A multi-centre qualitative study exploring the experiences of UK South Asian and White Diabetic Patients referred for renal care

Background An exploration of renal complications of diabetes from the patient perspective is important for developing quality care through the diabetic renal disease care pathway. Methods Newly referred South Asian and White diabetic renal patients over 16 years were recruited from nephrology outpatient clinics in three UK centres - Luton, West London and Leicester – and their experiences of the diabetes and renal care recorded. A semi-structured qualitative interview was conducted with 48 patients. Interview transcripts were analysed thematically and comparisons made between the White and South Asian groups. Results 23 South Asian patients and 25 White patients were interviewed. Patient experience of diabetes ranged from a few months to 35 years with a mean time since diagnosis of 12.1 years and 17.1 years for the South Asian and White patients respectively. Confusion emerged as a response to referral shared by both groups. This sense of confusion was associated with reported lack of information at the time of referral, but also before referral. Language barriers exacerbated confusion for South Asian patients. Conclusions The diabetic renal patients who have been referred for specialist renal care and found the referral process confusing have poor of awareness of kidney complications of diabetes. Healthcare providers should be more aware of the ongoing information needs of long term diabetics as well as the context of any information exchange including language barriers

Target Mass Effects in Polarized Virtual Photon Structure Functions

We study target mass effects in the polarized virtual photon structure functions $g_1^\gamma (x,Q^2,P^2)$, $g_2^\gamma (x,Q^2,P^2)$ in the kinematic region $\Lambda^2\ll P^2 \ll Q^2$, where $-Q^2 (-P^2)$ is the mass squared of the probe (target) photon. We obtain the expressions for $g_1^\gamma (x,Q^2,P^2)$ and $g_2^\gamma (x,Q^2,P^2)$ in closed form by inverting the Nachtmann moments for the twist-2 and twist-3 operators. Numerical analysis shows that target mass effects appear at large $x$ and become sizable near $x_{\rm max}(=1/(1+\frac{P^2}{Q^2}))$, the maximal value of $x$, as the ratio $P^2/Q^2$ increases. Target mass effects for the sum rules of $g_1^\gamma$ and $g_2^\gamma$ are also discussed.Comment: 24 pages, LaTeX, 9 eps figure

Polarized Virtual Photon Structure Function g2γg_2^\gamma and Twist-3 Effects in QCD

We investigate the twist-3 effects in the polarized virtual photon structure. The structure functions $g_1^\gamma$ and $g_2^\gamma$ of polarized photon could be experimentally studied in the future polarized $ep$ or $e^+e^-$ colliders. The leading contributions to $g_1^\gamma$ are the twist-2 effects, while another structure function $g_2^\gamma$, which only exists for the virtual photon target, receives not only the twist-2 but also twist-3 contributions. We first show that the twist-3 effects actually exist in the box-diagram contributions and we extract the twist-3 part, which can also be reproduced by the pure QED operator product expansion. We then calculate the non-trivial lowest moment ($n=3$) of the twist-3 contribution to $g_2^\gamma$ in QCD. For large $N_c$ (the number of colors), the QCD analysis of the twist-3 effects in the flavor nonsinglet part of $g_2^\gamma$ becomes tractable and we can obtain its moments in a compact form for all $n$.Comment: 27 pages, LaTeX, 9 eps figures, eqsection.sty file included, Appendix A added, some minor changes for Fig.

The role of research in global food and nutrition security

The present discussion document gives an overview of where European research can add the most value in relation to tackling food and nutrition security challenges and points to areas where we can expand our research potential. Moreover, it highlights the need to develop a governance structure that will allow sharing of best practices and facilitate the transfer of knowledge and innovation to feed the planet sustainably. It should stimulate a global discussion with stakeholders and the general public, ultimately shaping a legacy for Expo 2015.JRC.A.TF-EXPO 201

Where are the High Velocity Clouds in Local Group Analogs?

