Parallel Distributed Grammar Engineering for Practical Applications

Based on a detailed case study of parallel grammar development distributed across two sites, we review some of the requirements for regression testing in grammar engineering, summarize our approach to systematic competence and performance profiling, and discuss our experience with grammar development for a commercial application. If possible, the workshop presentation will be organized around a software demonstration

Monitoring cortical excitability during repetitive transcranial magnetic stimulation in children with ADHD: a single-blind, sham-controlled TMS-EEG study

Background: Repetitive transcranial magnetic stimulation (rTMS) allows non-invasive stimulation of the human brain. However, no suitable marker has yet been established to monitor the immediate rTMS effects on cortical areas in children. Objective: TMS-evoked EEG potentials (TEPs) could present a well-suited marker for real-time monitoring. Monitoring is particularly important in children where only few data about rTMS effects and safety are currently available. Methods: In a single-blind sham-controlled study, twenty-five school-aged children with ADHD received subthreshold 1 Hz-rTMS to the primary motor cortex. The TMS-evoked N100 was measured by 64-channel-EEG pre, during and post rTMS, and compared to sham stimulation as an intraindividual control condition. Results: TMS-evoked N100 amplitude decreased during 1 Hz-rTMS and, at the group level, reached a stable plateau after approximately 500 pulses. N100 amplitude to supra-threshold single pulses post rTMS confirmed the amplitude reduction in comparison to the pre-rTMS level while sham stimulation had no influence. EEG source analysis indicated that the TMS-evoked N100 change reflected rTMS effects in the stimulated motor cortex. Amplitude changes in TMS-evoked N100 and MEPs (pre versus post 1 Hz-rTMS) correlated significantly, but this correlation was also found for pre versus post sham stimulation. Conclusion: The TMS-evoked N100 represents a promising candidate marker to monitor rTMS effects on cortical excitability in children with ADHD. TMS-evoked N100 can be employed to monitor real-time effects of TMS for subthreshold intensities. Though TMS-evoked N100 was a more sensitive parameter for rTMS-specific changes than MEPs in our sample, further studies are necessary to demonstrate whether clinical rTMS effects can be predicted from rTMS-induced changes in TMS-evoked N100 amplitude and to clarify the relationship between rTMS-induced changes in TMS-evoked N100 and MEP amplitudes. The TMS-evoked N100 amplitude reduction after 1 Hz-rTMS could either reflect a globally decreased cortical response to the TMS pulse or a specific decrease in inhibition

The Grammar Matrix: An Open-Source Starter-Kit for the Rapid Development of Cross-Linguistically Consistent Broad-Coverage Precision Grammars

The grammar matrix is an open-source starter-kit for the development of broadcoverage HPSGs. By using a type hierarchy to represent cross-linguistic generalizations and providing compatibility with other open-source tools for grammar engineering, evaluation, parsing and generation, it facilitates not only quick start-up but also rapid growth towards the wide coverage necessary for robust natural language processing and the precision parses and semantic representations necessary for natural language understanding

The group-based social skills training SOSTA-FRA in children and adolescents with high functioning autism spectrum disorder - study protocol of the randomised, multi-centre controlled SOSTA - net trial

Background: Group-based social skills training (SST) has repeatedly been recommended as treatment of choice in high-functioning autism spectrum disorder (HFASD). To date, no sufficiently powered randomised controlled trial has been performed to establish efficacy and safety of SST in children and adolescents with HFASD. In this randomised, multi-centre, controlled trial with 220 children and adolescents with HFASD it is hypothesized, that add-on group-based SST using the 12 weeks manualised SOSTA–FRA program will result in improved social responsiveness (measured by the parent rated social responsiveness scale, SRS) compared to treatment as usual (TAU). It is further expected, that parent and self reported anxiety and depressive symptoms will decline and pro-social behaviour will increase in the treatment group. A neurophysiological study in the Frankfurt HFASD subgroup will be performed pre- and post treatment to assess changes in neural function induced by SST versus TAU. Methods/design: The SOSTA – net trial is designed as a prospective, randomised, multi-centre, controlled trial with two parallel groups. The primary outcome is change in SRS score directly after the intervention and at 3 months follow-up. Several secondary outcome measures are also obtained. The target sample consists of 220 individuals with ASD, included at the six study centres. Discussion: This study is currently one of the largest trials on SST in children and adolescents with HFASD worldwide. Compared to recent randomised controlled studies, our study shows several advantages with regard to in- and exclusion criteria, study methods, and the therapeutic approach chosen, which can be easily implemented in non-university-based clinical settings. Trial registration: ISRCTN94863788 – SOSTA – net: Group-based social skills training in children and adolescents with high functioning autism spectrum disorder

