Getting your DUCs in a row - standardising the representation of Digital Use Conditions

Improving patient care and advancing scientific discovery requires responsible sharing of research data, healthcare records, biosamples, and biomedical resources that must also respect applicable use conditions. Defining a standard to structure and manage these use conditions is a complex and challenging task. This is exemplified by a near unlimited range of asset types, a high variability of applicable conditions, and differing applications at the individual or collective level. Furthermore, the specifics and granularity required are likely to vary depending on the ultimate contexts of use. All these factors confound alignment of institutional missions, funding objectives, regulatory and technical requirements to facilitate effective sharing. The presented work highlights the complexity and diversity of the problem, reviews the current state of the art, and emphasises the need for a flexible and adaptable approach. We propose Digital Use Conditions (DUC) as a framework that addresses these needs by leveraging existing standards, striking a balance between expressiveness versus ambiguity, and considering the breadth of applicable information with their context of use

Double-diffusive natural convection in an inclined enclosure with heat generation and Soret effect

International audiencePurpose - The purpose of this paper is to study numerically thermosolutal natural convection within an inclined rectangular cavity in the presence of Soret effect and heat generation. The enclosure is heated and salted from its long sides with constant but different temperatures and concentrations. The study focuses on the effects of three main parameters which are, the Soret parameter (Sr=0 and -0.5), the internal to external Rayleigh numbers ratio 0 <= R <= 80 and the cavity inclination gamma, varied from 0 degrees (vertical position) to 60 degrees. The combined effects of these parameters on fluid flow and heat and mass transfer characteristics are examined for the external Rayleigh number Ra-E=10(5), the Prandtl number Pr=0.71, the buoyancy ratio N=1, the Lewis number Le=2 and the aspect ratio of the cavity A =2. Design/methodology/approach - A hybrid lattice Boltzmann-finite difference method (LBM-FD) was used to tackle the problem under consideration. The LBM with the simple relaxation time was used for the fluid flow in the presence of the gravity force, while the temperature and concentration equations were solved separately using an explicit finite-difference technique at the Boltzmann scale. Findings - The monocellular nature of the flow, obtained for R=0 is not destroyed by varying the cavity inclination and the Soret parameter but rather by the increase of the parameter R. The Soret parameter and the cavity inclination become perceptible at high values of R. The inclination gamma=60 degrees leads to high mean temperatures compared to the other inclinations. The effect of R on mean concentration is amplified in the presence of Soret effect but limited in the absence of the latter. The negative Soret parameter combined with high internal heat generation and a relatively high inclination is important when the objective is to maintain the fluid at a high concentration of species. The presence of bicellular flow combined with the important elevation undergone by the fluid temperature, makes both the cold and hot walls playing a cooling role with the most important exchanges taking place at the upper part of these walls. The analysis of the mean mass transfer shows that the increase of the inclination may lead to an increase or a decrease of the mass transfer depending on the range of R, in the case of Sr=0. However, for Sr= -0.5, it is observed that the increase of gamma is generally accompanied by a reduction of the mass transfer. Originality/value - To the best of the authors' knowledge, the hybrid LBM-FD was not used before to study such a problem. Combined effect of R and inclination may be useful in charging the fluid with species when the objective is to maintain high concentrations in the medium

Complications non-chirurgicales de la chirurgie bariatrique :à propos de quatre cas et revue de la littérature

info:eu-repo/semantics/publishe

Exposure of the gilthead seabream (Sparus aurata) to sediments contaminated with heavy metals down-regulates the gene expression of stress biomarkers