High-velocity clouds (HVCs) are clouds of HI seen around the Milky Way with velocities inconsistent with Galactic rotation, have unknown distances and masses and controversial origins. One possibility is that HVCs are associated with the small dark matter halos seen in models of galaxy formation and distributed at distances of 150 kpc - 1 Mpc. We report on our attempts to detect the analogs to such putative extragalactic clouds in three groups of galaxies similar to our own Local Group using the ATNF Parkes telescope and Compact Array. Eleven dwarf galaxies were found, but no HI clouds lacking stars were detected. Using the population of compact HVCs around the Milky Way as a template, we find that our non-detection of analogs implies that they must be clustered within 160 kpc of the Milky Way (and other galaxies) with an average HI mass <4x10^5 M(sun) at the 95% confidence level. This is in accordance with recent limits derived by other authors. If our groups are true analogs to the Local Group, then this makes the original Blitz et al. and Braun & Burton picture of HVCs residing out to 1 Mpc from the Milky Way extremely unlikely. The total HI mass in HVCs, < 10^8 M(sun), implies that there is not a large reservoir of neutral hydrogen waiting to be accreted onto the Milky Way. Any substantial reservoir of baryonic matter must be mostly ionized or condensed enough as to be undetectable.Comment: 5 pages, 2 figures, ApJ letters, in pres

An HI survey of six Local Group analogs: I. Survey description and the search for high-velocity clouds

We have conducted an HI 21 cm emission-line survey using the Parkes 20cm multibeam instrument and the Australia Telescope Compact Array (ATCA) of six loose groups of galaxies chosen to be analogs to the Local Group. The goal of this survey is to make a census of the HI-rich galaxies and high-velocity clouds (HVCs) within these groups and compare these populations with those in the Local Group. The Parkes observations covered the entire volume of each group with a rms M(HI) sensitivity of 4-10x10^5 M(sun) per 3.3 km/s channel. All potential sources detected in the Parkes data were confirmed with ATCA observations at ~2' resolution and the same M(sun) sensitivity. All the confirmed sources have associated stellar counterparts; no starless HI clouds--HVC analogs--were found in the six groups. In this paper, we present a description of the survey parameters, its sensitivity and completeness. Using the population of compact HVCs (CHVCs) around the Milky Way as a template coupled with the detailed knowledge of our survey parameters, we infer that our non-detection of CHVC analogs implies that, if similar populations exist in the six groups studied, the CHVCs must be clustered within 90 kpc of group galaxies, with average M(HI) < 4x10^5 M(sun) at the 95% confidence level. The corollary is that the same must apply to Milky Way CHVCs. This is consistent with our previous results from a smaller sample of groups, and in accordance with recent observational and theoretical constraints from other authors. These results confirm that there is very little neutral matter around galaxies, and that any substantial reservoir of baryons must be in other phases.Comment: 10 pages, ApJ accepte

Report from the First Snake Genomics and Integrative Biology Meeting

This report summarizes the proceedings of the 1st Snake Genomics and Integrative Biology Meeting held in Vail, CO USA, 5-8 October 2011. The meeting had over twenty registered participants, and was conducted as a single session of presentations. Goals of the meeting included coordination of genomic data collection and fostering collaborative interactions among researchers using snakes as model systems.Organismic and Evolutionary Biolog

Report from the First Snake Genomics and Integrative Biology Meeting

This report summarizes the proceedings of the 1st Snake Genomics and Integrative Biology Meeting held in Vail, CO USA, 5-8 October 2011. The meeting had over twenty registered participants, and was conducted as a single session of presentations. Goals of the meeting included coordination of genomic data collection and fostering collaborative interactions among researchers using snakes as model systems

The New Galaxy: Signatures of its Formation

The formation and evolution of galaxies is one of the great outstanding problems of astrophysics. Within the broad context of hierachical structure formation, we have only a crude picture of how galaxies like our own came into existence. A detailed physical picture where individual stellar populations can be associated with (tagged to) elements of the protocloud is far beyond our current understanding. Important clues have begun to emerge from both the Galaxy (near-field cosmology) and the high redshift universe (far-field cosmology). Here we focus on the fossil evidence provided by the Galaxy. Detailed studies of the Galaxy lie at the core of understanding the complex processes involved in baryon dissipation. This is a necessary first step towards achieving a successful theory of galaxy formation.Comment: 51 pages (with figs embedded) + 4 colour plates. The interested reader is strongly encouraged to ignore the latex version and low res figures within; instead, download the properly typeset paper (6 Mby) and colour plates (3 Mby) from ftp://www.aao.gov.au/pub/local/jbh/araa/Galley

A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition

Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative colitis remain incompletely defined. Here, we aimed to identify novel associations between IBD and functional genetic variants using the Illumina ExomeChip (San Diego, CA)