A közösségi életre nevelés speciális pedagógiai eszközei

Az ember szellemi és lelki értelemben szociális lény. A közösség egyidejűleg életének mind eszköze, mind értelme és célja. Minden emberi cselekedet a csoporthoz, egy adott közösséghez viszonyítva történik. A túlélés előfeltételei a kooperáció és közösségi érzés. Az együttélés vaslogikája alól senki sem tudja magát kivonni. A személyiség fejlődése, az önmegvalósítás csak mintegy az én és a te közötti interakcióként szemlélhető, illetve az összetartozás által strukturált csoportban, közösségben képzelhető el. E fontos alapvetésekre építve, tanulmányunkban a közösségi életre nevelés speciális pedagógiai eszközeinek megismertetését célzó, szakirányú pedagógiai továbbképzésre kidolgozott tananyagok főbb tartalmi elemeit ismertetjük

Targeting vascular endothelial growth factor receptor 2 and protein kinase d1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro.

Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2) and protein kinase D1 (PKD1) signaling axis plays a critical role in normal and pathological angiogenesis and inflammation related processes. Despite all efforts, the currently available therapeutic interventions are limited. Prior studies have also proved that a multiple target inhibitor can be more efficient compared to a single target one. Therefore, development of novel inflammatory pathway-specific inhibitors would be of great value. To test this possibility, we screened our molecular library using recombinant kinase assays and identified the previously described compound VCC251801 with strong inhibitory effect on both VEGFR2 and PKD1. We further analyzed the effect of VCC251801 in the endothelium-derived EA.hy926 cell line and in different inflammatory cell types. In EA.hy926 cells, VCC251801 potently inhibited the intracellular activation and signaling of VEGFR2 and PKD1 which inhibition eventually resulted in diminished cell proliferation. In this model, our compound was also an efficient inhibitor of in vitro angiogenesis by interfering with endothelial cell migration and tube formation processes. Our results from functional assays in inflammatory cellular models such as neutrophils and mast cells suggested an anti-inflammatory effect of VCC251801. The neutrophil study showed that VCC251801 specifically blocked the immobilized immune-complex and the adhesion dependent TNF-alpha -fibrinogen stimulated neutrophil activation. Furthermore, similar results were found in mast cell degranulation assay where VCC251801 caused significant reduction of mast cell response. In summary, we described a novel function of a multiple kinase inhibitor which strongly inhibits the VEGFR2-PKD1 signaling and might be a novel inhibitor of pathological inflammatory pathways

Development of Linguistic-Communication Competences in Preschools. Factors Influencing Language Competences – Their Level and Measurement

Children entering institutional education can activate the linguistic and non-linguistic norms they bring from home. These norms, however, are very diverse in their nature and children from the same age-group remain at different levels in terms of language-acquisition. In our paper we seek to identify where and what sort of problems may arise in acquiring the mother-tongue, what factors may hinder the acquisition of the first language, what are the symptoms of backwardness in the field of linguistic–communication and which areas measuring tests tend to focus upon. Finally by presenting an indication system we would like to show what opportunities observation may have in purposeful development.Keywords: native language acquisition, linguistic competence, measurementof communication skills, observation of children’s language performance