Fundamental Shifts in Research, Ethics and Peer Review in the Era of the COVID-19 Pandemic

The era of the coronavirus disease 2019 (COVID-19) pandemic has led to fundamental shifts in research, ethics, and peer review including reframing of the research design, adapting methodologies to the study type, transitioning of research mechanics, changing research methodologies, overcoming data collection and standardization constraints, upholding research standards and ethics, maintaining informativeness and social value, and providing guarded peer review flexibility. Indeed, the COVID-19 crisis, despite disrupting research worldwide to an unprecedented degree, has also become a catalyst to develop strategies of adaptation to this disruption. As the COVID-19 pandemic continuous to evolve, new, cost-effective, and highly flexible research models need to be developed. Planning is crucial for ensuring short-term and long-term contingency funds to support research logistics and personnel. A mental shift must accompany changes in methodologies to mentor and support researchers who are vital to the continuity of high-caliber research in the long term. A global research perspective through interinstitutional and interprofessional collaboration will sustain adherence to the highest standards of data collection and research reporting

Extrinsic and Intrinsic Aspirations of students of Divine Word Colleges in Ilocos Region, Philippines and their Academic performance

The study wants to determine the relationship between extrinsic and intrinsic motivation and academic performanceInternational audienceThe study wanted to determine the relationship between extrinsic and intrinsic aspirations of students of Divine Word Colleges in Ilocos Region and their academic performance as measured by self-reported general average grades. To support the theory, related literature and studies were reviewed and proper research methodology was applied. The population of the study was Grade XII Senior High School students of Divine Word Colleges in Ilocos Region and total enumeration of sampling design was used. The study applied descriptive correlational research design and aided by fact finding inquiry. The variables of the study and the questionnaires are validated variables and validated questionnaires of Self-Determination Theory of Kasser and Ryan (2000). The weighted mean was used to determine the level of extrinsic and intrinsic aspirations and Pearson (r), or the Product Moment Correlation Coefficient was used to determine the relationship between extrinsic and intrinsic and academic performance. The study found that students have moderate level of extrinsic aspirations but very high level of intrinsic motivation. Further, the study concluded that there is no correlation between extrinsic aspirations and academic performance but there is extensive correlation between intrinsic aspirations and academic performance. Keywords-Intrinsic and extrinsic aspirations, academic performance, intrinsic and intrinsic motivation

Methodologies in Identification, Analysis, and Measurement of Visual Pollution: The Case Study of Intramuros

The problem of visual pollution in the Philippines has been increasingly evident, and people are becoming aware of it. But to create effective solutions, a deep understanding of the problem should first be established. This paper was aimed to identify, analyze, and measure the visual pollution present in Intramuros, a heritage city in the Philippines that encapsulates the Philippine colonial architecture in the 1890s. The site is known for its preservation of its city image but also modern landscape changes. To achieve the goal, the application of the Indirect and Direct Method of Landscape Evaluation was executed. These methods led to two results: (1) the identification of components— which are landscape attributes and indicators, that make up a visual landscape; and (2) the understanding of how it is perceived by the observer through a survey and interviews, which are quantified by ratings. To further understand the relationship of indicators and ratings with each other, a series of correlational studies was done. This resulted to the establishment of Disturbance, Stewardship, and Image Rating as the primary descriptors of visual pollution. A weighted average formula was then established, which quantified the visual pollution of Intramuros through indicator values and response ratings. It was concluded that visual pollution in Intramuros, through research-based methodology, can be identified, analyzed, and measured. Specific viewpoints in the district were identified as unacceptably visually-polluted. Magallanes St. cor. Victoria St. in Intramuros had the highest VP Score at -4.886. Elements that contributed to visual pollution were also identified

