Evaluasi Ekstrak Tali Putri (Cassytha Filiformis Linn) Terhadap Efek Diuretik Dan Daya Larut Batu Ginjal

                                                ABSTRAK                                    Batu ginjal merupakan salah satu penyebab terjadinya gejala gagal ginjal kronik dan akut. Tali putri ini secara tradisional dipercaya mengobati batu saluran kencing. Penelitian ini bertujuan untuk mengetahui efek diuretik terhadap tikus jantan dan daya larut batu ginjal secara in vitro. Efek diuretik diuji dengan lima kelompok yang terdiri dari kontrol positif diberi furosemid, kontrol negatif diberi larutan NaCMC 5% dan tiga kelompok lagi diberi ekstrak tali putri dengan dosis 37,5mg/kgBB, 75 mg/kgBB dan 150 mg/kgBB secara berurutan. Tikus diberi perlakuan selama 15 hari dengan pengumpulan volume urin 2 jam dan 24 jam pada hari ke-5,10 dan 15. Hasil analisa ANOVA-two ways dengan Duncan’s Test menunjukkan adanya pengaruh volum urin 24 jam terhadap faktor perlakuan secara sangat bermakna (P<0,01) dan faktor waktu secara bermakna (P<0,05). Sedangkan hasil pengukuran volume urin 2 jam terhadap faktor perlakuan dan waktu berbeda secara sangat bermakna (P<0,01). Efek daya larut batu ginjal ekstrak tali putri meningkat dengan peningkatan konsentrasi.Kata kunci: Cassytha filiformis, diuretik, batu ginjal Kidney stones are one of the causes of symptoms of chronic and acute kidney failure. Cassytha filiformis is believed to be able to cure kidney stones. This study aims to determine the diuretic effect on rat and solubility of kidney stone in vitro. The diuretic effect with five groups consisting of positive control was given furosemide, negative control was given 5% NaCMC and three more groups with extracts of 37.5mg / kgBW, 75 mg / kgBW and 150 mg / kgBW respectively. Rats were treated for 15 days with a volume of urine 2 hours and 24 hours on days 5.10 and 15. The results of the two-way ANOVA analysis with the Duncan’s test to determine the 24-hour urine volume factor significantly (P <0, 01) and time factor significantly (P <0.05). While the results of measurements of urine volume 2 hours against factors and time were significantly different (P <0.01). The solubility of kidney stones to Cassytha filiformis’s extract increases by increasing it’s concentration.Keyword: Cassytha filiformis, diuretic, kidney stoneÂ

Evaluasi Ekstrak Tali Putri (Cassytha Filiformis Linn) Terhadap Efek Diuretik Dan Daya Larut Batu Ginjal

                                                ABSTRAK                                    Batu ginjal merupakan salah satu penyebab terjadinya gejala gagal ginjal kronik dan akut. Tali putri ini secara tradisional dipercaya mengobati batu saluran kencing. Penelitian ini bertujuan untuk mengetahui efek diuretik terhadap tikus jantan dan daya larut batu ginjal secara in vitro. Efek diuretik diuji dengan lima kelompok yang terdiri dari kontrol positif diberi furosemid, kontrol negatif diberi larutan NaCMC 5% dan tiga kelompok lagi diberi ekstrak tali putri dengan dosis 37,5mg/kgBB, 75 mg/kgBB dan 150 mg/kgBB secara berurutan. Tikus diberi perlakuan selama 15 hari dengan pengumpulan volume urin 2 jam dan 24 jam pada hari ke-5,10 dan 15. Hasil analisa ANOVA-two ways dengan Duncan’s Test menunjukkan adanya pengaruh volum urin 24 jam terhadap faktor perlakuan secara sangat bermakna (P<0,01) dan faktor waktu secara bermakna (P<0,05). Sedangkan hasil pengukuran volume urin 2 jam terhadap faktor perlakuan dan waktu berbeda secara sangat bermakna (P<0,01). Efek daya larut batu ginjal ekstrak tali putri meningkat dengan peningkatan konsentrasi.Kata kunci: Cassytha filiformis, diuretik, batu ginjal Kidney stones are one of the causes of symptoms of chronic and acute kidney failure. Cassytha filiformis is believed to be able to cure kidney stones. This study aims to determine the diuretic effect on rat and solubility of kidney stone in vitro. The diuretic effect with five groups consisting of positive control was given furosemide, negative control was given 5% NaCMC and three more groups with extracts of 37.5mg / kgBW, 75 mg / kgBW and 150 mg / kgBW respectively. Rats were treated for 15 days with a volume of urine 2 hours and 24 hours on days 5.10 and 15. The results of the two-way ANOVA analysis with the Duncan’s test to determine the 24-hour urine volume factor significantly (P <0, 01) and time factor significantly (P <0.05). While the results of measurements of urine volume 2 hours against factors and time were significantly different (P <0.01). The solubility of kidney stones to Cassytha filiformis’s extract increases by increasing it’s concentration.Keyword: Cassytha filiformis, diuretic, kidney stone

