885 research outputs found
Secure Similar Sequence Query on Outsourced Genomic Data
The growing availability of genomic data is unlocking research potentials on genomic-data analysis. It is of great importance to outsource the genomic-analysis tasks onto clouds to leverage their powerful computational resources over the large-scale genomic sequences. However, the remote placement of the data raises personal-privacy concerns, and it is challenging to evaluate data-analysis functions on outsourced genomic data securely and efficiently. In this work, we study the secure similar-sequence-query (SSQ) problem over outsourced genomic data, which has not been fully investigated. To address the challenges of security and efficiency, we propose two protocols in the mixed form, which combine two-party secure secret sharing, garbled circuit, and partial homomorphic encryptions together and use them to jointly fulfill the secure SSQ function. In addition, our protocols support multi-user queries over a joint genomic data set collected from multiple data owners, making our solution scalable. We formally prove the security of protocols under the semi-honest adversary model, and theoretically analyze the performance. We use extensive experiments over real-world dataset on a commercial cloud platform to validate the efficacy of our proposed solution, and demonstrate the performance improvements compared with state-of-the-art works
In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion
Background: Metastasis is a leading cause of death among cancer patients. In the tumor microenvironment, altered levels of extracellular matrix proteins, such as collagens, can facilitate the first steps of cancer cell metastasis, including invasion into surrounding tissue and intravasation into the blood stream. However, the degree of misexpression of collagen genes in tumors remains understudied, even though this knowledge could greatly facilitate the development of cancer treatment options aimed at preventing metastasis. Methods: We systematically evaluate the expression of all 44 collagen genes in breast cancer and assess whether their misexpression provides clinical prognostic significance. We use immunohistochemistry on 150 ductal breast cancers and 361 cervical cancers and study DNA methylation in various epithelial cancers. Results: In breast cancer, various tests show that COL4A1 and COL4A2 overexpression and COL17A1 (BP180, BPAG2) underexpression provide independent prognostic strength (HR = 1.25, 95% CI = 1.17â1.34, p = 3.03 Ă 10; HR = 1.18, 95% CI = 1.11â1.25, p = 8.11 Ă 10; HR = 0.86, 95% CI = 0.81â0.92, p = 4.57 Ă 10; respectively). Immunohistochemistry on ductal breast cancers confirmed that the COL17A1 protein product, collagen XVII, is underexpressed. This strongly correlates with advanced stage, increased invasion, and postmenopausal status. In contrast, immunohistochemistry on cervical tumors showed that collagen XVII is overexpressed in cervical cancer and this is associated with increased local dissemination. Interestingly, consistent with the opposed direction of misexpression in these cancers, the COL17A1 promoter is hypermethylated in breast cancer and hypomethylated in cervical cancer. We also find that the COL17A1 promoter is hypomethylated in head and neck squamous cell carcinoma, lung squamous cell carcinoma, and lung adenocarcinoma, in all of which collagen XVII overexpression has previously been shown. Conclusions: Paradoxically, collagen XVII is underexpressed in breast cancer and overexpressed in cervical and other epithelial cancers. However, the COL17A1 promoter methylation status accurately predicts both the direction of misexpression and the increased invasive nature for five out of five epithelial cancers. This implies that aberrant epigenetic control is a key driver of COL17A1 gene misexpression and tumor cell invasion. These findings have significant clinical implications, suggesting that the COL17A1 promoter methylation status can be used to predict patient outcome. Moreover, epigenetic targeting of COL17A1 could represent a novel strategy to prevent metastasis in patients
Vacuum Instabilities with a Wrong-Sign Higgs-Gluon-Gluon Amplitude
The recently discovered 125 GeV boson appears very similar to a Standard
Model Higgs, but with data favoring an enhanced h to gamma gamma rate. A number
of groups have found that fits would allow (or, less so after the latest
updates, prefer) that the h-t-tbar coupling have the opposite sign. This can be
given meaning in the context of an electroweak chiral Lagrangian, but it might
also be interpreted to mean that a new colored and charged particle runs in
loops and produces the opposite-sign hGG amplitude to that generated by
integrating out the top, as well as a contribution reinforcing the W-loop
contribution to hFF. In order to not suppress the rate of h to WW and h to ZZ,
which appear to be approximately Standard Model-like, one would need the loop
to "overshoot," not only canceling the top contribution but producing an
opposite-sign hGG vertex of about the same magnitude as that in the SM. We
argue that most such explanations have severe problems with fine-tuning and,
more importantly, vacuum stability. In particular, the case of stop loops
producing an opposite-sign hGG vertex of the same size as the Standard Model
one is ruled out by a combination of vacuum decay bounds and LEP constraints.
