Formation and anisotropic magnetoresistance of Co/Pt nano-contacts through aluminum oxide barrier

We report on the observation of anisotropic magnetoresistance (AMR) in vertical asymmetric nano-contacts (NCs) made through AlO$_x$ nano-oxide layer (NOL) formed by ion-assisted oxidation method in the film stack of Co/AlO$_x$-NOL/Pt. Analysis of NC formation was based on \emph{in situ} conductive atomic force microscopy and transmission electron microscopy. Depending on the purity of NCs from Al contamination, we observed up to 29% AMR ratio at room temperature

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

Copyright © 2014 Al-Mahdawi, Anjomani Virmouni and Pook. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.This article has been made available through the Brunel Open Access Publishing Fund.DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC) modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important epigenetic mark that is involved in the control of gene transcription for processes such as development and differentiation. However, recent studies have identified an alternative modification, 5-hydroxymethylcytosine (5hmC), which is formed by oxidation of 5mC by ten-eleven translocation (TET) enzymes. The overall levels of 5hmC in the mammalian genome are approximately 10% of 5mC levels, although higher levels have been detected in tissues of the central nervous system (CNS). The functions of 5hmC are not yet fully known, but evidence suggests that 5hmC may be both an intermediate product during the removal of 5mC by passive or active demethylation processes and also an epigenetic modification in its own right, regulating chromatin or transcriptional factors involved in processes such as neurodevelopment or environmental stress response. This review highlights our current understanding of the role that 5hmC plays in neurodegenerative diseases, including Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), fragile X-associated tremor/ataxia syndrome (FXTAS), Friedreich ataxia (FRDA), Huntington's disease (HD), and Parkinson's disease (PD).Sara Anjomani Virmouni was supported by funding to Mark A. Pook from the Friedreich’s Ataxia Research Alliance(FARA)

Epigenetics in Friedreich's ataxia: Challenges and opportunities for therapy

Copyright © 2013 Chiranjeevi Sandi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by homozygous expansion of a GAA·TTC trinucleotide repeat within the first intron of the FXN gene, leading to reduced FXN transcription and decreased levels of frataxin protein. Recent advances in FRDA research have revealed the presence of several epigenetic modifications that are either directly or indirectly involved in this FXN gene silencing. Although epigenetic marks may be inherited from one generation to the next, modifications of DNA and histones can be reversed, indicating that they are suitable targets for epigenetic-based therapy. Unlike other trinucleotide repeat disorders, such as Huntington disease, the large expansions of GAA·TTC repeats in FRDA do not produce a change in the frataxin amino acid sequence, but they produce reduced levels of normal frataxin. Therefore, transcriptional reactivation of the FXN gene provides a good therapeutic option. The present paper will initially focus on the epigenetic changes seen in FRDA patients and their role in the silencing of FXN gene and will be concluded by considering the potential epigenetic therapies.This study is supported by funding from the European Union Seventh Framework Programme (FP7/2007–2013) under Grant agreement no. 242193/EFACTS; and by funding from theWellcome Trust (089757)

Evaluation of salivary IL-10 and IL-8 as predictive biomarker in patient with oral and oropharyngeal squamous cell carcinoma

Background: The incidence and mortality rates of oral squamous cell carcinoma (OSCC) vary globally, yet the cancer continues to pose significant morbidity and mortality risks. This study sought to assess salivary IL-8 and IL-10 as biomarkers for identifying malignant oral lesions.  Methods: Between March 2022 and May 2023, a case-control study at the Dental Center of New Baquba, Diyala, Iraq, collected saliva for IL-8 and IL-10 measurement via ELISA. An independent t-test compared IL-8 and IL-10 means based on age and gender, while ROC analysis gauged specificity and sensitivity. Results: The prevalence of OSCC was evenly distributed across genders, with a higher occurrence among patients aged over 55 years (87.5%). OSCC distribution in the oral cavity indicated the lips as the most affected area (40.0%), followed by the tongue (37.0%), and the hard and soft palate (12.50%). Statistically significant differences were noted in IL-10 and IL-8 levels between the study and control groups across all age brackets, except for IL-8 in the age ≤55 (p ≤ 0.05). Elevated mean levels of IL-10 and IL-8 were observed in the older age group (>55), with IL-10 showing a greater increase in males (71.99±3.6), while IL-8 levels were higher in females. IL-10 demonstrated higher sensitivity (90%) and specificity (60%) with an optimal cutoff point value of 43.29, whereas IL-8 exhibited a sensitivity of 80% and a specificity of 47.5% with an optimal cutoff point value of 44.48. Conclusion: Individuals aged over 55 showed higher IL-10 and IL-8 levels, particularly in males for IL-10 and in females for IL-8. Salivary biomarkers hold promise for early OSCC detection

The Influence of Gender Differences on Jordanian Second Grade Pupils' Spelling in English

This study investigated The Influence of Gender Differences on Jordanian Second Grade Pupils' Spelling in English .The sample consisted of two second grade sections from Douqarah Co-educational Basic School (N= 33 male students and 29 female students) in the second semester of the academic year. 25 words spelling test was administered to identify differences in spelling skills. There were statistically significant differences between students' scores on the spelling achievement test due gender, in favor of the females. In light of these results, some recommendations were suggested

