Disposicional en asistente de ventas de la tienda Ripley - Mega Plaza de Chimbote, 2018

Esta investigación tuvo como propósito describir el optimismo disposicional en asistentes de ventas de la tienda Ripley - Mega Plaza de Chimbote, 2018, según género, edad y grado de instrucción. El tipo de diseño fue no experimental ?descriptivo -transaccional; la población estuvo conformada por 35 asistentes de ventas. El instrumento que se utilizó fue el Test de Orientación Vital revisado - LOT-R (Scheier et al., 1994) en la versión española de Otero, Luengo, Romero, Gómez y Castro (1998). Los resultados obtenidos fueron que el 62.9% de los asistentes de ventas son optimistas, el 22.9 % son medio optimista y el 14.3% son muy optimista. Con relación al sexo masculino el 81,3 % son optimistas. Según edad entre 20-30 años el 65.4% son optimistas y según el grado de instrucción superior, los técnicos en 81,3% son optimistas respectivamente.Tesi

Environmental changes during marl-limestone formation: evidence from the Gargasian (Middle Aptian) of La Marcouline Quarry (Cassis, SE France)

International audienceLimestone-marl alternations are usually interpreted to reflect cyclic paleoenvironmental fluctuations linked to Milankovitch-scale climate variations. However, the impact of diagenesis on lithological differentiation can be overprinted on the primary signal. In order to evaluate environmental variations during the deposition of the Gargasian hemipelagic limestone-marl alternations from the "La Marcouline" quarry (SE France), we have applied a multi-discipline approach (carbonate geochemistry, micropaleontology and mineralogy). The work uses of a method of granulometric separation of the main carbonate particles which (1) allows the characterization and quantification of the compositions of the carbonate phases of both lithologies and (2) gives access to the geochemical signatures of similar carbonate (bio-) particles in each lithology. The quantifications show that micarb constitutes a significant portion (around 40 per cent) of the sediments. Their geochemical signatures indicate that most of them were formed by fine fragmentation of nannoconid tests. Based on these interpretations, our results indicate that nannoconids are the major constituents of both the marly limestone and the marl layers and that both lithologies are similar in composition. The coccolith assemblages (mainly Watznaueria spp.) of the limestone and marl layers are similar and equally well-preserved. Changes in oxygen and carbon isotopic ratios express cyclic fertility and salinity/temperature variations in surface waters. The marls indicate higher fertility and lower salinity (or higher temperature) conditions than those denoted by the marly limestones. Although diagenesis has not altered these rhythmites no strong evidence has been found for linking classical processes such as dilution or productivity cycles to the composition of the sediments (carbonate constituents and clay mineralogy). This study demonstrates that La Marcouline succession has retained, as recorded by geochemical proxy, its primary environmental variations. Nevertheless, the homogeneity in both lithotypes of sedimentological parameters (clay mineralogy, sediment composition, ...) seems to indicate that these fluctuations did not affect the ecosystem strongly enough to cause marked differences in the composition of marls and marly-limestones

Fluctuations of sea-water chemistry during Gargasian (Middle Aptian) time. Data from trace-element content (Mg, Sr, Mn, Fe) in hemipelagic carbonates from La Marcouline Quarry (Cassis, SE France)

International audienceIn the Lower Aptian historical stratotype area (Cassis-La Bédoule, SE France), a geochemical study of the Gargasian (Middle Aptian) marl-limestone alternations of the La Marcouline quarry complements data already obtained from Bedoulian (Early Aptian) sediments there. Nannoconids are the main carbonate producers in both limestones and marls. Although diagenetic minerals, such as ankerite (2.5%) are present in small amounts, the trace-element content of bulk carbonate is very close to that of Nannoconus spp. so geochemical sequences can be defined. The long-term evolution of trace-element content was not affected by diagenetic processes, variations in carbonate mineralogy, or a change of carbonate producers. An increase of around 500 ppm in the strontium content of bulk carbonate occurs between the base of the Cabri zone (late Bedoulian) and the Algerianus zone (late Gargasian). This evolution is linked to fluctuations in seawater Sr/Ca ratios caused by variability in the influx of hydrothermal and river waters, by changes in the ratio of aragonite/calcite production and by shifts in sea level. The eustatic sequence Aptian 4, its parasequences and its key surfaces (sequence boundaries, maximum flooding surface) are clearly reflected in the evolution of the bulk-carbonate contents of manganese