ISOLASI BAKTERI DAN JAMUR TANAH PENGHASIL ANTIBIOTIKA

The isolation of soil microorganism producing antibiotics found in soil sample at the "Gunung Padang" West Sumatera have been conducted, by inoculating the diluted sample into Nutrient Agar and Potato Dextrose Agar media

AKTIVITAS ANTIDIARE SARI TUMBUHAN ELEPHANTOPUS SCABER LINN.

An antidiarrhoea activities of Elephantopus scaber Linn. extract has been performed on male mice. Intestinal transit method was used with defecation pattern as parameter obsebed. The dosage75,750,300 and 600 mglkg B\f were given orally. The result showed that the oral dosage ) 150 mglkg B\f depressed the intestinal pristaltic and eucounter the diarrhoea effect N'hich was affected by ricini oil without influenced the feces consistency on the treated animals relative to the control group

PARENTERAL NUTRITION IN NEONATUS AND COMPATIBILITY ISSUES: A REVIEW ARTICLE

Intravenous drug administration in Neonatal Intensive Care Unit is critical because of poor venous access, polymedication, fluid restriction, and lowinfusion rate. Since parenteral nutrition (PN) is infused intravenously, it is often considered as a vehicle for medication administration. Medicationsmay be added to PN formulations in an effort to decrease fluid requirements, reduce the need for Y-site injections, reduce the possibility of line contamination due to manipulation, and decrease labor time required for drug administration. Risk is further increased by inadequate information on the physicochemical compatibility of drugs.Keywords: Parenteral nutrition, Neonatus, Compatibility

Analisis Bentuk Tawar dan Fungsi Tuturan Tawar Pengobatan pada Masyarakat Dayak Bakumpai di Datah Bilang Kabupaten Mahakam Ulu

Tawar adalah sarana pengobatan yang di gunakan oleh masyarakat dayak Bakumpai di Desa Datah Bilang. Tuturan tawar Bakumpai memiliki fungsi yaitu sebagai pengobatan. Tawar dapat di lakukan kapan saja saat pasien membutuhkan atau disaat sakit, dan juga menyiapkan beberapa peralatan untuk melakukan tawar. Permasalahan yang dikaji dalam penelitian ini adalah (a) Bagaimana bentuk tuturan tawar pengobatan di Desa Datah Bilang Ilir Kabupaten Mahakam Ulu di tinjau dari sudut mantra; (b) Bagaimana fungsi tuturan tawar pengobatan pada masyarakat Dayak Bakumpai di Desa Datah Bilang Kabupaten Mahakam Ulu. Tujuan dari penelitian ini adalah (a) Untuk mendeskripsikan bentuk tuturan mantra pengobatan dalam kehidupan masyarakat Dayak Bakumpai di Desa Datah Bilang Ilir Kabupaten Mahakam Ulu; (b) Untuk mendeskripsikan fungsi tuturan Mantra pengobatan dalam kehidupan masyarakat Dayak Bakumpai di Desa Datah Bilang Ilir Kabupaten Mahakam Ulu. Metode yang di gunakan dalam penelitian ini adalah kulitatif menggunakan teknik observasi, wawancara, catat, rekam dan nyimak. Hasil penelitian yang di peroleh dari analisis data yang telah dilakukan penulis, maka ditemukan hasil penelitian berupa (i) mantra terdiri atas beberapa rangkaian kata berima; (ii) bersifat lisan, sakti atau magis; (iii) asoferik (bahasa khusus antara pembaca dengan lawar bicara); (iv) menggunakan kata-kata yang kurang umum di gunakan didalam kehidupan sehari-hari. Fungsi tuturan mantra tawar pengobatan suku Bakumpai berdasalkan hasil analisis fungsinya yakni (i) fungsi mantra sebagai alat pengendali social; (ii) fungsi mantra sebagai pengingat; (iii) fungsi mantra sebagai toleransi; (iv) fungsi mantra sebagai sarana untuk berdoa