We also show that scenarios with a sign flip from loops of color octet charged
scalars or new fermionic states are highly constrained.Comment: 20 pages, 8 figures; v2: references adde
Systematic decomposition of the neutrinoless double beta decay operator
We discuss the systematic decomposition of the dimension nine neutrinoless double beta decay operator, focusing on mechanisms with potentially small contributions to neutrino mass, while being accessible at the LHC. We first provide a (d = 9 tree-level) complete list of diagrams for neutrinoless double beta decay. From this list one can easily recover all previously discussed contributions to the neutrinoless double beta decay process, such as the celebrated mass mechanism or ÂżexoticsÂż, such as contributions from left-right symmetric models, R-parity violating supersymmetry and leptoquarks. More interestingly, however, we identify a number of new possibilities which have not been discussed in the literature previously. Contact to earlier works based on a general Lorentz-invariant parametrisation of the neutrinoless double beta decay rate is made, which allows, in principle, to derive limits on all possible contributions. We furthermore discuss possible signals at the LHC for mediators leading to the short-range part of the amplitude with one specific example. The study of such contributions would gain particular importance if there were a tension between different measurements of neutrino mass such as coming from neutrinoless double beta decay and cosmology or single beta decay
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP violation, which is necessary for the existence of such
electric dipole moments, are presented. These include the standard model of
particle physics and various extensions of it. Effective hadron level combined
charge conjugation (C) and parity (P) symmetry violating interactions are
derived taking into consideration different ways in which a nucleon interacts
with other nucleons as well as with electrons. Nuclear structure calculations
of the CP-odd nuclear Schiff moment are discussed using the shell model and
other theoretical approaches. Results of the calculations of atomic electric
dipole moments due to the interaction of the nuclear Schiff moment with the
electrons and the P and time-reversal (T) symmetry violating
tensor-pseudotensor electron-nucleus are elucidated using different
relativistic many-body theories. The principles of the measurement of the
electric dipole moments of diamagnetic atoms are outlined. Upper limits for the
nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained
combining the results of atomic experiments and relativistic many-body
theories. The coefficients for the different sources of CP violation have been
estimated at the elementary particle level for all the diamagnetic atoms of
current experimental interest and their implications for physics beyond the
standard model is discussed. Possible improvements of the current results of
the measurements as well as quantum chromodynamics, nuclear and atomic
calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for
EPJ
Reoperations after first lumbar disc herniation surgery; a special interest on residives during a 5-year follow-up
BACKGROUND: The overall rate of operations after recurrent lumbar disc herniation has been shown to be 3â11%. However, little is known about the rate of residives. Thus the aim of this study was to explore the cumulative rates of re-operations and especially residive disc herniations at the same side and level as the primary disc herniation after first lumbar disc herniation surgery and the factors that influence the risk of re-operations over a five year follow-up study. METHODS: 166 virgin lumbar disc herniation patients (mean age 42 years, 57% males) were studied. Data on patients' initial disc operations and type and timing of re-operations during the follow-up were collected from patient files. Back and leg pain on visual analog scale and employment status were collected by questionnaires. RESULTS: The cumulative rate of re-operations for lumbar disc herniation was 10.2% (95% Cl 6.0 to 15.1). The rate of residives at initial site was 7.4% (95% Cl 3.7 to 11.3) and rate of lumbar disc herniations at other sites was 3.1% (95% Cl 0.6 to 6.2). The occurrence of residive lumbar disc herniations was evenly distributed across the 5 years. Neither age, gender, preoperative symptoms, physical activity nor employment had effect on the probability of re-operation. CONCLUSION: Seven percent of the lumbar disc patients had a residive lumbar disc operation within five years of their first operation. No specific factors influencing the risk for re-operation were found
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