More positive group memberships are associated with greater resilience in Royal Air Force (RAF) personnel

© 2020 The Authors. British Journal of Social Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society In the current project, we examined how perceived group memberships (number, and characteristics, of), social and relational identification, and social identity leadership are associated with resilience in Royal Air Force (RAF) personnel. Based on social identity theorizing, we hypothesized positive associations between the number of groups, perceptions of their characteristics (e.g., positivity), and how they relate to each other (i.e., compatibility) and resilience (H1). We also hypothesized positive associations between both social identity leadership (H2) and resilience, and social and relational identification (H3) and resilience. Two hundred and forty-three personnel from 18 RAF bases completed an identity mapping exercise and measures of leadership, social and relational identification, and resilience. Our findings highlighted the importance of the association between positive group memberships and resilience, and social identification and resilience. Counter to our hypothesis, belonging to more groups was negatively associated with resilience, and there were non-significant relationships between three principles of social identity leadership and resilience, with embedding identity being significantly negatively associated with resilience. In support of social identity theorizing, the number of positive groups was positively associated with resilience, as was social identification. These findings indicate that, for RAF personnel, it is belonging to positive groups, both within and outside work, along with social identification, that is positively associated with resilience

Nonperiodic inspections to guarantee a prescribed level of reliability

A cost-optimal nonperiodic inspection policy is derived for complex multicomponent systems. The model takes into consideration the degradation of all the components in the system with the use of a Bessel process with drift. The inspection times are determined by a deterministic function and depend on the system’s performance measure. The nonperiodic policy is developed by evaluating the expected lifetime costs and the optimal policy by an optimal choice of inspection function. The model thus gives a guaranteed level of reliability throughout the life of the project

Preparation of magnetic carboxymethylchitosan nanoparticles for adsorption of heavy metals ions

The remediation of metal and heavy metal contaminants from water ecosystems is a long-standing problem in the field of water management. The development of efficient, cost effective, and environmentally friendly natural polymer-based adsorbents is reported here. Magnetic chitosan (CS) and carboxymethylchitosan (CMC) nanocomposites have been synthesized by a simple one-step chemical coprecipitation method. The nanoparticles were assessed for the removal of Pb2+, Cu2+, and Zn2+ ions from aqueous solution. Kinetic and thermodynamic models were used to describe and understand the adsorption process of the ions onto the nanomaterials. The interactions between the ions and the biopolymer-based composites are reversible, which means that the nanoparticles can be regenerated in weakly acidic or EDTA containing solution without losing their activity and stability for water cleanup applications

Optimizing DNA Extraction Methods for Nanopore Sequencing of Neisseria gonorrhoeae Directly from Urine Samples

Empirical gonorrhea treatment at initial diagnosis reduces onward transmission. However, increasing resistance to multiple antibiotics may necessitate waiting for culture-based diagnostics to select an effective treatment. There is a need for same-day culture-free diagnostics that identify infection and detect antimicrobial resistance. We investigated if Nanopore sequencing can detect sufficient Neisseria gonorrhoeae DNA to reconstruct whole genomes directly from urine samples. We used N. gonorrhoeae-spiked urine samples and samples from gonorrhea infections to determine optimal DNA extraction methods that maximize the amount of N. gonorrhoeae DNA sequenced while minimizing contaminating host DNA. In simulated infections, the Qiagen UCP pathogen mini kit provided the highest ratio of N. gonorrhoeae to human DNA and the most consistent results. Depletion of human DNA with saponin increased N. gonorrhoeae yields in simulated infections but decreased yields in clinical samples. In 10 urine samples from men with symptomatic urethral gonorrhea, ≥92.8% coverage of an N. gonorrhoeae reference genome was achieved in all samples, with ≥93.8% coverage breath at ≥10-fold depth in 7 (70%) samples. In simulated infections, if ≥104 CFU/ml of N. gonorrhoeae was present, sequencing of the large majority of the genome was frequently achieved. N. gonorrhoeae could also be detected from urine in cobas PCR medium tubes and from urethral swabs and in the presence of simulated Chlamydia coinfection. Using Nanopore sequencing of urine samples from men with urethral gonorrhea, sufficient data can be obtained to reconstruct whole genomes in the majority of samples without the need for culture

