Systematic review of beliefs, behaviours and influencing factors associated with disclosure of a mental health problem in the workplace

Stigma and discrimination present an important barrier to finding and keeping work for individuals with a mental health problem. This paper reviews evidence on: 1) employment-related disclosure beliefs and behaviours of people with a mental health problem; 2) factors associated with the disclosure of a mental health problem in the employment setting; 3) whether employers are less likely to hire applicants who disclose a mental health problem; and 4) factors influencing employers' hiring beliefs and behaviours towards job applicants with a mental health problem

Consensus Paper: Radiological Biomarkers of Cerebellar Diseases

Hereditary and sporadic cerebellar ataxias represent a vast and still growing group of diseases whose diagnosis and differentiation cannot only rely on clinical evaluation. Brain imaging including magnetic resonance (MR) and nuclear medicine techniques allows for characterization of structural and functional abnormalities underlying symptomatic ataxias. These methods thus constitute a potential source of radiological biomarkers, which could be used to identify these diseases and differentiate subgroups of them, and to assess their severity and their evolution. Such biomarkers mainly comprise qualitative and quantitative data obtained from MR including proton spectroscopy, diffusion imaging, tractography, voxel-based morphometry, functional imaging during task execution or in a resting state, and from SPETC and PET with several radiotracers. In the current article, we aim to illustrate briefly some applications of these neuroimaging tools to evaluation of cerebellar disorders such as inherited cerebellar ataxia, fetal developmental malformations, and immune-mediated cerebellar diseases and of neurodegenerative or early-developing diseases, such as dementia and autism in which cerebellar involvement is an emerging feature. Although these radiological biomarkers appear promising and helpful to better understand ataxia-related anatomical and physiological impairments, to date, very few of them have turned out to be specific for a given ataxia with atrophy of the cerebellar system being the main and the most usual alteration being observed. Consequently, much remains to be done to establish sensitivity, specificity, and reproducibility of available MR and nuclear medicine features as diagnostic, progression and surrogate biomarkers in clinical routine

Influence of powder characteristics on the behaviour of PIM feedstock

International audienceThis work aims to analyse the impact of powders which are not conventionally intended for powder injection moulding (PIM) and how their characteristics influence the behaviour of the feedstock during mixing. Tests were performed with different alumina powders using the same binder system. The results show that mixing has a strong impact on the packing density of powders inside the feedstock, while the deagglomeration of powders makes it possible to achieve high critical powder volume concentrations (CPVCs) equal to or greater than 58 vol%. The CPVC depends on the deagglomeration efficiency. The agglomeration state - especially cohesion of the agglomerates - has an influence on the CPVC. The comparative study of mixing torques shows that the grain size and surface area of powders have a major impact on the mixing behaviour of the feedstock. During the implementation of powders, variabilities in the homogenisation of the powder/binder system and in deagglomeration are achieved as a result of powder agglomeration. It was demonstrated that the powders in this study perfectly satisfy the criteria imposed by the mixing process although they are not intended for PIM

Experimental and Numerical Approaches of Contact with Friction and Wear in Large Deformation

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