Prognostic Value of Volumetric Parameters of PET-CT With Stage IIIB-IV Non-Small Cell Lung Cancer

Annual Congress of the European-Association-of-Nuclear-Medicine -- OCT 15-19, 2016 -- Barcelona, SPAINWOS: 000391802400538...European Assoc Nucl Me

Prognostic value of pre-and posttreatment PET/CT parameters in patients diagnosed with advanced stage NSCLC

Background: PET imaging involves several parameters. However, it is not well known which parameters in each measurable site of tumors may have a greater effect on oncologic outcomes. Method: This study included a total of 42 patients diagnosed with histology-proven NSCLC. Baseline and consecutive FDG-PET scans were carried out 3 weeks before and at least 3 months after treatment, respectively. Results: According to the PERCIST, 9 (21%) patients had Complete Response (CR), and 3 of them underwent surgical resection. Sixteen patients (38%) had Partial Response (PR), and 4 (9.5%) had Stable Disease (SD), the remaining 15 (35%) had Progressive Disease (PD). Patients who responded to the treatment had significantly higher Overall Survival (OS) and Progression Free Survival (PFS), 15 versus 9.5 months and 10 versus 6 months, respectively. The SUVmax values decreased from 12.2 to 3.7 (P=<0.001), and the mediastinal lymph nodes SUVmax decreased from 6 to 0 (P=<0.001) in the responder group. The median TLG of the primary lesion showed a statistically significant decrease from 279 to 13.6 (P=0.0001), the median TLG of the mediastinal lymph nodes decreased from 13.2 to 0 (P= 0.04), and the median Whole Body (WB) TLG decreased from 338 to 17 (P=0.002) in the responder group. The posttreatment WB TLG was significantly correlated with OS and PFS. Conclusion: This study showed that the posttreatment WB TLG is significantly associated with oncologic outcomes. The metabolic changes in the mediastinal lymph nodes, as shown by the SUVmax and TLG, have a prognostic value in patients who develop new metastases during treatment. Further study in a homogenous NSCLC population can help increase our understanding of the prognostic value of PET/CT parameters. © 2018 Bentham Science Publishers

Antiurease, antielastase and antioxidant activities of some monohydroxy tetradecanoic acid isomers

38th Congress of the Federation-of-European-Biochemical-Societies (FEBS) -- JUL 06-11, 2013 -- Saint Petersburg, RUSSIAyanardag, refiye/0000-0003-4185-4363WOS: 000325919202053…Federat European Biochemical So

Chemical Composition and Repellent Activity of the Essential Oil of Ocimum minimum L. on Drosophila Species

The chemical composition of the essential oil of Ocimum minimum L. from Istanbul, Turkey was investigated and repellent activity against Drosophila species were examined. Ocimum minimum L. grown in Istanbul with its high content of linalool (36-41 %) showed a good repellency