The Views of University Students Regarding Social Justice

Araştırmanın amacı üniversite öğrencilerinin sosyal adalete ilişkin görüşlerinin belirlenmesidir. Bu çalışma, betimsel bir çalışmadır. Araştırmanın çalışma grubunu Kırıkkale Üniversitesi Eğitim Fakültesi, Fen ve Edebiyat Fakültesi, İktisadi ve İdari Bilimler Fakültesi; Erzincan Üniversitesi Eğitim Fakültesi'nden 2011-2012 eğitim-öğretim yılı bahar döneminde 1.-4. sınıflarında öğrenim görmekte olan 248 öğrenci oluşturmaktadır. Çalışma grubunun seçiminde uygun örnekleme yöntemi kullanılmıştır. Araştırmada veri toplama aracı olarak üniversite öğrencilerinin sosyal adalet hakkındaki görüşlerini belirlemek amacıyla araştırmacılar tarafından geliştirilmiş Sosyal Adalet Kavramına İlişkin Görüşler Formu kullanılmıştır. Bu form, öğrencilerin bu konudaki görüşlerini belirtmelerine yönelik dört açık uçlu sorudan oluşmaktadır. Sosyal adalete dair öğrenci görüşlerine ilişkin frekans ve yüzdeler hesaplanmıştır. Sosyal adalete ilişkin üniversite öğrencilerinin görüşleri arasında; insanların sosyal adalet konusunda bilinçlendirilmesi, herkese adil, eşit, değerli, önyargısız ve saygılı davranma, bir toplumu oluşturan bireylerin eşit hak ve özgürlüklere sahip olması, bireyler arasında sosyal bir fark olmaması yer almıştır. Araştırma bulguları tartışılmış ve önerilerde bulunulmuşturIn this study, it is aimed to determine the views of university students regarding social justice. The study is a descriptive type of study. The study group consisted of 248 1-4th year students studying at Kırıkkale University Faculty of Education, Faculty of Letters and Science, Faculty of Economics & Administrative Sciences, and Erzincan University Faculty of Education in fall 2011-2012 academic year. In the choice of study group is used convenience sampling. In this study, Students' Views Regarding Social Justice Form were developed by the researchers in order to determine the views of university students. These forms consisted of four open ended questions related to the students' views about social justice. The answers given to the four open ended questions in the form were combined and gathered under common headers. Frequency and percentages were calculated about student opinions regarding social justice. University students opinions' regarding social justice revealed that the raising awareness about opinions about social justice, educating and learning justice with regards to legal, treating, fair, equal, valuable, respectful and unprejudiced to everybody, giving the individuals getting society equal right and freedom, not being any social differences between individuals. The findings of this study were discussions and suggestions were made in parallel with the finding

Developmental expression of p97/VCP (Valosin-containing protein) and Jab1/CSN5 in the rat testis and epididymis

<p>Abstract</p> <p>Background</p> <p>The ubiquitin proteasome system (UPS) is a key player in regulating many cellular processes via proteasomal degradation of ubiquitinated proteins. Recently published data show that Jab1/CSN5 interacts with p97/VCP and controls the ubiquitination status of proteins bound to p97/VCP in mouse and human cells. However, coexpression of p97/VCP and Jab1/CSN5 in the developing rat testis and epididymis has not previously been studied.</p> <p>Methods</p> <p>Testicular and epididymal tissues from 5-, 15-, 30-, and 60-day-old rats were examined by immunohistochemistry and Western blotting. Colocalisation of proteins was determined by immunofluorescence microscopy.</p> <p>Results</p> <p>In the 5-day-old rat testis, p97/VCP and Jab1/CSN5 were specifically expressed in gonocytes. The expression of p97/VCP and Jab1/CSN5 significantly increased at day 15 and was found in spermatogonia, Sertoli cells and spermatocytes. In 30- and 60-day-old rat testes, p97/VCP indicated moderate to strong expression in Sertoli cells, spermatogonia, round and elongating spermatids. However, moderate to weak expression was observed in spermatocytes. Jab1/CSN5 showed strong expression in spermatogonia and spermatocytes, while relatively moderate expression was observed in round and elongating spermatids in 30- and 60-day-old rat testes. In contrast, in the epididymis, the expression of both proteins gradually increased from 5 to 60 days of age. After rats reached 2 weeks of age, the expression of both proteins was mostly restricted to the basal and principal cells of the caput epididymis.</p> <p>Conclusions</p> <p>Our study suggests that p97/VCP and Jab1/CSN5 could be an important part of the UPS in the developing rat testis and epididymis and that both proteins may be involved in the regulation of spermatogenesis and epididymal epithelial functions.</p

