Sustainability with biogas as a form of alternative energy

ArticleThe vision of CUT as a sustainable university is to become a teaching, research and learning environment which maximizes and mainstreams environmental, economic and social sustainability in all its operations and educational activities. In driving this process, the university established a Sustainable Development Project to facilitate, oversee and report on the roll-out of this project

Designing for laser sintering

Published ArticleUntil recently solid freeform fabrication (SFF) technology has been used mostly for production of prototype parts. However, as this technology matures, the initiative of utilising it for the manufacture of end-use products is establishing itself. As this tendency to use SFF for actual production runs increases, a demand is developing for sets of process-specific design for manufacture (DFM) guidelines that will assist designers who are designing parts for manufacture by a specific rapid manufacturing (RM) process. The purpose of this paper is to provideRMdesigners with such a series of processspecific design for manufacture guidelines

Parameters affecting spin casting of decorative and mechanical parts

Published ArticleSpin casting is widely used as a batch manufacturing process for decorative products. In the process, moulds are filled by taking advantage of the centrifugal effect, which is used to increase the pressure within the moulds, resulting in more detailed products. In this study, we analyse the different parameters that could affect the casting of mechanical parts through spin casting. Through this study, the user will be guided in the selection of parameters that will result in a certain degree of accuracy. The parameters were determined by performing numerous experiments using zinc alloy and tin-based pewter as casting materials. Results were obtained by casting approximately 15 000 parts in various positions, and at various clamping pressures, rotational speeds and temperatures in both the mould and the material. The experiments were undertaken by varying one parameter at a time, and with each set parameter repeated once, resulting in 100 test pieces per parameter for evaluation. From the results obtained, a series of critical factors and parameters, which are driven by part characteristics or features, has been studied. Contrary to following a modelling approach, the research was conducted following an action-research approach, with planned activities, but where actual results have defined the follow-up procedures. These guidelines will help industrial users ensure the accuracy of parts produced by spin casting. Also, since this project attempted to create a database of results that can be applied in future, it furthermore implies that the data created for the first time can be used in a numerical modelling approach in further / follow-up research. No such data was available from any previous research

Gynaecological product development facilitated through RP and Rapid Tooling

Published ArticleAtkinson distinguishes between four types of prototypes, categorised through its end-use: •Design or aesthetic prototypes •Geometrical prototypes •Functional prototypes •Technological prototypes Shigley and Mitchell define the design process according to the following six phases: Recognition of need Definition of problem Synthesis Analysis and optimization Evaluation Presentation The Centre for Rapid Prototyping and Manufacture (CRPM) of the Central University of Technology, Free State was asked to assist in the development of a newly developed gynaecological cream applicator. Apart from needing a freeform fabrication system to give form fit and function to the very complex design, the product needed Rapid Tooling / Rapid Manufacturing support to enable a first batch production for medical trials and evaluation. The paper will describe the total product development process alongside prototype categories described by Atkinson and design phases defined by Shigley and Mitchell (including some iterations enabled through timeous prototyping, including various Rapid Prototyping (RP) Technologies, soft tooling and vacuum casting). More importantly, results from Rapid Tooling for limited run production (due to the complexity of the product the cycle time of the Prototype Tool is fairly long), as well as the economical impact made possible through the support of CAD / CAM and RP Technologies, will be discussed

Direct Drive Heavy-Ion-Beam Inertial Fusion at High Coupling Efficiency

Issues with coupling efficiency, beam illumination symmetry and Rayleigh Taylor (RT) instability are discussed for spherical heavy-ion-beam-driven targets with and without hohlraums. Efficient coupling of heavy ion beams to compress direct-drive inertial fusion targets without hohlraums is found to require ion range increasing several-fold during the drive pulse. One-dimensional implosion calculations using the LASNEX ICF target physics code shows the ion range increasing four-fold during the drive pulse to keep ion energy deposition following closely behind the imploding ablation front, resulting in high coupling efficiencies (shell kinetic energy/incident beam energy of 16 to 18%). Ways to increase beam ion range while mitigating Rayleigh-Taylor instabilities are discussed for future work

Gene-gene Interaction Analyses for Atrial Fibrillation

Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in a

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10-5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10-8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk

Energetic particle influence on the Earth's atmosphere

This manuscript gives an up-to-date and comprehensive overview of the effects of energetic particle precipitation (EPP) onto the whole atmosphere, from the lower thermosphere/mesosphere through the stratosphere and troposphere, to the surface. The paper summarizes the different sources and energies of particles, principally galactic cosmic rays (GCRs), solar energetic particles (SEPs) and energetic electron precipitation (EEP). All the proposed mechanisms by which EPP can affect the atmosphere are discussed, including chemical changes in the upper atmosphere and lower thermosphere, chemistry-dynamics feedbacks, the global electric circuit and cloud formation. The role of energetic particles in Earth’s atmosphere is a multi-disciplinary problem that requires expertise from a range of scientific backgrounds. To assist with this synergy, summary tables are provided, which are intended to evaluate the level of current knowledge of the effects of energetic particles on processes in the entire atmosphere

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies

On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection

A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)