B
- Ratcliffe L
- Ravencroft Phillip
- Reddington A
- Reddy A
- Reddy R.
- Redfearn H
- Redwood Dawn
- Reed Annabel
- Rees Meryl
- Rees Tabitha
- Regan Karen
- Reynolds W
- Ribeiro Carla
- Richards A.
- Richardson Emma
- Richardson Matthew
- Rivera-Ortega P.
- Roberts K.
- Robertson E.
- Robinson E
- Robinson Leanne
- Roche Lisa
- Roddis C
- Rodger J
- Rogers Natalie
- Ross Alexandra
- Ross Gavin
- Rossdale J.
- Rostron A
- Rowe Anna
- Rowland A
- Rowland J.
- Rowland Matthew J.
- Rowland-Jones Sarah L
- Roy K
- Roy Maura
- Rudan I
- Russell Emily
- Russell Richard
- Saalmink Gwen
- Sabit Ramsey
- Sage E.K.
- Samakomva T
- Samani Nilesh
- Samat Azlan Helmy A
- Sampson Claire
- Samuel Katherine
- Samuel R
- Sanders Zeena-Britt
- Sanderson Amy
- Sapey E
- Saralaya Dinesh
- Sargant J
- Sarginson C
- Sass T
- Sattar N
- Saunders Kathryn
- Saunders Laura C
- Saunders Peter
- Saunders Ruth M
- Savill Heather
- Saxon W.
- Sayer A.
- Schronce J.
- Schwaeble W
- Scott Janet T.
- Scott Kathryn
- Selby N.
- Semple Malcolm G.
- Sereno Marco
- Sewell Terri Ann
- Shah Ajay M
- Shah K.
- Shah P.
- Shankar-Hari M
- Sharma M
- Sharpe C.
- Sharpe M.
- Shashaa Sharlene
- Shaw Alison
- Shaw Karen
- Shaw V.
- Sheikh Aziz
- Shelton Sarah
- Shenton Liz
- Shevket K.
- Shikotra Aarti
- Short J
- Siddique Sulman
- Siddiqui Salman
- Sidebottom J
- Sigfrid L
- Simons G
- Simpson J.
- Simpson Neil
- Singapuri Amisha
- Singh Claire
- Singh Sally J
- Singh Suver
- Sissons D
- Skeemer J
- Slack Katie
- Smith Andrew
- Smith D.
- Smith Jacqui
- Smith Laurie
- Smith Nikki
- Smith Stephen
- Smith Susan
- Soares M
- Solano Teresa S
- Solly Reanne
- Solstice A.R.
- Soulsby T
- Southern David
- Sowter D
- Spears M
- Spencer L G
- Speranza Fabio
- Stadon Louise
- Stanel S
- Steeds Rick
- Steele N
- Steiner Mike
- Stensel D.
- Stephens G
- Stephenson Lorraine
- Stern M
- Stewart I
- Stimpson R
- Stockdale Sue
- Stockley J
- Stoker Wendy
- Stone Roisin
- Storrar Will
- Storrie Andrew
- Storton Kim
- Stringer E
- Strong-Sheldrake Sophia
- Stroud Natalie
- Subbe Christian
- Sudlow C L
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland Debbie
- Sykes D.L.
- Sykes R.
- Talbot Nick
- Tan Ai Lyn
- Tarusan Lawrence
- Tavoukjian Vera
- Taylor Abigail
- Taylor Chris
- Taylor Jessica
- Te Amelie
- Tedd H.
- Tee Caroline
- Teixeira J
- Tench Helen
- Terry Sarah
- Thackray-Nocera Susannah
- Thaivalappil Favas
- Thamu B
- Thickett D
- Thomas Andrew K.
- Thomas Caradog
- Thomas David C.
- Thomas S.
- Thomas-Woods T.
- Thompson A A Roger
- Thompson T
- Thornton T
- Thorpe M
- Thwaites Ryan S.
- Tilley Jo
- Tinker N
- Tiongson Gerlynn F
- Tobin Martin
- Tomlinson Johanne
- Tong C
- Toshner Mark
- Touyz R.
