Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Lineamientos para una gestión integral de los residuos de artículos eléctricos y electrónicos (RAEE) para los hogares de la ciudad de Ibagué

Los residuos de aparatos eléctricos y electrónicos -RAEE por sus siglas en español- es un tema de creciente interés en la comunidad científica por sus múltiples retos, no solo a nivel nacional sino también internacional: su rápida tasa de crecimiento anual, los componentes tanto tóxicos como valiosos que los componen, y por el nivel de informalidad en cuanto a su manejo que es entre otras la principal causa para la contaminación ambiental y los problemas de salud humana. En Colombia se han hecho algunos estudios frente a la generación de este flujo de residuos, se han generado diferentes normativas que finalizaron en la Política Nacional de Gestión de RAEE. Sin embargo, a nivel municipal aún siguen existiendo muchos vacíos de información sobre esta problemática, conllevando a una disposición incorrecta de RAEE. Parte de esta desinformación radica en la ausencia de casos de estudio de centros urbanos que aborden sus particularidades geográficas, socioeconómicas, ambientales y político-administrativas. Es por ello por lo que este trabajo busca presentar un diagnóstico y finalmente unos lineamientos para el manejo integral de RAEE en la ciudad de Ibagué, para lo cual se recopiló información de diagnóstico de RAEE en Ibagué, se realizaron entrevistas y a partir de estadísticas descriptivas e inferenciales, se obtienen conclusiones y lineamientos desde la ecología y la gestión ambiental para encontrar las estrategias oportunas, efectivas y ajustadas al contexto de esta ciudad.The waste of electrical and electronic equipment -RAEE by its acronym in Spanish- is a subject of growing interest in the scientific community for its many challenges, not only at the national level but also internationally: its rapid annual growth rate, the toxic components as valuable that compose them, and for the level of informality in terms of their management which is, among others, the main cause for environmental pollution and human health problems. In Colombia, some studies have been made regarding the generation of this waste stream, different regulations have been generated that ended in the National WEEE Management Policy. However, at the municipal level there are still many information gaps about this problem, leading to an incorrect provision of WEEE. Part of this misinformation lies in the absence of case studies of urban centers that address their geographical, socioeconomic, environmental and political-administrative particularities. That is why this work seeks to present a diagnosis and finally guidelines for the comprehensive management of WEEE in the city of Ibagué, for which WEEE diagnostic information was collected in Ibagué, interviews were conducted and from descriptive statistics and Inferential, conclusions and guidelines are obtained from the ecology and environmental management to find the opportune strategies, effective and adjusted to the context of this city

L'affinage des fromages fermiers lactiques

L'affinage des fromages fermiers lactique

Qualité des fromages fermiers lactiques : locaux et maitrise de l’affinage (LACTAFF)

Le programme LACTAFF (2012 – 2015) a eu pour objectif d’améliorer la maîtrise de l’affinage des fromages fermiers lactiques, technologie la plus couramment utilisée à la ferme, en fournissant des outils et des références aux producteurs et aux techniciens qui les accompagnent. Des enquêtes menées dans 49 fermes des 6 principales régions produisant ce type de fromage ont permis de caractériser la grande diversité des fromages fabriqués, des locaux, des équipements et des pratiques et d’établir des liens entre les grandes catégories de fromages et les pratiques, locaux et conditions d’ambiance. Par ailleurs, au laboratoire et en fromageries expérimentales, le rôle clé de l’hygrométrie a été quantifié en affinage, ainsi qu’au séchage où la vitesse d’air joue un rôle encore plus important. Les effets des paramètres d’ambiance sur la composition physico-chimique et les caractéristiques sensorielles des fromages ont été quantifiés pour un type de fromage donné.The « LACTAFF » program (2012-2015) aimed at improving the control of goat lactic farmhouse cheese ripening, a technology frequently used by farmers, by producing tools and references for producers and the technicians guiding them. Surveys conducted in 49 farms in the 6 main regions producing this kind of cheeses allowed to characterize the great diversity of cheeses, premises, equipment and practices, and to link cheese categories with practices, premises characteristics and air production conditions. In laboratory and experimental dairies, the key role of humidity was quantified during ripening and during drying, in which air speed is even more important. Atmospheric parameters effects on cheeses physicochemical composition and sensory characteristics were quantified for one type of cheeses. Specialist experience of cheese technology, premises design and climate control equipment and technician experience were capitalized at the same time. This project led to the writing of technical documents available online and a book about lactic farmhouse cheeses ripening