Apparent Metabolizable Energy of Corn and Rice Bran for Philippine Mallard Duck

The metabolizable energy (ME) value of common feedstuffs for Philippine mallard duck (PMD) need to be established to formulate specific and balance diet for PMD.  For this, the study was conducted to determine the apparent ME expressed in classical ME (AME) and nitrogen corrected ME (AMEn) of corn and rice bran for PMD. Eight PMD were used in the energy assay using the total collection method. An improvised digestibility cage was fabricated and used in the experiment modifying the basin technique in excreta collection. The homogenous wet mash of corn and rice bran were tube-fed to the PMD twice with an interval of six hours. Excreta collection was done for 54 hours from the last scheduled tube feeding. Feed and excreta samples were sent to UPLB for protein and gross energy analyses. The experiment was carried out using the Completely Randomized Design. The calculated AME and AMEn of corn and rice bran for PMD were 3.63 and 3.61 kcal/g and 1.97 and 1.95 kcal/g, respectively. Corn tends to have a higher ME value than rice bran. The ME value of corn and rice bran for PMD is greater than the data of PHILSAN, which is the reference standard for poultry and livestock nutrient requirements in the Philippines. The result show that corn and rice bran have higher energetic value for growing PMD than book values for poultry.  PMD is efficient in utilizing the energy content of corn and rice bran as manifested by the higher ME value

Culturally-adapted resilience-building curriculum for medical students: a comprehensive approach at Showa University School of Medicine, Japan

The growing prevalence of psychological morbidity, depersonalization, and low personal accomplishment among medical students underscores the need for resilience-enhancing programs tailored to their specific needs. Incorporating cultural perspectives and societal context into these interventions is crucial to ensure their effectiveness and relevance. In response, Showa University School of Medicine in Japan has pioneered a culturally-adapted, resilience-based curriculum for medical students from their first through sixth years since 2020. This presentation will outline the comprehensive framework of the resilience-focused curriculum, including course objectives, content, learning resources, timetables, and pedagogical approaches. Key components of the curriculum encompass self-assessment and reflection, stress management strategies, effective communication and conflict resolution skills, and fostering a growth mindset. Additionally, interdisciplinary collaborations with psychology and social work departments provide individual supports and resources for students. Emphasizing the distinct challenges faced by medical students, such as academic stressors, relationships with senior clinical educators, patient and family interactions, and managing errors and burnout, the presentation will highlight the classes on the curriculum, support systems and mentorship programs in promoting mental well-being and resilience. The experiences and outcomes of the 2020-2022 cohorts will be shared, offering valuable insights into the effectiveness of the resilience-building curriculum in the Japanese context. Lessons learned from the implementation process, including challenges faced and strategies employed, will provide practical examples for other medical schools seeking to develop similar programs

Complete Genome Sequences of Mycobacterium smegmatis Phages Chewbacca, Reptar3000, and Riparian, Isolated in Las Vegas, Nevada

Here, we present the complete genome sequences of Mycobacterium smegmatis phages Chewbacca, Reptar3000, and Riparian, isolated from soil in Las Vegas, NV. The phages were isolated and annotated by undergraduate students enrolled in the Phage Discovery course offered by the School of Life Sciences at the University of Nevada, Las Vega

Dynamics of Air Temperature, Velocity and Ammonia Emissions in Enclosed and Conventional Pig Housing Systems

This study aimed to compare the dynamics of air temperature and velocity under two different ventilation and housing systems during summer and winter in Korea. The NH3 concentration of both housing systems was also investigated in relation to the pig’s growth. The ventilation systems used were; negative pressure type for the enclosed pig house (EPH) and natural airflow for the conventional pig house (CPH). Against a highly fluctuating outdoor temperature, the EPH was able to maintain a stable temperature at 24.8 to 29.1°C during summer and 17.9 to 23.1°C during winter whilst the CPH had a wider temperature variance during summer at 24.7 to 32.3°C. However, the temperature fluctuation of the CPH during winter was almost the same with that of EPH at 14.5 to 18.2°C. The NH3 levels in the CPH ranged from 9.31 to 16.9 mg/L during summer and 5.1 to 19.7 mg/L during winter whilst that of the EPH pig house was 7.9 to 16.1 mg/L and 3.7 to 9.6 mg/L during summer and winter, respectively. These values were less than the critical ammonia level for pigs with the EPH maintaining a lower level than the CPH in both winter and summer. The air velocity at pig nose level in the EPH during summer was 0.23 m/s, enough to provide comfort because of the unique design of the inlet feature. However, no air movement was observed in almost all the lower portions of the CPH during winter because of the absence of an inlet feature. There was a significant improvement in weight gain and feed intake of pigs reared in the EPH compared to the CPH (p<0.05). These findings proved that despite the difference in the housing systems, a stable indoor temperature was necessary to minimize the impact of an avoidable and highly fluctuating outdoor temperature. The EPH consistently maintained an effective indoor airspeed irrespective of season; however the CPH had defective and stagnant air at pig nose level during winter. Characteristics of airflow direction and pattern were consistent relative to housing system during both summer and winter but not of airspeed. The ideal air velocity measurement favored the EPH and therefore can be appropriate for the Korean environment. Further emphasis on its cost effectiveness will be the subject of future investigations