- Treibel Thomas A
- Tripp K.A.
- Tunnicliffe Elizabeth M.
- Turnbull A
- Turner E
- Turner Kim
- Turner Sarah
- Turner Victoria
- Turney Sharon
- Turtle Lance
- Turton Helena
- Ugoji Jacinta
- Ugwuoke R
- Upthegrove R
- Valabhji J.
- Ventura M
- Vere Joanne
- Vickers Carinna
- Vinson B
- Wade Elaine
- Wade Phillip
- Wain Louise V
- Wainwright Tania
- Wajero Lilian O.
- Walder S
- Walker S
- Walker S.
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
- Wild James M
- Wilkins M.
- Wilkinson D
- Williams B
- Williams Jenny
- Williams N
- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Paradox and Infinity
- Publication venue
- Publication date
- 01/12/2006
- Field of study
In this class we will study a cluster of puzzles, paradoxes and intellectual wonders - from Zeno's Paradox to Godel's Theorem - and discuss their philosophical implications
Delusional beliefs and their characteristics: A comparative study between dissociative identity disorder and schizophrenia spectrum disorders
- Author
- Amy Nesbit
- Anton P. Martinez
- Armstrong
- Bebbington
- Bell
- Bentall
- Bentall
- Bernstein
- Briggs
- Bucci
- Carlson
- Chefetz
- Chu
- Collins
- Combs
- Danylchuk
- Dorahy
- Dorahy
- Field
- Foote
- Freeman
- Holmes
- Honig
- Kluft
- Laddis
- Lewis
- Longden
- Longden
- Martin J. Dorahy
- McKay
- Moskowitz
- Moskowitz
- Nijenhuis
- Perona-Garcelán
- Perona-Garcelán
- Perona-Garcelán
- Peters
- Pilton
- Putnam
- Rachael Palmer
- Renard
- Ross
- Ross
- Sar
- Schäfer
- Steele
- Sun
- Varese
- Waller
- Warwick Middleton
- Wearne
- Şar
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Faster Sensitivity Loss around Dense Scotomas than for Overall Macular Sensitivity in Stargardt Disease: ProgStar Report No. 14
- Author
- Akihito Uji
- Alejandro J. Roman
- Alex Ho
- Alexa King
- Allikmets
- Allikmets
- Amirhossein Hariri
- Amy Lock
- Anamika Jha
- Andrew Carter
- Andrew Webster
- Angela Borer
- Anita Menchaca
- Ann-Margret Ervin
- Anne Georgiou
- Anne Pinter
- Anthony Elshafei
- Anthony Moore
- Anthony Robson
- Anushika Ganegoda
- Artur V. Cideciyan
- Artur V. Cideciyan
- Aurore Girmens
- Avani Rughani
- Barbara Wilhelm
- Beatriz Munoz
- Beatriz Muñoz
- Benjamin Beier
- Bernstein
- Bonnie Carlstrom
- Brendan Kramer
- Brian Seo
- Briana Lauren Sawyer
- Carol Applegate
- Carolina Mendiguren
- Caroline Laurent-Coriat
- Catherine Grigg
- Charbel Issa
- Charles Amoah
- Chen
- Christina Zeitz
- Christine Petrossian
- Christopher Sison
- Cideciyan
- Cideciyan
- Cideciyan
- Cideciyan
- Clara Alfageme
- Cynthia Chan
- Cyrie Fry
- Céline Chaumette
- Daisy Linares
- Daniel Bluemel
- Daniela Ivanova Cajas Narvaez
- David Birch
- David Ellenbogen
- David G. Birch
- David G. Emmert
- Dennis Cain
- Dennis Jenkins
- Dominic Carrington
- Donnel Creel
- Eberhart Zrenner
- Edward Strnad
- Elias Traboulsi
- Elmira Baghdasaryan
- Emerson Ting
- Eric Ito
- Ervin
- Etienne M. Schönbach
- Etienne Schönbach
- Etienne Schönbach
- Fadi Nasser
- Feliz Samson
- Fiona Boyard
- Fujinami
- Gerald Liew
- Gesa Astrid Hahn
- Glen Jenkins
- Gloria Blanquel
- Graham Holder
- Grantley Bynum-Bain
- Haefliger
- Haefliger
- Hamida Begum
- Hanany
- Handan Akil
- Hannah Dunbar
- Harpreet Shinmar
- Hendrik P.N. Scholl
- Hendrik P.N. Scholl
- Hendrik P.N. Scholl
- Hilary Swann
- Ieva Sliesoraityte
- Isabelle Audo
- Jade Barnfield