Valor clínico de las escalas Hospital Admission Risk Profile (HARP) e Identification of Seniors at Risk (ISAR) para predecir el deterioro funcional asociado al ingreso hospitalario en una unidad geriátrica de agudos en Colombia

Los adultos mayores ingresados ​​en un hospital por una enfermedad aguda tienen un mayor riesgo de deterioro funcional asociado al hospital durante la estadía y después del alta. Objetivo: Este estudio tuvo como objetivo evaluar las capacidades de calibración y discriminación de las escalas de perfil de riesgo de admisión hospitalaria (HARP) e identificación de personas mayores en riesgo (ISAR) como predictores del deterioro funcional asociado al hospital al alta en una cohorte de pacientes mayores de 65 años que reciben manejo en una unidad de cuidados geriátricos de agudos en Colombia. Métodos: Este estudio es una validación externa de los modelos de predicción ISAR y HARP en una cohorte de pacientes mayores de 65 años atendidos en una unidad de cuidados geriátricos de agudos. El estudio incluyó pacientes con índice de Barthel medido al ingreso y al alta. La evaluación discrimina capacidad y calibración, dos aspectos fundamentales de las básculas. Resultados: De 833 pacientes evaluados, 363 (43,6%) presentaron deterioro funcional asociado al hospital al alta. El HARP subestimó el riesgo de deterioro funcional asociado al hospital para pacientes en categorías de riesgo bajo e intermedio (relación entre eventos observados/esperados (ROE) 1,82 y 1,51, respectivamente). El HARP sobrestimó el riesgo de deterioro funcional asociado al hospital para pacientes en la categoría de alto riesgo (ROE 0.91). El ISAR subestimó el riesgo de deterioro funcional asociado al hospital para pacientes en categorías de bajo y alto riesgo (ROE 1.59 y 1.11). Ambas escalas mostraron una pobre capacidad discriminativa, con un área bajo la curva (AUC) entre 0,55 y 0,60. Conclusiones: Este estudio encontró que las escalas HARP e ISAR tienen una capacidad discriminatoria limitada para predecir HAFD en el momento del alta. Las escalas HARP e ISAR deben usarse con cautela en la población colombiana ya que subestiman el riesgo de deterioro funcional asociado al hospital y tienen baja capacidad discriminativa.Q3Older adults admitted to a hospital for acute illness are at higher risk of hospital-associated functional decline during stays and after discharge. Objective: This study aimed to assess the calibration and discriminative abilities of the Hospital Admission Risk Profile (HARP) and the Identification of Seniors at Risk (ISAR) scales as predictors of hospital-associated functional decline at discharge in a cohort of patients older than age 65 receiving management in an acute geriatric care unit in Colombia. Methods: This study is an external validation of ISAR and HARP prediction models in a cohort of patients over 65 years managed in an acute geriatric care unit. The study included patients with Barthel index measured at admission and discharge. The evaluation discriminate ability and calibration, two fundamental aspects of the scales. Results: Of 833 patients evaluated, 363 (43.6%) presented hospital-associated functional decline at discharge. The HARP underestimated the risk of hospital-associated functional decline for patients in low- and intermediate-risk categories (relation between observed/expected events (ROE) 1.82 and 1.51, respectively). The HARP overestimated the risk of hospital-associated functional decline for patients in the high-risk category (ROE 0.91). The ISAR underestimated the risk of hospital-associated functional decline for patients in low- and high-risk categories (ROE 1.59 and 1.11). Both scales showed poor discriminative ability, with an area under the curve (AUC) between 0.55 and 0.60. Conclusions: This study found that HARP and ISAR scales have limited discriminative ability to predict HAFD at discharge. The HARP and ISAR scales should be used cautiously in the Colombian population since they underestimate the risk of hospital-associated functional decline and have low discriminative ability.https://orcid.org/0000-0002-8584-3191https://scholar.google.com/citations?user=ns-9aAgAAAAJ&hl=es&oi=aohttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001337521Revista Nacional - IndexadaS

Variations des paramètres de l'environnement au cours de la sédimentation d'alternances marne-calcaire : Exemple de la série gargasienne (Aptien moyen) de la carrière de La Marcouline (Cassis, SE France)

