The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(¿6-C10H14)(Cl2)(dmoPTA)]

Complexes [Ru(¿6-C10H14)(Cl2)(HdmoPTA)](OSO2CF3) (1), [Ru(¿6-C10H14)(Cl2)(dmoPTA)] (2) and [Ru(¿6-C10H14)(Cl2)-µ-dmoPTA-1¿P:2¿2N, N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA=3, 7-dimethyl-1, 3, 7-triaza-5-phosphabicyclo[3.3.1]nonane) have been synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structures of 1, 3 and 5 were obtained by single-crystal X-ray diffraction. The antiproliferative activity of the complexes was evaluated against colon cancer cell line Caco-2/TC7 by using the MTT protocol. The monometallic ruthenium complexes 1 and 2 were found to be inactive, but the bimetallic complexes 3, 4 and 5 display an increased activity (IC50 3: 9.07±0.27, 4: 5.40±0.19, 5: 7.15±0.30 µM) compared to cisplatin (IC50=45.6±8.08 µM). Importantly, no reduction in normal cell viability was observed in the presence of the complexes. Experiments targeted to obtain information on the possible action mechanism of the complexes, such as cell cycle, ROS and gene expression studies, were performed. The results showed that the complexes display different properties and action mechanism depending on the nature of metal, M, bonded to the CH3NdmoPTA atoms. © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH Gmb

Geodynamic evolution of the lithosphere and upper mantle beneath the Alboran region of the western Mediterranean: Constraints from travel time tomography

An edited version of this paper was published by the American Geophysical Union. Copyright 2000, AGU. See also: http://www.agu.org/pubs/crossref/2000/2000JB900024.shtml; http://atlas.geo.cornell.edu/morocco/publications/calvert2000.htmA number of different geodynamic models have been proposed to explain the extension that occurred during the Miocene in the Alboran Sea region of the western Mediterranean despite the continued convergence and shortening of northern Africa and southern Iberia. In an effort to provide additional geophysical constraints on these models, we performed a local, regional, and teleseismic tomographic travel time inversion for the lithospheric and upper mantle velocity structure and earthquake locations beneath the Alboran region in an area of 800 x 800 km^2. We picked P and S arrival times from digital and analog seismograms recorded by 96 seismic stations in Morocco and Spain between 1989 and 1996 and combined them with arrivals carefully selected from local and global catalogs (1964-1998) to generate a starting data set containing over 100,000 arrival times. Our results indicate that a N-S line of intermediate depth earthquakes extending from crustal depths significantly inland from the southern Iberian coat to depths of over 100 km beneath the center of the Alboran Sea coincided with a W to E transition from high to low velocities imaged in the uppermost mantle. A high-velocity body, striking approximately NE-SW, is imaged to dip southeastwards from lithospheric depths beneath the low-velocity region to depths of ~350 km. Between 350 and 500 km the imaged velocity anomalies become more diffuse. However, pronounced high-velocity anomalies are again imaged at 600 km near an isolated cluster of deep earthquakes. In addition to standard tomographic methods of error assessment, the effects of systematic and random errors were assessed using block shifting and bootstrap resampling techniques, respectively. We interpret the upper mantle high-velocity anomalies as regions of colder mantle that originate from lithospheric depths. These observations, when combined with results from other studies, suggest that delamination of a continental lithosphere played an important role in the Neogene and Quaternary evolution of the region

Propagation of regional seismic phases (Lg and Sn) and Pn velocity structure along the Africa-Iberia plate boundary zone

An edited version of this paper was published by Blackwell Publishing. Copyright 2000, Blackwell Publishing. See also: http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-246x.2000.00160.x; http://atlas.geo.cornell.edu/morocco/publications/calvert2000GJI.htmWe used over 1000 regional waveforms recorded by 60 seismic stations located in northwest Africa and Iberia to map the efficiency of L g and Sn wave propagation beneath the Gulf of Cadiz, Alboran Sea and bounding Betic, Rif and Atlas mountain belts. Crustal attenuation is inferred from the tomographic inversion of L g/Pg amplitude ratios. Upper mantle attenuation is inferred from maps of Sn propagation efficiency derived by inversion of well-defined qualitative efficiency assignments based on waveform characteristics. Regions of L g attenuation correlate well with areas of thinned continental or oceanic crust, significant sedimentary basins, and lateral crustal variations. Comparison of the Sn efficiency results with velocities obtained from an anisotropic Pn traveltime inversion shows a fairly good correlation between regions of poor Sn efficiency and low Pn velocity. A low Pn velocity (7.6?7.8 km s-1) and significant Sn attenuation in the uppermost mantle is imaged beneath the Betics in southern Spain, in sharp contrast to the relatively normal Pn velocity (8.0?8.1 km s-1) and efficient Sn imaged beneath the Alboran Sea. Slow Pn velocity anomalies are also imaged beneath the Rif and Middle Atlas in Morocco. We do not identify any conclusive evidence of lithospheric-scale upper mantle attenuation beneath the Rif, although the crust in the Gibraltar region appears highly attenuating, making observations at stations in this region ambiguous. Paths crossing the Gulf of Cadiz, eastern Atlantic and the Moroccan and Iberian mesetas show very efficient Sn propagation and are imaged with high Pn velocities (8.1?8.2 km s-1). The spatial distribution of attenuation and velocity anomalies lead us to conclude that some recovery of the mantle lid beneath the Alboran Sea must have occurred since the early Miocene episode of extension and volcanism. We interpret the low velocity and attenuating regions beneath the Betics and possibly the Rif as indicating the presence of partial melt in the uppermost mantle which may be underlain by faster less attenuating mantle. In the light of observations from other geophysical and geological studies, the presence of melt at the base of the Betic crust may be an indication that delamination of continental lithosphere has played a role in the Neogene evolution of the Alboran Sea region