Heavy metals incidence in the aquatic environment and its accumulation in fish are under constant review. Gilthead seabream (Sparus aurata) specimens were exposed for two weeks to sediments highly concentrated in metals, collected at the Portman Bay (Murcia, Spain). The metals bioaccumulation was tested in liver, muscle and skin. The potential of the sediment exposure to induce variation of the stress biomarkers genes was conducted in liver and skin. Results revealed that sediments were highly contaminated with metals. However, following 2 weeks exposure to the sediments, Cd accumulates only in liver. Interestingly, the expression of the genes mta, hsp 70 and hsp 90 were significantly down-regulated in skin. Nevertheless, cyp1a1 gene was up-regulated only in liver. Results uphold that the stress response magnitude was organ-dependent and the skin was the most responsive tissue to metal stress conditions. These results suggest that skin should be considered as target organ for biomarkers analysis in fishes. Keywords: Heavy metals, Gene expression, Stress biomarkers, Gilthead seabream (Sparus aurata

The FAIR Data Point: Interfaces and Tooling

While the FAIR Principles do not specify a technical solution for ‘FAIRness’, it was clear from the outset of the FAIR initiative that it would be useful to have commodity software and tooling that would simplify the creation of FAIR-compliant resources. The FAIR Data Point is a metadata repository that follows the DCAT(2) schema, and utilizes the Linked Data Platform to manage the hierarchical metadata layers as LDP Containers. There has been a recent flurry of development activity around the FAIR Data Point that has significantly improved its power and ease-of-use. Here we describe five specific tools—an installer, a loader, two Web-based interfaces, and an indexer—aimed at maximizing the uptake and utility of the FAIR Data Point

TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals

International audienceTranslationally Controlled Tumor Protein (TCTP) controls growth by regulating the G1/S transition during cell cycle progression. Our genetic interaction studies show that TCTP fulfills this role by interacting with CSN4, a subunit of the COP9 Signalosome complex, known to influence CULLIN-RING ubiquitin ligases activity by controlling CULLIN (CUL) neddylation status. In agreement with these data, downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP, respectively, demonstrating a conserved mechanism between plants and animals. Together, our data show that CSN4 is the missing factor linking TCTP to the control of cell cycle progression and cell proliferation during organ development and open perspectives towards understanding TCTP's role in organ development and disorders associated with TCTP miss-expression

Integrative genome-wide analysis reveals the role of WIP proteins in inhibition of growth and development

International audienc

Cantaloupe melon genome reveals 3D chromatin features and structural relationship with the ancestral Cucurbitaceae karyotype

International audienceCucumis melo displays a large diversity of horticultural groups with cantaloupe melon the most cultivated type. Using a combination of single-molecule sequencing, 10X Genomics link-reads, high-density optical and genetic maps, and chromosome conformation capture (Hi-C), we assembled a chromosome scale C. melo var. cantalupensis Charentais mono genome. Integration of RNA-seq, MeDip-seq, ChIP-seq, and Hi-C data revealed a widespread compartmentalization of the melon genome, segregating constitutive heterochromatin and euchromatin. Genome-wide comparative and evolutionary analysis between melon botanical groups identified Charentais mono genome increasingly more divergent from Harukei-3 (reticulatus), Payzawat (inodorus), and HS (ssp. agrestis) genomes. To assess the paleohistory of the Cucurbitaceae, we reconstructed the ancestral Cucurbitaceae karyotype and compared it to sequenced cucurbit genomes. In contrast to other species that experienced massive chromosome shuffling, melon has retained the ancestral genome structure. We provide comprehensive genomic resources and new insights in the diversity of melon horticultural groups and evolution of cucurbits

Evaluation des risques du bisphénol A (BPA) pour la santé humaine et aux données toxicologiques et d’usage des bisphénols S, F, M, B, AP, AF, et BADGE: Tome 1

info:eu-repo/semantics/published1 (Membres du Groupe de Travail "Perturbateurs Endocriniens et Reprotoxiques de Catégorie 3"

Evaluation des risques du bisphénol A (BPA) pour la santé humaine – Annexes - Expertise collective: Tome 2 - Annexes -- 2

info:eu-repo/semantics/publishedMembres du Groupe de Travail "Perturbateurs Endocriniens et Reprotoxiques de Catégorie 3