Il est classiquement admis que les systèmes alternants marne-calcaire reflètent des variations climatiques orbito-dépendantes. Toutefois, des processus diagénétiques conduisant à la différentiation lithologique peuvent avoir masqué ce signal primaire. Afin de caractériser les variations des paramètres environnementaux associés à la formation des alternances marno-calcaires gargasiennes de La Marcouline (SE France), nous avons mené une étude pluridisciplinaire (géochimique, micropaléontologique et minéralogique) basée sur l'utilisation d'une méthode de séparation granulométrique des particules sédimentaires. Cette approche nous a permis, d'une part de caractériser et quantifier les compositions des phases carbonatées des deux types de lithologies et d'autre part de disposer des signatures géochimiques de (bio-) particules carbonatées identiques dans les marnes et les calcaires marneux. Les quantifications ont mis en évidence la présence, en proportions importantes (environ 40% des échantillons) de micarb. À partir des données géochimiques obtenues sur fractions séparées, nous avons proposé pour ces particules une origine liée à la fragmentation fine de tests de nannoconidés. Il en résulte donc que les nannoconidés sont les constituants majeurs aussi bien des marnes que des calcaires marneux et qu'ils sont présents en proportions équivalentes dans les deux lithologies. Les assemblages de coccolithes (principalement Watznaueria spp.) ne présentent pas de variations de composition, ni de préservation d'une lithologie à l'autre. L'évolution de leurs signatures isotopiques signe des fluctuations marquées des conditions de fertilité et de température et/ou salinité dans la zone photique au cours de la sédimentation de ces alternances. Les épisodes marneux correspondent à des périodes plus chaudes et/ou moins salées au cours desquelles les apports de matériel terrigène sont importants induisant une augmentation de la fertilité des eaux de surface par rapport aux périodes de formation des niveaux plus carbonatés. Malgré le fait que la diagenèse ne semble pas avoir joué un rôle significatif dans la mise en place de ces alternances marno-calcaires, nous n'avons pas pu mettre en évidence de relation nette entre des processus classiques du type cycles de dilution ou de production et les compositions des sédiments (particules carbonatées et cortèges argileux). Cette étude montre donc que la série de La Marcouline a conservé un signal primaire lié à des variations environnementales clairement enregistrées par les marqueurs géochimiques (salinité, température et fertilité). Néanmoins, il semble que ces variations n'aient pas suffisamment perturbé l'environnement pour que cela se traduise dans les paramètres sédimentologiques (matériel terrigène, assemblages biologiques, etc.).Limestone-marl alternations are usually interpreted to reflect cyclic paleoenvironmental fluctuations linked to MILANKOVITCH-scale climate variations. However, the impact of diagenesis on lithological differentiation can be overprinted on the primary signal. In order to evaluate environmental variations during the deposition of the Gargasian hemipelagic limestone-marl alternations from the "La Marcouline" quarry (SE France), we have applied a multi-discipline approach (carbonate geochemistry, micropaleontology and mineralogy). The work uses of a method of granulometric separation of the main carbonate particles which (1) allows the characterization and quantification of the compositions of the carbonate phases of both lithologies and (2) gives access to the geochemical signatures of similar carbonate (bio-) particles in each lithology. The quantifications show that micarb constitutes a significant portion (around 40 per cent) of the sediments. Their geochemical signatures indicate that most of them were formed by fine fragmentation of nannoconid tests. Based on these interpretations, our results indicate that nannoconids are the major constituents of both the marly limestone and the marl layers and that both lithologies are similar in composition. The coccolith assemblages (mainly Watznaueria spp.) of the limestone and marl layers are similar and equally well–preserved. Changes in oxygen and carbon isotopic ratios express cyclic fertility and salinity/temperature variations in surface waters. The marls indicate higher fertility and lower salinity (or higher temperature) conditions than those denoted by the marly limestones. Although diagenesis has not altered these rhythmites no strong evidence has been found for linking classical processes such as dilution or productivity cycles to the composition of the sediments (carbonate constituents and clay mineralogy). This study demonstrates that La Marcouline succession has retained, as recorded by geochemical proxy, its primary environmental variations. Nevertheless, the homogeneity in both lithotypes of sedimentological parameters (clay mineralogy, sediment composition, …) seems to indicate that these fluctuations did not affect the ecosystem strongly enough to cause marked differences in the composition of marls and marly-limestones

Fluctuations de la chimie de l'eau de mer au cours du Gargasien (Aptien Moyen). Apports des teneurs en éléments traces (Mg, Sr, Mn et Fe) des carbonates hémipélagiques de la carrière de La Marcouline (Cassis, Sud-Est France)