- Janet S. Sunness
- Janet S. Sunness
- Jason Charng
- Jennifer Bassinger
- Jennifer Jones
- Jessica L. Janes
- Jhanisus Melendez
- Jianqin Lei
- Jianyan Huang
- Johana Carmona
- Jonathan Aboshiha
- Jonathan Chau
- José-Alain Sahel
- Julia Higgins
- Juliette Amaudruz
- Justis Ehlers
- Kanom Bibi
- Kaoru Fujinami
- Karen Carig
- Karine Girard-Claudon
- Katherine Aguilar
- Katy Barnard
- Kellian Farnsworth
- Kelly Miyasato
- Khalil G. Falavarjani
- Kim
- Kimberley Wegner
- Kirsten Locke
- Kirstie Baker
- Kong
- Kong
- Kong
- Kristina Espino
- Kurt Dreger
- Leslie Russell
- Linda Burton
- Lisa Liberto
- Lisa Santos
- Lorane Nava
- Luis Rodriguez
- Manfred Li
- Maria Mendoza
- Maria Pefkianaki
- Mark Herring
- Mark Romero
- Martin Klein
- Mathias Chapon
- Meghan Marino
- Mei Tran
- Meleth
- Melissa Chandler
- Michael S. Ip
- Michael S. Ip
- Michaela Gruzensky
- Michel Michaelides
- Michelle Oberoi
- Midena
- Millena Bittencourt
- Minh Ha Tran
- Mohamed A. Ibrahim
- Mohamed Ahmed
- Mohamed Ahmed
- Mohamed Nafaz Illiyas
- Monica Kim
- Monika Smith
- Muneeswar Gupta Nittala
- Natalie Sarreal
- Netali Roded
- Ngoc Lam
- Nikki Burgnoni
- Nizar Saleh
- Norma Gonzalez
- Parish
- Paul Bernstein
- Paulina Mejia
- Ping Huang
- Rachael Briggs
- Rita Tawdros
- Robert Wojciechowski
- Rodrigo Matsui
- Rupert W. Strauss
- Rupert W. Strauss
- Rupert W. Strauss
- Saddaf Shaheen
- Saddek Mohand-Said
- Samuel G. Jacobson
- Schönbach
- Schönbach
- Schönbach
- Sean Pitetta
- Selma Lewism
- Serge Sancho
- Sharon B. Schwartz
- Shazia Khan
- Sheila West
- Silvia Perez
- Simona Degli Esposti
- Siva Balasubramanian
- Sophie Connor
- Sophie Leahy
- Sowmya J. Srinivas
- SriniVas R. Sadda
- Srinivas Sadda
- Stephanie Chao
- Strauss
- Strauss
- Strauss
- Sunness
- Susan Crowe
- Susanne Kramer
- Swetha B. Velaga
- Syed Mahmood Shah
- Syed Mahmood Shah
- Tami Fecko
- Teresa Margaryan
- Teresa Margaryan
- Testa
- Theo Sanford
- Tilman Koenig
- Tobias Peters
- Tudor Tepelus
- Tyler Brown
- Vicky Robledo
- Victoria Ganem
- Victoria McCudden
- Vivian Chiguil
- Wenying Fan
- Wong
- Xiangrong Kong
- Xiwen Huang
- Yamileth Murillo
- Yetunde Obadeyi
- Yi-Zhong Wang
- Yong Dong Zhou
- Yue Shi
- Yulia Wolfson
- Yulia Wolfson
- Zaid Salchi
- Zoila Luna
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Students' participation in collaborative research should be recognised
- Author
- Aashay Vaidya
- Abbas Palkhi
- Abdul Badran
- Abdulmajid Ali
- Abdurrahman Islim
- Abhi Sharma
- Abhishek Chitnis
- Abiola Adeogun
- Abraham Francis
- Ace Mcdermott
- Adam Gwozdz
- Adam Williams
- Adeeb Naasan
- Aditya Borakati
- Aditya Kale
- Adnan Ali
- Adreana Zulkifli
- Ahmad Chaudhry
- Ahmed Daoub
- Ahmed Hassane
- Ahmed Kerwan
- Ahmed Soualhi
- Aidan Mellan
- Ailin Rogers
- Aishah Azri Yahaya
- Ajay Mohite
- Ajit Kishore
- Akashdeep Dhillon
- Alec Engledow
- Alejandro Marcos Rodrigo
- Alethea Tang
- Alex Boddy
- Alex Fowler
- Alex Rogers
- Alex von Roon
- Alex Ward
- Alex Wilkins
- Alexa Lazarou
- Alexander Baldwin
- Alexander Light
- Alexander Mehta
- Alexander Smith
- Alexandra Thatcher
- Alexandra Urquhart
- Alexandros Charalabopoulos
- Ali Ghaffar
- Alia Al-Mousawi
- Alice Castle
- Alice Mortimer
- Alice Ormrod
- Alisha Burman
- Alison Downey
- Aliya Mackenzie
- Amanda Gilbert
- Ameer Mustafa
- Ameerah Mohd Azmilssss
- Amina Bhatti
- Amir Afzul
- Amirul Adlan
