Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction.: Ultrafast cooling & postischemic cardiac function

International audienceAIMS: We investigated whether rapid cooling instituted by total liquid ventilation (TLV) improves cardiac and mitochondrial function in rabbits submitted to ischaemia-reperfusion. METHODS AND RESULTS: Rabbits were chronically instrumented with a coronary artery occluder and myocardial ultrasonic crystals for assessment of segment length-shortening. Two weeks later they were re-anaesthetized and underwent either a normothermic 30-min coronary artery occlusion (CAO) (Control group, n = 7) or a comparable CAO with cooling initiated by a 10-min hypothermic TLV and maintained by a cold blanket placed on the skin. Cooling was initiated after 5 or 15 min of CAO (Hypo-TLV and Hypo-TLV(15') groups, n = 6 and 5, respectively). A last group underwent normothermic TLV during CAO (Normo-TLV group, n = 6). Wall motion was measured in the conscious state over three days of reperfusion before infarct size evaluation and histology. Additional experiments were done for myocardial sampling in anaesthetized rabbits for mitochondrial studies. The Hypo-TLV procedure induced a rapid decrease in myocardial temperature to 32-34 degrees C. Throughout reperfusion, segment length-shortening was significantly increased in Hypo-TLV and Hypo-TLV(15') vs. Control and Normo-TLV (15.1 +/- 3.3%, 16.4 +/- 2.3%, 1.8 +/- 0.6%, and 1.1 +/- 0.8% at 72 h, respectively). Infarct sizes were also considerably attenuated in Hypo-TLV and Hypo-TLV(15') vs. Control and Normo-TLV (4 +/- 1%, 11 +/- 5%, 39 +/- 2%, and 42 +/- 5% infarction of risk zones, respectively). Mitochondrial function in myocardial samples obtained at the end of ischaemia or after 10 min of reperfusion was improved by Hypo-TLV with respect to ADP-stimulated respiration and calcium-induced opening of mitochondrial permeability transition pores (mPTP). Calcium concentration opening mPTP was, e.g., increased at the end of ischaemia in the risk zone in Hypo-TLV vs. Control (157 +/- 12 vs. 86 +/- 12 microM). Histology and electron microscopy also revealed better preservation of lungs and of cardiomyocyte ultrastructure in Hypo-TLV when compared with Control. CONCLUSION: Institution of rapid cooling by TLV during ischaemia reduces infarct size as well as other sequelae of ischaemia, such as post-ischaemic contractile and mitochondrial dysfunction

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Measurement of the impact-parameter dependent azimuthal anisotropy in coherent ρ0 photoproduction in Pb–Pb collisions at √sNN = 5.02 TeV

The first measurement of the impact-parameter dependent angular anisotropy in the decay of coherently photoproduced ρ0 mesons is presented. The ρ0 mesons are reconstructed through their decay into a pion pair. The measured anisotropy corresponds to the amplitude of the cos(2ϕ) modulation, where ϕ is the angle between the two vectors formed by the sum and the difference of the transverse momenta of the pions, respectively. The measurement was performed by the ALICE Collaboration at the LHC using data from ultraperipheral Pb−Pb collisions at a center-of-mass energy of sNN−−−√ = 5.02 TeV per nucleon pair. Different impact-parameter regions are selected by classifying the events in nuclear-breakup classes. The amplitude of the cos(2ϕ) modulation is found to increase by about one order of magnitude from large to small impact parameters. Theoretical calculations, which describe the measurement, explain the cos(2ϕ) anisotropy as the result of a quantum interference effect at the femtometer scale that arises from the ambiguity as to which of the nuclei is the source of the photon in the interaction

Investigating strangeness enhancement in jet and medium via ϕ\phi(1020) production in p−-Pb collisions at sNN\sqrt{s_{\rm NN}} = 5.02 TeV

International audienceThis work aims to differentiate strangeness produced from hard processes (jet-like) and softer processes (underlying event) by measuring the angular correlation between a high-momentum trigger hadron (h) acting as a jet-proxy and a produced strange hadron ($\phi(1020)$ meson). Measuring h$-\phi$ correlations at midrapidity in p$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV as a function of event multiplicity provides insight into the microscopic origin of strangeness enhancement in small collision systems. The jet-like and the underlying-event-like strangeness production are investigated as a function of event multiplicity. They are also compared between a lower and higher momentum region. The evolution of the per-trigger yields within the near-side (aligned with the trigger hadron) and away-side (in the opposite direction of the trigger hadron) jet is studied separately, allowing for the characterization of two distinct jet-like production regimes. Furthermore, the h$-\phi$ correlations within the underlying event give access to a production regime dominated by soft production processes, which can be compared directly to the in-jet production. Comparisons between h$-\phi$ and dihadron correlations show that the observed strangeness enhancement is largely driven by the underlying event, where the $\phi/\mathrm{h}$ ratio is significantly larger than within the jet regions. As multiplicity increases, the fraction of the total $\phi(1020)$ yield coming from jets decreases compared to the underlying event production, leading to high-multiplicity events being dominated by the increased strangeness production from the underlying event

