The particularity of emotional words. A grounded approach

This work focuses on emotional concepts. We define concepts as patterns of neural activation that re-enact a given external or internal experience, for example the interoceptive experience related to fear. Concepts are mediated and expressed through words. In the following, we will use “words” to refer to word meanings, assuming that words mediate underlying concepts. Since emotional concepts and the words that mediate them are less related to the physical environment than concrete ones, at first sight they might be depicted as abstract concepts. Evidence coming from several studies shows, instead, that the issue is more complex. In this work, we will briefly outline the debate and illustrate results from recent studies on comprehension of concrete, emotional and abstract words in children and adults. We will argue that emotional words can be accounted for from a grounded perspective and will contend that emotional words represent a particular set of words that differs from both the concrete and purely abstract ones

Words as social tools: flexibility, situatedness, language and sociality in abstract concepts. Reply to comments on “Words as social tools: language, sociality and inner grounding in abstract concepts”

The article is a reply to comments by other authors on the topic of abstract concepts

STAR Results on High Transverse Momentum, Heavy Flavor and Electromagnetic Probes

We summarize here recent results from the STAR collaboration focusing on processes involving large momentum transfers. Measurements of angular correlations of di-hadrons are explored in both the pseudorapidity (eta) and azimuthal (phi) projections. In central Au+Au, an elongated structure is found in the eta projection which persists up to the highest measured pT. After quantifying the particle yield in this structure and subtracting it from the near-side yield, we observe that the remainder exhibits a behavior strikingly similar to that of the near-side yield in d+Au. For heavy flavor production, using electron-hadron correlations in p+p collisions, we obtain an estimate of the b-quark contribution to the non-photonic electrons in the pT region 3-6 GeV/c, and find it consistent with FONLL calculations. Together with the observed suppression of non-photonic electrons in Au+Au, this strongly suggests suppression of b-quark production in Au+Au collisions. We discuss results on the mid-rapidity Upsilon cross-section in p+p collisions. Finally, we present a proof-of-principle measurement of photon-hadron correlations in p+p collisions, paving the way for the tomographic study of the matter produced in central Au+Au via gamma-jet measurements.Comment: 8 pages, 4 figures. Proceedings of "Quark Matter 2006", 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collision

Astrocytes actively support long-range molecular clock synchronization of segregated neuronal populations

In mammals, the suprachiasmatic nucleus of the hypothalamus is the master circadian pacemaker that synchronizes the clocks in the central nervous system and periphery, thus orchestrating rhythms throughout the body. However, little is known about how so many cellular clocks within and across brain circuits can be effectively synchronized. In this work, we investigated the implication of two possible pathways: (i) astrocytes-mediated synchronization and (ii) neuronal paracrine factors-mediated synchronization. By taking advantage of a lab-on-a-chip microfluidic device developed in our laboratory, here we report that both pathways are involved. We found the paracrine factors-mediated synchronization of molecular clocks is diffusion-limited and, in our device, effective only in case of a short distance between neuronal populations. Interestingly, interconnecting astrocytes define an active signaling channel that can synchronize molecular clocks of neuronal populations also at longer distances. At mechanism level, we found that astrocytes-mediated synchronization involves both GABA and glutamate, while neuronal paracrine factors-mediated synchronization occurs through GABA signaling. These findings identify a previously unknown role of astrocytes as active cells that might distribute long-range signals to synchronize the brain clocks, thus further strengthening the importance of reciprocal interactions between glial and neuronal cells in the context of circadian circuitry

Towards Complex Tissues Replication: Multilayer Scaffold Integrating Biomimetic Nanohydroxyapatite/Chitosan Composites

This study explores an approach to design and prepare a multilayer scaffold mimicking interstratified natural tissue. This multilayer construct, composed of chitosan matrices with graded nanohydroxyapatite concentrations, was achieved through an in situ biomineralization process applied to individual layers. Three distinct precursor concentrations were considered, resulting in 10, 20, and 30 wt% nanohydroxyapatite content in each layer. The resulting chitosan/nanohydroxyapatite (Cs/n-HAp) scaffolds, created via freeze-drying, exhibited nanohydroxyapatite nucleation, homogeneous distribution, improved mechanical properties, and good cytocompatibility. The cytocompatibility analysis revealed that the Cs/n-HAp layers presented cell proliferation similar to the control in pure Cs for the samples with 10% n-HAp, indicating good cytocompatibility at this concentration, while no induction of apoptotic death pathways was demonstrated up to a 20 wt% n-Hap concentration. Successful multilayer assembly of Cs and Cs/n-HAp layers highlighted that the proposed approach represents a promising strategy for mimicking multifaceted tissues, such as osteochondral ones

Development of L-Lysine-Loaded PLGA Microparticles as a Controlled Release System for Angiogenesis Enhancement

Vascularization is a highly conserved and considerably complex and precise process that is finely driven by endogenous regulatory processes at the tissue and systemic levels. However, it can reveal itself to be slow and inadequate for tissue repair and regeneration consequent to severe lesions/damages. Several biomaterial-based strategies were developed to support and enhance vasculogenesis by supplying pro-angiogenic agents. Several approaches were adopted to develop effective drug delivery systems for the controlled release of a huge variety of compounds. In this work, a microparticulate system was chosen to be loaded with the essential amino acid L-lysine, a molecule that has recently gained interest due to its involvement in pro-angiogenic, pro-regenerative, and anti-inflammatory mechanisms. Poly (lactic-co-glycolic acid), the most widely used FDA-approved biodegradable synthetic polymer for the development of drug delivery systems, was chosen due to its versatility and ability to promote neovascularization and wound healing. This study dealt with the development and the effectiveness evaluation of a PLGA-based microparticulate system for the controlled release of L-lysine. Therefore, in order to maximize L-lysine encapsulation efficiency and tune its release kinetics, the microparticle synthesis protocol was optimized by varying some processing parameters. All developed formulations were characterized from a morphological and physicochemical point of view. The optimized formulation was further characterized via the evaluation of its preliminary biological efficacy in vitro. The cellular and molecular studies revealed that the L-lysine-loaded PLGA microparticles were non-toxic, biocompatible, and supported cell proliferation and angiogenesis well by stimulating the expression of pro-angiogenic genes such as metalloproteinase-9, focal adhesion kinases, and different growth factors. Thus, this work showed the potential of delivering L-lysine encapsulated in PLGA microparticles as a cost-effective promoter system for angiogenesis enhancement and rapid healing