Identification and discussion of the main factors affecting fertility: the impact of the per capita monetary income indicator on the fertility rate of the population of the Russian Federation

The purpose of the study is to study and establish the nature of the relationship between the level of well-being of the population and the birth rate.Цель исследования – изучить и установить характер взаимосвязи между уровнем благосостояния населения и уровнем рождаемости

Neprilysin inhibirors in pharmacotherapy of various diseases

Current research illustrates the role of neprilysin as a possible point of application in the treatment of a number of diseases, including heart failure, diabetes mellitus and Alzheimer's disease. The article describes these studies with an emphasis on the role of neprilysin in these diseases pathogenesisСовременные исследования иллюстрируют роль неприлизина в качестве возможной точки приложения в терапии ряда заболеваний, среди которых сердечная недостаточность, сахарный диабет и болезнь Альцгеймера. В статье приведено описание этих исследований с указанием роли неприлизина в патогенезе обозначенных заболевани

Capabilities of traditional integrated approach to diagnosis and management of acute pulmonary embolism

The work is dedicated to one of the most dangerous disorders - acute pulm onary em bolism (A P E). The authors analyze the experience of treating 77 patients with A PE of moderate and low risk at the city hospital. Objective - to improve the diagnosis and treatment of APE by analyzing features of diagnosis and treatment of pulm onary embolism of moderate and low risk, based on the integrated evaluation of classical param eters, alw ays available in non-specialized health facilities. It is shown that the greatest difficulties arise in diagnosing the presence of obstruction of medium and small branches of the pulm onary artery. This fact leads to the delayed hospitalization of patients, as well as late beginning of treatment. In a conventional health facility where there are no conditions for the implementation of high-tech diagnostic methods, doctors should verify the diagnose of A PE using routine combination of methods: clinical symptoms, physical examination, indicators of coagulation system , ECG and X-ray, ECHO-cardiography. The unspecialized hospital provides conservative treatment with the help of direct anticoagulants, followed by prolonged use of indirect anticoagulants or antiagregants.Работа посвящена одной из опаснейших патологий - тромбоэмболии легочной артерии (ТЗ/1А). Авторы анализируют опыт лечения 77 пациентов с ТЭЛ А умеренного и низкого риска в условиях неспециализированного ЛПУ. Цель исследования - улучшить диагностику и лечение ТЭЛА, проанализировав особенности течения ТЭЛА умеренного и низкого риска, на основе интегральной оценки классических параметров, всегда имеющихся в распоряжении неспециализированных ЛПУ. Показано, что наибольшие трудности в диагностике возникают при наличии обструкции средних и мелких ветвей легочной артерии. Это приводит к тому, что госпитализация больных запаздывает, равно как и лечение. В условиях обычного ЛПУ, где нет условий для осуществления высокотехнологичных методов диагностики, практическим врачам следует проявлять максимальную тромбоэмбологенную настороженность и верифицировать диагноз по совокупности рутинных методов: клиническая симптоматика, физикальное обследование, показатели состояния свертывающей системы, ЭКГ и рентгенологическое исследование, ЭХО-кардиография. В неспециализированном стационаре методом выбора является сугубо консервативное лечение антикоагулянтными препаратами прямого действия с последующим пролонгированным использованием непрямых антикоагулянтов или дезагрегантов

Dicobalt-μ-oxo Polyoxometalate Compound, [(α₂‑P₂W₁₇O₆₁Co)₂O]^14–: A Potent Species for Water Oxidation, C–H Bond Activation, and Oxygen Transfer

High-valent oxo compounds of transition metals are often implicated as active species in oxygenation of hydrocarbons through carbon–hydrogen bond activation or oxygen transfer and also in water oxidation. Recently, several examples of cobalt-catalyzed water oxidation have been reported, and cobalt­(IV) species have been suggested as active intermediates. A reactive species, formally a dicobalt­(IV)-μ-oxo polyoxometalate compound [(α₂-P₂W₁₇O₆₁Co)₂O]^14–, [(POMCo)₂O], has now been isolated and characterized by the oxidation of a monomeric [α₂-P₂W₁₇O₆₁Co^II(H₂O)]^8–, [POMCo^IIH₂O], with ozone in water. The crystal structure shows a nearly linear Co–O–Co moiety with a Co–O bond length of ∼1.77 Å. In aqueous solution [(POMCo)₂O] was identified by ³¹P NMR, Raman, and UV–vis spectroscopy. Reactivity studies showed that [(POMCo)₂O]₂O] is an active compound for the oxidation of H₂O to O₂, direct oxygen transfer to water-soluble sulfoxides and phosphines, indirect epoxidation of alkenes via a Mn porphyrin, and the selective oxidation of alcohols by carbon–hydrogen bond activation. The latter appears to occur via a hydrogen atom transfer mechanism. Density functional and CASSCF calculations strongly indicate that the electronic structure of [(POMCo)₂O]₂O] is best defined as a compound having two cobalt­(III) atoms with two oxidized oxygen atoms

Role of compressive tectonics on gas charging into the Ordovician sandstone reservoirs in the Sbaa Basin, Algeria: constrained by fluid inclusions and mineralogical data

International audienc

Matrix-matched quantitative analysis of trace-elements in calcium carbonate shells by laser-ablation ICP-MS: application to the determination of daily scale profiles in scallop shell (Pecten maximus)

International audienceA micro-scale method has been developed for analysis of trace-element concentration profiles in the calcium carbonate shell of the Great Scallop (Pecten maximus). UV laser ablation at 266-nm coupled with ICP-MS detection was used to analyse daily calcite striae of shell samples to obtain high temporal resolution of trace element incorporation. Analysis of scallop shells was carefully examined to determine the quality of calcium carbonate ablation and calibration. An accurate external calibration method based on matrix matching was developed. Twelve sodium-free enriched calcium carbonate standards containing up to twenty-four elements were prepared, by co-precipitation with aqueous ammonia and NH4HCO3, and subsequently back-calibrated in the laboratory. These CaCO3 standards were found to be homogenous and their use enabled sensitive quantitative analysis (detection limits of a few ng g−1) over a wide range of concentrations (0.1 to 500 μg g−1). Use of these CaCO3 standards was also evaluated by analysis of three calcium-rich certified reference materials. Because calibration was consistent with the certified results, this analytical method is a sensitive tool for analysis of environmental calcium carbonate matrices. Repeated analysis of scallop shell samples collected simultaneously at the same location showed that the trace elements are homogeneously distributed along a stria. The reliability of such in-situ records of biogenic calcium carbonate (scallop shells) is apparent from the inter-individual and inter-annual reproducibility of the trace element profiles