Measurement of Λ3H{}_{\Lambda}^{3}\mathrm{H} production in Pb-Pb collisions at sNN\sqrt{s_{\mathrm{NN}}} = 5.02 TeV

International audienceThe first measurement of $_{\Lambda}^{3}\mathrm{H}$ and $^3_ {\overline{\Lambda}}\overline{\mathrm{H}}$ differential production with respect to transverse momentum and centrality in Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$~TeV is presented. The $_{\Lambda}^{3}\mathrm{H}$ has been reconstructed via its two-charged-body decay channel, i.e., $_{\Lambda}^{3}\mathrm{H} \rightarrow {}^{3}\mathrm{He} + \pi^{-}$. A Blast-Wave model fit of the $p_{\rm T}$-differential spectra of all nuclear species measured by the ALICE collaboration suggests that the $_{\Lambda}^{3}\mathrm{H}$ kinetic freeze-out surface is consistent with that of other nuclei. The ratio between the integrated yields of $_{\Lambda}^{3}\mathrm{H}$ and $^3\mathrm{He}$ is compared to predictions from the statistical hadronisation model and the coalescence model, with the latter being favoured by the presented measurements

Investigating Λ\Lambda baryon production in p-Pb collisions in jets and underlying event using angular correlations

International audienceFirst measurements of hadron(h)$-\Lambda$ azimuthal angular correlations in p$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV using the ALICE detector at the LHC are presented. These correlations are used to separate the production of associated $\Lambda$ baryons into three different kinematic regions, namely those produced in the direction of the trigger particle (near-side), those produced in the opposite direction (away-side), and those whose production is uncorrelated with the jet-axis (underlying event). The per-trigger associated $\Lambda$ yields in these regions are extracted, along with the near- and away-side azimuthal peak widths, and the results are studied as a function of associated particle $p_{\rm T}$ and event multiplicity. Comparisons with the DPMJET event generator and previous measurements of the $\phi(1020)$ meson are also made. The final results indicate that strangeness production in the highest multiplicity p$-$Pb collisions is enhanced relative to low multiplicity collisions in the jet-like regions, as well as the underlying event. The production of $\Lambda$ relative to charged hadrons is also enhanced in the underlying event when compared to the jet-like regions. Additionally, the results hint that strange quark production in the away-side of the jet is modified by soft interactions with the underlying event

Measurement of the production cross section of prompt Ξ0c baryons in p–Pb collisions at √sNN = 5.02 TeV

The transverse momentum (pT) differential production cross section of the promptly-produced charm-strange baryon Ξ0c (and its charge conjugate Ξ0c¯¯¯¯¯¯) is measured at midrapidity via its hadronic decay into π+Ξ− in p−Pb collisions at a centre-of-mass energy per nucleon−nucleon collision sNN−−−√ = 5.02 TeV with the ALICE detector at the LHC. The Ξ0c nuclear modification factor (RpPb), calculated from the cross sections in pp and p−Pb collisions, is presented and compared with the RpPb of Λ+c baryons. The ratios between the pT-differential production cross section of Ξ0c baryons and those of D0 mesons and Λ+c baryons are also reported and compared with results at forward and backward rapidity from the LHCb Collaboration. The measurements of the production cross section of prompt Ξ0c baryons are compared with a model based on perturbative QCD calculations of charm-quark production cross sections, which includes only cold nuclear matter effects in p−Pb collisions, and underestimates the measurement by a factor of about 50. This discrepancy is reduced when the data is compared with a model in which hadronisation is implemented via quark coalescence. The pT-integrated cross section of prompt Ξ0c-baryon production at midrapidity extrapolated down to pT = 0 is also reported. These measurements offer insights and constraints for theoretical calculations of the hadronisation process. Additionally, they provide inputs for the calculation of the charm production cross section in p−Pb collisions at midrapidity