- Amogh Patil
- Amy Burrows
- Amy Campbell
- Amy Hough
- Amy Pendrill
- Ana Catarina Pinho-Gomes
- Anand Alagappan
- Anand Radhakrishnan
- Anant Sinha
- Andrea Gonzalez-Ciscar
- Andreas Luhmann
- Andrew Ang
- Andrew Atayi
- Andrew Beamish
- Andrew Gaukroger
- Andrew Logan
- Andrew Simon
- Andrew Williamson
- Andrew Wilson
- Aneel Bhangu
- Angela Yan
- Angelos G. Kolias
- Angus McNair
- Angus Radford
- Angus Watson
- Aniket Sonsale
- Aniruddh Shenoy
- Anita Bolina
- Anna Betts
- Anna Craig-Mcquaide
- Anna Kinsella
- Anna Kolodziejczyk
- Anna Parry
- Anne Karunatilleke
- Ansh Radotra
- Anusha Prem Kumar
- Apar Shah
- Aparnah Sureshkumar
- Apoorva Khajuria
- Arachchige Ponweera
- Arathi Menon
- Ardit Begaj
- Areej Abdel-Fattah
- Arham Qureshi
- Aria Rahem
- Arin Saha
- Arpan Doshi
- Arun Nair
- Aseem Mishra
- Ashleigh Draper
- Ashni Kheterpal
- Ashveen Gill
- Ashwin Suri
- Awad Shamali
- Ayushah Khan
- Azelea Rushd
- Behrad Barmayehvar
- Belinda Hughes
- Ben Cresswell
- Ben Murphy
- Ben Murphy
- Ben Roberts
- Ben Stubbs
- Beniamino Forte
- Benjamin France
- Benjamin Ng
- Beth Taylor
- Bhangu
- Bharpoor Singh
- Bhavi Patel
- Bhavi Patel
- Bhavik Patel
- Bilal Alkhaffaf
- Bilal Ibrahim
- Bill Campbell
- Bill Campbell
- Bradley Storey
- Brendan Skelly
- Brooke Powell
- Bryony Peiris
- Byron Lu Morrell
- Caitlin Billyard
- Caoimhe Murray
- Carey Girling
- Carla White
- Caroline Baillie
- Caroline Osborne
- Cathal McCarthy
- Cathleen Grossart
- Chaamanti Sivakumar
- Chandan Sanghera
- Chantal Patel
- Chapman
- Charlotte Grieco
- Charlotte Horseman
- Charlotte Phillips
- Charlotte Roberts
- Charlotte Smith
- Chern Choy
- Chetan Khatri
- Chia Yew Kong
- Chinomso Ogbuokiri
- Chloe Roy
- Chloe Searle
- Chris Laing
- Chris Manson
- Chris Thompson
- Christianne Guillotte
- Christopher Blore
- Christopher Graham
- Christos Episkopos
- Chuanyu Gao
- Ciaran Doehrty
- Ciaran Murphy
- Cissy Yong
- Claire Guy
- Claire Joyner
- Claudia Ciurleo
- Clementina Calabria
- Colin Peirce
- Cong Luo
- Connor Barker
- Connor Bruce
- Conor Jones
- Conor Magee
- Conor Mccann
- Constantine Halkias
- Courtney Johnson
- Damien Brown
- Damien Salekin
- Daniah Thomas
- Daniel Cave
- Daniel Fletcher
- Daniel George
- Daniel Guerero
- Daniel Weinberg
- Danielle Banfield
- David Bartlett
- David Bosanquet
- David Gold
- David Golding
- David Henshall
- David Holroyd
- David Messenger
- Dee Varma
- Denise Kelly
- Denisha Ramjas
- Dermot Burke
- Diana Lim
- Dilan Joshi
- Dimitri Pournaras
- Dimitrios Karponis
- Dinisha Patel
- Divya Ramakrishnan
- Dmitri Nepogodiev
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- Tanya Dhir
- Tapani Pratumsuwan
- Tara Bergara
- Tara Dogra
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- Teresa Fung
- Tharindri Wijekoon
- Theophilus Anyomih
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- Thomas M. Drake
- Thomas Oakley
- Thomas Pinkney
- Thomas Stringfellow
- Thomas Ward
- Tiago Martins
- Tim White
- Tim Wilson
- Timen Swartbol
- Tinaye Mandishona
- Toby Jackman
- Toby Noton
- Tom Malik
- Tom Newman
- Tomas Urbonas
- Tonia Forjoe
- Tricia Yeoh
- Trupesh Patel
- Tseun Han James Kong
- Umarah Muhammad
- Ursula Mc Gee
- Usama Asif
- Vani Agarwal
- Vartan Balian
- Vasudev Zaver
- Veeru Kasivisvanathan
- Vicky Fretwell
- Victor Jones
- Victoria Dawe
- Vincent Ng
- Vladislav Kutuzov
