Introducing a Framework for Open and Reproducible Research Training (FORRT)

The Framework for Open and Reproducible Research Training (FORRT) addresses the underappreciated pedagogical aspect of open and reproducible science and its associated challenges, including a need for curricular reform, an account of epistemological pluralism, the development of new methods of education, and questions around how open science practices relate to social justice and a principled academic education. Teachers’ and researchers’ time constraints are substantial, posing a challenge to developing course materials and integrating new research practices in teaching. FORRT has developed strategies and proposed solutions to mitigate time constraints and help scholars implement open and principled education in their workflows. FORRT’s e-learning platform is a hub for community-driven initiatives and resources. FORRT’s community conceptualized our educational Nexus as integrating diverse components into one infrastructure serving those wishing to learn, adopt, and disseminate open and reproducible science tenets. In this talk, we will explain each element of FORRT’s open educational resources, FORRT’s ethos and modus operandi. Elements of the Nexus (https://forrt.org/nexus) are: FORRT’s Clusters (a pedagogically-driven organization of OS literature), Curated Resources (database of >1000 resources on OS), Initiatives Towards Social Justice in Academia (where we link mentees of unprivileged backgrounds to mentors of privileged ones), Open & Reproducible Science Summaries (having more than 300 summaries of OS literature), 7-ways to adopt principled teaching and mentoring practices (listing 100+ low commitment ways to interact with OS), Open & Reproducible Science Syllabus (a boiler-plate template for OS course that can be readily adapted and implemented in teachers’ courses), Self-Assessment Tool (a dynamic survey giving teachers feedback on how to integrate OS into their teaching), and finally, Educator’s Corner (offering a platform for educators of all stripes to share their stories, experiences, successes and hardships in teaching and mentoring, as well as for sharing educational practices and initiatives that are of interest to the OS community).&nbsp

Expression of MMP-13 in Human Temporomandibular Joint Disc Derangement and Osteoarthritis

Objective: MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis. Methods: Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples). Immunostaining of the TMJ discs was statistically compared between the groups. Results: There was no statistically significant difference for the area of MMP-13 immunostaining between the control group, ADDwR, and ADDwoR, nor between groups with and without osteoarthrosis. Conclusion: This study suggests MMP-13 is not significantly involved in collagen degradation in human TMJ disc displacement or osteoarthrosis

Expansão da firma na indústria do petróleo: uma análise das estratégias da Petrobras

Analisa as estratégias adotadas pelas empresas na indústria do petróleo. O objetivo é concluir acerca das estratégias adotadas pela Petrobras, maior empresa da indústria brasileira de petróleo, para o crescimento de seus negócios. Desta forma, revisou-se a produção teórica que aborda o crescimento das firmas, e foi analisada a cadeia da indústria do petróleo. O estudo sobre a história da indústria no Brasil e no mundo permitiu verificar de que maneira as estratégias adotadas pelas grandes empresas do setor, inclusive pela Petrobras, foram importantes para seu crescimento. A Petrobras, por ser uma empresa de capital aberto, divulga alguns relatórios em seu website, contendo informações importantes sobre as atividades da empresa. A análise das estratégias da Petrobras foi feita através da leitura dos planos de negócios e dos relatórios de atividades divulgados publicamente pela mesma entre 2009 e 2011

FasL Expression in Articular Discs of Human Temporomandibular Joint and Association with Osteoarthrosis

Background Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis. Fas ligand (FasL) is an apoptosis‐inducing factor, known to trigger apoptosis through distinct signal pathways. This study aims to examine, by immunohistochemistry, the expression of FasL in temporomandibular joint (TMJ) articular discs of patients with anterior disc displacement with reduction (ADDwR) and without reduction (ADDwoR) in patients with and without osteoarthrosis (OA). Methods Forty‐two (n = 42) TMJ articular discs were divided into two cut‐offs: (i) 8 control, 17 ADDwR, 17 ADDwoR, and (ii) without OA (n = 25) and with OA (n = 17). The area of immunostaining was compared statistically between groups (P \u3c 0.05). Results Statistically significant differences were found in the expression of FasL in TMJ discs between the three groups (P = 0.001). ADDwR presented significant higher FasL expression when compared with ADDwoR (P \u3c 0.001). Significant higher FasL expression was observed in the group without OA (P = 0.001). All patients without OA presented ADDwR, while all the patients with OA presented ADDwoR. Conclusion A higher area of in situ immunostaining of FasL was found in temporomandibular discs with reduction, which is the less severe condition. Moreover, a reduced expression of FasL in the discs of patients with osteoarthrosis was found, suggesting that some aspects of apoptosis might underlie the progression of TMJ disorders

Interleukin-6 Expression in Disc Derangement of Human Temporomandibular Joint and Association with Osteoarthrosis

