Coxsackie B2 Virus Infection Causing Multiorgan Failure and Cardiogenic Shock in a 42-Year-Old Man

Infections from coxsackie B2 viruses often cause viral myocarditis and, only rarely, multisystem organ impairment. We present the unusual case of a 42-year-old man in whom coxsackie B2 virus infection caused multiorgan infection, necessitating distal pancreatectomy, splenectomy, renal dialysis, and venoarterial extracorporeal membrane oxygenation with mechanical ventilation. In addition, the patient had a rapid-eye-movement sleep-related conduction abnormality that caused frequent sinus pauses of longer than 10 s, presumably due to myocarditis from the coxsackievirus infection. He recovered after permanent pacemaker placement and was discharged from the hospital. We discuss our aggressive supportive care and the few other reports of multiorgan impairment from coxsackieviruses

Central Nervous System Strategy for Roche Pharmaceuticals

Roche is the fifth largest pharmaceutical and biotechnology company in the world with $52B in sales during 2013 and 4.9% market share in the pharmaceutical industry. Its main competitors include Novartis, Pfizer, Johnson & Johnson, Sanofi, Merck & Co., and GlaxoSmithKline. Roche’s mission is to develop treatments for medical needs that have gone unmet and to create more efficient treatment options through cutting edge research. The Central Nervous System market segment makes up 19.6% of total industry sales and includes products treating such ailments as depression, epilepsy, psychosis, and Alzheimer’s disease. Though historically Roche has been a market leader in this segment, in recent years its Share of Market (SOM) has declined. Alzheimer’s disease is a progressive degenerative illness that causes memory loss, personality changes, loss of mobility, and death. Currently 35MM people, word wide, are suffering from the disease. The greatest predictors of Alzheimer’s disease are age and genetics. Therefore the number of people infected with the disease is expected to increase dramatically in the coming years as the global populate ages. Currently there are five FDA approved treatments for the disease, however they are ineffective as the best possible outcome is an increase in life expectancy of only 12 months. The objective of this undergraduate research project is to recommend a central nervous system corporate strategy for Roche, which would involve the development of a new drug to treat Alzheimer’s disease. This strategy would help Roche to retain or even strengthen its SOM against competitors

The Effect of Perceived Level of Social Support on the Fear of Falling

Background: Perhaps the most prevalent cause of anxiety among the elderly is the fear of falling (FOF), considering that a fall can lead to serious complications and the decline of health. Kumar et al. found that subjects with a FOF usually have less social support. Therefore, increased social support could possibly decrease the FOF, thus decreasing the likelihood of a fall overall. The purpose of this study is to examine the relationship between the amount of perceived social support one receives and the FOF among people ages 60 and up. Methods: In order to measure FOF and social support among participants, the Falls Efficacy Scale-International and the Multidimensional Scale of Perceived Social Support were administered to forty-three individuals ages 60 and older either living in assisted living facilities, independently or with a loved one. Both scales have been shown to be both valid and reliable. Results: Overall, this population did not yield significant results for FOF vs. social support; however, many significant results were found regarding important social and physical factors

Treatment of Iron Tailings at the Forecariah Guinea Mine - Guinea Conakry

Forecariah Guinea Mine SA (FGMSA) in Guinea - Conakry mines and processes Iron ore. About 0.5 Mt of tailings material has already been generated with additional 4000 tons generated daily. This paper presents a re-treatment technology for the Iron tailings obtained from the processing plant of FGMSA. Metallurgical tests were carried out on the tailings to determine which process route gives the most satisfactory result in terms of recovery and cost. Two representative samples (FCOPD-01 and FCDOP-02), taking from the tailings, were investigated. Particle Size Distribution (PSD) and chemical composition of various size fractions of representative samples of the tailings were performed. Dense Medium Separation (DMS) and Magnetic Separation (WHIMS) were also performed on a number of size fractions. The initial chemical composition of the various size fractions shows that the highest Fe grades were present in the +1 mm fractions at 58.8% and 58.6% for FCOPD-01 and FCOPD-02 respectively. The PSD of the tailings also indicated a mass yield of 77.9% for the +1 mm fraction and 22.1% for the -1 mm fraction. Contaminant Oxides, such as Al2O3 and SiO2 tend to be higher in the finer size fractions (-1 mm) of both samples. Result from the DMS analysis performed on the (-4 +0.5) mm fraction shows an underflow mass yields of 45.98% with Fe grade of 65.55% and overflow mass yield of 53.08% with Fe grade of just 13.5%. Magnetic separation (WHIMS) results on the (-4 +0.5) mm samples also gave varied mass yield and Fe grade at different magnetic intensities (3000 Gauss, 6000 Gauss and 10,000 Gauss). However, the highest Fe mass yield and grade produced from the magnetic separation were 18.10% and 50.8% respectively. The results show that DMS technique has the potential to re-treat the tailings at FGMSA. Keywords: Treatment, Iron ore, Tailings, Magnetic separation, Dense Medium Separatio

Acute reperfusion intramyocardial hemorrhage leads to regional chronic iron deposition in the heart

Intramyocardial hemorrhage commonly occurs in large reperfused myocardial infarctions. However, its long-term fate remains unexplored. We hypothesized that acute reperfusion intramyocardial hemorrhage leads to chronic iron deposition

Parental Co‐Construction of 5‐ to 13‐Year‐Olds\u27 Global Self‐Esteem Through Reminiscing About Past Events

The current study explored parental processes associated with children\u27s global self‐esteem development. Eighty 5‐ to 13‐year‐olds and one of their parents provided qualitative and quantitative data through questionnaires, open‐ended questions, and a laboratory‐based reminiscing task. Parents who included more explanations of emotions when writing about the lowest points in their lives were more likely to discuss explanations of emotions experienced in negative past events with their child, which was associated with child attachment security. Attachment was associated with concurrent self‐esteem, which predicted relative increases in self‐esteem 16 months later, on average. Finally, parent support also predicted residual increases in self‐esteem. Findings extend prior research by including younger ages and uncovering a process by which two theoretically relevant parenting behaviors impact self‐esteem development