- Waleed Al-Khyatt
- Wan Jane Liew
- Wenn Goh
- William Beasley
- William Bolton
- William English
- William Rook
- William Simpson
- Xue Wang
- Yan Ning Neo
- Yanish Poolovadoo
- Yao Ren Liew
- Yao Zong Tay
- Yasir Suleman
- Yat Wing Smart
- Yiwang Xu
- Ysabelle Embury-Young
- Yun Cao
- Yunzi Chen
- Yusuf Patrick
- Zainab Al-Nasser
- Zakaria Rob
- Zara Taylor
- Zehra Naqvi
- Zenab China
- Zhan Herr Ng
- Zhi Lim
- Zhi Min Soh
- Zhubene Mesbah
- Zoe Johnston
- Zong Lee
- Publication venue
- 'Elsevier BV'
- Publication date
- 04/02/2017
- Field of study
Letter to the editor
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
- Author
- A Ashish (17039598)
- A Ayoub (13751773)
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- Sophie Marsh (19671022)
- Sophie West (17191165)
- Stefan Marciniak (5049737)
- Stefan Neubauer (88474)
- Stefan Stanel (6987892)
- Stella-Maria Paddick (8960204)
- Stephen Drain (19670530)
- Steve Bain (5428325)
- Steve McAdoo (19670878)
- Steven Kerr (2126383)
- Sue Palmer (19671487)
- Sue Stockdale (19671103)
- Suhani Patel (8990123)
- Sulaimaan Haq (19670824)
- Sulman Siddique (19671511)
- Susan Francis (13584247)
- Susan Kilroy (10212038)
- Susan Smith (377252)
- Susan Young (153895)
- Susannah Thackray-Nocera (19670776)
- Suver Singh (19671268)
- Sylviane Defres (2557888)
- T Dong (19671223)
- T Felton (9720461)
- T Gorsuch (18377202)
- T Hillman (13297572)
- T Hiwot (19671628)
- T Jackson (13328955)
- T Samakomva (18382377)
- T Sass (18382482)
- T Thomas-Woods (19670650)
- T Thornton (7705070)
- T Treibel (19671610)
- Tabitha Rees (19671523)
- Tamanah Fayzan (19670818)
- Tamika Thompson (19671664)
- Tania Wainwright (19671499)
- Tatiana Plekhanova (7247093)
- TE Nichols (13397331)
- Teresa Mcnally (19671694)
- Teresa Solano (19670731)
- Teriann Evans (19670605)
- Terri Ann Sewell (19671457)
- Terry Brugha (19671745)
- Tessa Light (19671184)
- Thelma Craig (19670527)
- Thomas De Deyn (19564189)
- Thomas Kabir (4216771)
- Tim Hardy (19670950)
- Tim Nicholson (7955477)
- Tim Wallis (3236289)
- TJC Ward (19671709)
- Tom Newman (16499163)
- Tom Yates (294776)
- Tracey Cosier (19670674)
- Tracy Burdett (19670752)
- Tracy Hazelton (19670677)
- Tracy Hussell (245851)
- Tracy Soulsby (19671658)
- Trudie Chalder (37639)
- Tunde Peto (295260)
- Uchechi Nwanguma (19670842)
- Unber Munawar (19670836)
- Uttam Nanda (19671679)
- V Ferreira (16099430)
- V Whitworth (19671472)
- Vanessa Brown (12645325)
- Vera Tavoukjian (19671514)
- Vicky Kamwa (9957182)
- Victoria C Harris (13267137)
- Victoria Harris (4738755)
- Victoria Highett (19671001)
- Victoria Lewis (331841)
- Victoria Shaw (19671043)
- Victoria Turner (6441422)
- Victoria Whitehead (19670572)
- W Ibrahim (7724552)
- W Jang (19671193)
- W Lilaonitkul (19671583)
- W McCormick (12146169)
- W Saxon (19670569)
- Wadzanai Matimba-Mupaya (19671322)
- Wayne Lovegrove (19671454)
- Wendy Stoker (19670698)
- Will Monteiro (10168238)
- Will Reynolds (19671775)
- Will Storrar (18371370)
- William Greenhalf (171584)
- William Man (19670866)
- William R Trender (19564192)
- William Schwaeble (19671727)
- WY James (19670521)
- X Fu (8960267)
- X Li (4169308)
- Yanchun Peng (74671)
- Yutung Cheng (19671337)
- Yvette Ellis (19670764)
- Z Peterkin (19671655)
- Zach Coburn (19671346)
- ZB Sanders (17599890)
- Zehra Suleiman (19671661)
