Maine Guide to Museums and Historic Homes

Maine Guide to Museums and Historic Homes Peter D. Bachelder, Editor - Fifth Edition A Publication of The Maine Publicity Bureau In Cooperation with the Maine Historic Preservation Commission, 1984-85 .https://digitalcommons.usm.maine.edu/me_collection/1020/thumbnail.jp

Fused Reality for Enhanced Flight Test Capabilities

The feasibility of using Fused Reality-based simulation technology to enhance flight test capabilities has been investigated. In terms of relevancy to piloted evaluation, there remains no substitute for actual flight tests, even when considering the fidelity and effectiveness of modern ground-based simulators. In addition to real-world cueing (vestibular, visual, aural, environmental, etc.), flight tests provide subtle but key intangibles that cannot be duplicated in a ground-based simulator. There is, however, a cost to be paid for the benefits of flight in terms of budget, mission complexity, and safety, including the need for ground and control-room personnel, additional aircraft, etc. A Fused Reality(tm) (FR) Flight system was developed that allows a virtual environment to be integrated with the test aircraft so that tasks such as aerial refueling, formation flying, or approach and landing can be accomplished without additional aircraft resources or the risk of operating in close proximity to the ground or other aircraft. Furthermore, the dynamic motions of the simulated objects can be directly correlated with the responses of the test aircraft. The FR Flight system will allow real-time observation of, and manual interaction with, the cockpit environment that serves as a frame for the virtual out-the-window scene

When Artificial Intelligence and Computational Neuroscience Meet

International audienceComputational Intelligence and Artificial Intelligence are both aiming at building machines and softwares capable of intelligent behavior. They are consequently prone to interactions, even if the latter is not necessarily interested in understanding how cognition emerges from the brain substrate. In this chapter, we enumerate, describe and discuss the most important fields of interactions. Some are methodological and are concerned with information representation, processing and learning. At the functional level, the focus is set on major cognitive functions like perception, navigation, decision making and language. Among the salient characteristics of the critical contributions of Computational Neuroscience to the development of intelligent systems, its systemic view of the cerebral functioning is particularly precious to model highly multimodal cognitive functions like decision makin

Regulatory networks defining EMT during cancer initiation and progression

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability

Molecular mechanisms of epithelial–mesenchymal transition

The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial–mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels. The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues. Among these, transforming growth factor-β (TGFβ) family signalling has a predominant role; however, the convergence of signalling pathways is essential for EMT