Tratamiento de defectos óseos sépticos masivos femorales mediante artroplastia total de fémur

Asociado al aumento en la frecuencia de artroplastia primaria, la cirugía protésica de recambio, en el contexto de un déficit de stock óseo es un escenario clínico cada vez más frecuente. En este tipo de pacientes, la artroplastia total de fémur aparece como una alternativa terapéutica válida, aunque no exenta de complicaciones. Presentamos 5 casos intervenidos de artroplastia total de fémur en nuestro centro entre los años 2012 y 2016. Todos los casos corresponden a pacientes que presentaban infección de artroplastia de cadera o rodilla, en quienes el déficit de stock óseo impedía una nueva cirugía de recambio. Fueron intervenidos 3 hombres y 2 mujeres con una media de edad de 60 años. El tiempo de seguimiento varió entre 6 y 67 meses. Tuvimos 3 casos de infección del implante femoral y un caso de luxación. El nivel de funcionalidad postoperatoria de los pacientes se midió con el score MSTS. El valor medio obtenido fue de 18,75 sobre un máximo de 30 puntos. Los mejores resultados se observaron en los apartados dolor y estado emocional. Por el contrario, los niveles más bajos resultaron de la necesidad de todos los pacientes, de utilizar algún dispositivo de ayuda para deambular. A pesar de la alta tasa de complicaciones obtenida, el nivel de satisfacción de los pacientes fue elevado. La mayoría de ellos refería estar muy contento con la intervención y no estar arrepentido de haberse operad

Obtained and characterization of composite materials W-Cu for electrical contact

9 páginas, 5 figuras, 4 tablas.-- Nota técnica.[ES] En el Centro de Investigaciones Metalúrgicas (CIME), cubano, se fabrican por pulvimetalurgia, calzos de material compuesto volframio-cobre, que se utilizan en los contactos eléctricos de los paneles de control de las grúas pórtico que operan en el puerto de Ciudad de La Habana. El material base que se utiliza contiene un 70 % en masa de polvo de cobre electrolítico y polvo de volframio (30 %), que se obtiene por reducción del óxido de volframio. Los polvos se someten a las etapas de mezclado, prensado y sinterización obteniéndose un material compuesto con las fases metálicas formadas por partículas libres de volframio ocluidas en una matriz de cobre, que no interaccionan entre sí. Este material compuesto proporciona al calzo de ajuste las siguientes propiedades: alta temperatura de fusión, alta electrotermoconductividad y resistencia a la corrosión, alta resistencia mecánica y a la erosión eléctrica, baja soldabilidad y estabilidad durante su explotación. Sin embargo, al no reaccionar las partículas de volframio con el cobre, el material compuesto comenzará a fundir a la temperatura del cobre; por otro lado y, por la misma razón la resistencia a la corrosión debe ser similar a la del cobre puro. Los calzos de ajuste se fijan a los cuerpos de cobre de alta pureza mediante una soldadura de una aleación de plata, la cual no afecta las buenas cualidades del cobre, como elasticidad, resistencia a la tracción, conductividad térmica y eléctrica, así como resistencia a la corrosión.[EN] In the Cuban Metallurgical Research Center (CIME), are manufactured by powder metallurgy, shims of adjustment of a W-Cu composite material, that are used in the electrical contacts of the panels of control of the portico derricks that operate in the port of Havana City. The base material used has a composition of 70 % in mass electrolytic copper powder and wolfram powder of (30 %) that is obtained by reduction from the oxide from wolfram. The powders are submitted to the stages of mixed, pressed and agglomeration and is obtained a composite material with free particles of W occluded in a counterfoil of Cu matrix, that do not interact and they provide the following properties: high melting temperature, high electro and thermo conductivity and corrosion resistance, high mechanical and electrical strengtheners, decrease weldability and stability during their development. However, when not reacting the volframio particles with the copper, the compound material will begin to fuse to the temperature of the copper, on the other hand and for the same reason the resistance to the corrosion should be similar to that of the pure copper. The shims of adjustment are fixed to the bodies of high purity copper welding with a silver alloy, the one which provides the maximum qualities of the Cu, as elasticity, breaking strength, thermal and electrical conductivities, as well corrosion resistance.Peer reviewe