- Zoe Guy (19671856)
- Zohra Omar (19670788)
- Zunaira Kausar (19671091)
- Zuzanna Skorniewska (19564186)
- Publication venue
- Publication date
- 31/07/2024
- Field of study
Background: COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge or persist more than 1 year after hospitalisation for COVID-19, to identify which early aspects of COVID-19 illness predict longer-term symptoms, and to establish how these symptoms relate to occupational functioning. Methods: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study of adults (aged ≥18 years) who were hospitalised with a clinical diagnosis of COVID-19 at participating National Health Service hospitals across the UK. In the C-Fog study, a subset of PHOSP-COVID participants who consented to be recontacted for other research were invited to complete a computerised cognitive assessment and clinical scales between 2 years and 3 years after hospital admission. Participants completed eight cognitive tasks, covering eight cognitive domains, from the Cognitron battery, in addition to the 9-item Patient Health Questionnaire for depression, the Generalised Anxiety Disorder 7-item scale, the Functional Assessment of Chronic Illness Therapy Fatigue Scale, and the 20-item Cognitive Change Index (CCI-20) questionnaire to assess subjective cognitive decline. We evaluated how the absolute risks of symptoms evolved between follow-ups at 6 months, 12 months, and 2–3 years, and whether symptoms at 2–3 years were predicted by earlier aspects of COVID-19 illness. Participants completed an occupation change questionnaire to establish whether their occupation or working status had changed and, if so, why. We assessed which symptoms at 2–3 years were associated with occupation change. People with lived experience were involved in the study. Findings: 2469 PHOSP-COVID participants were invited to participate in the C-Fog study, and 475 participants (191 [40·2%] females and 284 [59·8%] males; mean age 58·26 [SD 11·13] years) who were discharged from one of 83 hospitals provided data at the 2–3-year follow-up. Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months (explaining 35·0–48·8% of the variance in anxiety, depression, fatigue, and subjective cognitive decline); by a biocognitive profile linking acutely raised D-dimer relative to C-reactive protein with subjective cognitive deficits at 6 months (explaining 7·0–17·2% of the variance in anxiety, depression, fatigue, and subjective cognitive decline); and by anxiety, depression, fatigue, and subjective cognitive deficit at 6 months. Objective cognitive deficits at 2–3 years were not predicted by any of the factors tested, except for cognitive deficits at 6 months, explaining 10·6% of their variance. 95 of 353 participants (26·9% [95% CI 22·6–31·8]) reported occupational change, with poor health being the most common reason for this change. Occupation change was strongly and specifically associated with objective cognitive deficits (odds ratio [OR] 1·51 [95% CI 1·04–2·22] for every SD decrease in overall cognitive score) and subjective cognitive decline (OR 1·54 [1·21–1·98] for every point increase in CCI-20). Interpretation: Psychiatric and cognitive symptoms appear to increase over the first 2–3 years post-hospitalisation due to both worsening of symptoms already present at 6 months and emergence