Readout and Control of a Power-recycled Interferometric Gravitational-wave Antenna

Interferometric gravitational wave antennas are based on Michelson interferometers whose sensitivity to small differential length changes has been enhanced by adding multiple coupled optical resonators. The use of optical cavities is essential for reaching the required sensitivity, but sets challenges for the control system which must maintain the cavities near resonance. The goal for the strain sensitivity of the Laser Interferometer Gravitational-wave Observatory (LIGO) is 10^-21 rms, integrated over a 100 Hz bandwidth centered at 150 Hz. We present the major design features of the LIGO length and frequency sensing and control system which will hold the differential length to within 5 10^-14 m of the operating point. We also highlight the restrictions imposed by couplings of noise into the gravitational wave readout signal and the required immunity against them.Comment: Presentation at ICALEPCS 2001, San Jose, November 2001, (WECT003), 3 page

Magnetocardiography with a modular spin-exchange relaxation free atomic magnetometer array

We present a portable four-channel atomic magnetometer array operating in the spin exchange relaxation-free regime. The magnetometer array has several design features intended to maximize its suitability for biomagnetic measurement, specifically foetal magnetocardiography, such as a compact modular design, and fibre coupled lasers. The modular design allows the independent positioning and orientation of each magnetometer, in principle allowing for non-planar array geometries. Using this array in a magnetically shielded room, we acquire adult magnetocadiograms. These measurements were taken with a 6-11 fT Hz^(-1/2) single-channel baseline sensitivity that is consistent with the independently measured noise level of the magnetically shielded room.Comment: 15 pages, 5 figure

Management of upper airway edema caused by hereditary angioedema

Hereditary angioedema is a rare disorder with a genetic background involving mutations in the genes encoding C1-INH and of factor XII. Its etiology is unknown in a proportion of cases. Recurrent edema formation may involve the subcutis and the submucosa - the latter can produce obstruction in the upper airways and thereby lead to life-threatening asphyxia. This is the reason for the high, 30-to 50-per-cent mortality of undiagnosed or improperly managed cases. Airway obstruction can be prevented through early diagnosis, meaningful patient information, timely recognition of initial symptoms, state-of-the-art emergency therapy, and close monitoring of the patient. Prophylaxis can substantially mitigate the risk of upper airway edema and also improve the patients' quality of life. Notwithstanding the foregoing, any form of upper airway edema should be regarded as a potentially life-threatening condition. None of the currently available prophylactic modalities is capable of preventing UAE with absolute certainty

Seismic isolation and suspension systems for Advanced LIGO

To meet the overall isolation and alignment requirements for the optics in Advanced LIGO, the planned upgrade to LIGO, the US laser interferometric gravitational wave observatory, we are developing three sub-systems: a hydraulic external pre-isolator for low frequency alignment and control, a two-stage active isolation platform designed to give a factor of ~1000 attenuation at 10 Hz, and a multiple pendulum suspension system that provides passive isolation above a few hertz. The hydraulic stage uses laminar-flow quiet hydraulic actuators with millimeter range, and provides isolation and alignment for the optics payload below 10 Hz, including correction for measured Earth tides and the microseism. This stage supports the in-vacuum two-stage active isolation platform, which reduces vibration using force feedback from inertial sensor signals in six degrees of freedom. The platform provides a quiet, controlled structure to mount the suspension system. This latter system has been developed from the triple pendulum suspension used in GEO 600, the German/UK gravitational wave detector. To meet the more stringent noise levels required in Advanced LIGO, the baseline design for the most sensitive optics calls for a quadruple pendulum, whose final stage consists of a 40 kg sapphire mirror suspended on fused silica ribbons to reduce suspension thermal noise

Proton capture cross section of Sr isotopes and their importance for nucleosynthesis of proton-rich nuclides

The (p,$\gamma$) cross sections of three stable Sr isotopes have been measured in the astrophysically relevant energy range. These reactions are important for the $p$-process in stellar nucleosynthesis and, in addition, the reaction cross sections in the mass region up to 100 are also of importance concerning the $rp$-process associated with explosive hydrogen and helium burning. It is speculated that this $rp$-process could be responsible for a certain amount of $p$-nuclei in this mass region. The (p,$\gamma$) cross sections of $^{84,86,87}$Sr isotopes were determined using an activation technique. The measurements were carried out at the 5 MV Van de Graaff accelerator of the ATOMKI, Debrecen. The resulting cross sections are compared with the predictions of statistical model calculations. The predictions are in good agreement with the experimental results for $^{84}$Sr(p,$\gamma$)$^{85}$Y whereas the other two reactions exhibit differences that increase with mass number. The corresponding astrophysical reaction rates have also been computed.Comment: Phys. Rev. C in pres

AntiFam: a tool to help identify spurious ORFs in protein annotation

As the deluge of genomic DNA sequence grows the fraction of protein sequences that have been manually curated falls. In turn, as the number of laboratories with the ability to sequence genomes in a high-throughput manner grows, the informatics capability of those labs to accurately identify and annotate all genes within a genome may often be lacking. These issues have led to fears about transitive annotation errors making sequence databases less reliable. During the lifetime of the Pfam protein families database a number of protein families have been built, which were later identified as composed solely of spurious open reading frames (ORFs) either on the opposite strand or in a different, overlapping reading frame with respect to the true protein-coding or non-coding RNA gene. These families were deleted and are no longer available in Pfam. However, we realized that these may perform a useful function to identify new spurious ORFs. We have collected these families together in AntiFam along with additional custom-made families of spurious ORFs. This resource currently contains 23 families that identified 1310 spurious proteins in UniProtKB and a further 4119 spurious proteins in a collection of metagenomic sequences. UniProt has adopted AntiFam as a part of the UniProtKB quality control process and will investigate these spurious proteins for exclusion

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression

Based on an increased frequency of early death (death within the first treatment cycle) in our two latest randomized trials of combination chemotherapy in small-cell lung cancer (SCLC), we wanted to identify patients at risk of early non-toxic death (ENTD) and early toxic death (ETD). Data were stored in a database and logistic regression analyses were performed to identify predictive factors for early death. During the first cycle, 118 out of 937 patients (12.6%) died. In 38 patients (4%), the cause of death was sepsis. Significant risk factors were age, performance status (PS), lactate dehydrogenase (LDH) and treatment with epipodophyllotoxins and platinum in the first cycle (EP). Risk factors for ENTD were age, PS and LDH. Extensive stage had a hazard ratio of 1.9 (P = 0.07). Risk factors for ETD were EP, PS and LDH, whereas age and stage were not. For EP, the hazard ratio was as high as 6.7 (P = 0.0001). We introduced a simple prognostic algorithm including performance status, LDH and age. Using a prognostic algorithm to exclude poor-risk patients from trials, we could minimize early death, improve long-term survival and increase the survival differences between different regimens. We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification. © 1999 Cancer Research Campaig