The effect of ethanol extract of beetroot (L.) on the number, morphology spermatozoa and testis weighin Male Mice (Mus Musculus) by exposure to heat

This research aimed to know the influence of ethanol extract of beetroot (L.) on the number, morphology spermatozoa and testis weighin male mice (Mus musculus) by by exposure to heat. This research was conducted by using Post Test Only Control Group Design. Data was statistically analyzed by using onewayANOVA followed by Duncan Post Hoc Test (P<0.05).The study used 30 male mice aged 2-3 months, weight 20-35 g and were randomly divided into 5 groups with 6 mice each groups. Group K- (negative control) were given distilled water, Group K+ (positive control) is exposed to temperatures of 40 ° C for 60 minutes/day, third group (P1)is exposed to temperatures of 40 ° C for 60 minutes/day and a solution of tuber extract bits dose of 100 mg / kgBB / day, fourth group (P2)is exposed to temperatures of 40 ° C for 60 minutes/day and a solution of tuber extract bits dose of 200 mg / kgBB / day, fifth group (P3) )is exposed to temperatures of 40 ° C for 60 minutes/day and a solution of tuber extract bits dose of 400 mg / kgBB / day. This research lasted for 36 days, at 37 th day all mice were terminated, then the sperm count, morphology spermatozoa and testis weigh was done. The results showed significant differences in the number, morphology of spermatozoa and testis weight between groups (P <0.05). But Duncan's test based on the number and morphology did not show any significant difference. Where the ethanol extract of root beet (Beta vulgaris L.) with a dose of 100 mg / kgBB / day, 200 mg / kgBB / day and 400 mg / kgBB/day can not fix and increase the amount of morphologically normal spermatozoa in mice induced heat for 60 minutes. And testis weight at a dose of 200 mg / kgBB / day and 400 mg / kgBB / day showed a significant difference where the results showed that the ethanol extract of the tuber bit heavy testes capable of repairing damaged by exposure to heat. Keywords: extract, beetroot, spermatozoa ,exposure to heat ____________________________________________________________________________________________

Evaluation of Parents’ Adherence in Giving Antibiotics on Respiratory Tract Infections (RTI) and Factors Associated with Adherence

Parents’ adherence in giving antibiotics plays an important role in therapeutic management of pediatric patients with respiratory tract infections and can avoid antibiotic resistance. The aims of this research are to evaluate parents’ adherence in giving antibiotic and factors associated with adherence. This research is conducted involving respondents from a primary health care center in Andalas, Padang who attended during April to August 2015. Adherence measurement has been done using pill counting method and MMAS (Morisky Medication Adherence Scale) containing 4 questions. By pill counting method, 43 respondents (65.15%) were found to be adherent in giving the antibiotic and 23 respondents (34.85%) were not. Assessment adherence using MMAS obtained 23 respondents (34.85%) had a high adherence, 31 respondents (46.97%) had a medium adherence, and 12 respondents (18.18%) had a low adherence. In this research, respondents are categorized as adherent if the rest of the antibiotics up to 20% and a score of MMAS are 0. Statistical analysis using Chi-square test, Fisher test and Kolmogorov-Smirnov have been done to investigate respondent and patient characteristic, and parents or patients habit factor associated with adherence. It can be concluded that from 66 recruited respondents, 23 respondents (34.85%) were adhere in giving antibiotic to patients. Factors associated with adherence are busy respondent, forgetful, patient seemed to recover, and patient cannot swallow