A proposed core curriculum for dental English education in Japan

Background: Globalization of the professions has become a necessity among schools and universities across the world. It has affected the medical and dental professions in terms of curriculum design and student and patient needs. In Japan, where medicine and dentistry are taught mainly in the Japanese language, profession-based courses in English, known as Medical English and Dental English, have been integrated into the existing curriculum among its 83 medical and 29 dental schools. Unfortunately, there is neither a core curriculum nor a model syllabus for these courses. Methods: This report is based on a survey, two discussion forums, a workshop, and finally, the drafting of a proposed core curriculum for dental English approved by consensus of the participants from each university. Results: The core curriculum covers the theoretical aspects, including dental English terms and oral pathologies; and practical aspects, including blended learning and dentist-patient communication. It is divided into modules and is recommended to be offered for at least two semesters. Conclusions: The core curriculum is expected to guide curriculum developers in schools where dental English courses are yet to be offered or are still in their early development. It may also serve as a model curriculum to medical and dental schools in countries in Asia, Europe, Africa, and Central and South America, where English is not the medium of instruction

Osteocytes Serve as a Progenitor Cell of Osteosarcoma

Osteosarcoma (OSA) is the most common primary bone tumor in humans. However, the cell of origin of OSA is not clearly defined although there is evidence that osteoblasts may serve as OSA progenitors. The role of osteocytes, terminally differentiated osteoblasts, as OSA progenitors has yet to be described. Analysis of patient cDNA from publicly available microarray data revealed that patients with OSA have increased expression of dentin matrix phosphoprotein 1 (DMP1), a marker of osteocytes. Analysis of multiple murine, human, and canine OSA cell lines revealed DMP1 expression. To test the tumorigenic potential of osteocytes, MLO‐Y4, a SV‐40 immortalized murine osteocyte cell line, was injected into subcutaneous and orthotopic (intratibial) sites of mice. Tumor growth occurred in both locations. Orthotopic MLO‐Y4 tumors produced mixed osteoblastic/osteolytic radiographic lesions; a hallmark of OSA. Together, these data demonstrate for the first time that osteocytes can serve as OSA progenitors. J. Cell. Biochem. 115: 1420–1429, 2014. © 2014 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107570/1/jcb24793.pd

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

The proto-oncogenic protein c-Myb is an essential regulator of hematopoiesis and is frequently deregulated in hematological diseases such as lymphoma and leukemia. To gain insight into the mechanisms underlying the aberrant expression of c-Myb in myeloid leukemia, we analyzed and compared c-myb gene transcriptional regulation using two cell lines modeling normal hematopoietic progenitor cells (HPCs) and transformed myelomonocytic blasts. We report that the transcription factors HoxA9, Meis1, Pbx1 and Pbx2 bind in vivo to the c-myb locus and maintain its expression through different mechanisms in HPCs and leukemic cells. Our analysis also points to a critical role for Pbx2 in deregulating c-myb expression in murine myeloid cells cotransformed by the cooperative activity of HoxA9 and Meis1. This effect is associated with an intronic positioning of epigenetic marks and RNA polymerase II binding in the orthologous region of a previously described alternative promoter for c-myb. Taken together, our results could provide a first hint to explain the abnormal expression of c-myb in leukemic cells