Dans la région du stratotype historique de l'Aptien inférieur (Cassis-La Bédoule, SE France), les sédiments alternants du Gargasien (Aptien supérieur) de la carrière de la Marcouline ont été étudiés du point de vue géochimique. Le dosage des éléments traces (Sr, Mg, Mn et Fe) du carbonate total a permis de compléter les données déjà obtenues sur le Bédoulien et de définir une zonation chimiostratigraphique du Gargasien. Les Nannoconus sont les producteurs carbonatés principaux aussi bien dans les bancs calcaires que dans les bancs marneux. Les différences géochimiques observées entre les marnes (enrichies en Sr et Mg) et les calcaires (enrichis en Mn et Fe) ne peuvent être réduites à une variation des producteurs ou à une diagenèse différentielle. En dépit de la présence de traces d'ankérite d'origine diagénétique (2,5%), l'enregistrement des éléments-traces au sein du carbonate total reste très proche de celui des fractions pures en Nannoconus et permet de définir les séquences géochimiques. Dans la continuité du processus initié dans le Bédoulien supérieur (base de la zone à Cabri), les teneurs en strontium croissent régulièrement durant le Gargasien. Au total une augmentation de l'ordre de 500 ppm survient entre la base de la zone à Cabri (Bédoulien supérieur) et la zone à Algerianus (Gargasien supérieur). Elle traduit une variation du rapport Sr/Ca de l'eau de mer, à mettre en relation avec le bilan des apports hydrothermaux et fluviatiles, le rapport de la sédimentation aragonitique à la sédimentation calcitique et les variations du niveau marin. Les teneurs en manganèse ont permis de mettre en évidence la séquence eustatique Aptien 4 et les paraséquences qui la composent, ainsi que de localiser ses surfaces clefs (limites de séquence et surface d'inondation maximale).In the Lower Aptian historical stratotype area (Cassis-La Bédoule, SE France), a geochemical study of the Gargasian (Middle Aptian) marl-limestone alternations of the La Marcouline quarry complements data already obtained from Bedoulian (Early Aptian) sediments there. Nannoconids are the main carbonate producers in both limestones and marls. Although diagenetic minerals, such as ankerite (2.5%) are present in small amounts, the trace-element content of bulk carbonate is very close to that of Nannoconus spp. so geochemical sequences can be defined. The long-term evolution of trace-element content was not affected by diagenetic processes, variations in carbonate mineralogy, or a change of carbonate producers. An increase of around 500 ppm in the strontium content of bulk carbonate occurs between the base of the Cabri zone (late Bedoulian) and the Algerianus zone (late Gargasian). This evolution is linked to fluctuations in seawater Sr/Ca ratios caused by variability in the influx of hydrothermal and river waters, by changes in the ratio of aragonite/calcite production and by shifts in sea level. The eustatic sequence Aptian 4, its parasequences and its key surfaces (sequence boundaries, maximum flooding surface) are clearly reflected in the evolution of the bulk-carbonate contents of manganese

Software Citation Implementation Challenges

The main output of the FORCE11 Software Citation working group (https://www.force11.org/group/software-citation-working-group) was a paper on software citation principles (https://doi.org/10.7717/peerj-cs.86) published in September 2016. This paper laid out a set of six high-level principles for software citation (importance, credit and attribution, unique identification, persistence, accessibility, and specificity) and discussed how they could be used to implement software citation in the scholarly community. In a series of talks and other activities, we have promoted software citation using these increasingly accepted principles. At the time the initial paper was published, we also provided guidance and examples on how to make software citable, though we now realize there are unresolved problems with that guidance. The purpose of this document is to provide an explanation of current issues impacting scholarly attribution of research software, organize updated implementation guidance, and identify where best practices and solutions are still needed

Application of quality by design tools to upstream processing of platelet precursor cells to enable in vitro manufacture of blood products