Valorización de fosfoyeso como material de construcción: Aspectos radiológicos

Nowadays, alternative uses of phosphogypsum (PG) in the building industry are being considered in several countries; however, the natural radioactivity level in the PG could be a restriction for those uses. United States Environmental Protection Agency (US-EPA) classified PG as Technologically Enhanced Naturally Occurring Radioactive Material (TENORM). This drawback could be avoided controlling its percentage in the cement preparation and the radionuclides content in the other raw materials used in its production, and calculating the activity concentration index (I) in the final by-products. The valorization of PG as a building material has been studied, from a radiological point of view, by developing a new stabilisation/solidification process. PG is incorporated within a polymeric sulphur matrix, obtaining a concrete-like material, which presents lower natural radioactive content than the initial PG. The 226Ra content of this material ranged between 26-27 Bq·kg-1 and it is quite similar to that of common Spanish building materials.Actualmente, en muchos países se está contemplando el uso alternativo del fosfoyeso (PG) en la industria de la construcción, aunque su contenido en radionucleidos naturales puede presentar ciertas restricciones para dicha aplicación (material clasificado por la US-EPA como TENORM: “Technologically Enhanced Naturally Occurring Materials). No obstante, estos inconvenientes podrían paliarse controlando el porcentaje del PG y los niveles de radioactividad en las materias primas a incorporar al cemento y calculando el índice de concentración de actividad (I) en los productos finales. La valorización del PG como material de construcción se ha estudiado en este trabajo desde el punto de vista radiológico, desarrollando un nuevo proceso de estabilización/solidificación, obteniéndose un material de características similares al cemento y que presenta menor contenido de radionucleidos naturales que el PG inicial. Los niveles de 226Ra de este material (26-27 Bq·kg-1) son similares a los de algunos materiales de construcción utilizados comúnmente en España

Changes in the Diversity of Soil Arbuscular Mycorrhizal Fungi after Cultivation for Biofuel Production in a Guantanamo (Cuba) Tropical System

The arbuscular mycorrhizal fungi (AMF) are a key, integral component of the stability, sustainability and functioning of ecosystems. In this study, we characterised the AMF biodiversity in a native vegetation soil and in a soil cultivated with Jatropha curcas or Ricinus communis, in a tropical system in Guantanamo (Cuba), in order to verify if a change of land use to biofuel plant production had any effect on the AMF communities. We also asses whether some soil properties related with the soil fertility (total N, Organic C, microbial biomass C, aggregate stability percentage, pH and electrical conductivity) were changed with the cultivation of both crop species. The AM fungal small sub-unit (SSU) rRNA genes were subjected to PCR, cloning, sequencing and phylogenetic analyses. Twenty AM fungal sequence types were identified: 19 belong to the Glomeraceae and one to the Paraglomeraceae. Two AMF sequence types related to cultured AMF species (Glo G3 for Glomus sinuosum and Glo G6 for Glomus intraradices-G. fasciculatum-G. irregulare) did not occur in the soil cultivated with J. curcas and R. communis. The soil properties (total N, Organic C and microbial biomass C) were higher in the soil cultivated with the two plant species. The diversity of the AMF community decreased in the soil of both crops, with respect to the native vegetation soil, and varied significantly depending on the crop species planted. Thus, R. communis soil showed higher AMF diversity than J. curcas soil. In conclusion, R. communis could be more suitable for the long-term conservation and sustainable management of these tropical ecosytems

Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain

Circadian nutritional behaviors, defined by the daily eating/fasting cycle, have been linked with breast cancer. This study aimed to further disentangle the association of nighttime fasting duration and time of breakfast with breast cancer risk. We analyzed data from 1,181 breast cancer cases and 1,326 population controls from the Spanish multicase-control study (MCC-Spain), 2008-2013. We collected circadian nutritional behaviors at mid-age via a telephonic interview. We applied logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of nighttime fasting duration and time of breakfast with breast cancer risk in all women and stratified by menopausal status. Models were adjusted for age, center, education, family history of breast cancer, age at menarche, number of children, breastfeeding, age at first child, body mass index (BMI), contraceptive use, and hormonal replacement therapy (HRT). A later time of breakfast was associated with a non-significant increased risk of breast cancer (OR = 1.05, 95% CI: 0.95-1.16, per hour increase). This association was stronger among premenopausal women, among whom each hour later, the time of breakfast was associated with an 18% increase in breast cancer risk (OR = 1.18, 95% CI: 1.01-1.40). The association was not observed in postmenopausal women. We did not observe an association between nighttime fasting duration and breast cancer risk after adjusting for the time of breakfast. In this study, late breakfast was associated with increased breast cancer risk, especially among premenopausal women, compared with early breakfast. Aside from nutritional quality, circadian nutritional behaviors should be further studied in relation to cancer