Eschatology in a Time of War: The Poetry of H.D. and Robert Lowell

The first half of the twentieth century was a fertile time for poetry with a new form and new content to match the sweeping changes of modernity. There is no doubt that the traumatic experience of two world wars had a profound effect on the art and culture of the time, urging writers to fathom the deep and disturbing ways in which war impacted upon the human spirit. This was a huge challenge, and an opportunity at the same time, for American poets to forge a new personal and authentic vision in response to political, cultural and intellectual changes, particularly within the context of religious belief. The thesis examines the work of H.D. and Robert Lowell, two American poets who were greatly preoccupied with war and its aftermath. Like many writers at that time, they were interested in the eschatologies of traditional religious beliefs and their role in changing people’s perceptions in trying times. Both poets write from the perspective of a Christian upbringing, but in their poems they articulate non-conformist eschatological visions, the formation process of which varies between revising, inverting or even negating these old conventions. They seek to delineate a new understanding and a new interpretation of orthodox eschatological and apocalyptic models, so as to relate more intensely and effectively with the momentous upheavals of the modern era. The purpose of the study is to shed light, within a personal and artistic framework, on the differences and similarities in the ways that the two poets approach the theme of war, focusing primarily on the poems written during or immediately after the Second World War. The thesis starts with an Introduction, which explores the significance of eschatology and the appeal of apocalypse in the modern age, especially in a time of war and catastrophe. The Introduction also touches upon the significance of bringing these two poets together in a single study. The first chapter presents H.D., a first-hand witness to the First World War, and her Imagist poems written during and after that war; while the second chapter discusses two of her most important collections of poems, What Do I love? and Trilogy. Written during the early 1940’s, the two books respond to the Second World War through syncretizing a modern feminine faith from different traditional systems of beliefs. Similarly, Lowell is designated two chapters. Chapter Three explores the poet’s presentation of an inverted version of the eschatological convention of Puritan Calvinism, his ancestors’ faith. His first two volumes, Land of Unlikeness and Lord Weary's Castle, written also during the early 1940’s, are discussed in this chapter. The last chapter of the thesis tackles Lowell’s important and well-known volume, Life Studies, written in late 1950’s, during the period of the Cold War. This work shows Lowell, the confessional and manic-depressive poet who, despite relinquishing his faith and (with it) his earlier poetic style of the 1940’s, is still preoccupied with war. The thesis claims that his modern spiritual eschatology is hidden under the mask of secularism and sceptical faith. It concludes with a Coda that sums up its main findings

Evaluation of salivary IL-10 and IL-8 as predictive biomarker in patient with oral and oropharyngeal squamous cell carcinoma

Background: The incidence and mortality rates of oral squamous cell carcinoma (OSCC) vary globally, yet the cancer continues to pose significant morbidity and mortality risks. This study sought to assess salivary IL-8 and IL-10 as biomarkers for identifying malignant oral lesions.  Methods: Between March 2022 and May 2023, a case-control study at the Dental Center of New Baquba, Diyala, Iraq, collected saliva for IL-8 and IL-10 measurement via ELISA. An independent t-test compared IL-8 and IL-10 means based on age and gender, while ROC analysis gauged specificity and sensitivity. Results: The prevalence of OSCC was evenly distributed across genders, with a higher occurrence among patients aged over 55 years (87.5%). OSCC distribution in the oral cavity indicated the lips as the most affected area (40.0%), followed by the tongue (37.0%), and the hard and soft palate (12.50%). Statistically significant differences were noted in IL-10 and IL-8 levels between the study and control groups across all age brackets, except for IL-8 in the age ≤55 (p ≤ 0.05). Elevated mean levels of IL-10 and IL-8 were observed in the older age group (>55), with IL-10 showing a greater increase in males (71.99±3.6), while IL-8 levels were higher in females. IL-10 demonstrated higher sensitivity (90%) and specificity (60%) with an optimal cutoff point value of 43.29, whereas IL-8 exhibited a sensitivity of 80% and a specificity of 47.5% with an optimal cutoff point value of 44.48. Conclusion: Individuals aged over 55 showed higher IL-10 and IL-8 levels, particularly in males for IL-10 and in females for IL-8. Salivary biomarkers hold promise for early OSCC detection

Effect of Hyper and Hypothyroidism on Lipid Profile and Liver Function of Male Rats

This study was designed to investigate the effect of thyroid hormone disturbance on lipids profiles and liver functions. Eighteen mature male rats Rattus norvegicus were divided into three groups. The first and the second groups were injected subcutaneously with thyroxine (T4) and carbimazol (both at 600 µg/kg BW) respectively on alternate days, to produce recurrent periods of hyper and hypothyroidism .The control group which is the third group was injected with physiological saline. The process continued 4 weeks, after that, injection, blood specimens were collected to estimate serum levels of T3 and T4, Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were determined in the serum. In addition to that, we measure GOT, GPT and CPK enzymes activity. The results showed no significant difference in body weight and a significant increase (

Optimization of open flow controller placement in software defined networks

The world is entering into the era of Big Data where computer networks are an essential part. However, the current network architecture is not very convenient to configure such leap. Software defined network (SDN) is a new network architecture which argues the separation of control and data planes of the network devices by centralizing the former in high level, centralised devices and efficient supervisors, called controllers. This paper proposes a mathematical model that helps optimizing the locations of the controllers within the network while minimizing the overall cost under realistic constrains. Our method includes finding the minimum cost of placing the controllers; these costs are the network latency, controller processing power and link bandwidth. Different types of network topologies have been adopted to consider the data profile of the controllers, links of controllers and locations of switches. The results showed that as the size of input data increased, the time to find the optimal solution also increased in a non-polynomial time. In addition, the cost of solution is increased linearly with the input size. Furthermore, when increasing allocating possible locations of the controllers, for the same number of switches, the cost was found to be less