Teaching intercultural skills in the multicultural classroom

This paper evaluates the adaptation of the ExcelL Intercultural Skills Program to an international human resource management course, and critically examines the effectiveness of integrating case study methods with the skills based ExcelL program. The ExcelL program is a theory-driven and evidence-based group program that utilises classroom cultural diversity, student experiences and role-plays to develop specific intercultural skills. The primary purpose of the study was to assess the usefulness of ExcelL within a sample of 85 third-year university business students. Four methodologies were used: (1) questionnaires, (2) case studies, (3) course evaluation survey and (4) focus groups. After completing the program, participants demonstrated improvements in intercultural competencies required in business contexts as well as increased self-confidence and feelings of self-efficacy in cross-cultural situations. Additionally, participants demonstrated improved identification and articulation of cross-cultural business problems and formulation of appropriate intervention strategies to address these problems

Linear estimation of flux sensitivity to uncertainty in porous media

We derive an integral expression for the flux of a single-phase fluid through a porous medium with prescribed boundary conditions. Taking variations with respect to the parameters of a given permeability model yields an integral expression for the sensitivity of the flux. We then extend the method to consider linear changes in permeability. This yields a linearised flux expression which is independent of changes in the pressure field that result from the changes in the permeability. For demonstration purposes, we first consider an idealised layered porous medium with a point source and point sink. We show how the effects of changes in permeability are affected by the position of the source and sink relative to the layered structure as well as the layer height and orientation of the layered structure. The results demonstrate that, even in a simple porous system, flux estimates are sensitive to the way in which the permeability is represented. We derive relationships between the statistical moments of the flux and of the permeability parameters which are modelled as random variables. This allows us to estimate the number of permeability parameters that should be varied in a fully nonlinear calculation to determine the variance of the flux. We demonstrate application of the methods to permeability fields generated through fast Fourier transform and kriging methods. We show that the linear estimates for the variability in flux show good agreement with fully nonlinear calculations for sufficiently small standard deviations in the underlying permeability.The support of an Industrial CASE studentship from EPSRC and BP for A. J. Evans entitled "Optimal Reservoir Modelling" is gratefully acknowledged.This is the accepted manuscript. The final version is available from CUP at http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9603056&fileId=S0022112015001020

Incidence of acute mountain sickness in UK Military Personnel on Mount Kenya.

BACKGROUND: Acute mountain sickness (AMS) is a common problem of trekkers to high altitude. The UK military train at high altitude through adventurous training (AT) or as exercising troops. The ascent of Point Lenana at 4985 m on Mount Kenya is frequently attempted on AT. This study sought to establish the incidence of AMS within this population, to aid future planning for military activities at altitude. METHODS: A voluntary questionnaire was distributed to all British Army Training Unit Kenya based expeditions attempting to ascend Mount Kenya during the period from February to April 2014. The questionnaire included twice daily Lake Louise and Borg (perceived exertion scale) self-scoring. All expeditions were planned around a 5-day schedule, which included reserve time for acclimatisation, illness and inclement weather. RESULTS: Data were collected on 47 participants, 70% of whom reached the summit of Point Lenana. 62% (29/47) self-reported AMS (defined as Lake Louise score (LLS) ≥3) on at least one occasion during the ascent, and 34% (10/29) suffered severe AMS (LLS ≥6). Those who attempted the climb within 2 weeks of arrival in Kenya had a higher incidence of AMS (12/15 (80%) vs 17/32 (53%), p=0.077). Participants recording a high Borg score were significantly more likely to develop AMS (16/18 vs 9/21, p=0.003). CONCLUSIONS: This represents the first informative dataset for Mount Kenya ascents and altitude. The incidence of AMS during AT on Mount Kenya using this ascent profile is high. Adapting the current ascent profile, planning the ascent after time in country and reducing perceived exertion during the trek may reduce the incidence of AMS

A computational method for the investigation of multistable systems and its application to genetic switches

BACKGROUND: Genetic switches exhibit multistability, form the basis of epigenetic memory, and are found in natural decision making systems, such as cell fate determination in developmental pathways. Synthetic genetic switches can be used for recording the presence of different environmental signals, for changing phenotype using synthetic inputs and as building blocks for higher-level sequential logic circuits. Understanding how multistable switches can be constructed and how they function within larger biological systems is therefore key to synthetic biology. RESULTS: Here we present a new computational tool, called StabilityFinder, that takes advantage of sequential Monte Carlo methods to identify regions of parameter space capable of producing multistable behaviour, while handling uncertainty in biochemical rate constants and initial conditions. The algorithm works by clustering trajectories in phase space, and iteratively minimizing a distance metric. Here we examine a collection of models of genetic switches, ranging from the deterministic Gardner toggle switch to stochastic models containing different positive feedback connections. We uncover the design principles behind making bistable, tristable and quadristable switches, and find that rate of gene expression is a key parameter. We demonstrate the ability of the framework to examine more complex systems and examine the design principles of a three gene switch. Our framework allows us to relax the assumptions that are often used in genetic switch models and we show that more complex abstractions are still capable of multistable behaviour. CONCLUSIONS: Our results suggest many ways in which genetic switches can be enhanced and offer designs for the construction of novel switches. Our analysis also highlights subtle changes in correlation of experimentally tunable parameters that can lead to bifurcations in deterministic and stochastic systems. Overall we demonstrate that StabilityFinder will be a valuable tool in the future design and construction of novel gene networks

Valkai András (1540–1586) Báthory-genealógiája. Báthory István király mint az Árpádok leszármazottja

