An approach to Sustainable Product Lifecycle Management (Green PLM)

Sustainable development has been, is and will be one of the worldwide main issues. Many initiatives have been launched to drive global conscientiousness to the problem of the impact of manufactured products. In order to become a green company , ecobrands and recycling are well understood but many initiatives are in silos and the unintended wasteful impact to other activities in the company is not always noticed. The key of sustainability also covers all the in-between activities and it depends on a real commitment of society, research and manufacturing firms. The factory of the future must have a Green Product Lifecycle Management strategy sharing responsibilities within the whole supply chain that must be achieved through committed people. The present work describes an approach to green product lifecycle involving mainstay phases: design, manufacturing and service, including usability and renewal. The contribution suggests a framework for sustainable product development that takes the whole product lifecycle into accountVila, C.; Abellán Nebot, JV.; Albiñana, J.; Hernandez, G. (2015). An approach to Sustainable Product Lifecycle Management (Green PLM). Procedia Engineering. 132:585-592. https://doi.org/10.1016/j.proeng.2015.12.608S58559213

An Approach to Conceptual and Embodiment Design within a New Product Development Lifecycle Framework

[EN] The design of new innovative products is the result of an accurate and precise management of knowledge sources all over its life cycle, such as technology, market, competitors and suppliers. The work contributes with a framework that shows how the knowledge sources influence in the state-of-the-art and market needs so that they become opportunities for innovating products addressing the whole product life cycle. It provides a systematic path from the early generation of ideas to the production of a new product proposal. Through a deep analysis of previous research works of new product innovation life cycle development frameworks and linking it with knowledge management, strategic planning and scorecards, we came out with a structured contribution. The result considers the concurrent activities and its relationships all the way through the product life cycle that can help in creativity and innovation, combined with a process management proposal. Managing the sources of knowledge in highly dynamic markets and technologies is one of the major difficulties involved in innovative products design and development. The emerging knowledge from external sources is confronted with organisation internal knowledge and experience in order to achieve the first product correct.This work was supported by the Spanish Government and the Universitat Jaume I of Castellon (Spain) through research [project number P11B2009-37], entitled 'Methodologies for Implementing Product lifecycle management tools for mechanical Small and Medium Enterprises'.Vila, C.; Albinana, JC. (2016). An Approach to Conceptual and Embodiment Design within a New Product Development Lifecycle Framework. International Journal of Production Research. 54(10):2856-2874. https://doi.org/10.1080/00207543.2015.1110632S28562874541

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

This is the final version. Available on open access from Nature Research via the DOI in this record. Data availability: Individual cohorts contributing to the meta-analysis should be contacted directly as each cohort has different data access policies. GWAS summary statistics from this study are available via the EGG website (https://egg-consortium.org/placental-weight-2023.html, https://www.ebi.ac.uk/gwas/), as well as the GWAS catalog (https://www.ebi.ac.uk/gwas/, accession numbers GCST90275189, GCST90275190, GCST90275191, GCST90275192, GCST90275193, GCST90275194, GCST90275195, GCST90275196, GCST90275197, GCST90275198, GCST90275199). Access to personal-level information from Gen3G (including methylation array data) is subject to controlled access according to participants’ consent concerning sharing of personal data. Request for conditions of access and for data access should be addressed to Center Hospitalier Universitaire de Sherbrooke institutional ethics committee: [email protected] availability: Analysis code is available from https://github.com/EarlyGrowthGenetics/placental_weight_codeA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.Wellcome Trus

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Estudio económico de los centros de enseñanza no estatal de la provincia de Navarra

Ayudar a los directivos y administradores a realizar un análisis sistemático de los costos en los propios centros, acomodándolos a las directrices oficiales actualmente existentes, en vistas a posibles conciertos económicos con el Estado. Conseguir unos datos homogéneos y estandarizados que permitan los estudios de tendencias y ratios para la mejora de la gestión de los centros, a la vez que facilite un estudio de costos totales y universitarios para las planificaciones del Sistema Educativo no estatal en la provincia. 49 Centros no estatales de la provincia de Navarra. Primero del modelo de gestión para centros docentes. Variables independientes: número de alumnos; número de secciones; alumnos por sección; horas semana de estancia alumnos en el centro docente; alumnos por profesor nominal; alumnos por profesor dedicación exclusiva; profesores por categorías laborales; profesores a dedicación exclusiva por categorías laborales; número de personas a dedicación exclusiva por sección; número de trienios; superficie; total de metros cuadrados dedicados a la enseñanza; metros cuadrados dedicados a la enseñanza por alumnos; metros cuadrados dedicados a la enseñanza por sección; gastos de personal por alumno (normal); gastos de personal por sección (normal); resto de gastos por alumno (normal); resto de gastos por sección (normal); gastos totales por conceptos y niveles (normal); gastos totales por alumno (normal); gastos totales por sección (normal); porcentaje de gastos totales por conceptos y niveles; gastos de personal por alumno (real); gastos de personal por sección (real); gastos totales (real); gastos totales por alumno (real) y así hasta 48 variables. Variable dependiente: costos de la educación. Encuestas de elaboración ad hoc autoadministradas por los responsables de los centros. Media. Mediana. Desviación típica. Ordenador. Los centros más grandes son aquellos que imparten todos los niveles y el tamaño medio por centro va decreciendo desde los centros que imparten desde Preescolar hasta el Curso de Orientación Universitaria, hasta los que únicamente imparten Preescolar. La media es de 36.73 alumnos por sección lo que les sitúa por debajo del máximo de 40 alumnos por sección que señala el Ministerio de Educación y Ciencia. Las horas estancia alumno aumentan con los niveles. Los alumnos por profesor nominal disminuyen con los niveles. Los alumnos por profesor a dedicación exclusiva disminuye con los niveles. Con gastos 'normales' la pérdida económica para la muestra es de 346.962.000 pesetas, lo que da una pérdida media por centro de 7.080.860 pesetas y para toda la provincia de 481.891.660 pesetas. El porcentaje de no cobertura es del 38.42 por ciento. Se manifiesta la importancia de aumentar las subvenciones a sus niveles de costo auténtico y en ampliación a los niveles de Preescolar y Bachillerato Unificado Polivalente.País VascoES

Development of Product Engineering Skills with PLM Applications Through Collaborative Educational Projects

Part 5: Education in the Field of Industry 4.0International audienceIn the industrial discipline of product design and manufacturing, training and learning methods for last academic course engineering students is difficult and complex since they have to integrate technical knowledge with computer-aided applications (CAx) and new skills in collaborative work. With the trends of Industry 4.0, companies request new talents and improved competences from the very first time. The fact that Product Lifecycle Management (PLM) platforms with a huge variety of tools support structured collaborative practices drives us to use them as a gear to integrate all the engineering and put it into practice for engineering content creation. In this contribution we present an innovative academic project for the last academic course students integrating several subjects in order to develop an industrial project working in a PLM platform. The platform allows us to control not only the data but also the scheduled activities of a project while the participants use different engineering applications in each phase of the project. Traditionally, engineering education deals with the learning of CAD, CAE and CAM tools separately, giving a partial learning experience and vision to the students. This communication presents a structured integrated vision of this learning project and the achieved results