Increased performance uncertainty in children with ADHD? - Elevated post-imperative negative variation (PINV) over the ventrolateral prefrontal cortex

Background: We aimed to investigate the influences of attention deficit/hyperactivity disorder (ADHD) on response evaluation, as reflected by the postimperative negative variation (PINV), a slow event-related potential. Methods: We investigated PINV as an indicator of performance uncertainty in an audio-visual contingent negative variation (CNV) paradigm with an interstimulus interval of 3 seconds. A constant, unilateral, quick motor reaction with either the right or the left thumb was required after an auditory forewarned (S1) visual imperative stimulus (S2). We examined 18 ADHD patients (combined or hyperactive-impulsive subtype) aged between 8 and 14 years and an age-, sex and IQ-matched control group of 19 healthy subjects using 64-channel high-density EEG. A first run was recorded drug-free, a second one under methylphenidate (MPH) medication in the ADHD group. Results: We found a significantly increased negativity of the PINV-component over the ventrolateral prefrontal cortex in ADHD children compared to the healthy control group. PINV amplitude was influenced by movement side, most likely due to the slightly more difficult task when left hand responses were required. After the intake of MPH, PINV amplitudes of ADHD children normalized. Conclusions: We conclude that children with ADHD are likely to be more uncertain about the correctness of their performance and interpret the increased PINV as a hint towards compensatory mechanisms for a deficit in the evaluation of contingencies. Further studies are needed to assess the exact extent to which remainders of eye-movement related potentials contribute to PINV amplitude despite the correction for eye-artifacts

Global Stationary Phase and the Sign Problem

We present a computational strategy for reducing the sign problem in the evaluation of high dimensional integrals with non-positive definite weights. The method involves stochastic sampling with a positive semidefinite weight that is adaptively and optimally determined during the course of a simulation. The optimal criterion, which follows from a variational principle for analytic actions S(z), is a global stationary phase condition that the average gradient of the phase Im(S) along the sampling path vanishes. Numerical results are presented from simulations of a model adapted from statistical field theories of classical fluids.Comment: 9 pages, 3 figures, submitted for publicatio

A Comparison of Methods for Determining Significant Wave Heights-Applied to a 3-m Discus Buoy during Hurricane Katrina

In August 2005, the eye of Hurricane Katrina passed 90 km to the west of a 3-m discus buoy deployed in the Mississippi Sound and operated by the Central Gulf of Mexico Ocean Observing System (CenGOOS). The buoy motions were measured with a strapped-down, 6 degrees of freedom accelerometer, a three-axis magnetometer, and from the displacement of a GPS antenna measured by postprocessed-kinematic GPS. Recognizing that an accelerometer experiences a large offset due to gravity, the authors investigated four different means of computing wave heights. In the most widely used method for a buoy with a strapped-down, 1D accelerometer, wave heights are overestimated by 26% on average and up to 56% during the peak of the hurricane. In the second method, the component of gravity is removed from the deck relative z-axis accelerations, requiring pitch and roll information. This is most similar to the motion of the GPS antenna and reduces the overestimation to only 5% on average. In the third method, the orientation data are used to obtain a very accurate estimate of the vertical acceleration, reducing the overestimation of wave heights to 1%. The fourth method computes an estimate of the true earth-referenced vertical accelerations using the accelerations from all three axes but not the pitch and roll information. It underestimates the wave heights by 2.5%. The fifth method uses the acceleration from all three axes and the pitch and roll information to obtain the earth-referenced vertical acceleration of the buoy, the most accurate measure of the true wave vertical acceleration. The primary conclusion of this work is that the measured deck relative accelerations from a strapped- down, 1D accelerometer must be tilt corrected in environments of high wave heights

Hurricane Katrina Winds Measured By a Buoy-Mounted Sonic Anemometer

The eye of Hurricane Katrina passed within 49 n mi of an oceanographic observing system buoy in the Mississippi Bight that is part of the Central Gulf of Mexico Ocean Observing System. Although a mechanical anemometer failed on the buoy during the hurricane, a two-axis sonic anemometer survived and provided a complete record of the hurricane\u27s passage. This is the first reported case of a sonic anemometer surviving a hurricane and reporting validated data, and it demonstrates that this type of anemometer is a viable alternative to the mechanical anemometers traditionally used in marine applications. The buoy pitch and roll record during the storm show the importance of compensating the anemometer records for winds oblique to the horizontal plane of the anemometers. This is made apparent in the comparison between the two wind records from the anemometers during the hurricane