Peirce's sign theory as an open-source R package.

Throughout Peirce’s writing, we witness his developing vision of a machine that scientists will eventually be able to create. Nadin (2010) raised the question:Why do computer scientists continue to ignore Peirce’s sign theory? A review of the literature on Peirce’s theory and the semiotics machine reveals that many authors discussed the machine;however, they donot differentiate between a physical computer machine and its software. This paper discusses the problematic issues involved in converting Peirce’s theory into a programming language, machine and software application. We demonstrate this challenge by introducing Peirce’s sign theory as a software application that runs under an open-source R environmen

Nodes and Arcs: Concept Map, Semiotics, and Knowledge Organization.

Purpose – The purpose of the research reported here is to improve comprehension of the socially-negotiated identity of concepts in the domain of knowledge organization. Because knowledge organization as a domain has as its focus the order of concepts, both from a theoretical perspective and from an applied perspective, it is important to understand how the domain itself understands the meaning of a concept. Design/methodology/approach – The paper provides an empirical demonstration of how the domain itself understands the meaning of a concept. The paper employs content analysis to demonstrate the ways in which concepts are portrayed in KO concept maps as signs, and they are subjected to evaluative semiotic analysis as a way to understand their meaning. The frame was the entire population of formal proceedings in knowledge organization – all proceedings of the International Society for Knowledge Organization’s international conferences (1990-2010) and those of the annual classification workshops of the Special Interest Group for Classification Research of the American Society for Information Science and Technology (SIG/CR). Findings – A total of 344 concept maps were analyzed. There was no discernible chronological pattern. Most concept maps were created by authors who were professors from the USA, Germany, France, or Canada. Roughly half were judged to contain semiotic content. Peirceian semiotics predominated, and tended to convey greater granularity and complexity in conceptual terminology. Nodes could be identified as anchors of conceptual clusters in the domain; the arcs were identifiable as verbal relationship indicators. Saussurian concept maps were more applied than theoretical; Peirceian concept maps had more theoretical content. Originality/value – The paper demonstrates important empirical evidence about the coherence of the domain of knowledge organization. Core values are conveyed across time through the concept maps in this population of conference paper

Measures of greatness: A Lotkaian approach to literary authors using OCLC WorldCat

This study examines the productivity, eminence, and impact of literary authors using Lotka\u27s law, a bibliometric approach developed for studying the published output of scientists. Data on literary authors were drawn from two recent surveys that identified and ranked authors who had made the greatest contributions to world lit- erature. Data on the number of records of works by and about selected authors were drawn from OCLC WorldCat in 2007 and 2014. Findings show that the distribution of literary authors followed a pattern consistent with Lotka\u27s law and show that these studies enable one to empirically test subjective rankings of eminent authors. Future examination of distribution of author productivity might include studies based on language, location, and culture

Breaching the Blood-Brain Barrier as a Gate to Psychiatric Disorder

The mechanisms underlying the development and progression of psychiatric illnesses are only partially known. Clinical data suggest blood-brain barrier (BBB) breakdown and inflammation are involved in some patients groups. Here we put forward the “BBB hypothesis” and abnormal blood-brain communication as key mechanisms leading to neuronal dysfunction underlying disturbed cognition, mood, and behavior. Based on accumulating clinical data and animal experiments, we propose that events within the “neurovascular unit” are initiated by a focal BBB breakdown, and are associated with dysfunction of brain astrocytes, a local inflammatory response, pathological synaptic plasticity, and increased network connectivity. Our hypothesis should be validated in animal models of psychiatric diseases and BBB breakdown. Recently developed imaging approaches open the opportunity to challenge our hypothesis in patients. We propose that molecular mechanisms controlling BBB permeability, astrocytic functions, and inflammation may become novel targets for the prevention and treatment of psychiatric disorders

Bioenergetic mechanisms of seizure control

Epilepsy is characterized by the regular occurrence of seizures, which follow a stereotypical sequence of alterations in the electroencephalogram. Seizures are typically a self limiting phenomenon, concluding finally in the cessation of hypersynchronous activity and followed by a state of decreased neuronal excitability which might underlie the cognitive and psychological symptoms the patients experience in the wake of seizures. Many efforts have been devoted to understand how seizures spontaneously stop in hope to exploit this knowledge in anticonvulsant or neuroprotective therapies. Besides the alterations in ion-channels, transmitters and neuromodulators, the successive build up of disturbances in energy metabolism have been suggested as a mechanism for seizure termination. Energy metabolism and substrate supply of the brain are tightly regulated by different mechanisms called neurometabolic and neurovascular coupling. Here we summarize the current knowledge whether these mechanisms are sufficient to cover the energy demand of hypersynchronous activity and whether a mismatch between energy need and supply could contribute to seizure control

Leveraging Peer Feedback to Improve Visualization Education

Peer review is a widely utilized pedagogical feedback mechanism for engaging students, which has been shown to improve educational outcomes. However, we find limited discussion and empirical measurement of peer review in visualization coursework. In addition to engagement, peer review provides direct and diverse feedback and reinforces recently-learned course concepts through critical evaluation of others' work. In this paper, we discuss the construction and application of peer review in a computer science visualization course, including: projects that reuse code and visualizations in a feedback-guided, continual improvement process and a peer review rubric to reinforce key course concepts. To measure the effectiveness of the approach, we evaluate student projects, peer review text, and a post-course questionnaire from 3 semesters of mixed undergraduate and graduate courses. The results indicate that course concepts are reinforced with peer review---82% reported learning more because of peer review, and 75% of students recommended continuing it. Finally, we provide a road-map for adapting peer review to other visualization courses to produce more highly engaged students

Min-Rank Conjecture for Log-Depth Circuits

A completion of an m-by-n matrix A with entries in {0,1,*} is obtained by setting all *-entries to constants 0 or 1. A system of semi-linear equations over GF(2) has the form Mx=f(x), where M is a completion of A and f:{0,1}^n --> {0,1}^m is an operator, the i-th coordinate of which can only depend on variables corresponding to *-entries in the i-th row of A. We conjecture that no such system can have more than 2^{n-c\cdot mr(A)} solutions, where c>0 is an absolute constant and mr(A) is the smallest rank over GF(2) of a completion of A. The conjecture is related to an old problem of proving super-linear lower bounds on the size of log-depth boolean circuits computing linear operators x --> Mx. The conjecture is also a generalization of a classical question about how much larger can non-linear codes be than linear ones. We prove some special cases of the conjecture and establish some structural properties of solution sets.Comment: 22 pages, to appear in: J. Comput.Syst.Sci