”New” POPs in marine mammals in Nordic Arctic and NE Atlantic areas during three decades

The report describes the findings of a Nordic study aiming to depict possible trends in “new” contaminants in marine mammals in Nordic Arctic waters over three decennia. The “new” contaminants in focus are the brominated flame retardants, BFRs, methoxylated PBDEs, perfluorinated compounds including the PFOS family, and polychlorinated naphthalenes, PCNs. In addition, brominated dioxins and dibenzofurans were analysed in a subset of the samples. The study aims at giving a wide scope of the presence of a selection of these “new” contaminants in marine mammals in recent time and so far back as is possible with extracting samples from specimen banks. The marine mammal species analysed were fin whale, minke whale, pilot whale, white-sided dolphins, harbour porpoise, ringed seal and hooded seal. The study is the result of collaboration between Norway, Denmark/Greenland, Faroe Island, Iceland and Sweden. The funding for large parts of the project has been made available by the Nordic Council of Ministers via the working group on Akvatiska Ekosystemer

Per- and poly-fluoroalkyl substances (PFASs) in follicular fluid from women experiencing infertility in Australia

Per- and poly-fluoroalkyl substances (PFASs) have been widely used and detected in human matrices. Evidence that PFAS exposure may be associated with adverse human reproductive health effects exists, however, data is limited. The use of a human matrix such as follicular fluid to determine chemical exposure, along with reproductive data will be used to investigate if there is a relationship between PFAS exposure and human fertility. Objective: This study aims to: (1) assess if associations exist between PFAS concentrations and/or age and fertilisation rate (as determined in follicular fluid of women in Australia who received assisted reproductive treatment (ART)); and (2) assess if associations exist between PFAS concentrations and infertility aetiology. Methods: Follicular fluids were originally collected from participants who underwent fully stimulated ART treatment cycles at an in vitro fertilisation (IVF) clinic in the period 2006–2009 and 2010–11 in Queensland, Australia. The samples were available for analysis of 32 PFASs including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA) using high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). 97 samples were matched with limited demographic data (age and fertilisation rate) and five infertility factors (three known female factors): 1) endometriosis, 2) polycystic ovarian syndrome (PCOS), and 3) genital tract infections - tubal/pelvic inflammation disease; as well as 4) male factor, and 5) idiopathic or unknown from either males or females. SPSS was used for linear regression analysis. Results: PFASs were detected in all follicular fluid samples with the mean concentrations of PFOS and PFOA, 4.9, and 2.4 ng/ml, respectively. A lower fertilisation rate was observed at higher age when age was added as a covariate, but there was no relationship between PFAS concentrations and fertilisation rate. There were few statistically significant associations between PFAS concentrations in follicular fluid and infertility factors. Log-transformed PFHxS concentrations were lower in females with endometriosis (factor 1) than in women who had reported ‘male factors’ as a reason of infertility, while PFHpA was higher in women who had infertile due to female factors (factor 1–3) compared to those who had infertile due to male factor. Conclusion: PFASs were detected in follicular fluid of Australian women who had been treated at an IVF clinic. PFAS exposure found in follicular fluids is linked to increased risk of some infertility factors, and increased age was associated with decreased fertilisation rate in our data. But there was no relationship between PFAS and ferlitisation rate. Further large-scale investigations of PFAS and health effects including infertility are warranted

Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring

Perfluoralkyl and polyfluoralkyl substances have been measured in plasma and serum of pregnant women as a measure of prenatal exposure. Increased concentrations of individual perfluoroalkyl acids (PFAAs), (typically perfluorooctanoic acid (PFOA) and perfluoroctane sulfonate (PFOS) have been reported to be associated with reductions in birth weight and other birth outcomes. We undertook a study of 14 PFAAs in whole blood (including PFOS, PFHxS, PFHpA, PFOA, PFNA, PFDA and PFUnDA) from 98 pregnant women in Western Australia from 2008 to 2011. Median concentrations (in μg/L) were: PFOS 1.99; PFHxS 0.33; PFOA 0.86; PFNA 0.30; PFDA 0.12 and PFUnDA 0.08. Infants born to women with the highest tertile of PFHxS exposure had an increased odds of being b95% of their optimal birth weight (OR 3.5, 95% CI 1.1 11.5). Conversely, maternal blood concentrations of PFUnDA were associated with non-significant increases in average birth weight (+102 g, 95% CI −41, 245) and significant increases in proportion of optimal birth weight (+4.7%, 95% CI 0.7, 8.8) per ln-unit change. This study has reported a range of PFAAs in the whole blood of pregnant women and suggests that PFHxS and PFUnDA may influence foetal growth and warrant further attention. Additional studies are required to identify the sources of PFAA exposure with a view to prevention, in addition to further studies investigating the long term health effects of these ubiquitous chemicals

"New" POPs in marine mammals in Nordic Arctic and NE Atlantic areas during three decades

Marine mammals hold a special position in the hearts of people inhabiting Nordic Arctic areas and in coastal communities around the North Atlantic Ocean as they are an essential part of the diet and traditional life-style. However, marine mammals are in a particularly vulnerable position as regards environmental pollutants, because of the large fat stores in their bodies which serve as a “magnet” to a large number of persistent and toxic pollutants.     A Nordic Council of Ministers supported collaboration between Norway, Denmark/Greenland, Faroe Island, Iceland and Sweden set out to look for possible trends in “new” contaminants in marine mammals in Nordic Arctic waters. The “new” contaminants in focus are the brominated flame retardants including the PBDEs, methoxylated PBDEs, perfluorinated compounds including the PFOS family, and polychlorinated naphthalenes. In addition, a subset of the samples was analysed for brominated dioxins and dibenzofurans. The marine mammals studied were fin whale, minke whale, pilot whale, white-sided dolphins, harbour porpoise, ringed seal and hooded seal. The study aims at giving a wide scope of the presence of  these ”new” contaminants in marine mammals in recent time and going back to the 1980s using samples from specimen banks