Doğu Akdeniz Bölgesi’nde Örtü Altı Organik Domates Üretiminde Hastalık, Zararlı ve Yabancı Otların Mücadelesinin Yönetimi

Bu çalışma, 2004-2007 yılları arasında Alata Bahçe Kültürleri Araştırma Enstitüsü’ne ait organik-topraklı, topraksız kültür (organik-inorganik yetiştirme ortamları) ve kontrol seralarında yürütülmüş olup, örtü altı organik domates yetiştiriciliğinde karşılaşılan hastalık, zararlı ve yabancı otlara karşı organik tarıma uygun mücadele yöntemlerinin uygulanabilirliği, en uygun sulama programı araştırılmıştır. Organik-topraklı sera ve organik-inorganik kökenli dört farklı yetiştirme ortamlarından oluşan topraksız kültür seralarında her türlü girdiler ve yapılacak işlemler Tarım Bakanlığınca yayımlanan organik tarım yönetmeliğe uygun olarak seçilmiştir. Organik-topraklı seradan elde edilen ürüne ‘organik ürün’ sertifikası alımına yönelik gerekli denetlemeler danışman kuruluş tarafından yapılarak ürün sertifikalandırılmıştır. Örtü altı organik domates yetiştiriciliğinde kültürel önlemlerden solarizasyonun yanı sıra yararlı mikrorganizmalardan da yararlanılması ile hastalık, zararlı ve yabancı ot kontrollerinde mücadele sayısının azaltıldığı ve verimde geleneksel yetiştiriciliğe oranla ekonomik anlamda bir azalma görülmediği sonucuna varılmıştır. Organik topraklı, kontrol serası ve farklı yetiştirme ortamlarında organik domates yetiştiriciliğinde su kullanım etkinliği değerleri her üç deneme yılında da artan sulama suyuna bağlı olarak azalma göstermiştir. Organik-inorganik kökenli farklı yetiştirme ortamlarından oluşan topraksız kültür yetiştiriciliğinin ise gerek topraktan kaynaklanan hastalık, nematod ve yabancı ot çıkışının olmaması gerekse erkenci olması açısından dolayı özellikle toprağın bulaşık olduğu alanlarda organik-topraklı tarıma alternatif bir yetiştiricilik olabileceği kanısına varılmıştır

Vibration-controlled transient elastography for non-invasive screening of liver fibrosis and steatosis in Turkish patients with A cross-sectional

Background and Aim: The prevalence of fibrosis and steatosis in patients with psoriasis, as determined by vibration-controlled transient elastography (VCTE), has not been evaluated in Turkiye to date. The present cross-sectional study aims to present the first systematic screening results, focusing on two primary objectives: 1) establishing the prevalence of fibrosis and steatosis, and 2) identifying independent predictors for liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) values in this patient population. Materials and Methods: Patients were eligible for inclusion if they had a confirmed diagnosis of psoriasis by a qualified dermatologist based on characteristic signs and symptoms and histopathological examination, and had undergone VCTE for LSM and CAP measurements. Results: The diagnosis of severe fibrosis and cirrhosis - identified by LSM values of 10.0-13.9 and >= 14.0 kPa, respectively - was significantly prevalent (7.0% and 10.1%, respectively) among a sizeable cohort of relatively young Turkish patients with psoriasis (n=328; mean age: 49.5 +/- 12.7 years). Additionally, severe steatosis, as diagnosed by VCTE and characterized by a CAP value exceeding 290 dB/m, was identified in up to 43.3% of patients. Although body mass index (BMI) was the only variable found to be an independently associated with LSM, multivariable linear regression analysis failed to identify any statistically independent predictor of CAP values. Conclusion: The prevalence of hepatic fibrosis and steatosis in Turkish patients with psoriasis is far from negligible, with BMI identified as an independent risk factor for fibrosis

Assessment of electromechanically stimulated bone marrow stem cells seeded acellular cardiac patch in a rat myocardial infarct model

In this study, we evaluated cardiomyogenic differentiation of electromechanically stimulated rat bone marrow-derived stem cells (rt-BMSCs) on an acellular bovine pericardium (aBP) and we looked at the functioning of this engineered patch in a rat myocardial infarct (MI) model. aBP was prepared using a detergent-based decellularization procedure followed by rt-BMSCs seeding, and electrical, mechanical, or electromechanical stimulations (3 millisecond pulses of 5 V cm-1at 1 Hz, 5% stretching) to enhance cardiomyogenic differentiation. Furthermore, the electromechanically stimulated patch was applied to the MI region over 3 weeks. After this period, the retrieved patch and infarct region were evaluated for the presence of calcification, inflammatory reaction (CD68), patch to host tissue cell migration, and structural sarcomere protein expressions. In conjunction with any sign of calcification, a higher number of BrdU-labelled cells, and a low level of CD68 positive cells were observed in the infarct region under electromechanically stimulated conditions compared with static conditions. More importantly, MHC, SAC, Troponin T, and N-cad positive cells were observed in both infarct region, and retrieved engineered patch after 3 weeks. In a clear alignment with other results, our developed acellular patch promoted the expression of cardiomyogenic differentiation factors under electromechanical stimulation. Our engineered patch showed a successful integration with the host tissue followed by the cell migration to the infarct region

