119 research outputs found

    Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease

    Get PDF
    Cigarette smoking is the most important cause of chronic obstructive pulmonary disease (COPD). Although the precise sequence of events that leads a smoker to experience airway obstruction is not completely clear, airway inflammation is a relevant factor. To investigate airway inflammation, 12 nonatopic smoking COPD patients with a forced expiratory volume in one second (FEV1

    ‘Turpe senex miles, turpe senilis amor’ (Amores, 1, 9, 4): Ovidio, Cranach y Cervantes

    Get PDF
    Aristotle and Flora, Virgil in the basket, Susanna and the elders… These are different samples of a theme which enjoyed a notorious success in Europe from the last decades of the Fifteenth-century onwards. More than a simple mockery or moral lesson, the topic appears related to decorum as a basic principle in both art and life. In his paintings, Cranach paid special attention to ill-matched couples, as shown in a series of erotic scenes where a young damsel has an old man for lover; in his Quixote, guided by the Ovidian saying ‘Turpe senex miles, turpe senilis amor’ (Amores, 1, 9, 4), Cervantes transforms the traditional Perceval pattern in a new one. Contrary to expectations, it is an old man, not a youngster who undertakes the double adventure of war and love.Aristóteles y Flora, Virgilio en el cesto, Susana y los viejos… Por distintas vías, el tema del viejo lascivo se enseñorea del arte europeo, plástico y literario, desde las postrimerías del siglo XV en adelante. El asunto, amén de su dimensión jocosa y moral, interesa por su relación con el principio artístico del decoro. En las parejas desiguales (con una joven damisela y un anciano por amante) Cranach encuentra uno de sus asuntos recurrentes; en el Quijote, Cervantes da la vuelta al patrón de Perceval guiado por la máxima de Ovidio ‘Turpe senex miles, turpe senilis amor’ (Amores, 1, 9, 4). De ese modo, no es un joven sino un anciano quien se lanza a una doble aventura, militar y amorosa

    Adherence issues related to sublingual immunotherapy as perceived by allergists

    Get PDF
    Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers. © 2010 Scurati et al, publisher and licensee Dove Medical Press Ltd
    corecore