Purpose Heat adaptation (HA) is critical to performance and health in a hot environment. Transition from short-term heat acclimatisation (STHA) to long-term heat acclimatisation (LTHA) is characterised by decreased autonomic disturbance and increased protection from thermal injury. A standard heat tolerance test (HTT) is recommended for validating exercise performance status, but any role in distinguishing STHA from LTHA is unreported. The aims of this study were to (1) define performance status by serial HTT during structured natural HA, (2) evaluate surrogate markers of autonomic activation, including heart rate variability (HRV), in relation to HA status. Methods Participants (n = 13) were assessed by HTT (60-min block-stepping, 50% VO2peak) during STHA (Day 2, 6 and 9) and LTHA (Day 23). Core temperature (Tc) and heart rate (HR) were measured every 5 min. Sampling for HRV indices (RMSSD, LF:HF) and sympathoadrenal blood measures (cortisol, nephrines) was undertaken before and after (POST) each HTT. Results Significant (P < 0.05) interactions existed for Tc, logLF:HF, cortisol and nephrines (two-way ANOVA; HTT by Day). Relative to LTHA, POST results differed significantly for Tc (Day 2, 6 and 9), HR (Day 2), logRMSSD (Day 2 and Day 6), logLF:HF (Day 2 and Day 6), cortisol (Day 2) and nephrines (Day 2 and Day 9). POST differences in HRV (Day 6 vs. 23) were + 9.9% (logRMSSD) and − 18.6% (logLF:HF). Conclusions Early reductions in HR and cortisol characterised STHA, whereas LTHA showed diminished excitability by Tc, HRV and nephrine measures. Measurement of HRV may have potential to aid real-time assessment of readiness for activity in the heat

An open-label randomised clinical trial to compare the efficacy of dietary caloric restriction and physical activity for weight loss in overweight pet dogs

Canine obesity is usually managed with a combination of dietary caloric restriction and increasing physical activity, but no previous study has compared both of these strategies in a prospective randomised controlled trial. Thirteen overweight dogs (body condition score 6–9/9) were randomised to one of two interventions: dietary caloric restriction or physical activity. The dietary caloric restriction intervention comprised feeding a therapeutic weight loss diet, while the physical activity intervention comprised increasing the dog’s current physical activity pattern by at least a third. The primary outcome measure was change in body weight, while secondary outcome measures included change in neck, thorax and abdominal circumference and change in physical activity measured by triaxial accelerometer. Bodyweight decreased significantly with the dietary caloric restriction (median −10% of starting body weight [SBW], 5 to −12%; P = 0.028) but not with the physical activity intervention (−2% SBW, +3% to −6%; P = 0.107). Abdominal circumference (dietary caloric restriction: median −12.0%; physical activity: median −7.8%, P = 0.016) and thoracic circumference (dietary caloric restriction: median −7.5%, P = 0.031; physical activity: median −3.6%, P = 0.031) changed significantly in both groups. There was no change in activity levels within the dietary caloric restriction group, but vigorous activity increased significantly in the physical activity group (P = 0.016). Dietary caloric restriction was more effective than physical activity for controlled weight loss in overweight pet dogs. Although advising owners to increase their dog’s activity by a third led to a modest increase in measured vigorous physical activity, this was insufficient to promote weight loss on its own

Madness decolonized?: Madness as transnational identity in Gail Hornstein’s Agnes’s Jacket

The US psychologist Gail Hornstein’s monograph Agnes’s Jacket: A Psychologist’s Search for the Meanings of Madness (2009) is an important intervention in the identity politics of the mad movement. Hornstein offers a resignified vision of mad identity that embroiders the central trope of an “anti-colonial” struggle to reclaim the experiential world “colonized” by psychiatry. A series of literal and figurative appeals make recourse to the inner world and (corresponding) cultural world of the mad, as well as to the ethno-symbolic cultural materials of dormant nationhood. This rhetoric is augmented by a model in which the mad comprise a diaspora without an origin, coalescing into a single transnational community. The mad are also depicted as persons displaced from their metaphorical homeland, the “inner” world “colonized” by the psychiatric regime. There are a number of difficulties with Hornstein’s rhetoric, however. Her “ethnicity-and-rights” response to the oppression of the mad is symptomatic of Western parochialism, while her proposed transmutation of putative psychopathology from limit upon identity to parameter of successful identity is open to contestation. Moreover, unless one accepts Hornstein’s porous vision of mad identity, her self-ascribed insider status in relation to the mad community may present a problematic “re-colonization” of mad experience

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying obesity-induced IR in skeletal muscle remains controversial; reduced post-receptor signalling of the insulin receptor substrate 1 (IRS1) adaptor protein and downstream effectors such as protein kinase B (PKB) have previously been implicated. We examined expression and/or activation of a number of components of the insulin-signalling cascade in skeletal muscle of 22 healthy young men (with body mass index (BMI) range, 20–37 kg/m2). Whole body insulin sensitivity (M value) and body composition was determined by the hyperinsulinaemic (40 mU. min−1.m−2.), euglycaemic clamp and by dual energy X-ray absorptiometry (DEXA) respectively. Skeletal muscle (vastus lateralis) biopsies were taken before and after one hour of hyperinsulinaemia and the muscle insulin signalling proteins examined by western blot and immunoprecipitation assay. There was a strong inverse relationship between M-value and BMI. The most striking abnormality was significantly reduced insulin-induced activation of p42/44 MAP kinase, measured by specific assay, in the volunteers with poor insulin sensitivity. However, there was no relationship between individuals' BMI or M-value and protein expression/phosphorylation of IRS1, PKB, or p42/44 MAP kinase protein, under basal or hyperinsulinaemic conditions. In the few individuals with poor insulin sensitivity but preserved p42/44 MAP kinase activation, other signalling defects were evident. These findings implicate defective p42/44 MAP kinase signalling as a potential contributor to obesity-related IR in a non-diabetic population, although clearly multiple signalling defects underlie obesity associated IR