of new symptoms. New symptoms occur mostly in people with other symptoms already present at 6 months. Early identification and management of symptoms might therefore be an effective strategy to prevent later onset of a complex syndrome. Occupation change is common and associated mainly with objective and subjective cognitive deficits. Interventions to promote cognitive recovery or to prevent cognitive decline are therefore needed to limit the functional and economic impacts of COVID-19. Funding: National Institute for Health and Care Research Oxford Health Biomedical Research Centre, Wolfson Foundation, MQ Mental Health Research, MRC-UK Research and Innovation, and National Institute for Health and Care Research.</p
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Berg Bianca
- Bergin Colin
- Bernard Andre
- Bernard Andre
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boer Hans Donald
- Boereboom Catherine
- Boggiano Victoria
- Bokkel-Andela Janneke
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
- Calderwood Claire
- Callaghan Mark
- Campbell Debbie
- Campbell Doug
- Campbell Doug
- Campbell Douglas
- Campbell Gill
- Campbell Graham
- Campbell Kathleen
- Campbell Marta
- Campbell Tara
- Campey Lorraine
- Campos Ferreira Mariana Fosch
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
- Caser Eliana
- Castaño Beatriz
- Castle Gail
- Castro Gabriel Isaac Pereira
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
- Chaloulis Panagiotis
- Chan Alexander
- Chan Hey Man Heymans
- Chan Mathew
- Chan Matthew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conceição Soares Maria
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
- Cooper Richard
- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Corti Daniele
- Costa Fischer Bruna Ferreira
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
- Cotter Rochelle
- Cotterell Sharon
- Cotterill Donna
- Coughlan Elaine
- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
- Cowton Amanda
- Cox Hannah
- Cozar Octavian Ionut
- Craig Jayne
- Craven Rachael
- Craw Nicholas
- Craw Sarah
- Creary Thais
- Cripps Heather
- Critchley Rebecca
- Cronje Larissa
- Cruickshank Ross
- Cruikshanks Andrew
- Cruz Salome
- Cuenca Vicente Chisbert
- Cueva Andreu
- Cunha Pedro
- Currow Helen
- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- Cádiz Maria José Hernández
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
- Dali-Kemmery Lola
- Dalton Emma
- Damant Rose
- Daniel Conway
- Daniel Gayatri Daniel
- Daniel Harvey
- Daniel Hull
- Daniel Sonya
- Darko Julia
- Darwish Sharif
- Das Suparna
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- Datson Amanda
- Daubeny Thomas
- Daugaard Morten
- Davari Maria
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- Davis Simon
- Daya Bhavika
- De Andres Jose
- De Baerdemaeker Luc
- De Bruyne Ann
- De Hert Stefan
- De Jongh Karen
- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
- Deacon Matthew
- Deblaere Isabel
- Dedemadi Georgia
- Deen Tariq
- Deepak Shantal
- Deighton Kerry
- Deja Maria
- Del Valle Santiago Garcia
- Delgado García David R
- Demartines Nicolas
- Dempsey Ged
- Dempster Angie
- Denham Samuel
- Dent Kathy
- Dermitzaki Despina
- Desbordes Jacques
- Despotidis Vasileios
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- Dias Fernando
- Dias Sandra