Annually 4.5 million platelet units are transfused in Europe and the United States. These are obtained solely from allogeneic donations and have a shelf life of 5-7 days. To address the corresponding supply challenge, Moreau et al.1 devised a novel process for producing megakaryocytes (MKs, the platelet precursor cell) in vitro. A transcription-factor driven, forward-programming (FOP) approach converts human pluripotent stem cells into MKs. This strategy has the unique advantage of generating high yields of pure MKs in chemically defined medium which could lead to the production of a consistent, reliable supply of platelets which overcomes the logistical, financial and biosafety challenges for health organisations worldwide. Here we follow a Quality by Design (QbD) approach to enable improvements to the upstream processing of FOPMKs. Firstly, we created a process flow diagram for production of in vitro platelets for transfusion, which segregated processes into individual unit operations for control and optimisation. Next, we developed a Quality Target Product Profile (QTPP) and identified Critical Quality Attributes (CQAs) for each stage. We conducted a range of experiments utilising Design of Experiments (DOE) and mechanistic modelling2 tools to link Critical Process Parameters (CPPs) to CQAs. For adherent culture, we identified a productivity limit related to surface area available for growth and a cell loss phase which was dependent on cell seeding density, RhoK inhibitor usage and seed density. Using suspension cultures of FOPMK. We noted that TPO and Doxycycline concentration were CPPs as these impacted cell net growth rate and phenotype trajectory. Furthermore, we noted that medium exhaustion led to a 30% loss of viable cells over 8 hours. Proof of concept studies also showed that FOPMKs can be cultured in scaled-down suspension systems (ambr-15 and spinner flask culture) whilst retaining CQAs. 1. Moreau, T. et al. Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nat. Commun. 7, 1–15 (2016). 2. Stacey, A. J., Cheeseman, E. A., Glen, K. E., Moore, R. L. L. & Thomas, R. J. Experimentally integrated dynamic modelling for intuitive optimisation of cell-based processes and manufacture. Biochem. Eng. J. 132, 130–138 (2018)

Planeamiento estratégico para Stefanini IT Perú

El objetivo del presente documento fue la elaboración del planeamiento estratégico para la empresa Stefanini IT Perú , teniendo como meta principal la de alcanzar la visión planteada para que en el año 2021 sea reconocida como el mejor proveedor de servicios de tecnología de la información, por brindar soluciones integrales que generen valor y ventajas competitivas sostenibles a las empresas del sector de banca y finanzas del Perú ; contribuyendo a su desarrollo tecnológico, económico y a la mejora de su impacto social. Así mismo en el presente trabajo se planteo como misión de la empresa, la de brindar a las empresas del sector de banca y finanzas del Perú las mejores soluciones tecnológicas y de gestión mediante la implementación de sistemas integrados e innovadores, aplicando altos estándares globales de calidad en sus servicios, y aportando a su productividad y al uso eficiente de sus recursos, con el fiel compromiso de la búsqueda de la excelencia y mejora continua. La visión y misión propuestas en este planeamiento estratégico, alineadas con los puntos cardinales y los intereses de la organización brindaron una perspectiva amplia, la cual permitió plantear las estrategias que alinearían los objetivos de largo plazo de la empresa. Los objetivos de largo plazo se orientaron al incremento de la facturación, al incremento de la rentabilidad, a la penetración en el mercado de Banca y Finanzas, al lanzamiento de nuevos productos que no existen actualmente en el mercado, así como a las mejoras en los sistemas de gestión de la compañía, y finálmente la disminución de la rotación de personal. Luego de completar el proceso de planeamiento estratégico, se retuvieron once estrategias, cuyo éxito de implementación depende del compromiso de la Alta Dirección y de toda la empresa, para lo cual se deberán alinear los esfuerzos de todas las áreas de la organización, de acuerdo a la nueva estructura jerarquica propuesta, bajo el liderazgo del Director General y con el apoyo del Grupo Stefanini desde su casa matrizThe present document elaborates the Strategic Planning of Stefanini IT; having as the main focus to reach the outlined vision for the offer of integral products and services of software and information technology for the sector of Banking and Finance to 2021. In this way, it will allow the organization to contribute to the improvement of the processes of the companies of the financial sector to grow in a sustainable way, efficient use of the resources and being profitable in the long term. These strategies will enable them to serve customers, displaying competitive advantages. The strategic plan is the result of a detailed analysis of the general situation of the information technology systems industry, the influence of external and internal factors, and the analysis and evaluation of the current situation of Stefanini IT. In addition, through the development of different matrices it is possible to identify the main opportunities, strengths and weaknesses of the company. It is also important to present the main interests of the company that lead to meeting the short and long term goals in order to achieve the vision outlined, which will be achieved by designing action plans periodically measured under a monitoring system of indicators managementTesi