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels >2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p < 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168

Long-term oriented internal management philosophies, their effects on HRM implementation and shop climates in franchised small businesses

This dissertation examines the effects of (1) owner’s long-term oriented internal management philosophies and (2) owner’s and shop manager’s transformational and transactional leadership styles on HRM content (i.e., HPWS) and process (i.e., HRM strength), shop climates (i.e., climates of concern for employees and service), and service quality. The study context consisted of franchised sales and service shops of a corporation operating in the Turkish retail sector providing technological products and services to the mass market. The research model and measures were constructed after a qualitative study conducted through visits to 15 shops and 73 in-depth interviews with various parties. Survey responses were collected from 1,278 employees, 587 shop managers, and 277 shop owners from a total of 1,031 shops. The results of the multilevel analyses indicated that owner’s long-term orientation was positively related to HRM strength, but not related to use of HPWS practices. Owner’s and shop manager’s transformational and transactional leadership behaviors were generally positively linked to HPWS and HRM strength. Owner’s long-term orientation was found to buffer the negative influence of manager’s transactional leadership on HRM strength. In addition to the positive main effect of HRM strength, HPWS and HRM strength had joint influences on both climate types. The interactions were such that HRM strength dominated over the positive influence of HPWS on shop climates. Furthermore, group cohesion moderated the HRM strength-climate relationships. Finally, service climate was positively related to service quality and this effect was also moderated by group cohesion. The implications of the results for theory and practice are discussed

Canavar otu türlerinin (Orobanche spp.) Çukurova Bölgesi'ndeki önemi ve mücadele olanakları üzerine araştırmalar

TEZ4399Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2002.Kaynakça (s. 145-156) var.xvıı, 157 s. ; 30 cm.…Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No:FBE.99.D.3

Uzun süreli biyouyumluluğun geliştirilmesi amacıyla biyomedikal poliüretanların sentezi ve yüzey modifikasyonu çalışmaları.

Thrombus formation and blood coagulation is a major problem associated with blood contacting products such as catheters, vascular grafts and artificial hearts. An intense research is being conducted towards the synthesis of new hemocompatible materials and mdifications of surfaces with biological molecules. In this study, polyurethane (PU) films were synthesized in medical purity from diisocyanate and polyol without using any other ingredients and the chemical, thermal and mechanical properties were characterized by solid state NMR, FTIR, GPC, mechanical tests, DMA and TGA. The surfaces of PU films were modified by covalent immobilization of different molecular weight heparins; low molecular weight heparin (LMWH) and unfractionated heparin (UFH) and these surfaces were examined by ESCA, ATR-FTIR, AFM and contact angle goniometer. Cell adhesion studies were conducted with whole human blood and examined by SEM. The effects of different types of heparins on blood protein adsorption and on platelet adhesion were analyzed by electrophresis and SEM, respectively. The surfaces of the UFH immobilized polyurethane films (PU-UFH) resulted in lesser red blood cell adhesion in comparison to LMWH immobilized polyurethane film surfaces (PU-LMWH). When the PU films were treated with blood plasma, the surfaces modified with two different heparin types showed a clearly different protein adsorption behavior especially in the early stage of blood plasma interaction. PU-LMWH samples showed about three times less protein adsorption compared to PU-UFH samples. The morphologies of platelets adhered on material surfaces demonstrated differences; such as PU-UFH had clusters with some pseudopodia extensions, while PU-LMWH had round shaped platelets with little clustering. PU surfaces modified by immobilization of LMWH and UFH, demonstrated promising results for the improvement of non-thrombogenic devices and surfaces.Ph.D. - Doctoral Progra

Trait activation in commitment to difficult goals: the role of achievement striving and situational cues

The current study utilized trait activation theory (TAT) (Tett & Burnett, 2003; Tett et al., 2013) to explain how the salience of goal-relevant performance-oriented social (i.e., manager's transformational leadership and peer performance norms) and organizational cues (i.e., reward expectancy) release or constrain employees' achievement striving (AS) personality trait and regulate the commitment to assigned difficult work goals. We also examined the effects of discretionary cues (signified by psychological empowerment) as trait activators. Hypotheses were tested using survey data collected from 297 managers employed in six large firms operating under a large Turkish family business group and using a common management-by-objectives system. In line with our predictions, when goals were perceived to be difficult, the associations between situational cues and goal commitment were inverse for employees with high versus low AS. When goal difficulty was high, performance-oriented situational cues were generally positively related to goal commitment for employees with high AS, but the relationships were negative for those with low AS. The results also showed that, for commitment to difficult goals, psychological empowerment activated the expression of high and low AS in a similar manner. Overall, the findings challenge the prevailing universalistic approaches to goal motivation