Anatomical evaluation of nasopalatine canal on cone beam computed tomography images

Background: Nasopalatine canal (NPC) (incisive canal) morphology is important for oral surgery techniques carried out on the maxilla, in the treatment of naso- palatine cyst, palatal pathologies that require a surgical intervention. Materials and methods: The morphology of NPC was classified in sagittal, coronal and axial planes on the cone beam computed tomography (CBCT). The length of NPC was found by measuring the distance between the mid-points of nasopalatine foramen and incisive foramen. The numbers, shapes and diameters of incisive and nasopalatine foramina were examined. Nasopalatine angle present between the NPC and the palate and anterior to the NPC was measured.  Results: In the sagittal plane, the shape of NPC was classified in six groups: 26.7% hourglass, 14.7% cone, 13.3% funnel, 16.0% banana, 28.7% cylindrical and 0.7% reverse-cone-shaped. In the coronal plane, shape of NPC was classified in three groups: 63.3% Y-shaped, 36.0% single canal, 0.7% double canal and external border of NPC was classified in four groups: 26.7% U, 28.7% Y, 44.0% V and 0.7% reverse-V-shaped. In the axial plane, the shape of nasopalatine foramen, incisive foramen and NPC at the mid-level was evaluated. The shape of the canal was detected as four types at three evaluated levels: round, oval, heart- and triangle-shaped. It was seen in every three axial planes that the round group is more than the others.  Conclusions: The morphological properties and variations of NPC should be con- sidered with a correct radiological evaluation so as to prevent the complications and improper practices in local anaesthesia, maxillary surgery and implant surgery practices. Especially dentists, otolaryngologist and plastic surgeons need to know the anatomy and variations of NPC.

Kemalpasazade of ‘Gelür Gider” Rhymed of His Gazel Poem

Divan Edebiyatının önemli şairleri arasında yer alan Kemalpaşazâde, üretken bir müelliftir. Asıl adı Şemseddin Ahmed b. Süleyman olan Kemalpaşazâde, Kemalpaşaoğlu veya İbn Kemal diye de anılır. Yaşadığı XV. ve XVI. yüzyıl Osmanlı Devleti’nin ilim, kültür ve medeniyette zirveye yerleştiği bir dönemdir. Bu medeniyetin yetiştirdiği Kemalpaşazâde, farklı konularda tarih, edebiyat, hukuk ve din ilimlerinde Türkçe, Farsça, Arapça olmak üzere farklı dillerde eserler vermiştir. Şiiri hikmetli bir söz gibi değerlendiren ve eserlerinde de hikemî konulara ağırlık veren şairimiz, divan şiiri geleneğine kendi tarzıyla bir soluk katmıştır. Sade ve anlaşılır bir dille olan bu gazelinde tasavvuf temi şiirin omurgasını oluşturmuştur. Aşağıda incelediğimiz sufiyane gazel, şairin şiir dünyası ve kabiliyeti hakkında bizlere bir fikir verecektir.Kemalpaşazade, who is one of the important poets of the Divan Literature, is a believer. The real name is Şemseddin Ahmed b. Kemalpaşazâde, who is Süleyman, is called Kemalpaşaoğlu or Ibn Kemal. He lives in XV. and XVI. century Ottoman Empire is a period of climax in science, culture and civilization. Kemalpaşazâde, which this civilization cultivated, gave works in various languages including history, literature, law and religious sciences in Turkish, Persian and Arabic. Our poet, who treats poetry like a wise word and emphasizes witchcraft in his works, has added a breath of his own style to the divan poetry tradition. A mysterious example of mysticism in the gazelle is the backbone of poetry. The sufiyane gazel which we have studied below will give us an idea about the poetry's world of poetry and its ability

The Drosophila Dbf4 Ortholog Chiffon Forms A Complex with Gcn5 That Is Necessary for Histone Acetylation and Viability

Metazoans contain two homologs of the Gcn5-binding protein Ada2, Ada2a and Ada2b, which nucleate formation of the ATAC and SAGA complexes respectively. In Drosophila melanogaster, there are two splice isoforms of Ada2b: Ada2b-PA and Ada2b-PB. Here we show only the Ada2b-PB isoform is in SAGA; in contrast, Ada2b-PA associates with Gcn5, Ada3, Sgf29 and Chiffon forming the Chiffon Histone Acetyltransferase (CHAT) complex. Chiffon is theDrosophila ortholog of Dbf4, which binds and activates the cell cycle kinase Cdc7 to initiate DNA replication. In flies, Chiffon and Cdc7 are required in ovary follicle cells for gene amplification, a specialized form of DNA re-replication. Although chiffon was previously reported to be dispensable for viability, here we find that Chiffon is required for both histone acetylation and viability in flies. Surprisingly, we show that chiffon is a dicistronic gene that encodes distinct Cdc7- and CHAT-binding polypeptides. Although the Cdc7-binding domain of Chiffon is not required for viability in flies, Chiffon’s CHAT-binding domain is essential for viability but is not required for gene amplification, arguing against a role in DNA replication

Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice

Peer reviewedPublisher PD

Lay Perspectives on Receiving Different Types of Genomic Secondary Findings : a Qualitative Vignette Study

available at: https://rdcu.be/4BhDGenome-wide sequencing may generate secondary findings (SFs). It is recommended that validated, clinically actionable SFs are reported back to patients/research participants. To explore publics’ perspectives on the best ways to do this, we performed a vignette study among Finnish adults. Our aim was to explore how lay people react to different types of hypothetical genomic SFs. Participants received a hypothetical letter revealing a SF predisposing to a severe but actionable disease - cardiovascular disease (familial hypercholesterolemia, long QT syndrome) or cancer (Lynch syndrome, Li–Fraumeni syndrome). Participants (N=29) wrote down their initial reactions, and discussed (N=23) these in focus groups. Data were analyzed using inductive thematic analysis. Reactions to hypothetical SFs varied according to perceived severity and familiarity of the diseases. SFs for cancer were perceived as more threatening than for cardiovascular diseases, but less distressing than risk for psychiatric or neurological disorders, which participants spontaneously brought up. Illness severity in terms of lived experience, availability of treatment, stigma, and individual’s responsibility to control risk were perceived to vary across these disease types. In addition to clinical validity and utility, SF reporting practices need to take into account potential familiarity and lay illness representations of different diseases. Illness representations may influence willingness to receive SFs, and individuals’ reactions to this information.Peer reviewe