The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims to examine, by immunohistochemistry, the expression of interleukin-6 (IL-6), an important inflammatory marker, in temporomandibular articular discs of patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR) and its association with osteoarthrosis (OA). Thirty-eight (n = 38) articular discs were divided into two cutoffs: 1) analysis 1: 4 control (acute pathology), 17 ADDwR, 17 ADDwoR; and 2) analysis 2: without OA (n = 21) and with OA (n = 17). The area of immunostaining was compared statistically between groups (p \u3c 0.05). In the disc samples, no significant differences were observed between the groups ADDwR and ADDwoR, and with and without OA, in respect to the expression of IL-6 by immunohistochemical examination. Future studies should be conducted with a larger sample size, which could clarify the association of the inflammatory mediator IL-6 with temporomandibular joint dysfunction

The Paranoid Style in American Politics Revisited: An Ideological Asymmetry in Conspiratorial Thinking

It is often claimed that conspiracy theories are endorsed with the same level of intensity across the left‐right ideological spectrum. But do liberals and conservatives in the United States embrace conspiratorial thinking to an equivalent degree? There are important historical, philosophical, and scientific reasons dating back to Richard Hofstadter's book The Paranoid Style in American Politics to doubt this claim. In four large studies of U.S. adults (total N = 5049)—including national samples—we investigated the relationship between political ideology, measured in both symbolic and operational terms, and conspiratorial thinking in general. Results reveal that conservatives in the United States were not only more likely than liberals to endorse specific conspiracy theories, but they were also more likely to espouse conspiratorial worldviews in general (r = .27, 95% CI: .24, .30). Importantly, extreme conservatives were significantly more likely to engage in conspiratorial thinking than extreme liberals (Hedges' g = .77, SE = .07, p < .001). The relationship between ideology and conspiratorial thinking was mediated by a strong distrust of officialdom and paranoid ideation, both of which were higher among conservatives, consistent with Hofstadter's account of the paranoid style in American politics

Intestinal constipation in intensive care units

Constipation is a common complication identified among critically ill patients. Its incidence is highly variable due to lack of definition of such patients. Besides the already known consequences of constipation, in recent years it was observed that this complication may also be related to worse prognosis of critically ill patients. This review endeavors to describe the main available scientific evidence showing that constipation is a prognostic marker and a clinical representation of intestinal dysfunction, in addition to eventually interfering in the prognosis with treatment. Ogilvie syndrome, a major cause of morbidity and mortality in intensive care units was also reviewed. Considering the above cases it was concluded that more attention to this disorder is required in intensive care units as well as development of protocols for diagnosis and management of critically ill patients.A constipação intestinal é uma complicação comumente identificada entre pacientes graves. Sua incidência é bastante variável devido à carência de uma definição aplicável a estes pacientes. Além das consequências já conhecidas da constipação, nos últimos anos tem-se percebido que essa complicação também pode estar relacionada ao pior prognóstico de pacientes críticos. Ao longo desta revisão procurou-se descrever as principais evidências científicas disponíveis mostrando ser a constipação um marcador prognóstico e uma das representações clínicas da disfunção intestinal, além da possibilidade de interferir no prognóstico com o tratamento. Revisou-se também a síndrome de Ogilvie, importante causa de morbidade e mortalidade nas unidades de terapia intensiva. Conclui-se, por todo o exposto, ser necessária mais atenção a esse distúrbio nas unidades de terapia intensiva, com elaboração de protocolos de diagnóstico e manejo em pacientes graves.Universidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Maturity and readiness of the Manaus industrial pole: case study of the television product / Maturidade e prontidão do polo industrial de Manaus: estudo de caso do produto televisor

The Manaus Industrial Pole is an important mechanism for regional development, in addition to enabling conservation of the Amazon Forest, having the Basic Productive Process as the main instrument of industrial policy. This article evaluates aspects for its continuity with the advent of Industry 4.0, through a Maturity and Readiness Model applied to its highest billing product: the television. The statistical validation of the research was obtained through structural equations modeling, using the SmartPLS® 3.0 software. The founded results were compared to those of an already tested Maturity and Readiness Model named PIM M4.0®, highlighting logistical interoperability

“Not Racist, But...”: Beliefs About Immigration Restrictions, Collective Narcissism, and Justification of Ethnic Extremism

Surveys conducted across multiple countries show that most people view seeking lower immigration to help maintain the majority group's population share as a sign of racial self-interest—as opposed to racism. We investigated whether the belief that it is not racist to want immigration restrictions for cultural reasons is associated with ingroup identification (a positive attachment to and solidarity with one's group) or collective narcissism (a conviction that the ingroup is exceptional and deserves special treatment). We argue that if this belief reflects concern for the ingroup, it should be linked to ingroup identification. However, if it is a defensive justification of the ingroup's privileged position, it should be linked to collective narcissism. Across four studies, national (Study 1: United Kingdom, N = 46