Developing performance using rational emotive behavior therapy (REBT): A case study with an elite archer

© 2017 Human Kinetics, Inc. Rational emotive behavior therapy (REBT; Ellis, 1957) is a psychotherapeutic approach receiving increasing interest within sport. REBT is focused on identifying, disputing, and replacing irrational beliefs (IBs) with rational beliefs (RBs) to promote emotional well-being and goal achievement. This study provides a detailed case outlining the application and effect of seven one-to-one REBT sessions with an elite level archer who was experiencing performance-related anxiety, before and during competition. The case also offers an insight into common misconceptions, challenges, and guidance for those who may consider applying REBT within their practice. Data revealed meaningful short and long-term (6-months) reductions in IBs and improvements in RBs, self-efficacy, perception of control and archery performance. The case supports the effective application of REBT as an intervention with athletic performers, promoting lasting changes in an athlete's ability to manage their cognitions, emotions and behaviors in the pursuit of performance excellence

Pharmacokinetic studies in children: recommendations for practice and research.

Optimising the dosing of medicines for neonates and children remains a challenge. The importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised both in medicines regulation and paediatric clinical pharmacology, yet there remain barriers to undertaking high-quality PK and PD studies. While these studies are essential in understanding the dose-concentration-effect relationship and should underpin dosing recommendations, this review examines how challenges affecting the design and conduct of paediatric pharmacological studies can be overcome using targeted pharmacometric strategies. Model-based approaches confer benefits at all stages of the drug life-cycle, from identifying the first dose to be used in children, to clinical trial design, and optimising the dosing regimens of older, off-patent medications. To benefit patients, strategies to ensure that new PK, PD and trial data are incorporated into evidence-based dosing recommendations are needed. This review summarises practical strategies to address current challenges, particularly the use of model-based (pharmacometric) approaches in study design and analysis. Recommendations for practice and directions for future paediatric pharmacological research are given, based on current literature and our joint international experience. Success of PK research in children requires a robust infrastructure, with sustainable funding mechanisms at its core, supported by political and regulatory initiatives, and international collaborations. There is a unique opportunity to advance paediatric medicines research at an unprecedented pace, bringing the age of evidence-based paediatric pharmacotherapy into sight

Types of Stem Cells in Regenerative Medicine: A Review

Two basic and clinical researches accomplished during the recent years on embryonic and adult stem cells constituted a mutation in regenerative therapy. These cells can be used for treating some degenerative diseases. Between them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson’s and Alzheimer’s diseases, arthritis and muscular, skin, lung, eye, and digestive disorders, aggressive and regressive cancers can be treated by cell therapies. This review focused on types of stem cells used in regenerative medicine

Investigating the effects of irrational and rational self-statements on motor-skill and hazard-perception performance

© 2017 American Psychological Association. Rational emotive behavior therapy (REBT) is a psychotherapeutic approach based on the premise that when individuals are faced with adversity, irrational beliefs determine unhealthy negative emotions and maladaptive behaviors, whereas rational beliefs lead to healthy and adaptive alternatives. The detrimental effects of irrational beliefs on psychological health are established; however, less is known about their deleterious effects on human behavior and performance. In the present study, we examined the effects of irrational and rational self-statements on motor-skill performance (Experiment 1), performance effectiveness, and efficiency during a modified hazard-perception task, and on persistence during a breath-holding task (Experiment 2). Using a repeatedmeasures counterbalanced design, we recruited 2 cohorts of 35 undergraduate university students for Experiments 1 and 2, each participating in no self-statement, irrational, and rational self-statement conditions. Data indicated no differences in motor-skill and task performance, performance efficiency, task persistence, mental effort, and preperformance anxiety between irrational and rational self-statement conditions. In contrast to previous research, our findings provide insight into a juxtaposition that irrational beliefs hinder psychological health yet may help performance, highlighting important distinctions in factual and practical rationality that have been overlooked within the extant literature. The findings have important practical implications for practitioners who may look to REBT to enhance the psychological health and performance for individuals who operate in high-performance contexts. Further, the short-and longterm effects of irrational and rational beliefs on performance and psychological health warrants greater investigation