Beneficial effects of melatonin and BQ-123 on the rat testis damage caused by cigarette smoke

Background/aim: Several studies have demonstrated that cigarette smoke has detrimental effects on testicular function. However, it is unknown whether melatonin or BQ-123 has beneficial effects on the rat testis damage caused by cigarette smoke. The aim of the present study was to investigate the beneficial effects of melatonin or BQ-123 on the testicular damage caused by cigarette smoke. Materials and methods: Twenty Wistar rats were randomly divided into 4 equal groups: control group (n = 5), cigarette smoke group (n = 5), melatonin group (n = 5), and BQ-123 group (n = 5). At the end of 4 weeks, all the rats were sacrificed for histopathological evaluation and subsequent stereological analysis. The optical fractionator counting method, the most efficient and unbiased method, was used to estimate the total number of spermatogonia and spermatocytes. Results: All the control testes demonstrated complete spermatogenesis. There was a significant decrease in the germ cells of rats exposed to cigarette smoke for 4 weeks. After the application of melatonin or BQ-123, the total number of spermatogonia and spermatocytes in the testes was significantly higher. Conclusion: Based on these findings, melatonin and BQ-123 are able to minimize the degenerative effects of cigarette smoke by increasing the germ cell count.Gaziosmanpasa University Research FundGaziosmanpasa University [2006/19]This study was supported by Gaziosmanpasa University Research Fund Project no. 2006/19. We thank Dr Bahadir Ungor (rest in peace) for all his assistance

TURKISH JOURNAL of ONCOLOGY Leptomeningeal Carcinomatosis in a Krukenberg Tumor Associated with Signet Ring Cell Gastric Cancer

SUMMARY Leptomeningeal carcinomatosis (LCM) is a rare complication of gastric cancer. It usually occurs late in advanced stage of disease and is sometimes misdiagnosed as toxicity of chemotherapeutic agents. Here we report a rare case of gastric cancer that developed LCM in follow-up. A 28-year-old woman with signet ring cell gastric cancer associated with Krukenberg tumor was admitted with persistent headache, nausea, vomiting, vertigo, and diplopia. Linear appearance of contrast enhancement in cerebellar fissures and around cranial nerves was seen in magnetic resonance imaging and cerebrospinal fluid was hypercellular with numerous carcinoma cells. LMC was confirmed and treated with intrathecal methotrexate and additional whole-brain irradiation. LCM is a rare complication, but occurs more often than expected and is often misdiagnosed. If patient who is being treated for gastric cancer presents with neurological symptoms, LCM should be kept in mind. Clinical improvement can be achieved with current treatment modalities, including radiotherapy, chemotherapy, or targeted molecules

İncisional endometrioma mimicking a malignant mass: report of two cases

Endometriozis dogurganlık çagındaki kadınlarda sık görülen klinik bir problemdir. Insizyon yerlesimli endometriomaya ise nadir rastlanır. Hastalarda genellikle sezaryen veya histerektomi gibi ameliyat öyküsü vardır. Endometriomayı olusturan dokudan malignite gelisebildigi bildirilmistir. Jinekolojik bir patoloji olmasına ragmen insizyonel herni ya da karın duvarı tümörleri gibi bulgu verebilmekte ve bu nedenle hastalar genellikle genel cerrahi polikliniklerine basvurmaktadırlar. Biz bu çalısmada dogurganlık çagında olan ve daha önce sezaryen ameliyatı öyküsü bulunan, klinik ve laboratuar olarak malignite süphesi tasıyan iki olguyu sunduk. Tedavide sezaryen skarındaki kitlelere genis eksizyon yapıldı ve olusan fasya defekti primer onarıldı. Patolojik inceleme sonucu kitlelerin endometrium dokusuna sahip endometrioma oldugu saptandı.Endometriosis is a common clinical problem of the child-bearing women. Incisional endometrioma is very rare. Patients frequently presented with a history of previous gynecological surgery such as cesarean section or hysterectomy. Although being a gynecological disorder, it may seem like an incisional hernia or abdominal wall tumor. Therefore, it is frequently referred to general surgery outpatient clinics. Here, we report two cases with previous histories of cesarean sections and questinable clinical and laboratory findings of malignancy. The masses located on the previous incision scars were excised widely, and pathological examination of surgical specimens revealed the diagnosis of endometrioma in both cases

Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes

This research was originally published in Blood Online. Tummala, H., et al. (2018). "Homozygous OB-fold variants in telomere protein TPP1 are associated with dyskeratosis congenita–like phenotypes." Blood 132(12): 1349-1353. Title. Blood. Prepublished Sept 20 2018; DOI https://doi.org/10.1182/blood-2018-03-837799Dyskeratosis congenita (DC) and its severe form, Hoyeraal-Hreidarsson syndrome (HHS), are rare and have life-threatening failure of hematopoiesis. Typically, DC patients present with disease features such as nail dystrophy, oral leukoplakia, and abnormal skin pigmentation along with peripheral pancytopenia and marrow hypoplasia with strong predisposition to cancer.1 In DC, hematopoietic failure occurs due to critical shortening of telomeres,2,3 which enhances the DNA damage response4,5 and leads to premature senescence of hematopoietic stem cellsMedical Research Council (grant MR/P018440/1), Bloodwise (grant 14032), and Children with Cancer UK (grant 2013/144)

Beta1-Adrenoceptor Polymorphism Predicts Flecainide Action in Patients with Atrial Fibrillation

BACKGROUND: Antiarrhythmic action of flecainide is based on sodium channel blockade. Beta(1)-adrenoceptor (beta(1)AR) activation induces sodium channel inhibition, too. The aim of the present study was to evaluate the impact of different beta(1)AR genotypes on antiarrhythmic action of flecainide in patients with structural heart disease and atrial fibrillation. METHODOLOGY/PRINCIPAL FINDINGS: In 145 subjects, 87 with atrial fibrillation, genotyping was performed to identify the individual beta(1)AR Arg389Gly and Ser49Gly polymorphism. Resting heart rate during atrial fibrillation and success of flecainide-induced cardioversion were correlated with beta(1)AR genotype. The overall cardioversion rate with flecainide was 39%. The Arg389Arg genotype was associated with the highest cardioversion rate (55.5%; OR 3.30; 95% CI; 1.34-8.13; p = 0.003) compared to patients with Arg389Gly (29.5%; OR 0.44; 95% CI; 0.18-1.06; p = 0.066) and Gly389Gly (14%; OR 0.24; 95% CI 0.03-2.07; p = 0.17) variants. The single Ser49Gly polymorphism did not influence the conversion rate. In combination, patients with Arg389Gly-Ser49Gly genotype displayed the lowest conversion rate with 20.8% (OR 0.31; 95% CI; 0.10-0.93; p = 0.03). In patients with Arg389Arg variants the heart rate during atrial fibrillation was significantly higher (110+/-2.7 bpm; p = 0.03 vs. other variants) compared to Arg389Gly (104.8+/-2.4 bpm) and Gly389Gly (96.9+/-5.8 bpm) carriers. The Arg389Gly-Ser49Gly genotype was more common in patients with atrial fibrillation compared to patients without atrial fibrillation (27.6% vs. 5.2%; HR 6.98; 95% CI; 1.99-24.46; p<0.001). CONCLUSIONS: The beta(1)AR Arg389Arg genotype is associated with increased flecainide potency and higher heart rate during atrial fibrillation. The Arg389Gly-Ser49Gly genotype might be of predictive value for atrial fibrillation

An effective method for videorecording the nasal-dorsal part of a rhinoplasty - a multiple case study

WOS: 000391177400005PubMed ID: 27797290Rhinoplasty is a difficult procedure to record for several reasons which include the narrow, dark and deep surgical field cluttered with many instruments, and the heads and hands of the surgical team often blocking the view. This study discusses 13 rhinoplasty cases that were recorded using the authors' technique. A three-minute, unedited segment was extracted from the mid-portion of each surgical case, and that footage was evaluated by three specialist examiners. Results indicate that the authors' technique can offer a effective solution in the video recording of the nasal-dorsal part of a rhinoplasty

An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools

Concentrations of volatile organic compounds (VOCs), including formaldehyde, in classrooms, kindergartens, and outdoor playgrounds of three primary schools were measured in spring, winter, and fall terms in Izmir, Turkey. A health-risk assessment was conducted for odor detection, sensory irritation, chronic toxic effects, and cancer. Active sampling was applied for VOCs and formaldehyde on Tenax TA and DNPH tubes, respectively. VOCs were analyzed in a thermal desorption-GC-MS system. Formaldehyde analysis was performed using an HPLC instrument. Benzene, toluene, and formaldehyde were the most abundant compounds with 95th percentile indoor air concentrations of 29, 87, and 106μg/m3, respectively. Naphthalene and xylenes followed them with an order of magnitude lower concentrations. Two isomers of dichlorobenzene (1,3 and 1,4) were the other notable compounds. The concentrations were utilized to classify the indoor air pollutants with respect to potential health effects. In addition, carcinogenic and chronic toxic risks were estimated using Monte-Carlo simulation. Formaldehyde appears to be the most concerning pollutant with high chronic toxic and carcinogenic risk levels according to the health assessment followed by naphthalene, benzene, and toluene due to their chronic effects