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- Ditai James
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- Docherty Philip
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- Dominguez Saul Velaz
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- Douglas Jeanene
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- Dragoescu Nicoleta Alice
- Drake Matthew
- Drimala Maria
- Drinkwater Zoe
- Drummond Leanne
- Du Fang
- Du Fang
- Du Xindan
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- Duca Alejandro
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- Dudson Rosie
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- Durodola Adekunle
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- Dylst Dimitri
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- Dzulkipli Norizawati
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- Edwards Marc
- Edwards Mark
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- Egan Thomas
- Eggleston Christopher
- Eichwalder Andreas
- Eikman Johan
- Ekelund Kim
- El-Sayed Ahmed
- Elabib Ali
- Elferink-Vonk Renske
- Ellis Jessica
- Ellis Kate
- Elna Cifra
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- Everingham Kirsty
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- Fan Yu
- Fanfani Lucia Caterina
- Fang Xiangming
- Faponle Folayemi
- Faria Filomena
- Farid Nahla
- Farina Zane
- Farrell Helen
- Farrow Mehreen
- Fasina Oluyemi
- Fatungase Oluwabunmi Motunrayo
- Faulds Matthew
- Fei Yue
- Fellinger Paul
- Feng Yunlin
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- Fergey Lauren
- Ferguson Marissa
- Fernández Salvador
- Ferrando Carlos
- Filipescu Daniela
- Filippopoulos Andreas
- Finch Amanda
- Fiorentza Klara
- Fischbach Norbert
- Flatt Jim
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- Fleisher Lee
- Fleisher Lee A.
- Flores Armando Adolfo Alvarez
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- Foley Julia
- Fonck Kristine
- Foord Denise
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- Forstner Karin
- Foster Rebecca
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- Fowler Alexander
- Fowler Carolyn
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- Fragandreas George
- Franklin John
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- Freeman David
- Freeman Victoria
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- Freitas Katie
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- Freschini David
- Fretes Jennifer
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- Fritsch Gerhard
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- Fuentes Isabel
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- Funk Bonita
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- Futier E.
- Futier Emmanuel
- Futier Emmanuel
- Gaitanakis Stylianos
- Gall Lewis
- Gallacher Pete
- Gallard Sian
- Gallego Laura
- Gama N Sibusiso
- Gambhir Rajiv
- Ganter Donna Louise
- Ganter Michael T
- Gao Hong
- Garcia Carolina Soledad Romero
- Garcia Juliana
- Garcia-Saiz Irene
- García-Pérez Maria Luisa
- Gardikou Varvara Vanessa
- Gardiner Matthew
- Garg Atul
- Garg Sameer
- Garg Sanjeev
- Garrett Emily
- Gasperi Julia
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- Zbitnew Geoff
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- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally